المؤلفون: Jakob Bouton (9661745), Ludmila Ferreira de Almeida Fiuza (10500197), Camila Cardoso Santos (10500200), Maria Angela Mazzarella (10500203), Maria de Nazaré Correia Soeiro (10500206), Louis Maes (191127), Izet Karalic (1372623), Guy Caljon (119879), Serge Van Calenbergh (7411508)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, optimization efforts, Trypanosoma brucei, process purines, anti-Trypanosoma cruzi, vivo evaluation, nucleobase 7- position, pyrimidine Nucleosides, drug discovery, 7- modifications, antiparasitic agents, antileishmanial agents, Purine nucleoside analogues, anti-Trypanosoma cruzi activities, Chagas disease mouse model, purine synthesis, kinetoplastid parasites, Antileishmanial Agents Chagas disease

Relation: https://figshare.com/articles/journal_contribution/Revisiting_Pyrazolo_3_4_i_d_i_pyrimidine_Nucleosides_as_Anti-Trypanosoma_cruzi_and_Antileishmanial_Agents/14343053

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00135.s001

المؤلفون: Dorien Mabille, Camila Cardoso Santos, Rik Hendrickx, Mathieu Claes, Peter Takac, Christine Clayton, Sarah Hendrickx, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Guy Caljon

المصدر: Microorganisms; Volume 9; Issue 4; Pages: 826

مصطلحات موضوعية: trypanosomiasis, nucleoside analogues, RNAi, drug target, 4E-interacting protein

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Parasitology; https://dx.doi.org/10.3390/microorganisms9040826

الاتاحة: https://doi.org/10.3390/microorganisms9040826

المؤلفون: Tummala Rama Krishna Reddy, Marcos Meuser Batista, Asma Inam Ullah, Camila Cardoso Santos, Maria de Nazaré Correia Soeiro

المصدر: Parasitology. 148:98-104

مصطلحات موضوعية: Drug, Virtual screening, Antiparasitic, medicine.drug_class, media_common.quotation_subject, 030231 tropical medicine, Leishmaniasis, Pharmacology, Biology, medicine.disease, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Cutaneous leishmaniasis, medicine, Potency, Animal Science and Zoology, Parasitology, Amastigote, Pentamidine, medicine.drug, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a21d8ea436f26ca1c610f94069461ae3
https://doi.org/10.1017/s0031182020001900

المؤلفون: Natália Lins da Silva Gomes, Camila Cardoso-Santos, Ana Lia Mazzeti, Ludmila Ferreira de Almeida Fiuza, Denise da Gama Jaen Batista, Cristiane França da Silva, Serge Van Calenbergh, Maria de Nazaré Correia Soeiro, Guy Caljon, Otacilio C. Moreira, Gabriel Melo de Oliveira, Louis Maes, Fabian Hulpia, Roberson Donola Girão

المصدر: JAC-ANTIMICROBIAL RESISTANCE
JAC-Antimicrobial Resistance

مصطلحات موضوعية: Chagas disease, Purine, Drug resistance, Pharmacology, TRYPANOSOMA-CRUZI, chemistry.chemical_compound, In vivo, parasitic diseases, INFECTION, Medicine and Health Sciences, medicine, Trypanosoma cruzi, Biology, NUCLEOSIDE, ANALOGS, biology, Cordycepin, business.industry, Pharmacology. Therapy, EFFICACY, medicine.disease, biology.organism_classification, CANCER, Deoxyribonucleoside, Chemistry, chemistry, Benznidazole, Human medicine, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1731847b948decd661e97223fc6ed64e
https://doi.org/10.1093/jacamr/dlab168

المؤلفون: Edson Roberto da Silva, Camila Cardoso-Santos, Lucas Villas Bôas Hoelz, Julio Abel Alfredo dos Santos Simone Come, Nubia Boechat, Lívia M. Feitosa, Danielle L. Souza, Maria de Nazaré Correia Soeiro, Luiz C. S. Pinheiro, Marcos Meuser Batista

المصدر: Bioorganic & Medicinal Chemistry. 27:3061-3069

مصطلحات موضوعية: Clinical Biochemistry, Antiprotozoal Agents, Trypanothione, Pharmaceutical Science, 01 natural sciences, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, Drug Discovery, Amastigote, Molecular Biology, Ternary complex, Leishmania, chemistry.chemical_classification, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, 0104 chemical sciences, Arginase, 010404 medicinal & biomolecular chemistry, Pyrimidines, Enzyme, Molecular Medicine, Growth inhibition

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4483d867f7e8c2f300a4b800a36c634
https://doi.org/10.1016/j.bmc.2019.05.026

