المؤلفون: Grigorios Nikitidis (4508872), Anna-Carin C. Carlsson (3945737), Staffan Karlsson (1443904), Andrew D. Campbell (9772366), Calum Cook (3927476), Kuangchu Dai (6904937), Hans Emtenäs (1684684), Anna C. Jonson (4007507), Hanna Leek (4007504), Marcus Malmgren (6278591), Štefan Moravčík (6933980), Subhash Pithani (6919280), Matthew R. Tatton (1304370), Hucheng Zhao (6852461), Kristina Öhlén (11326106)

مصطلحات موضوعية: Biochemistry, Pharmacology, Sociology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, multigram synthesis, drug development projects, API purification, drug candidates, Chromatographic Challenges, sequence, Multigram Manufacture, atropisomer separation, chiral axis, biaryl fragment, KRAS G 12C Inhibitors, Suzuki reaction

Relation: https://figshare.com/articles/journal_contribution/Synthetic_and_Chromatographic_Challenges_and_Strategies_for_Multigram_Manufacture_of_KRAS_sup_G12C_sup_Inhibitors/16432385

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00179.s001

المؤلفون: James J. Douglas (4031537), Matthew R. Tatton (1304370), Daniël de Bruin (11571137), David Buttar (1981537), Calum Cook (3927476), Kuangchu Dai (6904937), Catalina Ferrer (2202394), Kevin Leslie (1324953), James Morrison (6904946), Rachel Munday (7513727), Thomas O. Ronson (6933983), Hucheng Zhao (6852461)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Cancer, Astronomical and Space Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, methanol ring opening, iodo unprotected anilines, early stage salt, complex atropisomeric nitroquinoline, >- substituted bromo, g12c , inhibitor route design, route design, atropisomeric kras, >- carboxy, ortho <, n <, substrate scope, resolution followed, previously led, nca ), formal two, atropisomer racemization, accessed via

Relation: https://figshare.com/articles/journal_contribution/Exploration_of_a_Nitromethane-Carbonylation_Strategy_during_Route_Design_of_an_Atropisomeric_KRAS_sup_G12C_sup_Inhibitor/16821230

الاتاحة: https://doi.org/10.1021/acs.joc.1c01736.s002

المؤلفون: James J. Douglas (4031537), Matthew R. Tatton (1304370), Daniël de Bruin (11571137), David Buttar (1981537), Calum Cook (3927476), Kuangchu Dai (6904937), Catalina Ferrer (2202394), Kevin Leslie (1324953), James Morrison (6904946), Rachel Munday (7513727), Thomas O. Ronson (6933983), Hucheng Zhao (6852461)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Cancer, Astronomical and Space Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, methanol ring opening, iodo unprotected anilines, early stage salt, complex atropisomeric nitroquinoline, >- substituted bromo, g12c , inhibitor route design, route design, atropisomeric kras, >- carboxy, ortho <, n <, substrate scope, resolution followed, previously led, nca ), formal two, atropisomer racemization, accessed via

Relation: https://figshare.com/articles/dataset/Exploration_of_a_Nitromethane-Carbonylation_Strategy_during_Route_Design_of_an_Atropisomeric_KRAS_sup_G12C_sup_Inhibitor/16821227

الاتاحة: https://doi.org/10.1021/acs.joc.1c01736.s001

المؤلفون: Staffan Karlsson (1443904), Helen Benson (3628523), Calum Cook (3927476), Gordon Currie (1981498), Jerome Dubiez (11139682), Hans Emtenäs (1684684), Janet Hawkins (2114890), Rebecca Meadows (11166933), Peter D. Smith (1436611), Jeffrey Varnes (7424534)

مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Immunology, Developmental Biology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, generation, AZD, Wolff, Application, Enzyme, yield, borylation, Manufacture, reactive, Possible, removal, availability, optimization, safety, oncology drug candidate, factor, crude, transformation, synthesis, mixture, material

Relation: https://figshare.com/articles/journal_contribution/From_Milligram_to_Kilogram_Manufacture_of_AZD4573_Making_It_Possible_by_Application_of_Enzyme_Iridium_and_Palladium-Catalyzed_Key_Transformations/15029802

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00058.s001