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المؤلفون: Zhengtao Wang, Shujuan Zhao, Rufeng Wang, Maoqi Hou
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1813-1834 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: FPPS (FPS), farnesyl diphosphate synthase, IPP, isopentenyl diphosphate, PPD, protopanaxadiol, ABA, abscisic acid, Review, UDP, uridine diphosphate, Non-coding RNAs, chemistry.chemical_compound, Ginseng, 0302 clinical medicine, FPP, farnesyl pyrophosphate, KcMS, Kandelia candel multifunctional triterpene synthases, Genus, Biotechnological approach, MVA, mevalonate, OCT, ocotillol, General Pharmacology, Toxicology and Pharmaceutics, MVD, mevalonate diphosphate decarboxylase, GDP, guanosine diphosphate, MeJA, methyl jasmonate, 0303 health sciences, Traditional medicine, DMAPP, dimethylallyl diphosphate, OAS, oleanolic acid synthase, SS (SQS), squalene synthase, JA-Ile, (+)-7-iso-jasmonoyl-l-isoleucine, JAR, JA-amino acid synthetase, food and beverages, CPQ, cucurbitadienol synthase, α-AS, α-amyrin synthase, Biosynthetic pathway, RNAi, RNA interference, ITS, internal transcribed spacer, Ginsenoside, PPTS, PPT synthase, 030220 oncology & carcinogenesis, CYP, cytochrome P450, Protopanaxadiol, OA, oleanane or oleanic acid, NDP, nucleotide diphosphate, SPL, squamosa promoter-binding protein-like, SUS, sucrose synthase, UGPase, UDP-glucose pyrophosphosphprylase, LAS, lanosterol synthase, HEJA, 2-hydroxyethyl jasmonate, PPDS, PPD synthase, RM1-950, Biology, β-AS, β-amyrin synthase, HMGR, HMG-CoA reductase, complex mixtures, JA, jasmonic acid, JAZ, jasmonate ZIM-domain, 03 medical and health sciences, Triterpenoid, Biosynthesis, SE (SQE), squalene epoxidase, Transcription factors, TDP, thymine diphosphate, SA, salicylic acid, WGD, whole genome duplication, Oleanane, 030304 developmental biology, LUP, lupeol synthase, Protopanaxatriol, DM, dammarenediol-II, CAS, cycloartenol synthase, PPT, protopanaxatriol, DDS, dammarenediol synthase, OSC, oxidosqualene cyclase, ADP, adenosine diphosphate, UGT, UDP-dependent glycosyltransferase, chemistry, MEP, methylerythritol phosphate, AtCPR (ATR), Arabidopsis thaliana cytochrome P450 reductase, Therapeutics. Pharmacology, BARS, baruol synthase, Panax species, CDP, cytidine diphosphate
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المؤلفون: Caroline Richard, Jean Buteau, John P. Kennelly, Tingting Ju, Stephanie Carlin, Ben P. Willing, Jelske N. van der Veen, Aducio Thiesen, René L. Jacobs, Randal Nelson
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, CTαIKO, intestinal epithelial cell–specific deletion of CTP:phosphocholine cytidylyltransferase-α, TNF-α, tumor necrosis factor-α, IEC, intestinal epithelial cell, PC, phosphatidylcholine, Mice, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Homeostasis, Intestinal Mucosa, Original Research, Mice, Knockout, Chemistry, IRE1α, inositol-requiring enzyme 1-α, LIF, leukemia inhibitory factor, Dextran Sulfate, Gastroenterology, MCP-1, monocyte chemoattractant protein-1, Lipid, CTα, CTP:phosphocholine cytidylyltransferase-α, Colitis, Endoplasmic Reticulum Stress, Intestinal epithelium, mRNA, messenger RNA, 3. Good health, rRNA, ribosomal RNA, XBP1, X-box binding protein 1, medicine.anatomical_structure, RIP, receptor-interacting serine/threonine-protein kinase, Necroptosis, Phosphatidylcholines, Female, 030211 gastroenterology & hepatology, FITC, fluorescein isothiocyanate, Goblet Cells, GM-CSF, granulocyte-macrophage colony-stimulating factor, ATF6, activating