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المؤلفون: Bert Chi, Andrew Patron, Michael Saganich, Sara Werner, Catherine Tachdjian, Guy Servant, Amy J. Arthur, Joseph R. Fotsing, Lily Ida, Hanghui Liu, Donald S. Karanewsky
المصدر: Toxicology Reports, Vol 4, Iss, Pp 507-520 (2017)
Toxicology Reportsمصطلحات موضوعية: 0301 basic medicine, CL, plasma clearance, Health, Toxicology and Mutagenesis, S2218, Pharmacology, Toxicology, LC/MS, liquid chromatography with mass spectrometry, AUC, area under the curve, t1/2, half-life, Ingredient, MC, methylcellulose, Genetic toxicological evaluation, GLP, Good Laboratory Practices, TK, toxicokinetics, Flavours with modifying properties, Chemistry, FL-no, FLAVIS number, 04 agricultural and veterinary sciences, 040401 food science, Micronucleus test, amu, atomic mass units, CYP, cytochrome P450, Gestation, CBPI, cytokinesis-blocked proliferation index, Tmax, time to reach Cmax, FEMA GRAS, 03 medical and health sciences, Clastogen, 0404 agricultural biotechnology, stomatognathic system, Pharmacokinetics, lcsh:RA1190-1270, Full Length Article, Vss, volume of distribution at steady-state, FMP, flavour with modifying properties, Developmental toxicity evaluation, OECD, Organization for Economic Cooperation and Development, lcsh:Toxicology. Poisons, Fetus, GMP, Good Manufacturing Practices, Subchronic toxicological evaluation, NOAEL, no-observed-adverse-effect-level, FEMA, Flavour and Extract Manufacturers Association of the United States, FDA, Food and Drug Administration, In vitro, EIC, extracted ion chromatogram, Bioavailability, 030104 developmental biology, HPBL, human peripheral blood lymphocytes, PK, pharmacokinetics, Cmax, peak plasma concentration