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المؤلفون: Grace L. Guo, Xiaoyun Chen, Zheng Dong, Bilon Khambu, Xiao Ming Yin, Shengmin Yan
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Gut Dysbiosis, OST-β, organic solute transporter subunit-β, SQSTM1, sequestosome-1, FGF15, CK19, cytokeratin 19, Gut flora, FEX, fexaramine, SHP, small heterodimer partner, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, AST, aspartate transaminase, MCA, muricholic acid, CYP8B1, cytochrome p450 family 8b1, BLU, Blu-9931, TCDCA, taurochenodeoxycholic acid, Original Research, FGFR4, fibroblast growth factor receptor 4, TBA, total bile acid, Liver injury, CA, cholic acid, biology, Bile acid, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, NRF2, nuclear factor erythroid 2-related factor 2, BA, bile acid, 030211 gastroenterology & hepatology, TDCA, taurodeoxycholic acid, medicine.drug, medicine.medical_specialty, GM, gut microbiota, ALT, alanine transaminase, medicine.drug_class, TCA, taurocholic acid, PBS, phosphate-buffered saline, IBABP, ileal bile acid-binding protein, OST-α, organic solute transporter subunit-α, Liver Injury, ASBT (SLC10A2), apical sodium–bile acid transporter, CDCA, chenodeoxycholic acid, Bile Acids and Salts, CYP7A1, cytochrome p450 7a1, 03 medical and health sciences, FXR, farnesoid X receptor, ATG, autophagy-related gene, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Autophagy, BAS, bile acid sequestrants, lcsh:RC799-869, Cholestyramine, ALP, alkaline phosphatase, FGF15, fibroblast growth factor 15, SE, standard error, Hepatology, Fibroblast growth factor receptor 4, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, 030104 developmental biology, Endocrinology, DCA, deoxycholic acid, PCoA, principal coordinates analysis, BSH, bile salt hydrolase, ABX, antibiotics, TLCA, taurolithocholic acid, TMCA, tauromuricholic acid, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease
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المؤلفون: Megan T. Hoffman, Samantha B. Kemp, Daniel J. Salas-Escabillas, Yaqing Zhang, Nina G. Steele, Stephanie The, Daniel Long, Simone Benitz, Wei Yan, Robert F. Margolskee, Filip Bednar, Marina Pasca di Magliano, Hui-Ju Wen, Howard C. Crawford
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: 0301 basic medicine, KrasG12D/+, Ptf1aCreERT/+, MDSC, CK19, cytokeratin 19, medicine.disease_cause, Ptf1aCre/+, KCERT, 0302 clinical medicine, MTC, metaplastic tuft cell, Original Research, gMDSC, granulocytic myeloid-derived suppressor cell, education.field_of_study, KC, KrasG12D/+, Gastroenterology, ELISA, enzyme-linked immunosorbent assay, PDA, pancreatic ductal adenocarcinoma, CXCL2, CXCL1, DCLK1, doublecortin-like kinase 1, medicine.anatomical_structure, PTOM, pancreatic progenitor and tumor organoid media, TAM, tumor-associated macrophage, 030211 gastroenterology & hepatology, Tuft cell, Pancreas, NK, natural killer, IHC, immunohistochemistry, Population, PBS, phosphate-buffered saline, Tuft Cell, CC3, cleaved caspase 3, Biology, TRPM5, transient receptor potential cation channel subfamily M member 5, ADM, acinar-to-ductal metaplasia, 03 medical and health sciences, FBS, fetal bovine serum, MDSC, myeloid-derived suppressor cell, Pancreatic cancer, UMAP, Uniform Manifold Approximation and Projection, medicine, Humans, mMDSC, monocytic myeloid-derived suppressor cell, education, Hepatology, GNAT3, α-gustducin, HBSS, Hank’s balanced salt solution, PanIN, pancreatic intraepithelial neoplasia, medicine.disease, WT, wild-type, Pancreatic Neoplasms, 030104 developmental biology, Cancer research, BSA, bovine serum albumin, Cytokine secretion, Carcinogenesis
