يعرض 1 - 20 نتائج من 2,598 نتيجة بحث عن '"CHEMICAL libraries"', وقت الاستعلام: 0.88s تنقيح النتائج
  1. 1
    Academic Journal
    Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery.

    المؤلفون: Halu, Arda1,2 (AUTHOR) arda.halu@channing.harvard.edu, Chelvanambi, Sarvesh2 (AUTHOR), Decano, Julius L.2 (AUTHOR), Matamalas, Joan T.2 (AUTHOR), Whelan, Mary2 (AUTHOR), Asano, Takaharu2 (AUTHOR), Kalicharran, Namitra2 (AUTHOR), Singh, Sasha A.2 (AUTHOR), Loscalzo, Joseph1,3 (AUTHOR), Aikawa, Masanori1,2 (AUTHOR) maikawa@bwh.harvard.edu

    المصدر: Genome Medicine. 1/20/2025, Vol. 17 Issue 1, p1-24. 24p.

    مصطلحات موضوعية: *DRUG discovery, *CHEMICAL libraries, *RECEIVER operating characteristic curves, *LIFE sciences, *GENE expression profiling, *PHARMACOGENOMICS

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  2. 2
    Academic Journal
    High-throughput tracking enables systematic phenotyping and drug repurposing in C. elegans disease models.

    المؤلفون: O'Brien, Thomas J.1,2, Barlow, Ida L.1,2, Feriani, Luigi1,2, Brown, André E. X.1,2 andre.brown@imperial.ac.uk

    المصدر: eLife. 1/8/2025, p1-17. 17p.

    مصطلحات موضوعية: *DRUG repositioning, *CHEMICAL libraries, *DRUG target, *CAENORHABDITIS elegans, *NEUROMUSCULAR diseases

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  3. 3
    Academic Journal
    Lucidin from Rubia cordifolia Outperforms FDA-Approved Lapatinib as a Potential Multitargeted Candidate for Breast Cancer Signalling Proteins.

    المؤلفون: Aloqbi, Akram Ahmed1 (AUTHOR) aaaloqbi@uj.edu.sa, Alahdal, Hadil2 (AUTHOR) hmalahdal@pnu.edu.sa, Alqosaibi, Amany I.3 (AUTHOR) amgosaibi@iau.edu.sa, Alnamshan, Mashael M.3 (AUTHOR) malnamshan@iau.edu.sa, Al-Dhuayan, Ibtesam S.3 (AUTHOR) ialdhuayan@iau.edu.sa, Al-Eidan, Ahood A.3 (AUTHOR) aeidan@iau.edu.sa, Alzahrani, Hind A. S.3 (AUTHOR) hizahrani@iau.edu.sa, ALaqeel, Nouf K.3 (AUTHOR) nalaqeel@iau.edu.sa, Alsharif, Fatmah Hazza4 (AUTHOR) falsharif@kau.edu.sa, Al Tuwaijri, Abeer5,6 (AUTHOR) altuwaijriab@ngha.med.sa

    المصدر: Pharmaceuticals (14248247). Jan2025, Vol. 18 Issue 1, p68. 27p.

    مصطلحات موضوعية: *MOLECULAR dynamics, *CHEMICAL libraries, *BREAST cancer, *DYNAMIC stability, *LAPATINIB

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  4. 4
    Academic Journal
    Discovery and Characterization of Two Selective Inhibitors for a Mu-Class Glutathione S-Transferase of 25 kDa from Taenia solium Using Computational and Bioinformatics Tools.

    المؤلفون: Sánchez-Juárez, César1 (AUTHOR) csj3140@xanum.uam.mx, Flores-López, Roberto2,3 (AUTHOR) robertof@comunidad.unam.mx, Sánchez-Pérez, Lluvia de Carolina1 (AUTHOR) lluvia_sanper@xanum.uam.mx, García-Gutiérrez, Ponciano1 (AUTHOR) pgarcia@xanum.uam.mx, Jiménez, Lucía2 (AUTHOR) lucia.jimenez@facmed.unam.mx, Landa, Abraham2 (AUTHOR) landap@servidor.unam.mx, Zubillaga, Rafael A.1 (AUTHOR) pgarcia@xanum.uam.mx

    المصدر: Biomolecules (2218-273X). Jan2025, Vol. 15 Issue 1, p7. 17p.

