نتائج البحث - "CARBONIC-ANHYDRASE"

1

Academic Journal

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX.

المؤلفون: Vaškevičius, Aivaras¹, Baronas, Denis¹, Leitans, Janis², Kvietkauskaitė, Agnė¹, Rukšėnaitė, Audronė³, Manakova, Elena⁴, Toleikis, Zigmantas⁵, Kaupinis, Algirdas⁶, Kazaks, Andris², Gedgaudas, Marius¹, Mickevičiūtė, Aurelija¹, Juozapaitienė, Vaida¹, Schiöth, Helgi B.⁷, Jaudzems, Kristaps⁸, Valius, Mindaugas⁶, Tars, Kaspars², Gražulis, Saulius⁹, Meyer-Almes, Franz-Josef¹⁰, Matulienė, Jurgita¹, Zubrienė, Asta¹

المصدر: eLife. 12/17/2024, p1-36. 36p.

مصطلحات موضوعية: *MEMBRANE proteins, *CARBONIC anhydrase, *CARBONIC anhydrase inhibitors, *CANCER cell proliferation, *COVALENT bonds

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2

Academic Journal

Combination of Carbonic Anhydrase Isoform IX Inhibitors and Gefitinib Suppresses on the Invasive Potential of Non-Small Cell Lung Cancer Cells.

المؤلفون: Bunev, Alexander S.¹ (AUTHOR), Shetnev, Anton A.² (AUTHOR), Shemchuk, Olga S.³ (AUTHOR), Kozhukhov, Pavel K.³ (AUTHOR), Sharonova, Tatyana V.⁴ (AUTHOR), Tyuryaeva, Irina I.^4,5 (AUTHOR), Khotin, Mikhail G.⁵ (AUTHOR), Ageev, Sergey V.^3,4 (AUTHOR), Kholmurodova, Dilafruz K.⁶ (AUTHOR), Rizaev, Jasur A.⁶ (AUTHOR), Semenov, Konstantin N.^3,4,6 (AUTHOR), Sharoyko, Vladimir V.^1,3,4,6 (AUTHOR) sharoyko@gmail.com

المصدر: Biochemistry (00062979). Dec2024, Vol. 89 Issue 12, p2227-2237. 11p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *HUMAN cell cycle, *NON-small-cell lung carcinoma, *MEDICAL sciences, *CARBONIC anhydrase

3

Academic Journal

Design, Synthesis, Anticancer Screening, and Mechanistic Study of Spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide Derivatives.

المؤلفون: El-Saghier, Ahmed M.¹ (AUTHOR) el.saghier@science.sohag.edu.eg, Hashem, Hamada² (AUTHOR), Maher, Sherif A.³ (AUTHOR) sherif.ali87@pha.nvu.edu.eg, Enaili, Souhaila S.⁴ (AUTHOR) s.enaili@zu.edu.ly, Alkhammash, Abdullah⁵ (AUTHOR) alkhammash@su.edu.sa, Bräse, Stefan⁶ (AUTHOR) el.saghier@science.sohag.edu.eg, Aziz, Hossameldin A.⁷ (AUTHOR) hossamaziz85@pha.nvu.edu.eg

المصدر: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p863. 21p.

مصطلحات موضوعية: *CARBONIC anhydrase, *CELL cycle, *ANTINEOPLASTIC agents, *MOLECULAR docking, *CELL lines, *DOXORUBICIN

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4

Academic Journal

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells.

المؤلفون: Inniss, Mara C.¹ (AUTHOR), Smith, Sean G.¹ (AUTHOR), Li, Dan Jun¹ (AUTHOR), Primack, Benjamin¹ (AUTHOR), Sun, Dexue¹ (AUTHOR), Olinger, Grace Y.¹ (AUTHOR), Sheahan, Kerri-Lynn¹ (AUTHOR), Ross, Theresa¹ (AUTHOR), Langley, Meghan¹ (AUTHOR), Young, Violet¹ (AUTHOR), Alvarado, Andres¹ (AUTHOR), Davoodi, Shabnam¹ (AUTHOR), Geng, Jiefei¹ (AUTHOR), Schebesta, Michael¹ (AUTHOR), Ols, Michelle L.¹ (AUTHOR), Tchaicha, Jeremy¹ (AUTHOR), ter Meulen, Jan¹ (AUTHOR), Sethi, Dhruv K.¹ (AUTHOR) dsethi@obsidiantx.com

المصدر: Communications Biology. 1/9/2025, Vol. 8 Issue 1, p1-16. 16p.