transcription factor 6, Colon, PE, phosphatidylethanolamine, Permeability, ER, endoplasmic reticulum, 03 medical and health sciences, medicine, Animals, Choline-Phosphate Cytidylyltransferase, IBD, inflammatory bowel diseases, lcsh:RC799-869, Inflammation, Goblet cell, Intestinal permeability, Mouse Model, Hepatology, PERK, protein kinase R-like ER kinase, Endoplasmic reticulum, medicine.disease, Molecular biology, Mucus, Epithelium, IL, interleukin, Gastrointestinal Microbiome, Mice, Inbred C57BL, UC, ulcerative colitis, Phosphatidylcholine, 030104 developmental biology, TUNEL, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling, lcsh:Diseases of the digestive system. Gastroenterology, CDP, cytidine diphosphate, PBA, 4-phenyl butyrate
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المؤلفون: Amalia Gastaldelli, Stefano Gatti, Miriam Longo, Stefano Romeo, Melania Gaggini, Paola Dongiovanni, Sara Badiali, Nicholas O. Davidson, Anna Ludovica Fracanzani, Guido Baselli, Serena Pelusi, Raffaela Rametta, Marica Meroni, Fabrizia Carli, Luca Valenti, Marco Maggioni
المصدر: EBioMedicine
EBioMedicine, Vol 52, Iss, Pp-(2020)مصطلحات موضوعية: Research paper, TGFβ, Transforming Growth Factor Beta, Intracellular Space, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, hHEPS, Human Hepatocytes, Mice, 0302 clinical medicine, LPIAT1, DAG, Diacylglycerol, i.p., Intraperitoneal, media_common, Fatty Acids, General Medicine, 3. Good health, 030220 oncology & carcinogenesis, HOMA-IR, homeostasis Model Assessment of Insulin Resistance, MPO, morpholino, lcsh:Medicine (General), medicine.medical_specialty, PE, Phosphatidyl-Ethanolamine, Nash, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, TNFα, tumor Necrosis Factor Alpha, LDL, Low Density Lipoproteins, Hyperinsulinism, NAFLD, SD, Standard Diet, media_common.cataloged_instance, Humans, CPT1, Carnitine Palmitoyltransferase I, Phosphatidylinositol, Gene Silencing, European union, VLDL, Very Low Density Lipoprotein, lcsh:R, hHSC, Human Hepatic Stellate Cells, medicine.disease, Lipid Metabolism, OA, Oleic Acid, CI, Confidence Interval, Mboat7, Membrane bound O-acyltransferase domain containing 7, MCD, methionine choline deficient diet, 030104 developmental biology, Endocrinology, chemistry, CDP, Cytidine-Diphosphate, FOXO1, Forkhead Box protein O1, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, BMI, Body Mass Index, CL, Cardiolipin, Acyltransferases, 0301 basic medicine, Alcoholic liver disease, CXCL10, C-X-C Motif Chemokine 10, lcsh:Medicine, chemistry.chemical_compound, Non-alcoholic Fatty Liver Disease, IFG, Impaired Fasting Glucose, APOB, Apolipoprotein B, Nonalcoholic fatty liver disease, PIP, Phosphatidyl-Inositol-Phosphate, qRT-PCR, quantitative Real Time Polymerase Chain Reaction, Mice, Knockout, lcsh:R5-920, ORO, Oil Red O Staining, PI, Phosphatidylinositol, Fatty liver, TM6SF2, Transmembrane 6 Superfamily Member 2, Phospholipid, TAG, Triglycerides, NASH, Nonalcoholic Steatohepatitis, Lipogenesis, LPA, Lyso-Phosphatidic Acid, Signal Transduction, PS, Phosphatidyl-Serine, PA, Palmitic Acid, ALD, alcoholic liver disease, PC, Phosphatidylcholine, i.v., Intravenous, FATP1, Fatty Acid Transport Protein 1, Models, Biological, Internal medicine, medicine, Animals, PPARα, Peroxisome Proliferator-Activated Receptor alpha, Obesity, G3P, Glyceraldehyde-3-Phosphate, SREBP1c, Sterol Regulatory Element-Binding Protein 1, HDL, High Density Lipoproteins, business.industry, PI3K, Phosphatidylinositol 3 Kinase, Membrane Proteins, NHEJ, Non-Homologues End Joining, PNPLA3, Patatin-like Phospholipase Domain-containing-3, MTTP, Microsomal Triglyceride Transfer Protein, LPIAT1, Lysophosphatidylinositol Acyltransferase 1, TMC4, Transmembrane Channel-Like 4, Disease Models, Animal, Gene Expression Regulation, Hepatocytes, FOXA2, Forkhead Box A2, mTOR, mammalian target of Rapamycin, Steatosis, Insulin Resistance, business, PG, Phosphatidyl-Glycerol, FABP1, Fatty Acid-Binding Protein 1, FAS, Fatty Acid Synthase, T2DM, Type 2 Diabetes Mellitus