المؤلفون: Camila, Cardoso-Santos, Ludmila, Ferreira de Almeida Fiuza, Cristiane, França da Silva, Ana Lia, Mazzeti, Roberson, Donola Girão, Gabriel, Melo de Oliveira, Denise, da Gama Jaen Batista, Otacilio, Cruz Moreira, Natália, Lins da Silva Gomes, Louis, Maes, Guy, Caljon, Fabian, Hulpia, Serge V, Calenbergh, Maria de Nazaré, Correia Soeiro

المصدر: JAC-Antimicrobial Resistance

مصطلحات موضوعية: AcademicSubjects/MED00290, parasitic diseases, AcademicSubjects/MED00740, Original Article, AcademicSubjects/MED00230

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d5bc5c8641b80fbd32683fb5beec9c6c
https://pubmed.ncbi.nlm.nih.gov/34806007

المؤلفون: Jakob, Bouton, Ludmila, Ferreira de Almeida Fiuza, Camila, Cardoso Santos, Maria Angela, Mazzarella, Maria de Nazaré Correia, Soeiro, Louis, Maes, Izet, Karalic, Guy, Caljon, Serge, Van Calenbergh

المصدر: Journal of medicinal chemistry. 64(7)

مصطلحات موضوعية: Male, Molecular Structure, Trypanosoma cruzi, Nucleosides, Trypanocidal Agents, Mice, Structure-Activity Relationship, Pyrimidines, Drug Stability, Drug Design, Microsomes, Liver, Animals, Humans, Pyrazoles, Chagas Disease, Leishmania infantum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7976eeb282d3cbf02788632b336476be
https://pubmed.ncbi.nlm.nih.gov/33784107

المؤلفون: Ludmila Ferreira de Almeida Fiuza, Cai Lin, Camila Cardoso Santos, Jakob Bouton, Guy Caljon, Serge Van Calenbergh, Maria de Nazaré Correia Soeiro, Louis Maes, Fabian Hulpia, Otacilio C. Moreira, Izet Karalic, Daniela Ferreira Nunes

المصدر: ChemMedChem

مصطلحات موضوعية: Purine, Chagas disease, Trypanosoma cruzi, Parasitemia, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Parasitic Sensitivity Tests, In vivo, Drug Discovery, medicine, General Pharmacology, Toxicology and Pharmaceutics, Amastigote, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Pharmacology. Therapy, Organic Chemistry, Nucleosides, medicine.disease, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Benznidazole, Purines, Molecular Medicine, Nucleoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79e1e9661ab58e87a9b003924809a29
https://pubmed.ncbi.nlm.nih.gov/33856742

المؤلفون: Maria Angela Mazzarella, Camila Cardoso Santos, Serge Van Calenbergh, Maria de Nazaré Correia Soeiro, Izet Karalic, Guy Caljon, Louis Maes, Jakob Bouton, Ludmila Ferreira de Almeida Fiuza

المصدر: Journal of medicinal chemistry

مصطلحات موضوعية: Purine, Chagas disease, 0303 health sciences, biology, Drug discovery, Pharmacology. Therapy, biology.organism_classification, medicine.disease, 01 natural sciences, Antiparasitic agent, Tubercidin, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biochemistry, Drug Discovery, parasitic diseases, medicine, Molecular Medicine, Trypanosoma cruzi, Purine metabolism, Nucleoside, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb46dcee8897f9727b0c27b58b1796eb

المؤلفون: Natália Lins da Silva-Gomes, Ifedayo Victor Ogungbe, Marcos Meuser Batista, Kelly Cristina Demarque, Camila Cardoso Santos, Huaisheng Zhang, Gabriel Melo de Oliveira, Otacilio C. Moreira, Maria de Nazaré Correia Soeiro

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: Pharmacology, Sulfonyl, chemistry.chemical_classification, 0303 health sciences, Miltefosine, 030306 microbiology, medicine.disease, Parasite load, In vitro, 03 medical and health sciences, chemistry.chemical_compound, Infectious Diseases, Cutaneous leishmaniasis, chemistry, In vivo, medicine, Pharmacology (medical), Experimental Therapeutics, IC50, Acetamide, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a64603b375d48d544e12e72b0bca773
https://europepmc.org/articles/PMC7674027/

المؤلفون: Camila, Cardoso Santos, Marcos, Meuser Batista, Asma, Inam Ullah, Tummala, Rama Krishna Reddy, Maria de Nazaré Correia, Soeiro

المصدر: Parasitology. 148(1)

