المؤلفون: D.W. Moreland, Juan C. Jaen, Penvose-Yi, Roy D. Schwarz, C.E. Augelli-Szafran, C. J. Blankley, Anthony Jerome Thomas, C.B. Nelson

المصدر: Journal of Medicinal Chemistry. 42:356-363

مصطلحات موضوعية: biology, Stereochemistry, Antagonist, biology.organism_classification, Pirenzepine, Chemical synthesis, Chinese hamster, chemistry.chemical_compound, chemistry, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Molecular Medicine, Phosphatidylinositol, Receptor, medicine.drug, Acetylcholine receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::99ae9fbcb3fa6b3d09c07d2e2341d960
https://doi.org/10.1021/jm980067l

المؤلفون: Sophie Levesque, Kent A. Berryman, M. Arshad Siddiqui, Jeremy J. Edmunds, Peter D. Winocour, John DiMaio, Annette Marian Doherty, Yves St-Denis, C.E. Augelli-Szafran, Benoit Bachand, Lorraine Leblond, Lakshmi S. Narasimhan, J. Ronald Rubin, Micheline Tarazi, J.R. Penvose-Yi

المصدر: Bioorganic & Medicinal Chemistry Letters. 8:3193-3198

مصطلحات موضوعية: Serine Proteinase Inhibitors, Lactams, Molecular model, medicine.drug_class, Stereochemistry, Peptidomimetic, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Fibrinolytic Agents, Drug Discovery, medicine, Animals, Molecular Biology, Bicyclic molecule, biology, Chemistry, Organic Chemistry, Rats, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197b252f0565e168178e927f9b2d1654
https://doi.org/10.1016/s0960-894x(98)00550-2

المؤلفون: N. Suman-Chauhan, Louise Webdale, Bharat K. Trivedi, Terri S. Purchase, Bruce D. Roth, Bradley Dean Tait, Michael W. Wilson, C.E. Augelli-Szafran

المصدر: Bioorganic & Medicinal Chemistry Letters. 7:2009-2014

مصطلحات موضوعية: chemistry.chemical_classification, Indole test, Stereochemistry, medicine.drug_class, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biological activity, Receptor antagonist, Biochemistry, Chemical synthesis, CI-988, chemistry, Heterocyclic compound, Drug Discovery, medicine, Molecular Medicine, Moiety, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5886e2071e1eb3e3a190e66876eee38b
https://doi.org/10.1016/s0960-894x(97)00356-9

المؤلفون: Martyn Clive Pritchard, Bruce D. Roth, N. Suman-Chauhan, Daniel F. Ortwine, C.E. Augelli-Szafran, David R. Hill, David Christopher Horwell, Clare O. Kneen, Bharat K. Trivedi, Louise Webdale, Terri S. Purchase

المصدر: Bioorganic & Medicinal Chemistry. 4:1733-1745

مصطلحات موضوعية: Steric effects, Indoles, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Substituent, Pharmaceutical Science, Ring (chemistry), Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Hormone Antagonists, Meglumine, Drug Discovery, Animals, Moiety, Molecular Biology, chemistry.chemical_classification, digestive, oral, and skin physiology, Organic Chemistry, Receptor, Cholecystokinin B, Rats, Receptor, Cholecystokinin A, chemistry, Lipophilicity, Polar effect, Molecular Medicine, Receptors, Cholecystokinin, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d470f86b23139f2e7260133064b94735
https://doi.org/10.1016/0968-0896(96)00185-x

المؤلفون: Haile Tecle, Robert E. Davis, Roy D. Schwarz, Bradley William Caprathe, T. Mirzadegan, Stephen Douglas Barrett, Walter H. Moos, Lauffer David Jeffrey, Juan C. Jaen, Anthony Jerome Thomas, D.W. Moreland, Michael R. Pavia, C.E. Augelli-Szafran

