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1
المؤلفون: Bruce Follows, Shawn Fessler, Timm Baumeister, Ann-Marie Campbell, Mary Margaret Zablocki, Hongbin Li, Deepali Gotur, Zhongguo Wang, Xiaozhang Zheng, Lisa Molz, Cokey Nguyen, Torsten Herbertz, Liann Wang, Kenneth Bair
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2375-2382
مصطلحات موضوعية: Models, Molecular, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, Humans, Myeloid Cell Leukemia Sequence 1 Protein, Molecular Medicine, Molecular Biology
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2
المؤلفون: Weiping Wang, Adan Pinto-Fernandez, Caravella Justin Andrew, Stephanos Ioannidis, Claire Heride, Benedikt M. Kessler, David Komander, Michael J. Clague, Simon J. Davis, Marie Katz, Victoria Smith, Hannah Elcocks, Tim Hammonds, Andreas Kallinos, Sylvie Urbé, Bruce Follows, Christopher J. Dinsmore, Sunkyu Kim, Katherine J. Kayser-Bricker, Steven Mischke, Shawn Fessler, Anne Clancy, Neil P. Jones, Axel Behrens, Jonathan O'Connell, Crystal McKinnon
المصدر: The Journal of Cell Biology
مصطلحات موضوعية: Protein Stability, Ubiquitination, Correction, Reproducibility of Results, Cell Biology, Computational biology, Biology, Ribosomal RNA, Ribosome, Antibodies, HEK293 Cells, Ribonucleoproteins, Cell Line, Tumor, Biocatalysis, Humans, Carrier Proteins, Ribosomes, Ubiquitin Thiolesterase
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3
المؤلفون: Weiping Wang, Adan Pinto-Fernandez, Simon J. Davis, Katherine J. Kayser-Bricker, Victoria Smith, Jonathan O'Connell, Christopher J. Dinsmore, Crystal McKinnon, Neil P. Jones, Bruce Follows, Marie Katz, Claire Heride, Sylvie Urbé, Anne Clancy, Benedikt M. Kessler, Andreas Kallinos, Sunkyu Kim, Axel Behrens, Steven Mischke, Stephanos Ioannidis, Shawn Fessler, David Komander, Caravella Justin Andrew, Tim Hammonds, Hannah Elcocks, Michael J. Clague
المصدر: The Journal of Cell Biology
Bioxrivمصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, DNA ligase, Protein Homeostasis, biology, Translation (biology), Cell Biology, Ribosomal RNA, Proteomics, Small molecule, Biochemistry, Ribosome, Cell biology, 03 medical and health sciences, 0302 clinical medicine, USP9X, chemistry, Ubiquitin, Centrosome, Report, Proteome, biology.protein, 030217 neurology & neurosurgery, 030304 developmental biology
وصف الملف: application/pdf
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4
المؤلفون: Bruce Follows, Steve J. Kirincich, Jinbo Lee, Douglas P. Wilson, Diane Joseph-McCarthy, David V. Erbe, James Tobin, Yan-Ling Zhang, Tam Steve Yik-Kai, Zhao-Kui Wan, Eva Binnun, Wei Li, Rajeev Hotchandani, Junjun Wu, Tarek S. Mansour, Weixin Xu, Manus Ipek, May Tam, Alessandro Moretto
المصدر: ChemMedChem. 3:1525-1529
مصطلحات موضوعية: Protein Tyrosine Phosphatase, Non-Receptor Type 1, Pharmacology, Arginine, biology, Chemistry, Organic Chemistry, Protein tyrosine phosphatase, Crystallography, X-Ray, Biochemistry, Receptor tyrosine kinase, Structure-Activity Relationship, Drug Design, Drug Discovery, Hydrolase, biology.protein, Molecular Medicine, Structure based, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics
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5
المؤلفون: Yan-Ling Zhang, Zhao-Kui Wan, Eddine Saiah, David V. Erbe, Tam Steve Yik-Kai, Junjun Wu, Eva Binnun, May Tam, Diane Joseph-McCarthy, Jinbo Lee, Steven J. Kirincich, Weixin Xu, Bruce Follows, Michael F. Smith, Douglas P. Wilson
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2913-2920
مصطلحات موضوعية: Molecular model, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Thiophene, Humans, Tetrazole, Carboxylate, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Small molecule, Sulfonamide, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases, Acids
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6
المؤلفون: Bruce Follows, Yan-Ling Zhang, Zhao-Kui Wan, David V. Erbe, Diane Joseph-McCarthy, Weixin Xu, Jinbo Lee
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4941-4945
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Protein tyrosine phosphatase, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Hydrolase, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Aspartic Acid, Molecular Structure, biology, Organic Chemistry, Rational design, Hydrogen Bonding, Enzyme, chemistry, Cyclization, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases, Hydrophobic and Hydrophilic Interactions, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Kenneth W. Foreman, David V. Erbe, Yan-Ling Zhang, Steven J. Kirincich, Zhao-Kui Wan, Alessandro Moretto, Eva Binnun, Douglas P. Wilson, Tam Steve Yik-Kai, S.K. Tam, Bruce Follows, Weixin Xu, Diane Joseph-McCarthy, Julie Lee, Michael J. Smith