    مصطلحات موضوعية: *VIRTUAL high-throughput screening (Drug development), *CHEMICAL libraries, *TAENIA solium, *ANTIPARASITIC agents, *MOLECULAR dynamics, *GLUTATHIONE transferase

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  5. 5
    Academic Journal
    A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases.

    المؤلفون: Nejatie, Ali1 (AUTHOR), Proceviat, Cameron1 (AUTHOR), Gros, Christina1 (AUTHOR), Steves, Elizabeth2 (AUTHOR), Moore, Margo M2 (AUTHOR), Vocadlo, David J1,3 (AUTHOR), Bennet, Andrew J1 (AUTHOR)

    المصدر: Glycobiology. Jan2025, Vol. 35 Issue 1, p1-10. 10p.

    مصطلحات موضوعية: *CHEMICAL libraries, *HIGH throughput screening (Drug development), *ASPERGILLUS terreus, *SMALL molecules, *ASPERGILLUS fumigatus


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  6. 6
    Academic Journal
    Electrochemical C−O and C−N Arylation using Alternating Polarity in flow for Compound Libraries.

    المؤلفون: Morvan, Jennifer1 (AUTHOR), Kuijpers, Koen P. L.2 (AUTHOR), Fanfair, Dayne2 (AUTHOR), Tang, Bingqing1 (AUTHOR), Bartkowiak, Karolina1 (AUTHOR), van Eynde, Lars1 (AUTHOR), Renders, Evelien1 (AUTHOR), Alcazar, Jesus3 (AUTHOR), Buijnsters, Peter J. J. A.1 (AUTHOR), Carvalho, Mary‐Ambre1 (AUTHOR) ajones40@its.jnj.com, Jones, Alexander X.1 (AUTHOR) mcarva11@its.jnj.com

    المصدر: Angewandte Chemie. 1/2/2025, Vol. 137 Issue 1, p1-10. 10p.

    مصطلحات موضوعية: *CHEMICAL libraries, *PHARMACEUTICAL chemistry, *FLOW chemistry, *ARYL halides, *ETHERIFICATION, *AMINATION


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  7. 7
    Academic Journal
    Bioluminescent Pseudomonas aeruginosa and Escherichia coli for whole-cell screening of antibacterial and adjuvant compounds.

    المؤلفون: Farkas, Eszter1,2 (AUTHOR), McKay, Geoffrey A.2 (AUTHOR), Hu, Lin Tao1 (AUTHOR), Nekouei, Mina3 (AUTHOR), Ho, Peying4 (AUTHOR), Moreira, Wilfried4,5 (AUTHOR), Chan, Chia Ching4 (AUTHOR), Dam, Linh Chi4,6,7 (AUTHOR), Auclair, Karine3 (AUTHOR), Gruenheid, Samantha1 (AUTHOR), Whyte, Lyle8 (AUTHOR), Dedon, Peter4,9 (AUTHOR), Nguyen, Dao1,2,10 (AUTHOR) dao.nguyen@mcgill.ca

    المصدر: Scientific Reports. 12/28/2024, Vol. 14 Issue 1, p1-13. 13p.

    مصطلحات موضوعية: *HIGH throughput screening (Drug development), *CHEMICAL libraries, *DRUG discovery, *ESCHERICHIA coli, *ANTIBACTERIAL agents

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  8. 8
    Academic Journal
    Novel Spirooxindole–Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2‐p53 Interaction.