مصطلحات موضوعية: Leishmania, Mice, Inbred BALB C, Pyridones, Antiprotozoal Agents, Drug Evaluation, Preclinical, Leishmaniasis, Cutaneous, In Vitro Techniques, Disease Models, Animal, Inhibitory Concentration 50, Mice, Macrophages, Peritoneal, Animals, Benzimidazoles, Oxazoles, Cells, Cultured, Pentamidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f0d3c03de5e9a483544bcbd059598b7c
https://pubmed.ncbi.nlm.nih.gov/33023678

المؤلفون: Jane C. Munday, An Matheeussen, Camila Cardoso-Santos, Titilola D. Kalejaiye, Marcos Meuser Batista, Rob Leurs, Iwan J. P. de Esch, Harry P. de Koning, Maria de Nazaré Correia Soeiro, Patrícia Bernardino da Silva, Irene G. Salado, Louis Maes, Erik de Heuvel, Raiza Brandão Peres, Geert Jan Sterk, Koen Augustyns, Julianna Siciliano de Araújo

المساهمون: AIMMS, Medicinal chemistry, Chemistry and Pharmaceutical Sciences

المصدر: Journal of antimicrobial chemotherapy, 75(4), 958-967. Oxford University Press
The journal of antimicrobial chemotherapy
De Araújo, J S, da Silva, P B, Batista, M M, Peres, R B, Cardoso-Santos, C, Kalejaiye, T D, Munday, J C, De Heuvel, E, Sterk, G J, Augustyns, K, Salado, I G, Matheeussen, A, De Esch, I, De Koning, H P, Leurs, R, Maes, L & Soeiro, M D N C 2020, ' Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi ', Journal of antimicrobial chemotherapy, vol. 75, no. 4, pp. 958-967 . https://doi.org/10.1093/jac/dkz516

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Chagas disease, Phosphodiesterase Inhibitors, Trypanosoma cruzi, 030106 microbiology, Pharmacology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, Extracellular, Humans, Pharmacology (medical), Chagas Disease, Amastigote, Biology, biology, Chemistry, Pharmacology. Therapy, Phosphodiesterase, biology.organism_classification, medicine.disease, Trypanocidal Agents, In vitro, 3. Good health, 030104 developmental biology, Infectious Diseases, Benznidazole, Human medicine, Intracellular, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ddcd06a37b70f7392d21298a13bf2a
https://pubmed.ncbi.nlm.nih.gov/31860098

المؤلفون: Jessica Lionel, Richard R. Tidwell, Svetlana M. Bakunova, Rodolpho C. Braga, Bruno J. Neves, Marcos Meuser Batista, Camila Cardoso Santos, Sandra Maria de Oliveira Souza, Patrícia Bernardino da Silva, Gabriel Melo de Oliveira, Maria de Nazaré Correia Soeiro, Donald A. Patrick, Carolina Horta Andrade, Cristiane França da Silva, Raiza Brandão Peres, Denise da Gama Jaen Batista

المصدر: Antimicrobial Agents and Chemotherapy. 62

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Chagas disease, biology, Chemistry, In silico, Parasitemia, medicine.disease, biology.organism_classification, In vitro, 03 medical and health sciences, 030104 developmental biology, Infectious Diseases, Pharmacokinetics, Benznidazole, In vivo, parasitic diseases, medicine, Experimental Therapeutics, Pharmacology (medical), Trypanosoma cruzi, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2811f1a7760e65ddc437efb6740535ca
https://doi.org/10.1128/aac.02205-17

المؤلفون: Camila Cardoso-Santos, Raiza Brandão Peres, D. G. J. Batista, C. F. Da Silva, J. S. De Araújo, M. R. Simões-Silva, Maria de Nazaré Correia Soeiro, P. B. Da Silva, I. D'Almeida-Melo, M. M. Batista, Gilkethyla Mexlayne de Oliveira, Kelly Cristina Demarque, M. T. Bahia

المصدر: Biochemical pharmacology. 145

مصطلحات موضوعية: 0301 basic medicine, Combination therapy, Trypanosoma cruzi, 030106 microbiology, Antiprotozoal Agents, Parasitemia, Pharmacology, Biochemistry, 03 medical and health sciences, Mice, Pharmacokinetics, In vivo, Metronidazole, medicine, Animal mortality, Animals, Chagas Disease, Myocytes, Cardiac, Nifurtimox, Cells, Cultured, biology, Molecular Structure, biology.organism_classification, medicine.disease, Benznidazole, Nitroimidazoles, Immunology, Drug Therapy, Combination, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a625155df8be91f1c6cd36a394ab5f2
https://pubmed.ncbi.nlm.nih.gov/28870526