المؤلفون: Kevin D. Freeman-Cook (2004784), Robert L. Hoffman (799027), Douglas C. Behenna (1334163), Britton Boras (10955067), Jordan Carelli (10955070), Wade Diehl (3104187), Rose Ann Ferre (2128093), You-Ai He (103797), Andrea Hui (10955073), Buwen Huang (2058541), Nanni Huser (2065525), Rhys Jones (1540795), Susan E. Kephart (4720167), John Lapek (10955076), Michele McTigue (1309425), Nichol Miller (4604398), Brion W. Murray (799034), Asako Nagata (2128075), Lisa Nguyen (89308), Sherry Niessen (395727), Sacha Ninkovic (2200828), Inish O’Doherty (2151259), Martha A. Ornelas (1309407), James Solowiej (3875254), Scott C. Sutton (2025337), Khanh Tran (2128105), Elaine Tseng (2025841), Ravi Visswanathan (7511996), Meirong Xu (773491), Luke Zehnder (2200813), Qin Zhang (58638), Cathy Zhang (4038041), Stephen Dann (10955079)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, broad-spectrum CDK inhibitors, phase 1, structure-based drug design, dynamics simulations, breast cancer, ADME profile, tumor types, PF -06873600, cell cycle, CDK 9, Cancer Control, cell cycle CDK isoforms, safety concerns

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_PF-06873600_a_CDK2_4_6_Inhibitor_for_the_Treatment_of_Cancer/14766330

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00159.s002

المؤلفون: Pei-Pei Kung (2200819), Connie Fan (3104166), Hovhannes J. Gukasyan (3104181), Buwen Huang (2058541), Susan Kephart (2128099), Manfred Kraus (58470), Joseph H. Lee (6661478), Scott C. Sutton (2025337), Shinji Yamazaki (2039911), Luke Zehnder (2200813)

مصطلحات موضوعية: Biochemistry, Pharmacology, Cancer, Hematology, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pyridone-containing EZH 2 inhibitors, B-cell lymphoma Karpas -422 cell li., parent compound, experiment, vivo tumor growth inhibition, Pyridone-Containing EZH 2 Inhibitor., zeste homolog 2, pyridone-derived phosphate prodrug

Relation: https://figshare.com/articles/journal_contribution/Design_and_Characterization_of_a_Pyridone-Containing_EZH2_Inhibitor_Phosphate_Prodrug/13696630

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02112.s001

المؤلفون: Kevin D. Freeman-Cook (2004784), Robert L. Hoffman (799027), Douglas C. Behenna (1334163), Britton Boras (10955067), Jordan Carelli (10955070), Wade Diehl (3104187), Rose Ann Ferre (2128093), You-Ai He (103797), Andrea Hui (10955073), Buwen Huang (2058541), Nanni Huser (2065525), Rhys Jones (1540795), Susan E. Kephart (4720167), John Lapek (10955076), Michele McTigue (1309425), Nichol Miller (4604398), Brion W. Murray (799034), Asako Nagata (2128075), Lisa Nguyen (89308), Sherry Niessen (395727), Sacha Ninkovic (2200828), Inish O’Doherty (2151259), Martha A. Ornelas (1309407), James Solowiej (3875254), Scott C. Sutton (2025337), Khanh Tran (2128105), Elaine Tseng (2025841), Ravi Visswanathan (7511996), Meirong Xu (773491), Luke Zehnder (2200813), Qin Zhang (58638), Cathy Zhang (4038041), Stephen Dann (10955079)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, broad-spectrum CDK inhibitors, phase 1, structure-based drug design, dynamics simulations, breast cancer, ADME profile, tumor types, PF -06873600, cell cycle, CDK 9, Cancer Control, cell cycle CDK isoforms, safety concerns

Relation: https://figshare.com/articles/dataset/Discovery_of_PF-06873600_a_CDK2_4_6_Inhibitor_for_the_Treatment_of_Cancer/14766327

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00159.s001

المؤلفون: Pei-Pei Kung (2200819), Connie Fan (3104166), Hovhannes J. Gukasyan (3104181), Buwen Huang (2058541), Susan Kephart (2128099), Manfred Kraus (58470), Joseph H. Lee (6661478), Scott C. Sutton (2025337), Shinji Yamazaki (2039911), Luke Zehnder (2200813)

مصطلحات موضوعية: Biochemistry, Pharmacology, Cancer, Hematology, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, pyridone-containing EZH 2 inhibitors, B-cell lymphoma Karpas -422 cell li., parent compound, experiment, vivo tumor growth inhibition, Pyridone-Containing EZH 2 Inhibitor., zeste homolog 2, pyridone-derived phosphate prodrug

Relation: https://figshare.com/articles/dataset/Design_and_Characterization_of_a_Pyridone-Containing_EZH2_Inhibitor_Phosphate_Prodrug/13696633

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02112.s002