المؤلفون: Jain, Puneet, Finger, Paul T, Filì, Maria, Damato, Bertil, Coupland, Sarah E, Heimann, Heinrich, Kenawy, Nihal, Brouwer, Niels J, Marinkovic, Marina, van Duinen, Sjoerd, Caujolle, Jean-Pierre, Maschi, Celia, Seregard, Stefan, Pelayes, David E, Folgar, Martin, Yousef, Yacoub, Krema, Hatem, Gallie, Brenda, Calle Vasquez, Carlos Alberto

المساهمون: Myrna and John Daniels Charitable Trust, The Eye Cancer Foundation

المصدر: British Journal of Ophthalmology ; page bjo-2024-326043 ; ISSN 0007-1161 1468-2079

الاتاحة: https://doi.org/10.1136/bjo-2024-326043
https://syndication.highwire.org/content/doi/10.1136/bjo-2024-326043

المؤلفون: Beenakker, Jan Willem M., Brouwer, Niels J., Chau, Cindy, Coupland, Sarah E., Fiorentzis, Miltiadis, Heimann, Heinrich, Heufelder, Jens, Joussen, Antonia M., Kiilgaard, Jens F., Kivelä, Tero T., Piperno-Neumann, Sophie, Rantala, Elina S., Romanowska-Dixon, Bozena, Shields, Carol L., Willerding, Gregor D., Wheeler-Schilling, Thomas, Scholl, Hendrik P.N., Jager, Martine J., Damato, Bertil E.

المصدر: Beenakker , J W M , Brouwer , N J , Chau , C , Coupland , S E , Fiorentzis , M , Heimann , H , Heufelder , J , Joussen , A M , Kiilgaard , J F , Kivelä , T T , Piperno-Neumann , S , Rantala , E S , Romanowska-Dixon , B , Shields , C L , Willerding , G D , Wheeler-Schilling , T , Scholl , H P N , Jager , M J & Damato , B E 2023 , ' Outcome Measures of New Technologies in Uveal ....

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/outcome-measures-of-new-technologies-in-uveal-melanoma(a5ccebcc-7e2b-4967-ba2d-11a9efc5d60f).html
https://doi.org/10.1159/000524372
https://curis.ku.dk/ws/files/396846687/000524372.pdf

المؤلفون: Brouwer, Niels J., Verdijk, Robert M., Heegaard, Steffen, Marinkovic, Marina, Esmaeli, Bita, Jager, Martine J.

المصدر: Brouwer , N J , Verdijk , R M , Heegaard , S , Marinkovic , M , Esmaeli , B & Jager , M J 2022 , ' Conjunctival melanoma : New insights in tumour genetics and immunology, leading to new therapeutic options ' , Progress in Retinal and Eye Research , vol. 86 , 100971 . https://doi.org/10.1016/j.preteyeres.2021.100971

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

وصف الملف: application/pdf

الاتاحة: https://pure.eur.nl/en/publications/817cf95a-4896-47dc-a564-697dbcbfd590
https://doi.org/10.1016/j.preteyeres.2021.100971
https://pure.eur.nl/ws/files/46287260/Conjunctival_melanoma_New_insights_in_tumour_genetics_and_immunology_leading_to_new_therapeutic_options.pdf
http://www.scopus.com/inward/record.url?scp=85106625089&partnerID=8YFLogxK

المؤلفون: Wierenga, Annemijn P.A., Brouwer, Niels J., Gelmi, Maria Chiara, Verdijk, Robert M., Stern, Marc Henri, Bas, Zeynep, Malkani, Kabir, van Duinen, Sjoerd G., Ganguly, Arupa, Kroes, Wilma G.M., Marinkovic, Marina, Luyten, Gregorius P.M., Shields, Carol L., Jager, Martine J.

