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المؤلفون: Alexei Diakov, Alexandr V. Ilyaskin, Christoph Korbmacher
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Epithelial sodium channel, Sgk1, serum and glucocorticoid-induced kinase 1, Patch-Clamp Techniques, Nedd4 Ubiquitin Protein Ligases, proteolytic channel activation, Xenopus, CD, collecting duct, NEDD4, connexon (hemichannel), clathrin-mediated endocytosis, ASDN, aldosterone-sensitive distal nephron, Biochemistry, Xenopus laevis, AP-2, clathrin adaptor protein 2, GJ, gap-junctions, ANOVA, analysis of variance, cRNA, complementary RNA, biology, Chemistry, ENaC, epithelial sodium channel, DCT2, late distal convoluted tubule, MTSET, (2-(trimethylammonium)ethyl) methanethiosulfonate bromide, respiratory system, salt-sensitive hypertension, Endocytosis, Cell biology, Ubiquitin ligase, Nedd4-2, neural precursor cell expressed developmentally downregulated protein 4-2, SDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, CNT, connecting tubule, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Research Article, inorganic chemicals, PVDF, polyvinylidene fluoride, Clathrin, patch clamp, 03 medical and health sciences, epithelial sodium channel (ENaC), cDNA, complementary DNA, Connexin 30, NMDG, N-methyl-D-glucamine, Animals, Humans, two-electrode voltage clamp, Cx, connexin, Epithelial Sodium Channels, oocyte, Molecular Biology, LJ, liquid junction, 030102 biochemistry & molecular biology, urogenital system, Cell Biology, Receptor-mediated endocytosis, biology.organism_classification, electrophysiology, 030104 developmental biology, Po, channel open probability, SGK1, biology.protein, Oocytes, Nedd4-2
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المؤلفون: Nada Bulus, Charles R. Sanders, Ambra Pozzi, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Reinhard Fässler, Roy Zent, Kyle L. Brown
المصدر: Journal of Biological Chemistry
The Journal of Biological Chemistry
J. Biol. Chem. 296:100361 (2021)مصطلحات موضوعية: IPP, ILK–pinch–parvin, Male, CD, collecting duct, Kidney development, Kidney, Cell morphology, Biochemistry, Mice, 0302 clinical medicine, Mice, Knockout, 0303 health sciences, biology, medicine.diagnostic_test, Chemistry, Microfilament Proteins, PBS, paxillin-binding site, LIM Domain Proteins, MD, molecular dynamics, ILK, integrin-linked kinase, Cell biology, Pleckstrin homology domain, embryonic structures, Female, Research Article, PH, pleckstrin homology, DMEM, Dulbecco's minimal essential media, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Cell Line, 03 medical and health sciences, Protein Domains, Western blot, Cell Adhesion, medicine, Animals, Integrin-linked kinase, Cell adhesion, Molecular Biology, Adaptor Proteins, Signal Transducing, 030304 developmental biology, cell culture, Focal Adhesions, western blot, molecular modeling, Membrane Proteins, PC, principal component, Cell Biology, molecular dynamics, Mice, Inbred C57BL, Cell culture, biology.protein, Paxillin, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المصدر: European Journal of Pharmaceutical Sciences
مصطلحات موضوعية: Tubular reabsorption, BCRP, breast cancer resistance protein, Metabolic Clearance Rate, TSA, tubular surface area, Freab, fraction of the drug reabsorbed in the renal tubule, CD, collecting duct, PT, proximal tubule, RMSE, root mean squared error, Models, Biological, Article, IVIVE, in vitro–in vivo extrapolation, TFR, tubular flow rate, Renal excretion clearance, P-gp, P-glycoprotein, Humans, AUC, area under the plasma concentration-time profile, fu,p, fraction of drug unbound in plasma, DT, distal tubule, OCT, organic cation transporter, Clinical Trials as Topic, LoH, loop of Henle, GFR, glomerular filtration rate, CLR, renal excretion clearance, Cp, plasma concentration, CLR, filt, renal filtration clearance, OATP, organic anion-transporting peptides, gmfe, geometric mean fold error, OCTN, organic cation/l-carnitine transporter, Renal Elimination, Kidney Tubules, CLR, int,reab, intrinsic permeability clearance in renal tubule, Papp, apparent permeability, Pharmaceutical Preparations, PBPK, physiologically-based pharmacokinetic, CLR,sec, renal secretion clearance, In vitro–in vivo extrapolation, OAT, organic anion transporter, Freab’, intermediate model parameter, representing the fraction of the equilibrium reached between unbound drug concentration in the plasma and urine, MRP, multidrug resistance protein, LogD, octanol-buffer distribution coefficient, Glomerular Filtration Rate, MATE, multidrug and toxin extrusion protein
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المؤلفون: Bruce C. Kone, Zhi Yuan Yu, Qun Kong
المصدر: Bioscience Reports
مصطلحات موضوعية: Af9, ALL1-fused gene from chromosome 9 protein, Transcription, Genetic, CD, collecting duct, SEC, super elongation complex, ECL, enhanced chemiluminescence, Biochemistry, H3K27me3, trimethylated histone H3 lysine 27, Mice, Transcription (biology), Protein Interaction Mapping, GST, glutathione transferase, Per1, Period 1, Promoter Regions, Genetic, Aldosterone, Polycomb Repressive Complex 1, Regulation of gene expression, 0303 health sciences, biology, ENaC, epithelial sodium channel, EZH2, enhancer of zeste homologue 2, 030302 biochemistry & molecular biology, Nuclear Proteins, HRP, horseradish peroxidase, qRT-PCR, quantitative real-time PCR, EGFP, enhanced green fluorescent protein, Chromatin, ChIP, chromatin immunoprecipitation, Protein Transport, CNT, connecting tubule, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, H3K79me3, histone H3 lysine 79 trimethylated, PRC, Polycomb repressive complex, PRC2, Protein Binding, Dot1a, disruptor of telomeric silencing isoform 1a, Ubiquitin-Protein Ligases, H2AK119, Biophysics, S2, Cell Line, 03 medical and health sciences, Histone H3, FBS, fetal bovine serum, Rnf, RING finger protein, CBX8, chromobox protein 8, Histone H2A, Animals, Kidney Tubules, Collecting, Epithelial Sodium Channels, Molecular Biology, Transcription factor, 030304 developmental biology, Original Paper, H3K27, QPCR, quantitative PCR, epigenetics, GRE, glucocorticoid responsive element, Cell Biology, MR, mineralocorticoid receptor, Molecular biology, Polycomb, Gene Expression Regulation, PcG, Polycomb group, siRNA, small interfering RNA, PH, polyhomeotic, biology.protein, methyltransferase, AFF1, AF4/FMR2 family member 1, Chromatin immunoprecipitation, DAPI, 4′,6-diamidino-2-phenylindole, H2AK119ub1, histone H2A lysine 119 monoubiquitination