المؤلفون: Yanran Lu (6686399), Sandip Vibhute (2563972), Linsen Li (548722), Antony Okumu (11530664), Steven C. Ratigan (9279098), Sheri Nolan (6686393), Jonathan L. Papa (9537544), Chelsea A. Mann (11530667), Anthony English (6686396), Anna Chen (424723), Justin T. Seffernick (5030693), Bryan Koci (11530670), Leonard R. Duncan (11530673), Brieanna Roth (11530676), Jason E. Cummings (2803606), Richard A. Slayden (552399), Steffen Lindert (115057), Craig A. McElroy (2355709), Daniel J. Wozniak (8968187), Jack Yalowich (9537553), Mark J. Mitton-Fry (1936516)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, promising new antibiotics, potent antistaphylococcal activity, microsomal metabolic stability, key safety liability, cardiovascular safety profile, 5 ‑ amino, previously reported dioxane, focused optimization enabled, reduced herg inhibition, herg inhibition, vivo <, vitro <, topoiv potency, topoisomerase iv, positive pathogens, murine model, low frequency, dna gyrase

Relation: https://figshare.com/articles/journal_contribution/Optimization_of_TopoIV_Potency_ADMET_Properties_and_hERG_Inhibition_of_5_Amino-1_3-dioxane-Linked_Novel_Bacterial_Topoisomerase_Inhibitors_Identification_of_a_Lead_with_i_In_Vivo_i_Efficacy_against_MRSA/16755332

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01250.s007

المؤلفون: Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, Emma Hughes, Patrick J. Morris, Jon C. Mirsalis, Linh H. Nguyen, Maria P. Arolfo, Bryan Koci, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Connie Schmaljohn, Lisa M. Johansen, Gene G. Olinger, Joshua T. Schiffer, Judith M. White

المصدر: Microorganisms; Volume 9; Issue 3; Pages: 566

مصطلحات موضوعية: filovirus, pandemic preparedness, synergy, viral pathogens, emerging viruses, mathematical modeling, projected benefit in humans, bepridil, sertraline, toremifene, apilimod

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Virology; https://dx.doi.org/10.3390/microorganisms9030566

الاتاحة: https://doi.org/10.3390/microorganisms9030566

المؤلفون: Linsen Li, Steffen Lindert, Yanran Lu, Anna Chen, Jason E. Cummings, Chelsea A Mann, Sandip Vibhute, Brieanna Roth, Anthony English, Sheri Nolan, Mark J. Mitton-Fry, Daniel J. Wozniak, Steven C Ratigan, Richard A. Slayden, Jack C. Yalowich, Bryan Koci, Antony A. Okumu, Jonathan L. Papa, Craig A. McElroy, Justin T Seffernick, Leonard R Duncan

المصدر: Journal of Medicinal Chemistry. 64:15214-15249

مصطلحات موضوعية: biology, medicine.drug_class, Chemistry, Topoisomerase IV, Antibiotics, hERG, Pharmacology, DNA gyrase, In vitro, In vivo, Drug Discovery, medicine, biology.protein, Molecular Medicine, Potency, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b3892c880ddb3b3758eba4c921a02b47
https://doi.org/10.1021/acs.jmedchem.1c01250

المؤلفون: Yanran, Lu, Sandip, Vibhute, Linsen, Li, Antony, Okumu, Steven C, Ratigan, Sheri, Nolan, Jonathan L, Papa, Chelsea A, Mann, Anthony, English, Anna, Chen, Justin T, Seffernick, Bryan, Koci, Leonard R, Duncan, Brieanna, Roth, Jason E, Cummings, Richard A, Slayden, Steffen, Lindert, Craig A, McElroy, Daniel J, Wozniak, Jack, Yalowich, Mark J, Mitton-Fry

المصدر: Journal of medicinal chemistry. 64(20)

مصطلحات موضوعية: DNA Topoisomerase IV, Dioxanes, Methicillin-Resistant Staphylococcus aureus, Structure-Activity Relationship, Dose-Response Relationship, Drug, Molecular Structure, DNA Gyrase, Humans, Microbial Sensitivity Tests, Enzyme Inhibitors, Ether-A-Go-Go Potassium Channels, Anti-Bacterial Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::dc8f7442e2cb53241c3d17ad1ee5eb4c
https://pubmed.ncbi.nlm.nih.gov/34614347

المؤلفون: Andrew Cook, Muthukrishnan Renganathan, Dazhi Xiong, Cassidy Kilpack, Ali Yehia, Bryan Koci

المصدر: Biophysical Journal. 121:382a

مصطلحات موضوعية: Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d1b9643b4e4b4452f891ed06a4482327
https://doi.org/10.1016/j.bpj.2021.11.839

المؤلفون: Nadine Becker, Mohammadreza Samieegohar, John Imredy, Jin Zhai, Anders Lindqvist, Søren Friis, Nina Brinkwirth, Tim Strassmaier, Jae Kwagh, James Kramer, Jingsong Fan, Paul Levesque, Sonja Stoelzle-Feix, Bradley J. Ridder, Herbert Himmel, Timm Danker, Derek J. Leishman, Markus Rapedius, Liudmila Polonchuk, Jiansong Sheng, Marc Rogers, Gary R. Mirams, Simon Hebeisen, Haiyang Wei, George Okeyo, Evgenia Gissinger, Tom A. Goetze, Phu N. Tran, Zhihua Li, Rémi Bardenet, Yuri A. Kuryshev, Muthukrishnan Renganathan, Maria Giustina Rotordam, Aaron Randolph, Daniel Konrad, Robert W. Kirby, Wendy W. Wu, Caiyun Wu, David G. Strauss, Matthew Bridgland-Taylor, Bryan Koci, Edward Humphries, Xiaomei Han