المصدر: Wierenga , A P A , Brouwer , N J , Gelmi , M C , Verdijk , R M , Stern , M H , Bas , Z , Malkani , K , van Duinen , S G , Ganguly , A , Kroes , W G M , Marinkovic , M , Luyten , G P M , Shields , C L & Jager , M J 2022 , ' Chromosome 3 and 8q Aberrations in Uveal Melanoma Show Greater Impact on Survival in Patients with Light Iris versus Dark Iris Color ' , Ophthalmology , vol. ....

وصف الملف: application/pdf

الاتاحة: https://pure.eur.nl/en/publications/fb1ec027-1c98-4b4b-acc9-ab4cd00ebff1
https://doi.org/10.1016/j.ophtha.2021.11.011
https://pure.eur.nl/ws/files/83318223/1_s2.0_S0161642021008678_main.pdf
http://www.scopus.com/inward/record.url?scp=85123866878&partnerID=8YFLogxK

المؤلفون: Brouwer, Niels J., Marinkovic, Marina, Bleeker, Jaco C., Luyten, Gregorius P.M., Jager, Martine J.

المساهمون: Horizon 2020, Leids Universitair Medisch Centrum

المصدر: American Journal of Ophthalmology ; volume 222, page 137-147 ; ISSN 0002-9394

الاتاحة: http://dx.doi.org/10.1016/j.ajo.2020.09.009
https://api.elsevier.com/content/article/PII:S000293942030502X?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S000293942030502X?httpAccept=text/plain

المؤلفون: Beenakker, Jan Willem M., Brouwer, Niels J., Chau, Cindy, Coupland, Sarah E., Fiorentzis, Miltiadis, Heimann, Heinrich, Heufelder, Jens, Joussen, Antonia M., Kiilgaard, Jens F., Kivelä, Tero T., Piperno-Neumann, Sophie, Rantala, Elina S., Romanowska-Dixon, Bozena, Shields, Carol L., Willerding, Gregor D., Wheeler-Schilling, Thomas, Scholl, Hendrik P.N., Jager, Martine J., Damato, Bertil E.