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المؤلفون: Rumei, Li, Anna, Palmiotti, Hilde D, de Vries, Milaine V, Hovingh, Martijn, Koehorst, Niels L, Mulder, Yue, Zhang, Kim, Kats, Vincent W, Bloks, Jingyuan, Fu, Henkjan J, Verkade, Jan Freark, de Boer, Folkert, Kuipers
المصدر: Journal of Lipid Research
مصطلحات موضوعية: Male, obesity, humanized mouse model, Cyp2c70, cytochrome P450, family 2, subfamily C, polypeptide 70, CK19, cytokeratin 19, WTD, Western-type high-fat diet, Bile Acids and Salts, CDCA, chenodeoxycholic acid, Mice, Cytochrome P-450 Enzyme System, Non-alcoholic Fatty Liver Disease, MCA, muricholic acid, scWAT, subcutaneous white adipose tissue, OTU, operational taxonomic unit, Animals, TEM, transmission electron microscopy, TGR5, Takeda G protein-coupled receptor 5, Mice, Knockout, bile acids, CA, cholic acid, BW, body weight, fat absorption, Cyp2c70, Fatty Liver, Mice, Inbred C57BL, BAT, brown adipose tissue, PL, phospholipid, DCA, deoxycholic acid, Diet, Western, BSTFA, N,O-bis(trimethylsilyl) trifluoroacetamide, BA, bile acid, fatty liver disease, Female, NAFLD, nonalcoholic fatty liver disease, NASH, nonalcoholic steatohepatitis, Cyp8b1, Research Article
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المؤلفون: Maureen Gannon, Peter A. Kropp, Xiaodong Zhu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 841-856 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, PDAC, pancreatic ductal adenocarcinoma, Acinar Cells, Epithelium, Nr5a2, nuclear receptor subfamily 5, group A, member 2, Transcriptome, Mice, 0302 clinical medicine, Transcriptional regulation, Morphogenesis, MPC, multipotent pancreatic progenitor cell, Ptf1a, Pancreas transcription factor, 1a, Original Research, Gastroenterology, Gene Expression Regulation, Developmental, Cell Differentiation, Pancreas, Exocrine, Pancreas Development, Cell biology, Hepatocyte Nuclear Factor 6, medicine.anatomical_structure, Cym, Chymosin, 030211 gastroenterology & hepatology, Pancreas, Inhba, Inhibin, Beta A, Sox9, SRY-related HMG-box 9, ChIP-Seq, chromatin immunoprecipitation followed by high-throughput sequencing, RNA-Seq, RNA-sequencing, Hnf6, hepatocyte nuclear factor 6, Biology, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, ADM, acinar-to-ductal metaplasia, 03 medical and health sciences, CK19, Cytokeratin 19, medicine, Acinar cell, Animals, Ihh, Indian hedgehog, Mist1, muscle, intestine, stomach transcription factor 1, lcsh:RC799-869, Transcription factor, Hnf1β, hepatocyte nuclear factor 1β, Cell Proliferation, Pancreatic duct, Oc1, Onecut1, Hepatology, Base Sequence, Ptch2, Patched 2, Smo, Smoothened, HH, Hedgehog, Embryo, Mammalian, Spink 1, serine protease inhibitor Kazal type 1, 030104 developmental biology, Animals, Newborn, lcsh:Diseases of the digestive system. Gastroenterology, FOXA2, Pdx1, pancreatic and duodenal homeobox 1, Exocrine
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المؤلفون: Michelle M. Cooley, Guy E. Groblewski
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 199-200 (2020)مصطلحات موضوعية: Male, Pancreatitis, Alcoholic, ZG, zymogen granule, Basic helix-loop-helix leucine zipper transcription factors, CK19, cytokeratin 19, Acinar Cells, Mice, Original Research, GFP, green fluorescent protein, Mice, Knockout, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Gastroenterology, Ad, adenovirus, TAP, trypsinogen activation peptide, Lysosome, Healthy Volunteers, Cell biology, mTOR, mechanistic target of rapamycin kinase, Atg, autophagy-related, Editorial, qPCR, quantitative