المصدر: Bioorganic & Medicinal Chemistry. 14:2162-2177
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Protein tyrosine phosphatase, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases, Lead compound, hormones, hormone substitutes, and hormone antagonists
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8
المصدر: The Journal of Organic Chemistry. 65:4509-4514
مصطلحات موضوعية: Stereochemistry, Bacillus cereus, Isozyme, chemistry.chemical_compound, Heterocyclic Compounds, Phosphatidylcholine, Hydroxyurea, Chelation, Enzyme Inhibitors, Chelating Agents, Diacylglycerol kinase, chemistry.chemical_classification, Binding Sites, biology, Phospholipase C, Organic Chemistry, Active site, biology.organism_classification, Zinc, Enzyme, chemistry, Biochemistry, Type C Phospholipases, biology.protein, lipids (amino acids, peptides, and proteins)
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9
المصدر: Biochemistry. 39:3410-3415
مصطلحات موضوعية: Stereochemistry, Phenylalanine, Bacillus cereus, Glutamic Acid, Phosphatidylserines, Biochemistry, Catalysis, Choline, Substrate Specificity, chemistry.chemical_compound, Phosphatidylcholine, Choline binding, chemistry.chemical_classification, Binding Sites, biology, Phospholipase C, Hydrolysis, Phosphatidylethanolamines, Mutagenesis, Active site, Substrate (chemistry), biology.organism_classification, Recombinant Proteins, Enzyme, Amino Acid Substitution, chemistry, Type C Phospholipases, Mutagenesis, Site-Directed, Phosphatidylcholines, biology.protein, Tyrosine
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10
المؤلفون: Bruce Follows, William R. Roush
المصدر: Tetrahedron Letters. 35:4935-4938
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Calicheamicin, Alkoxy group, Enantioselective synthesis, Organic chemistry, Stereoselectivity, Sugar, Biochemistry
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11
المؤلفون: William R. Roush, D. S. Coffey, Hou Chen, Bruce Follows, Sherry R. Chemler, Karl A. Scheidt
المصدر: ChemInform. 30
مصطلحات موضوعية: Tris, chemistry.chemical_compound, Silicon, Chemistry, Sulfonium, Reagent, Polymer chemistry, chemistry.chemical_element, General Medicine
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12
المؤلفون: Douglas P. Wilson, Diane Joseph-McCarthy, Weixin Xu, Junjun Wu, Eva Binnun, James Tobin, Min Zhu, David V. Erbe, Adam D. Shilling, Jinbo Lee, Louis Leung, Yan-Ling Zhang, Zhao-Kui Wan, Kenneth W. Foreman, Steven J. Kirincich, Xin Xu, Alessandro Moretto, Bruce Follows, Tam Steve Yik-Kai, May Tam, Tarek S. Mansour
المصدر: Journal of medicinal chemistry. 50(19)
مصطلحات موضوعية: Phosphotyrosine binding, Male, Models, Molecular, Cell Membrane Permeability, Membrane permeability, Protein tyrosine phosphatase, Thiophenes, In Vitro Techniques, Crystallography, X-Ray, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Structure–activity relationship, Animals, Humans, Tissue Distribution, Binding site, Phosphotyrosine, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Binding Sites, biology, Molecular Structure, Active site, Rats, Mice, Inbred C57BL, Enzyme, chemistry, Biochemistry, Solubility, Enzyme inhibitor, biology.protein, Hepatocytes, Microsomes, Liver, Molecular Medicine, Caco-2 Cells, Protein Tyrosine Phosphatases, hormones, hormone substitutes, and hormone antagonists, Half-Life
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13
المصدر: ChemInform. 31
مصطلحات موضوعية: chemistry.chemical_classification, Phospholipase C, biology, Bacillus cereus, Active site, General Medicine, biology.organism_classification, Isozyme, chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, Phosphatidylcholine, biology.protein, lipids (amino acids, peptides, and proteins), Chelation, Diacylglycerol kinase
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14
المؤلفون: Karl A. Scheidt, Bruce Follows, and D. Scott Coffey, William R. Roush, Hou Chen, Sherry R. Chemler
المصدر: The Journal of Organic Chemistry. 63:6436-6437
مصطلحات موضوعية: Tris, chemistry.chemical_compound, chemistry, Silicon, Silylation, Trimethylsilyl, Sulfonium, Reagent, Organic Chemistry, Organic chemistry, chemistry.chemical_element, Fluoride