المساهمون: HUS Head and Neck Center, Silmäklinikka, Clinicum

مصطلحات موضوعية: Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

Relation: Beenakker: part of the research shown is funded by the Dutch Cancer Society (KWF). Brouwer reports funding from the European Commission Horizon 2020 program UMCure (667787) and a MD/ PhD program grant from Leiden University Medical Center, Leiden, the Netherlands. Coupland reports funding from the European Commission Horizon 2020 program UMCure (667787). Chau reports grants from Oogfonds, ANVVB, and LSBS that contributed through UitZicht and Wealtheon. Jager reports grants from the European Commission Horizon 2020 program UMCure (667787), Oogfonds, ANVVB, LSBS, and Wealtheon. Kivuh ela reports support from the Finnish Cancer Foundation and the Helsinki University Hospital (Grant No. 2020315), both in Finland. Rantala reports support from the Eye Foundation, the Finnish Medical Foundation, the Mary and Georg C. Ehrnrooth Foundation, the Eye and Tissue Bank Foundation, the Evald and Hilda Nissi Foundation, and the Helsinki University Hospital (Grant No. 2020315) all in Finland. Scholl reports support from the Swiss National Science Foundation, the National Center of Competence in Research Molecular Systems Engineering Molecular Systems Engineering and project funding in biology and medicine (#310030_201165), the Wellcome Trust (PINNACLE study), the Translational Research Acceleration Program Award by the Foundation Fighting Blindness (#TA-NMT- 0621-0805-TRAP), and the Foundation Fighting Blindness Clinical Research Institute (ProgStar study). This workshop, which was supported by the European Vision Institute (EVI), featured numerous new technologies for outcome measures for UM. With the advancement of diagnostic tests, new genetic and imaging biomarkers, and especially potential treatments of metastatic disease, exciting new strategies to improve the care for patients with UM are being developed and integrated into clinical practice. Beenakker: part of the research shown is funded by the Dutch Cancer Society (KWF). Brouwer reports funding from the European Commission Horizon 2020 program UMCure (667787) and a MD/PhD program grant from Leiden University Medical Center, Leiden, the Netherlands. Coupland reports funding from the European Commission Horizon 2020 program UMCure (667787). Chau reports grants from Oogfonds, ANVVB, and LSBS that contributed through UitZicht and Wealtheon. Jager reports grants from the European Commission Horizon 2020 program UMCure (667787), Oogfonds, ANVVB, LSBS, and Wealtheon. Kivuh elä reports support from the Finnish Cancer Foundation and the Helsinki University Hospital (Grant No. 2020315), both in Finland. Rantala reports support from the Eye Foundation, the Finnish Medical Foundation, the Mary and Georg C. Ehrnrooth Foundation, the Eye and Tissue Bank Foundation, the Evald and Hilda Nissi Foundation, and the Helsinki University Hospital (Grant No. 2020315) all in Finland. Scholl reports support from the Swiss National Science Foundation, the National Center of Competence in Research Molecular Systems Engineering “Molecular Systems Engineering” and project funding in biology and medicine (#310030_201165), the Wellcome Trust (PINNACLE study), the Translational Research Acceleration Program Award by the Foundation Fighting Blindness (#TA-NMT-0621-0805-TRAP), and the Foundation Fighting Blindness Clinical Research Institute (ProgStar study).; Beenakker , J W M , Brouwer , N J , Chau , C , Coupland , S E , Fiorentzis , M , Heimann , H , Heufelder , J , Joussen , A M , Kiilgaard , J F , Kivelä , T T , Piperno-Neumann , S , Rantala , E S , Romanowska-Dixon , B , Shields , C L , Willerding , G D , Wheeler-Schilling , T , Scholl , H P N , Jager , M J & Damato , B E 2023 , ' Outcome Measures of New Technologies in Uveal Melanoma : Review from the European Vision Institute Special Interest Focus Group Meeting ' , Ophthalmic Research , vol. 66 , no. 1 , pp. 14-26 . https://doi.org/10.1159/000524372; ORCID: /0000-0001-5025-4269/work/153479336; http://hdl.handle.net/10138/571299; cdd0ae0c-b99d-438d-8f8d-7d8fd48e4875; 85137110188; 001128388200130

الاتاحة: http://hdl.handle.net/10138/571299

المؤلفون: Dogrusoz, Mehmet, Brouwer, Niels J., de Geus, Stefan J. R., Ly, Long, Böhringer, Stefan, van Duinen, Sjoerd G., Kroes, Wilma G. M., van der Velden, Pieter A., Haasnoot, Geert W., Marinkovic, Marina, Luyten, Gregorius P. M., Kivelä, Tero T., Jager, Martine J.

المساهمون: HUS Head and Neck Center, Silmäklinikka, University of Helsinki, Helsinki University Hospital Area

مصطلحات موضوعية: oncology, tumor, ocular, prognosis, genetics, CILIARY BODY, REPRODUCTIVE FACTORS, CHOROIDAL MELANOMA, SF3B1 MUTATIONS, SURVIVAL, DEATH, PREDICTORS, MONOSOMY-3, WOMEN, RISK, Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

Relation: Supported by grants from the Eye Cancer Foundation (New York, NY, USA), Stichting Blindenpenning (the Netherlands), Horizon 2020 grant no. 667787 UM CURE (European Commission), and the Sigrid Juselius Foundation (Finland). The authors alone are responsible for the content and writing of the paper.; Dogrusoz , M , Brouwer , N J , de Geus , S J R , Ly , L , Böhringer , S , van Duinen , S G , Kroes , W G M , van der Velden , P A , Haasnoot , G W , Marinkovic , M , Luyten , G P M , Kivelä , T T & Jager , M J 2020 , ' Prognostic Factors Five Years After Enucleation for Uveal Melanoma ' , Investigative Ophthalmology & Visual Science , vol. 61 , no. 3 , 31 . https://doi.org/10.1167/iovs.61.3.31; http://hdl.handle.net/10138/314718; 2e517220-a3b1-4991-9b7f-c832f0a90fbd; 000524168000031

الاتاحة: http://hdl.handle.net/10138/314718

المؤلفون: Brouwer, Niels J., Marinkovic, Marina, Bleeker, Jaco C., El Filali, Mariam, Stefansson, Einar, Luyten, Gregorius P.M., Jager, Martine J.