polymerase chain reaction, TFEB, transcriptional factor EB, MAPK1/ERK2, mitogen-activated protein kinase 1, ADM, acinar-to-ducal metaplasia, ER, endoplasmic reticulum, medicine, LC3, microtubule-associated protein light chain 3, Autophagy, Animals, Humans, lcsh:RC799-869, Pancreas, Inflammation, Cell Nucleus, Alcohol-induced pancreatitis, CLEAR, coordinated lysosomal expression and regulation, EM, electron microscopy, KO, knockout, Hepatology, Tissue Injury, Ethanol, business.industry, Autophagosomes, medicine.disease, WT, wild-type, Disease Models, Animal, Case-Control Studies, Zymogen, Pancreatitis, TFEB, lcsh:Diseases of the digestive system. Gastroenterology, business, Lysosomes, Biogenesis
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المؤلفون: Vanessa T. Garrido, Sulagna Banerjee
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: Carcinogenesis, PDAC, pancreatic ductal adenocarcinoma, HDAC, histone deacetylase, CK19, cytokeratin 19, medicine.disease_cause, RFP, red fluorescent protein, PCR, polymerase chain reaction, Klf, Krüppel-like factor, PC, Ptf1a-Cre, Cdh1f/f, Medicine, Original Research, P, postnatal day, γH2AX, γ histone 2AX, Gastroenterology, Cadherins, mRNA, messenger RNA, medicine.anatomical_structure, PanIN, pancreatic intraepithelial neoplasm, Pancreas, EMT, epithelial–mesenchymal transition, IHC, immunohistochemistry, PSR, Picro-Sirius red, p-ERK, phospho–extracellular signal-regulated kinase, PKC, Ptf1a-Cre, LSL-KrasG12D/+, ADM, acinar-to-ductal metaplasia, α-SMA, α-smooth muscle actin, Pancreatic Cancer, cDNA, complementary DNA, Text mining, Humans, Gene Regulation, Oncogene, PKC+C, lenti-Cdh1 in Ptf1a-Cre, Cdh1f/f organoids, E-Cadherin, Hepatology, business.industry, Cadherin, Pancreatic Diseases, medicine.disease, Ptf1a, pancreas transcription factor 1a, YFP, yellow fluorescent protein, Pancreatitis, PK, Ptf1a-Cre, 2D, 2-dimensional, Cancer research, DMEM, Dulbecco’s modified Eagle medium, business
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المؤلفون: Anna L. Means
المصدر: Cellular and Molecular Gastroenterology and Hepatology
مصطلحات موضوعية: Male, PYK2, proline-rich tyrosine kinase 2, endocrine system diseases, Acinar-to-Ductal Metaplasia, STAT3, signal transducer and activator of transcription 3, PDAC, pancreatic ductal adenocarcinoma, Cell Cycle Proteins, CK19, cytokeratin 19, Mice, PCR, polymerase chain reaction, Phosphorylation, Wnt Signaling Pathway, SDS-PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, beta Catenin, Original Research, Mice, Knockout, Gastroenterology, GSK3α/3β, glycogen synthase kinase 3α/3β, Cellular Reprogramming, TAZ, transcriptional co-activator with PDZ binding motif, Editorial, FAK, focal adhesion kinase, shRNA, short hairpin RNA, Female, Signal transduction, IHC, immunohistochemistry, Carcinoma in Situ, Signal Transduction, Carcinoma, Pancreatic Ductal, PBS, phosphate-buffered saline, Mice, Nude, Biology, Adenocarcinoma, G12D, glycine 12 to aspartic acid, ADM, acinar-to-ductal metaplasia, Proto-Oncogene Proteins p21(ras), Intersection, FBS, fetal bovine serum, Pancreatic cancer, medicine, KRAS, Humans, Animals, TGF-α, transforming growth factor α, Adaptor Proteins, Signal Transducing, Inflammation, Metaplasia, Hepatology, ERK1/2, extracellular signal–regulated kinase 1/2, Carcinoma, Acinar Cell, Wnt/β-Catenin Signaling, HBSS, Hank’s balanced salt solution, PanIN, pancreatic intraepithelial neoplasia, YAP-Signaling Proteins, medicine.disease, digestive system diseases, Mice, Inbred C57BL, Pancreatic Neoplasms, Disease Models, Animal, Focal Adhesion Kinase 2, TCGA, The Cancer Genome Atlas, Neuroscience, Precancerous Conditions