    المؤلفون: Al‐Muhanna, Muhanna K.1 (AUTHOR), Barakat, Assem2 (AUTHOR) ambarakat@ksu.edu.sa, Islam, Mohammad Shahidul2 (AUTHOR), Ali, M.2 (AUTHOR), Alayyaf, Abdulmajeed Abdullah2 (AUTHOR), Zia, Komal3 (AUTHOR), Ul‐Haq, Zaheer3 (AUTHOR), Dömling, Alexander4 (AUTHOR), El‐Senduny, Fardous F.5,6 (AUTHOR), Badria, Farid A.7 (AUTHOR) faridbadria@gmail.com

    المصدر: ChemistrySelect. 12/10/2024, Vol. 9 Issue 46, p1-13. 13p.

    مصطلحات موضوعية: *CHEMICAL libraries, *MOLECULAR docking, *WOUND healing, *HEPATOCELLULAR carcinoma, *CELL cycle


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  9. 9
    Academic Journal
    Inhibition of IRF3-STING axis interaction in silicosis using natural compounds: an in-silico study using molecular docking, ADMET, molecular dynamics and MMPBSA approach.

    المؤلفون: Sood, Ashita1 (AUTHOR) ashitasood01@gmail.com, Kulharia, Mahesh1 (AUTHOR) kulharia@gmail.com

    المصدر: In Silico Pharmacology. 12/9/2024, Vol. 13 Issue 1, p1-21. 21p.

    مصطلحات موضوعية: *CHEMICAL libraries, *MOLECULAR docking, *OCCUPATIONAL diseases, *MOLECULAR dynamics, *SILICOSIS

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  10. 10
    Academic Journal
    Interference of metal ions on the bioluminescent signal of firefly, Renilla, and NanoLuc luciferases in high-throughput screening assays.

    المؤلفون: Canyelles i Font, Francesca1 (AUTHOR), Żukowski, Krzysztof1 (AUTHOR), Khan, Masroor A.1 (AUTHOR), Kwiatek, Dorota1 (AUTHOR), Kolanowski, Jacek L.1 (AUTHOR) jkolanowski@ibch.poznan.pl

    المصدر: Frontiers in Chemistry. 2024, p1-19. 19p.

    مصطلحات موضوعية: *CHEMICAL libraries, *DRUG discovery, *BIOLOGICAL reagents, *METAL ions, *BIOLUMINESCENCE assay

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  11. 11
    Academic Journal
    Fragment Library of Colombian Natural Products: Generation and Comparative Chemoinformatic Analysis.

    المؤلفون: Chávez-Hernández, Ana L.1 (AUTHOR) anachavez3026@gmail.com, Rodríguez-Pérez, Johny R.2,3 (AUTHOR) johny.rodriguez@utp.edu.co, Cortés-Hernández, Héctor F.2 (AUTHOR) hfcortes@utp.edu.co, Valencia-Sanchez, Hoover A.2 (AUTHOR) hvalencia@utp.edu.co, Chávez-Fumagalli, Miguel Á.4 (AUTHOR) mchavezf@ucsm.edu.pe, Medina-Franco, José L.1 (AUTHOR) medinajl@unam.mx

    المصدر: Drugs & Drug Candidates. Dec2024, Vol. 3 Issue 4, p736-750. 15p.

    مصطلحات موضوعية: *CHEMICAL libraries, *DRUG discovery, *SYNTHETIC products, *NATURAL products, *OPEN scholarship


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  12. 12
    Academic Journal
    Synthesis of Diazacyclic and Triazacyclic Small-Molecule Libraries Using Vicinal Chiral Diamines Generated from Modified Short Peptides and Their Application for Drug Discovery.

    المؤلفون: Tantak, Mukund P.1 (AUTHOR) mukundtantak.2009@gmail.com, Rayala, Ramanjaneyulu1 (AUTHOR) rraya002@fiu.edu, Chaudhari, Prakash1 (AUTHOR) pchaudha@fiu.edu, Danta, Chhanda C.1 (AUTHOR) cdanta@fiu.edu, Nefzi, Adel1,2 (AUTHOR) anefzi@fiu.edu

    المصدر: Pharmaceuticals (14248247). Dec2024, Vol. 17 Issue 12, p1566. 18p.