المساهمون: Faculty of Medicine, Other departments, Landspitali - The National University Hospital of Iceland

مصطلحات موضوعية: Ophthalmology

وصف الملف: 2207-2215

Relation: Retina (Philadelphia, Pa.); 40(11); http://www.scopus.com/inward/record.url?scp=85083304480&partnerID=8YFLogxK; Brouwer , N J , Marinkovic , M , Bleeker , J C , El Filali , M , Stefansson , E , Luyten , G P M & Jager , M J 2020 , ' RETINAL OXIMETRY IS ALTERED IN EYES WITH CHOROIDAL MELANOMA BUT NOT IN EYES WITH CHOROIDAL NEVI ' , Retina (Philadelphia, Pa.) , vol. 40 , no. 11 , pp. 2207-2215 . https://doi.org/10.1097/IAE.0000000000002719; 952e5865-946c-40ee-8fdd-5932055b9b58; 85083304480; https://hdl.handle.net/20.500.11815/3427

الاتاحة: https://hdl.handle.net/20.500.11815/3427
https://doi.org/10.1097/IAE.0000000000002719

المؤلفون: Boudry, Christophe, Alvarez-Muñoz, Patricio, Arencibia-Jorge, Ricardo, Ayena, Didier, Brouwer, Niels, J, Chaudhuri, Zia, Chawner, Brenda, Epee, Emilienne, Erraïs, Khalil, Fotouhi, Akbar, Gharaibeh, Almutez, M, Hassanein, Dina, H, Herwig-Carl, Martina, C, Howard, Katherine, Kaimbo Wa Kaimbo, Dieudonne, Laughrea, Patricia-Ann, Lopez, Fernando, A, Machin-Mastromatteo, Juan, D, Malerbi, Fernando, K, Ndiaye, Amadou, Noor, Nina, A, Pacheco-Mendoza, Josmel, Papastefanou, Vasilios, P, Shah, Mufarriq, Shields, Carol, L, Wang, Ya, Xing, Yartsev, Vasily, Mouriaux, Frederic

المساهمون: Université de Caen Normandie (UNICAEN), Normandie Université (NU), Unité Régionale de Formation à l'Information Scientifique et Technique de Paris (URFIST Paris), École nationale des chartes (ENC), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL), Universidad Estatal de Milagro, Milagro, Ecuador, Empresa de Tecnologías de la Información (ETI), Grupo de las Industrias Biotecnológica y Farmacéutica (BioCubaFarma), Havana, Cuba, Université de Lomé, Faculté des Sciences de la santé, Hôpital de Bè, Lomé, Togo, Leiden University Medical Center, Department of Ophthalmology, Leiden, The Netherlands, University of Delhi, Lady Hardinge Medical College, PGIMER, Dr RML Hospital, New Delhi, India, Victoria University of Wellington, School of Information Management, Wellington, New Zealand, Université de Yaoundé, Faculté de Médecine et des Sciences Biomédicales, Yaoundé, Cameroon, University of Tunis El Manar, Tehran University of Medical Sciences, School of Public Health, Department of Epidemiology and Biostatistics, Tehran, Iran, University of Jordan, Faculty of Medicine, Amman, Jordan, Cairo University, Ophthalmology Department, Cairo, Egypt, University of Bonn, Department of Ophthalmology, Bonn, Germany, Flinders University Adelaide, Australia, University of Kinshasa (UNIKIN), Laval University, Department of Ophthalmology and Head and Neck Surgery, Quebec, Canada, Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires (CONICET), Universidad Autónoma de Chihuahua, Chihuahua, Mexico, Hospital Israelita Albert Einstein São Paulo, Brazil, Université Cheikh Anta Diop de Dakar Sénégal (UCAD), JEC Eye Hospitals and Clinics, Jakarta, Indonesia, Unidad de Investigación en Bibliometría, Universidad San Ignacio de Loyola, Lima, Peru, Royal London Hospital, Barts Health NHS Trust. Moorfields Eye Hospital, London, UK, Pakistan Institute of Community Ophthalmology, Hayatabad Medical Complex, Department of Optometry, Peshawar, Pakistan, Wills Eye Hospital, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China, Scientific Research Institute of Eye Diseases, Moscow, Russia, Service d'Ophtalmologie Rennes = Ophtalmology Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: ISSN: 2167-8359 ; PeerJ ; https://hal.science/hal-02346748 ; PeerJ, 2019, 7, pp.e7850. ⟨10.7717/peerj.7850⟩.