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المؤلفون: Zoë D. Burke, Shifaan Thowfeequ, Macarena Perán, David Tosh
المصدر: Biochemical Journal
مصطلحات موضوعية: DPPIV, dipeptidyl peptidase IV, transdifferentiation, Cellular differentiation, Hox, homeobox, Clinical uses of mesenchymal stem cells, Review Article, CK19, cytokeratin 19, Biology, liver, Biochemistry, Cdx1, caudal-related, C/EBP, CCAAT/enhancer-binding protein, 03 medical and health sciences, 0302 clinical medicine, ES cell, embryonic stem cell, Cancer stem cell, Pdx1, pancreatic and duodenal Hox 1, Animals, Humans, pancreas, intestine, Molecular Biology, AP, anterior–posterior, 030304 developmental biology, Stem cell transplantation for articular cartilage repair, Prt, Prometheus, Tcf, T-cell factor, 0303 health sciences, E, embryonic day, FAH, fumarylacetoacetate hydrolase, BMP, bone morphogenetic protein, Amniotic stem cells, Cell Biology, FGF, fibroblast growth factor, IHH, Indian hedgehog, Cell biology, stem cell, Intestines, cell differentiation, Adult Stem Cells, SCID, severe combined immunodeficiency, 030220 oncology & carcinogenesis, Amniotic epithelial cells, Immunology, Ngn3, neurogenin 3, HSC, haematopoietic stem cell, Stem cell, Adult stem cell
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المؤلفون: Hiroshi Kitani, Noriko Yamanaka, Takato Takenouchi, Miyako Yoshioka
المصدر: Cell Biology International Reports
مصطلحات موضوعية: HBSS, Hanks balanced salt solution, SV40 large T antigen, Liver morphogenesis, liver cell line, Morphogenesis, CK19, cytokeratin 19, Biology, epithelial–mesenchymal transition, immortalization, DMEM, Dulbecco’s modified Eagle’s medium, Cytokeratin, DF, DMEM/Ham’s F-12, FBS, fetal bovine serum, Epithelial–mesenchymal transition, TGF, transforming growth factor, VE-cadherin, vascular endothelial cadherin, EGF, epidermal growth factor, BEC, biliary epithelial cell, Mesenchymal stem cell, CK18, cytokeratin 18, Cell Biology, In vitro, HSC, hepatic stellate cell, ZO-1, zonula occludens 1, Cell biology, ECM, extracellular matrix, αSMA, α-smooth muscle actin, Cell culture, Immunology, sense organs, SV40LT, SV40 large T antigen, EMT, epithelial–mesenchymal transition, Research Article
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المؤلفون: Kurt D. Hankenson, David A. Piccoli, Ellen A. Tsai, Lara A. Underkoffler, Michael M. Wang, Binita M. Kamath, He Meng, Christopher M. Grochowski, Hailu Shitaye, Marcella Devoto, Nancy B. Spinner, Henry C. Lin, Melissa A. Gilbert, Xiaojie Zhang, Kathleen M. Loomes
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 5, Pp 663-675.e2 (2016)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, JAG1, Thrombospondin-2, Notch signaling pathway, ChiLDReN, Childhood Liver Disease Research Network, Genome-wide association study, CK19, cytokeratin 19, Biology, cDNA, complementary DNA, 03 medical and health sciences, Liver disease, PCR, polymerase chain reaction, 0302 clinical medicine, NOTCH2, Cholestasis, Alagille syndrome, medicine, lcsh:RC799-869, ddPCR, droplet digital polymerase chain reaction, GWAS, genome-wide association study, Original Research, GFP, green fluorescent protein, Hepatology, Bile duct, Gastroenterology, ALGS, Alagille syndrome, medicine.disease, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Gene Modifier, Genome-Wide Association Study, 030220 oncology & carcinogenesis, Immunology, THBS2, thrombospondin 2, Cancer research, BSA, bovine serum albumin, lcsh:Diseases of the digestive system. Gastroenterology, SNP, single-nucleotide polymorphism