المساهمون: Nanion Technologies, Computing Science Laboratory - Oxford University, University of Oxford [Oxford], The Life Expectancy Project, Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), College of Information and Technology Science [Jilin], Jilin Agricultural University (JAU), University of Oxford, ANR-16-CE23-0003,BoB,Inférence bayésienne à ressources limitées - données massives et modèles coûteux(2016)

المصدر: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩
Toxicology and Applied Pharmacology, 2020, 394, pp.114961. ⟨10.1016/j.taap.2020.114961⟩

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, congenital, hereditary, and neonatal diseases and abnormalities, Patch-Clamp Techniques, Computer science, hERG, Context (language use), [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Toxicology, Machine learning, computer.software_genre, Models, Biological, Risk Assessment, Article, 03 medical and health sciences, Bayes' theorem, 0302 clinical medicine, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Torsades de Pointes, Potassium Channel Blockers, Bayesian hierarchical modeling, Potency, Humans, Computer Simulation, cardiovascular diseases, ComputingMilieux_MISCELLANEOUS, Block (data storage), Pharmacology, Protocol (science), biology, business.industry, Bayes Theorem, 3. Good health, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Artificial intelligence, Safety, Risk assessment, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944e258ca318d261e63e5e97ce793630
http://europepmc.org/articles/PMC7166077

المؤلفون: Diane Werth, Jennifer Wesley, Bryan Koci, Andrew Cook

المصدر: Journal of Pharmacological and Toxicological Methods. 105:106730

مصطلحات موضوعية: Pharmacology, Automated patch clamp, Chemistry, Functional activity, Toxicology, Biomedical engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cfcf45c2051007add6342ec1a0d63027
https://doi.org/10.1016/j.vascn.2020.106730

المؤلفون: Bryan Koci, Haiyang Wei, Jennifer Wesley, Diane Werth, Muthukrishnan Renganathan

المصدر: Journal of Pharmacological and Toxicological Methods. 105:106729

مصطلحات موضوعية: Pharmacology, Materials science, Automated patch clamp, State dependent, Biophysics, Toxicology, Ion channel

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::429d3bbca49cd21020e563427e9ecfde
https://doi.org/10.1016/j.vascn.2020.106729

المؤلفون: Daniel J. Wozniak, Bryan Koci, Jack C. Yalowich, Jonathan L. Papa, Yanran Lu, Nicholas T. Cockroft, Mark J. Mitton-Fry, Antony A. Okumu, Sheri Dellos-Nolan, Judith C. Gallucci

المصدر: European Journal of Medicinal Chemistry. 199:112324

مصطلحات موضوعية: Topoisomerase Inhibitors, medicine.drug_class, hERG, Microbial Sensitivity Tests, Gram-Positive Bacteria, 01 natural sciences, DNA gyrase, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, medicine, Ion channel, 030304 developmental biology, Pharmacology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, Anti-Bacterial Agents, 0104 chemical sciences, Biochemistry, biology.protein, Linker, Topoisomerase inhibitor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a61a9b4177d26f95b261800e5e86f9
https://doi.org/10.1016/j.ejmech.2020.112324

المؤلفون: Daniel Konrad, James Kramer, John Imredy, Anders Lindqvist, Haiyang Wei, Evgenia Gissinger, Tim Strassmaier, Jae Kwagh, Søren Friis, Aaron Randolph, Caiyun Wu, Muthukrishnan Renganathan, David G. Strauss, Jingsong Fan, Edward Humphries, George Okeyo, Timm Danker, Nina Brinkwirth, Bradley J. Ridder, Robert W. Kirby, Wendy W. Wu, Markus Rapedius, Phu N. Tran, Nadine Becker, Mohammadreza Samieegohar, Jiansong Sheng, Marc Rogers, Paul Levesque, Sonja Stoelzle-Feix, Herbert Himmel, Bryan Koci, Yuri A. Kuryshev, Matthew Bridgland-Taylor, Liudmila Polonchuk, Jin Zhai, Tom A. Goetze, Zhihua Li, Xiaomei Han, Simon Hebeisen, Rémi Bardenet, Gary R. Mirams, Maria Giustina Rotordam, Derek J. Leishman

المصدر: Toxicology and Applied Pharmacology. 395:114983

مصطلحات موضوعية: Pharmacology, Clinical pharmacology, Actuarial science, biology, law, Published Erratum, hERG, biology.protein, Regret, Toxicology, Psychology, law.invention

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d9325ed3f56c1916f5af5315ccfb4082
https://doi.org/10.1016/j.taap.2020.114983

المؤلفون: Haiyang Wei, Diane Werth, Bryan Koci, Muthukrishnan Renganathan, Andi Cook

المصدر: Journal of Pharmacological and Toxicological Methods. 99:106595

مصطلحات موضوعية: Pharmacology, business.industry, Embedded system, Medicine, Current (fluid), Toxicology, business, Throughput (business)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9ba59b32af7c3bea810f51aa7029b66e
https://doi.org/10.1016/j.vascn.2019.05.029

المؤلفون: Luke Coyle, Joseph R. Woska, Heribert Bohlen, Walt Volberg, Warren W. Ku, Ralf Kettenhofen, Brian Knight, Anika Duenbostell, Greg Luerman, Bryan Koci, Martha Priscilla Brown

المصدر: Journal of Pharmacological and Toxicological Methods. 88:213

مصطلحات موضوعية: Pharmacology, In vivo, business.industry, Toxicity, Medicine, Toxicology, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::221093c213858693d91b7506d77bc21c
https://doi.org/10.1016/j.vascn.2017.09.147