    مصطلحات موضوعية: *DRUG discovery, *CHEMICAL libraries, *ORGANIC synthesis, *COMBINATORIAL chemistry, *SOLID-phase synthesis, *DIAMINES

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  13. 13
    Academic Journal
    The long road of drug development for endometriosis – Pains, gains, and hopes.

    المؤلفون: Liao, Zian1,2,3 (AUTHOR), Monsivais, Diana1,2 (AUTHOR), Matzuk, Martin M.1,2,3,4 (AUTHOR) mmatzuk@bcm.edu

    المصدر: Journal of Controlled Release. Dec2024, Vol. 376, p429-440. 12p.

    مصطلحات موضوعية: *HIGH throughput screening (Drug development), *CHEMICAL libraries, *UTERUS, *SYMPTOMS, *ENDOMETRIOSIS


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  14. 14
    Academic Journal
    Characterization of Anoectochilus roxburghii Bioactive Compounds and Its Inhibition on the Metabolism‐Related Enzyme Activities In Vitro.

    المؤلفون: Yuan, Jiahao1 (AUTHOR), Wu, Xiuna1 (AUTHOR), Karrar, Emad1 (AUTHOR), Zhang, Lingyu1,2 (AUTHOR), Huang, Zhiyong1,2 (AUTHOR), Wu, Daren1,2 (AUTHOR) darrenwu@jmu.edu.cn, Li, Jian1,2 (AUTHOR) lijian2013@jmu.edu.cn, Song, Xiaoyu (AUTHOR)

    المصدر: Journal of Food Biochemistry. 8/5/2024, Vol. 2024, p1-12. 12p.

    مصطلحات موضوعية: XANTHINE oxidase, CHEMICAL libraries, MOLECULAR docking, BIOACTIVE compounds, HIGH performance liquid chromatography, ENZYME inhibitors

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  15. 15
    Academic Journal
    Synthetic Methodology, SAR and Pharmacology of Commercialized Preparations Employing 1, 2, 4‐Triazole Analogues.

    المؤلفون: Singh, Sucheta1 (AUTHOR), Kaira, Meenakshi2 (AUTHOR), Dey, Hrithik2 (AUTHOR), Pandey, Kailash C.3 (AUTHOR), Tahlan, Sumit3 (AUTHOR) sumittahlan1989@gmail.com, Singh, Kuldeep4 (AUTHOR)

    المصدر: ChemistrySelect. Nov2024, Vol. 9 Issue 44, p1-29. 29p.

    مصطلحات موضوعية: *CHEMICAL libraries, *ANTINEOPLASTIC agents, *PHARMACEUTICAL chemistry, *TECHNOLOGICAL progress, *TRIAZOLES


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  16. 16
    Academic Journal
    Miniaturized Modular Click Chemistry‐enabled Rapid Discovery of Unique SARS‐CoV‐2 Mpro Inhibitors With Robust Potency and Drug‐like Profile.

    المؤلفون: Yang, Mianling1 (AUTHOR), Lee, Myoung Kyu2 (AUTHOR), Gao, Shenghua1 (AUTHOR), Song, Letian1 (AUTHOR), Jang, Hye‐Yeon2 (AUTHOR), Jo, Inseong2 (AUTHOR), Yang, Chun‐Chiao3 (AUTHOR), Sylvester, Katharina4 (AUTHOR), Ko, Chunkyu2 (AUTHOR), Wang, Shuo1 (AUTHOR), Ye, Bing1 (AUTHOR), Tang, Kai1 (AUTHOR), Li, Junyi1 (AUTHOR), Gu, Manyu1 (AUTHOR), Müller, Christa E.4 (AUTHOR) christa.mueller@uni-bonn.de, Sträter, Norbert3 (AUTHOR) strater@bbz.uni-leipzig.de, Liu, Xinyong1 (AUTHOR) xinyongl@sdu.edu.cn, Kim, Meehyein2 (AUTHOR) mkim@krict.re.kr, Zhan, Peng1 (AUTHOR) zhanpeng1982@sdu.edu.cn

    المصدر: Advanced Science. 11/20/2024, Vol. 11 Issue 43, p1-19. 19p.