مصطلحات موضوعية: Online Reprint Request, Google Scholar, Articles, Open access, Access to literature, Science publishing, Sci-Hub, Paywall, Bibliodiversity, Hinari, PubMed Central, ResearchGate, Ethical Issues, Legal Issues, Science Policy, Ophthalmology, Pay-per-view, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

Relation: info:eu-repo/semantics/altIdentifier/pmid/31687270; hal-02346748; https://hal.science/hal-02346748; https://hal.science/hal-02346748/document; https://hal.science/hal-02346748/file/peerj-7850%281%29.pdf; PUBMED: 31687270

الاتاحة: https://hal.science/hal-02346748
https://hal.science/hal-02346748/document
https://hal.science/hal-02346748/file/peerj-7850%281%29.pdf
https://doi.org/10.7717/peerj.7850

المؤلفون: Brouwer, Niels J, Marinkovic, Marina, Luyten, Gregorius P M, Shields, Carol L, Jager, Martine J

مصطلحات موضوعية: Original articles - Clinical science

وصف الملف: text/html

Relation: http://bjo.bmj.com/cgi/content/short/103/3/332; http://dx.doi.org/10.1136/bjophthalmol-2018-312018

الاتاحة: http://bjo.bmj.com/cgi/content/short/103/3/332
https://doi.org/10.1136/bjophthalmol-2018-312018

المؤلفون: Brouwer, Niels J., Marinkovic, Marina, Luyten, Gregorius P. M., Shields, Carol L., Jager, Martine J.

المساهمون: Leids Universitair Medisch Centrum

المصدر: Graefe's Archive for Clinical and Experimental Ophthalmology ; volume 257, issue 8, page 1783-1788 ; ISSN 0721-832X 1435-702X

الاتاحة: http://dx.doi.org/10.1007/s00417-019-04342-x
http://link.springer.com/content/pdf/10.1007/s00417-019-04342-x.pdf
http://link.springer.com/article/10.1007/s00417-019-04342-x/fulltext.html

المؤلفون: Brouwer, Niels J., Marinkovic, Marina, Bleeker, Jaco C., el Filali, Mariam, Stefansson, Einar, Luyten, Gregorius P. M., Jager, Martine J.

المصدر: Retina ; volume 40, issue 11, page 2207-2215 ; ISSN 0275-004X

الاتاحة: http://dx.doi.org/10.1097/iae.0000000000002719
https://journals.lww.com/10.1097/IAE.0000000000002719

المؤلفون: Jain, Puneet, Finger, Paul T., Damato, Bertil, Coupland, Sarah E., Heimann, Heinrich, Kenawy, Nihal, Brouwer, Niels J., Marinkovic, Marina, Van Duinen, Sjoerd G., Caujolle, Jean Pierre, Maschi, Celia, Seregard, Stefan, Pelayes, David, Folgar, Martin, Yousef, Yacoub A., Krema, Hatem, Gallie, Brenda, Calle-Vasquez, Alberto

المصدر: JAMA Ophthalmology ; volume 137, issue 8, page 905 ; ISSN 2168-6165

الاتاحة: http://dx.doi.org/10.1001/jamaophthalmol.2019.1640
https://jamanetwork.com/journals/jamaophthalmology/article-pdf/137/8/905/17773795/jamaophthalmology_jain_2019_oi_190034.pdf

المؤلفون: Cao, Jinfeng, Brouwer, Niels J., Jordanova, Ekaterina S., Marinkovic, Marina, Van Duinen, Sjoerd G., De Waard, Nadine E., Ksander, Bruce R., Mulder, Arend, Claas, Frans H.J., Heemskerk, Mirjam H.M., Jager, Martine J.