مصطلحات موضوعية: *CARBONIC anhydrase, *T cells, *LIFE sciences, *CYTOLOGY, *HEMATOLOGIC malignancies

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5

Academic Journal

Exploring the Inhibition of Toxoplasma gondii α-Carbonic Anhydrase by Sulfonamides: Insights into Potential Drug Targeting.

المؤلفون: Giovannuzzi, Simone¹ (AUTHOR) simone.giovannuzzi@unifi.it, De Luca, Viviana² (AUTHOR) viviana.deluca@ibbr.cnr.it, Capasso, Clemente² (AUTHOR) clemente.capasso@ibbr.cnr.it, Supuran, Claudiu T.¹ (AUTHOR) claudiu.supuran@unifi.it

المصدر: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 1, p116. 14p.

مصطلحات موضوعية: *TOXOPLASMA gondii, *CARBONIC anhydrase, *TARGETED drug delivery, *DRUG target, *TREATMENT effectiveness

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6

Academic Journal

Carbonic Anhydrase IX Enzyme in Triple Negative Breast Carcinoma: Relationship With Prognostic Factors and Response to Neoadjuvant Chemotherapy.

المؤلفون: Solmaz, Özgen Arslan (AUTHOR), Kutluer, Nizamettin (AUTHOR), Bozan, Mehmet Buğra (AUTHOR)

المصدر: European Journal of Breast Health. Jan2025, Vol. 27 Issue 1, p1-6. 6p.

مصطلحات موضوعية: *EPIDERMAL growth factor receptors, *CARBONIC anhydrase, *MEMBRANE glycoproteins, *ESTROGEN receptors, *PROGNOSIS

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7

Academic Journal

Inhibitory Effect of Human Anti‐CA I Autoantibodies and Development of Monoclonal Antibody mAb 2B8 Targeting Carbonic Anhydrase I.

المؤلفون: Chalova, Petra^1,2 (AUTHOR), Jankovicova, Barbora³ (AUTHOR), Dvorakova, Veronika³ (AUTHOR), Zelinkova, Eliska³ (AUTHOR), Bilkova, Zuzana³ (AUTHOR), Slovakova, Marcela³ (AUTHOR), Korecka, Lucie³ (AUTHOR), Muller, Petr⁴ (AUTHOR), Danchenko, Maksym⁵ (AUTHOR), Minichova, Lenka¹ (AUTHOR), Lakota, Jan⁶ (AUTHOR), Skultety, Ludovit^1,7 (AUTHOR) viruludo@gmail.com, Kim, Cheorl-Ho (AUTHOR) chkimbio@skku.edu

المصدر: Mediators of Inflammation. 12/29/2024, Vol. 2024, p1-11. 11p.

مصطلحات موضوعية: *SPONTANEOUS cancer regression, *CARBONIC anhydrase, *AMINO acid sequence, *EUKARYOTIC cells, *AUTOANTIBODIES

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8

Academic Journal

The synthesis of specifically isotope labelled fluorotryptophan and its use in mammalian cell-based protein expression for ¹⁹F-NMR applications.

المؤلفون: Toscano, Giorgia¹ (AUTHOR), Rosati, Martina² (AUTHOR), Barbieri, Letizia³ (AUTHOR), Maier, Katharina⁴ (AUTHOR), Banci, Lucia⁵ (AUTHOR), Luchinat, Enrico⁶ (AUTHOR), Konrat, Robert⁷ (AUTHOR), Lichtenecker, Roman J.⁸ (AUTHOR) roman.lichtenecker@univie.ac.at

المصدر: Chemical Communications. 12/14/2024, Vol. 60 Issue 96, p14188-14191. 4p.

مصطلحات موضوعية: *ESCHERICHIA coli, *CARBONIC anhydrase, *SUPEROXIDE dismutase, *NUCLEAR magnetic resonance spectroscopy, *RADIOLABELING

9

Academic Journal

A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from Acinetobacter baumannii for crafting innovative antimicrobial treatments.

المؤلفون: De Luca, Viviana¹ (AUTHOR), Giovannuzzi, Simone² (AUTHOR), Supuran, Claudiu T.² (AUTHOR) claudiu.supuran@unifi.it, Capasso, Clemente¹ (AUTHOR) clemente.capasso@ibbr.cnr.it

المصدر: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-9. 9p.

مصطلحات موضوعية: *CARBONIC anhydrase, *DRUG resistance in bacteria, *NOSOCOMIAL infections, *PATHOGENIC bacteria, *MOLECULAR cloning, *ACINETOBACTER baumannii

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10

Academic Journal

Cloning, expression, and purification of an α-carbonic anhydrase from Toxoplasma gondii to unveil its kinetic parameters and anion inhibition profile.