    مصطلحات موضوعية: *CHEMICAL libraries, *CLICK chemistry, *CYTOTOXINS, *SARS-CoV-2 Omicron variant, *ANTIVIRAL agents

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  17. 17
    Academic Journal
    Accelerated hit identification with target evaluation, deep learning and automated labs: prospective validation in IRAK1.

    المؤلفون: Kamuntavičius, Gintautas1 (AUTHOR) gkamuntavicius@ro5.ai, Prat, Alvaro1 (AUTHOR) aprat@ro5.ai, Paquet, Tanya1 (AUTHOR), Bastas, Orestis1 (AUTHOR), Aty, Hisham Abdel1 (AUTHOR), Sun, Qing2 (AUTHOR), Andersen, Carsten B.2 (AUTHOR), Harman, John2 (AUTHOR), Siladi, Marc E.2 (AUTHOR), Rines, Daniel R.2 (AUTHOR), Flatters, Sarah J. L.1 (AUTHOR) sflatters@ro5.ai, Tal, Roy1 (AUTHOR) rtal@ro5.ai, Norvaišas, Povilas1 (AUTHOR) pnorvaisas@ro5.ai

    المصدر: Journal of Cheminformatics. 11/14/2024, Vol. 16 Issue 1, p1-18. 18p.

    مصطلحات موضوعية: *DRUG discovery, *CHEMICAL libraries, *INTERLEUKIN receptors, *KNOWLEDGE graphs, *HIGH throughput screening (Drug development), *DEEP learning

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  18. 18
    Academic Journal
    vScreenML v2.0: Improved Machine Learning Classification for Reducing False Positives in Structure-Based Virtual Screening.

    المؤلفون: Andrianov, Grigorii V.1,2 (AUTHOR) grigorii.andrianov@gmail.com, Haroldsen, Emeline1 (AUTHOR) eharold1@jh.edu, Karanicolas, John1,3 (AUTHOR) john.karanicolas@abbvie.edu

    المصدر: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12350. 12p.

    مصطلحات موضوعية: *DRUG discovery, *CHEMICAL libraries, *VIRTUAL machine systems, *MACHINE learning, *DIGITAL libraries

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  19. 19
    Academic Journal
    Synthesis of a thiophene-based fluorinated library applied to fragment-based drug discovery via19F NMR with confirmed binding to mutant HRASG12V.

    المؤلفون: Bendahan, David1 (AUTHOR), Franca, Tanos C. C.1,2,3 (AUTHOR), Amiens, Kathleen C.1 (AUTHOR), Ayotte, Yann4 (AUTHOR), Forgione, Pat5 (AUTHOR), LaPlante, Steven R.1 (AUTHOR) Steven.Laplante@inrs.ca

    المصدر: New Journal of Chemistry. 11/7/2024, Vol. 48 Issue 41, p17872-17877. 6p.

    مصطلحات موضوعية: *DRUG discovery, *CHEMICAL libraries, *DRUG target, *DRUG marketing, *CHEMICAL synthesis


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  20. 20
    Academic Journal
    Phenotypic approaches for CNS drugs.

    المؤلفون: Sharma, Raahul1,2 (AUTHOR), Oyagawa, Caitlin R.M.1 (AUTHOR), Abbasi, Hamid3 (AUTHOR), Dragunow, Michael1 (AUTHOR) m.dragunow@auckland.ac.nz, Conole, Daniel1,2 (AUTHOR) daniel.conole@auckland.ac.nz

    المصدر: Trends in Pharmacological Sciences. Nov2024, Vol. 45 Issue 11, p997-1017. 21p.

    مصطلحات موضوعية: *CHEMICAL libraries, *DRUG discovery, *HIGH throughput screening (Drug development), *CENTRAL nervous system, *ARTIFICIAL intelligence


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