المصدر: Bioorganic & Medicinal Chemistry Letters. 5:631-636

مصطلحات موضوعية: Stereochemistry, Aryl, Propynyl, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Subtype selective, Oxime, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Muscarinic acetylcholine receptor, Molecular Medicine, Selectivity, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8357932845da7b87b82fc5231351818d
https://doi.org/10.1016/0960-894x(95)00086-9

المؤلفون: N. Suman-Chauhan, Bradley Dean Tait, Bharat K. Trivedi, Bruce D. Roth, Terri S. Purchase, Michael W. Wilson, C.E. Augelli-Szafran, Louise Webdale

المصدر: ChemInform. 28

مصطلحات موضوعية: Indole test, Stereochemistry, Chemistry, medicine.drug_class, medicine, Antagonist, Moiety, Biological activity, General Medicine, Receptor antagonist, Combinatorial chemistry, CI-988

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06a8803ad487daaab7bf095b4c211446
https://doi.org/10.1002/chin.199749220

المؤلفون: J.R. Penvose-Yi, D.W. Moreland, C.E. Augelli-Szafran, Roy D. Schwarz, Juan C. Jaen, C.B. Nelson

المصدر: ChemInform. 29

مصطلحات موضوعية: Chemistry, Stereochemistry, Muscarinic acetylcholine receptor, General Medicine, Receptor, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fe2cea867b3683df0427f46362e28bac
https://doi.org/10.1002/chin.199847179

المؤلفون: C.E. Augelli-Szafran, Roy D. Schwarz, Juan C. Jaen, J.R. Penvose-Yi, C.B. Nelson, D.W. Moreland

المصدر: Bioorganicmedicinal chemistry letters. 8(15)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Computational biology, Plasma protein binding, Muscarinic Antagonists, Biochemistry, Chemical synthesis, General Biochemistry, Genetics and Molecular Biology, Drug Discovery, Muscarinic acetylcholine receptor, General Pharmacology, Toxicology and Pharmaceutics, Receptor, Molecular Biology, IC50, Receptor, Muscarinic M4, Chemistry, Organic Chemistry, Antagonist, General Medicine, Isoquinolines, Receptors, Muscarinic, In vitro, Chemical coupling, Molecular Medicine, Identification (biology), Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a03dfa076d7750ccf9d67bdbb689df
https://pubmed.ncbi.nlm.nih.gov/9873472

المؤلفون: C.E. Augelli-Szafran, Lary C. Walker, Harry LeVine

المصدر: Annual Reports in Medicinal Chemistry ISBN: 9780120405343

مصطلحات موضوعية: chemistry.chemical_classification, Amyloid, P3 peptide, Peptide, Cleavage (embryo), medicine.disease, law.invention, Pathogenesis, chemistry, Biochemistry, law, AL amyloidosis, medicine, Senile plaques, Electron microscope

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9aad7d5fba86c1fc29ec46cc11d3326b
https://doi.org/10.1016/s0065-7743(08)60565-5

المؤلفون: C.E. Augelli-Szafran, Mark R. Brann, Charlotte Raby, Juan C. Jaen, Haile Tecle, T. Mirzadegan, Patricia D. Doyle, D.W. Moreland, David Eubanks, Roy D. Schwarz, Robert E. Davis, Walter H. Moos, Bradley William Caprathe, C.B. Nelson, and Anthony J. Thomas, Michael J. Callahan, William Lipiniski, Carolyn J. Spencer, Lauffer David Jeffrey, Stephen Douglas Barrett, Michael R. Pavia

المصدر: Journal of medicinal chemistry. 41(14)

مصطلحات موضوعية: Agonist, Male, medicine.drug_class, Stereochemistry, Propynyl, Inositol Phosphates, CHO Cells, Muscarinic Agonists, Transfection, Chemical synthesis, Muscarinic agonist, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Memory, Cricetinae, Drug Discovery, Muscarinic acetylcholine receptor, Oximes, medicine, Animals, Humans, Enzyme Inhibitors, Bicyclic molecule, Receptor, Muscarinic M1, Stereoisomerism, 3T3 Cells, Oxime, Bridged Bicyclo Compounds, Heterocyclic, Receptors, Muscarinic, Rats, chemistry, Drug Design, CI-1017, Adenylyl Cyclase Inhibitors, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcd1a3da4e6e0e17b8b08d4efdff44c
https://pubmed.ncbi.nlm.nih.gov/9651157