المؤلفون: De Luca, Viviana¹ (AUTHOR), Giovannuzzi, Simone² (AUTHOR), Capasso, Clemente¹ (AUTHOR) clemente.capasso@ibbr.cnr.it, Supuran, Claudiu T.² (AUTHOR) claudiu.supuran@unifi.it

المصدر: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-9. 9p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *ENZYME kinetics, *INORGANIC compounds, *TOXOPLASMOSIS, *INTRACELLULAR pathogens

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11

Academic Journal

Synthesis, carbonic anhydrase inhibition studies and modelling investigations of phthalimide–hydantoin hybrids.

المؤلفون: Abdoli, Morteza¹ (AUTHOR), Bonardi, Alessandro^2,3 (AUTHOR), Gratteri, Paola² (AUTHOR), Supuran, Claudiu T.³ (AUTHOR) claudiu.supuran@unifi.it, Žalubovskis, Raivis^1,4 (AUTHOR) raivis@osi.lv

المصدر: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-9. 9p.

مصطلحات موضوعية: *CARBONIC anhydrase, *PHTHALIMIDES, *MOLECULAR docking, *HYDANTOIN, *CONDENSATION, *ENZYME inhibitors

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12

Academic Journal

A Randomized Pilot Study of Four Dosing Schemes of Sublingual Methazolamide in Glaucoma Patients.

المؤلفون: Tan, Nicholas E (AUTHOR), Patnaik, Jennifer L (AUTHOR), McWilliams, Sara (AUTHOR), Seibold, Leonard K (AUTHOR), Kahook, Malik Y (AUTHOR)

المصدر: Clinical Ophthalmology. Dec2024, Vol. 18, p3893-3901. 9p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *OPEN-angle glaucoma, *INTRAOCULAR pressure, *FATIGUE (Physiology), *ELECTROLYTES

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13

Academic Journal

Acetazolamide as a therapeutic alternative for central sleep apnea in pediatric patient with FBXO28 gene mutation: A case report and review of literature.

المؤلفون: Sirianansopa, Kantisa^1,2 (AUTHOR) kantisa.sirianansopa@sickkids.ca, Amin, Reshma^1,3,4 (AUTHOR) reshma.amin@sickkids.ca

المصدر: Sleep Medicine. Dec2024, Vol. 124, p479-482. 4p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *GENETIC disorders, *CHILD patients, *SLEEP apnea syndromes, *ACIDOSIS

14

Academic Journal

Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold.

المؤلفون: Zengin, Merve¹ (AUTHOR) merveozdagli@hacettepe.edu.tr, Unsal Tan, Oya¹ (AUTHOR), Sabuncuoglu, Suna² (AUTHOR), Arafa, Reem K.^3,4 (AUTHOR) rkhidr@zewailcity.edu.eg, Balkan, Ayla¹ (AUTHOR)

المصدر: Drug Development Research. Dec2024, Vol. 85 Issue 8, p1-18. 18p.

مصطلحات موضوعية: *VASCULAR endothelial growth factor receptors, *CARBONIC anhydrase, *PROTEIN-tyrosine kinases, *MOLECULAR docking, *DRUG design

15

Academic Journal

Acetazolamide suppresses the progression of hepatocellular carcinoma induced by diethylnitrosamine in Wistar albino rats.

المؤلفون: Tamim, Yomna M.¹ (AUTHOR), Soliman, Mohamed L.² (AUTHOR), Sayed, Moataz M.² (AUTHOR), Abdul‐Rasheed, Muhammad S.³ (AUTHOR), Nagy, Ahmed A.⁴ (AUTHOR), Abdellah, Ahmed M.⁵ (AUTHOR), Osman, Ahmed H.⁶ (AUTHOR), Ismail, Amel F. M.⁷ (AUTHOR) afmismail@gmail.com

المصدر: Fundamental & Clinical Pharmacology. Dec2024, Vol. 38 Issue 6, p1045-1058. 14p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *LIVER enzymes, *HEPATOCELLULAR carcinoma, *LIVER cancer, *OXIDANT status, *ALPHA fetoproteins

16

Academic Journal

Novel Hydrazide‐Hydrazones Bearing a Benzimidazole Ring: Design, Synthesis, and Evaluation of Inhibitor Properties Against CA I and CA II Isozymes.

المؤلفون: Işık, Ayşen¹ (AUTHOR), Acar Çevik, Ulviye² (AUTHOR) uacar@anadolu.edu.tr, Celik, Ismail³ (AUTHOR), Küçükoğlu, Kaan⁴ (AUTHOR), Nadaroglu, Hayrunnisa⁵ (AUTHOR), Bostancı, Hayrani Eren⁶ (AUTHOR), Özkay, Yusuf² (AUTHOR), Kaplancıklı, Zafer Asım² (AUTHOR)

المصدر: Chemical Biology & Drug Design. Dec2024, Vol. 104 Issue 6, p1-13. 13p.