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المؤلفون: Fabian, Dorninger, Alexander, Brodde, Nancy E, Braverman, Ann B, Moser, Wilhelm W, Just, Sonja, Forss-Petter, Britta, Brügger, Johannes, Berger
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: RCDP, rhizomelic chondrodysplasia punctata, Docosahexaenoic Acids, Plasmalogens, DHA, docosahexaenoic acid, AA, arachidonic acid, Peroxisome, PE, phosphatidylethanolamine, Severity of Illness Index, Article, Plasmalogen, PC, phosphatidylcholine, PUFA, polyunsaturated fatty acid, Animals, Homeostasis, Humans, Genetic Predisposition to Disease, Gray Matter, HDG, hexadecylglycerol, Cells, Cultured, PlsEtn, ethanolamine plasmalogen, Mice, Knockout, Arachidonic Acid, SM, sphingomyelin, Chondrodysplasia Punctata, Rhizomelic, Phosphatidylethanolamines, GNPAT, glyceronephosphate acyltransferase, Fibroblasts, Alzheimer's disease, BA, batyl alcohol, PS, phosphatidylserine, Adaptation, Physiological, Mice, Inbred C57BL, Disease Models, Animal, Docosahexaenoic acid, Phenotype, AGPS, alkylglycerone phosphate synthase, CDP, cytidine diphosphate, Compensation, Acyltransferases
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المؤلفون: Lixin Sun, Xi Liu, Zheng Liu, Cuichai Liu, Fang Wang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 3, Pp 223-230 (2015)مصطلحات موضوعية: dGTP, deoxyguanosine triphosphate, Antibiotics, Drug action, Pharmacology, DMSO, dimethyl sulfoxide, UDP, uridine diphosphate, dCDP, deoxycytidine diphosphate, AUC, area under the curve, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, DNA, deoxyribonucleic acid, GMP, guanosine monophosphate, GTP, guanosine triphosphate, Potential biomarkers, Nucleotide, Ion-pair HPLC, General Pharmacology, Toxicology and Pharmaceutics, ANOVA, analysis of variance, RPMI-1640, Roswell Park Memorial Institute-1640, GDP, guanosine diphosphate, chemistry.chemical_classification, Dactinomycin, Nucleotides, dCTP, deoxycytidine triphosphate, dUTP, deoxyuridine triphosphate, Original Article, medicine.symptom, dUDP, deoxyuridine diphpsphate, Epirubicin, medicine.drug, ATP, adenosine triphosphate, medicine.drug_class, Daunorubicin, Principal component analysis, CTP, cytidine triphosphate, Biology, dGMP, deoxyribonucleic monophosphate, TCA, trichloroacetic acid, Tumor cells, EC, energy charge, PBS, phosphate buffered saline, Targeted metabolomics analysis, medicine, dATP, deoxyadenosine triphosphate, PCA, principal component analysis, Mechanism (biology), lcsh:RM1-950, Mechanisms of antitumor drug action, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, ADP, adenosine diphosphate, ROC, receiver operating characteristic, EDTA, ethylene diamine tetra-acetic acid, lcsh:Therapeutics. Pharmacology, chemistry, Mechanism of action, TBAHS, tetrabutylammonium hydrogen sulfate, AMP, adenosine monophosphate, RNA, ribonucleic acid, Antibiotic anticancer drugs, FCS, fetal calf serum, DMEM, Dulbecco׳s modified eagle׳s cell culture media, CDP, cytidine diphosphate, UTP, uridine triphosphate