المؤلفون: C.E. Augelli-Szafran, Essenburg Ad, B.R. Krause, R. L. Stanfield, Bharat K. Trivedi, R. F. Bousley, C. J. Blankley, K. L. Hamelehle, Bruce David Roth

المصدر: Journal of medicinal chemistry. 36(20)

مصطلحات موضوعية: Male, Stereochemistry, Sterol O-acyltransferase, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Microsomes, Drug Discovery, Potency, Animals, Anilides, IC50, biology, Anticholesteremic Agents, Biological activity, Ketones, Oxime, Rats, Intestines, Cholesterol, chemistry, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine, Rabbits, Sterol O-Acyltransferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f04352fbefbbb3956c2b85fb07a43e5
https://pubmed.ncbi.nlm.nih.gov/8411011

المؤلفون: Roy D. Schwarz, James N. Wiley, Juan C. Jaen, K.A. Frey, J.R. Penvose, C.E. Augelli-Szafran, C.B. Nelson

المصدر: Life Sciences. 60:1167

مصطلحات موضوعية: Chemistry, medicine, Muscarinic antagonist, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Subtype selective, General Biochemistry, Genetics and Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::837091962a56c06d9da1e0428c9c82db
https://doi.org/10.1016/s0024-3205(97)84307-x

المؤلفون: C.E. Augelli-Szafran, E. Mutschier, Roy D. Schwarz, Juan C. Jaen, S. Czeche, T. Friebe, J. Gross, J.R. Penvose-Yi, Günter Lambrecht

المصدر: Life Sciences. 60:1168

مصطلحات موضوعية: Chemistry, medicine, Muscarinic antagonist, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, General Biochemistry, Genetics and Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e445f9f84424b6956f73542dc30c151b
https://doi.org/10.1016/s0024-3205(97)84309-3

المؤلفون: C.E. Augelli-Szafran, Juan C. Jaen, T. Desmond, K.A. Frey, Roy D. Schwarz

المصدر: Life Sciences. 56:1036

مصطلحات موضوعية: Low affinity, Chemistry, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor, Biophysics, General Medicine, Muscarinic acetylcholine receptor M1, General Pharmacology, Toxicology and Pharmaceutics, Ligand (biochemistry), General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ba9e27264d18d256c53d860a09fb57c5
https://doi.org/10.1016/0024-3205(95)93785-d

المؤلفون: J.R. Penvose, C.B. Nelson, C.E. Augelli-Szafran, Roy D. Schwarz, Anthony Jerome Thomas, Juan C. Jaen, C. Christoffersen, Michael J. Callahan, James N. Wiley, L.T. Meltzer

المصدر: Life Sciences. 56:1017

مصطلحات موضوعية: Chemistry, medicine, Muscarinic antagonist, General Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, General Biochemistry, Genetics and Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6ecc6046df0468609fce222324b16d80
https://doi.org/10.1016/0024-3205(95)93746-2

المؤلفون: C.B. Nelson, C.J. Blankley, D.W. Moreland, Roy D. Schwarz, C.E. Augelli-Szafran, Juan C. Jaen, Anthony Jerome Thomas, J.R. Penvose

المصدر: Life Sciences. 56:1017

مصطلحات موضوعية: Chemistry, Muscarinic acetylcholine receptor, Identification (biology), General Medicine, Computational biology, General Pharmacology, Toxicology and Pharmaceutics, General Biochemistry, Genetics and Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1acd2213c81386c404443bd7b5ba8c02
https://doi.org/10.1016/0024-3205(95)93747-3