مصطلحات موضوعية: *CARBONIC anhydrase, *CHEMICAL synthesis, *BINDING energy, *CHEMICAL structure, *ISOENZYMES, *HYDRAZONE derivatives, *BENZIMIDAZOLES

17

Academic Journal

Light‐Induced Unlocking Reactivity of Fragments for Fast Target‐Guided Synthesis of Carbonic Anhydrase Inhibitors.

المؤلفون: Puteaux, Chloé¹ (AUTHOR), Toubia, Isabelle¹ (AUTHOR), Truong, Lina¹ (AUTHOR), Hubert‐Roux, Marie¹ (AUTHOR), Bailly, Laetitia¹ (AUTHOR), Oulyadi, Hassan¹ (AUTHOR), Renard, Pierre‐Yves¹ (AUTHOR), Sabot, Cyrille¹ (AUTHOR) cyrille.sabot@univ-rouen.fr

المصدر: Angewandte Chemie. 10/7/2024, Vol. 136 Issue 41, p1-9. 9p.

مصطلحات موضوعية: *CARBONIC anhydrase inhibitors, *LIGATION reactions, *DRUG discovery, *CARBONIC anhydrase, *DRUG target

18

Academic Journal

Hydrogen Sulfide-Releasing Carbonic Anhydrase Inhibitors Effectively Suppress Cancer Cell Growth.

المؤلفون: Bonardi, Alessandro¹ (AUTHOR) alessandro.bonardi@unifi.it, Nocentini, Alessio¹ (AUTHOR) alessandro.bonardi@unifi.it, de Luca, Viviana² (AUTHOR) viviana.deluca@ibbr.cnr.it, Capasso, Clemente² (AUTHOR) clemente.capasso@ibbr.cnr.it, Elkaeed, Eslam B.³ (AUTHOR) eslamkaeed@azhar.edu.eg, Eldehna, Wagdy M.^4,5 (AUTHOR) wagdy2000@gmail.com, Supuran, Claudiu T.¹ (AUTHOR)

المصدر: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p10006. 17p.

مصطلحات موضوعية: *CANCER cell growth, *CARBONIC anhydrase inhibitors, *CYTOTOXINS, *CARBONIC anhydrase, *CELL populations

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19

Academic Journal

Hippocampus carbonic anhydrase 1 via ERK pathway may be involved in depressive like behaviors.

المؤلفون: Cheng, Ke^1,2 (AUTHOR) jackchengke@163.com, Chen, Chong^1,3,4 (AUTHOR), Deng, Shilong^1,2 (AUTHOR), Xu, Fei^1,2 (AUTHOR), Chen, Xiangyu^1,3,4 (AUTHOR), Yang, Jian^1,5,6 (AUTHOR) yangjian@ccmu.edu.cn, Wang, Gang^1,5,6 (AUTHOR) gangwangdoc@ccmu.edu.cn, Xie, Peng^1,2,3 (AUTHOR) xiepeng@cqmu.edu.cn

المصدر: Journal of Affective Disorders. Mar2025, Vol. 373, p186-195. 10p.

مصطلحات موضوعية: *CARBONIC anhydrase, *MENTAL depression, *MENTAL illness, *RECOGNITION (Psychology), *CELLULAR signal transduction

20

Academic Journal

Preclinical evaluation and automated synthesis of [⁸⁹Zr]ZrDFOSquaramide-girentuximab for diagnostic imaging of carbonic anhydrase IX positive tumours.

المؤلفون: Noor, Asif¹ (AUTHOR) asif.noor@unimelb.edu.au, McGowan, Emily R.¹ (AUTHOR), Van Zuylekom, Jessica K.² (AUTHOR), Cullinane, Carleen^2,3 (AUTHOR), Roselt, Peter D.^3,4 (AUTHOR), Hicks, Rodney J.^2,3,5 (AUTHOR), Wheatcroft, Michael P.⁶ (AUTHOR), Donnelly, Paul S.¹ (AUTHOR) pauld@unimelb.edu.au

المصدر: EJNMMI Radiopharmacy & Chemistry. 11/26/2024, Vol. 9 Issue 1, p1-13. 13p.

مصطلحات موضوعية: *POSITRON emission tomography, *CARBONIC anhydrase, *RADIOCHEMICAL purification, *IMAGE analysis, *DIAGNOSTIC imaging

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