المصدر: Cao , J , Brouwer , N J , Jordanova , E S , Marinkovic , M , Van Duinen , S G , De Waard , N E , Ksander , B R , Mulder , A , Claas , F H J , Heemskerk , M H M & Jager , M J 2018 , ' HLA class I antigen expression in conjunctival melanoma is not associated with PD-L1/PD-1 status ' , Investigative Ophthalmology and Visual Science , vol. 59 , no. 2 , pp. 1005-1015 . https://doi.org/10.1167/iovs.17-23209

الاتاحة: https://research.vumc.nl/en/publications/57d50b9f-6edf-4a2d-b0b5-bfb07ff3be1e
https://doi.org/10.1167/iovs.17-23209
http://www.scopus.com/inward/record.url?scp=85042265503&partnerID=8YFLogxK

المؤلفون: Cao, Jinfeng, Pontes, Kelly Cs, Heijkants, Renier C, Brouwer, Niels J, Groenewoud, Arwin, Jordanova, Ekaterina S, Marinkovic, Marina, van Duinen, Sjoerd, Teunisse, Amina Fas, Verdijk, Robert M, Snaar-Jagalska, Ewa, Jochemsen, Aart G, Jager, Martine J

المصدر: Cao , J , Pontes , K C , Heijkants , R C , Brouwer , N J , Groenewoud , A , Jordanova , E S , Marinkovic , M , van Duinen , S , Teunisse , A F , Verdijk , R M , Snaar-Jagalska , E , Jochemsen , A G & Jager , M J 2018 , ' Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target ' , Journal of Pathology , vol. 245 , no. 4 , pp. 433-444 . https://doi.org/10.1002/path.5094

الاتاحة: https://research.vumc.nl/en/publications/6d4cbd8d-09f8-4a0d-bc9a-7fa63549cfdc
https://doi.org/10.1002/path.5094

المؤلفون: Brouwer, Niels J., Genders, Stijn W., Marinkovic, Marina, van Duinen, Sjoerd G., Jager, Martine J., Luyten, Gré P.M.

المصدر: Ocular Oncology and Pathology ; volume 5, issue 4, page 262-266 ; ISSN 2296-4681 2296-4657

الاتاحة: http://dx.doi.org/10.1159/000494978
https://www.karger.com/Article/Pdf/494978

المؤلفون: Jager, Martine J., Brouwer, Niels J., Esmaeli, Bita

المصدر: Ophthalmology ; volume 125, issue 8, page 1139-1142 ; ISSN 0161-6420

الاتاحة: http://dx.doi.org/10.1016/j.ophtha.2018.03.011
https://api.elsevier.com/content/article/PII:S0161642018305013?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0161642018305013?httpAccept=text/plain

المؤلفون: Brouwer, Niels J., Haanen, John B.A.G., Jager, Martine J.

المصدر: Ocular Oncology and Pathology ; volume 3, issue 3, page 188-192 ; ISSN 2296-4681 2296-4657

الاتاحة: http://dx.doi.org/10.1159/000455150
https://www.karger.com/Article/Pdf/455150

المؤلفون: Brouwer, Niels J., Marinkovic, Marina, Jochems, Anouk, Kapiteijn, Ellen W., van Duinen, Sjoerd G., Haeseker, Barbara I., Jager, Martine J., Luyten, Gregorius P.M.

المصدر: Ocular Oncology and Pathology ; volume 4, issue 2, page 107-111 ; ISSN 2296-4681 2296-4657

الاتاحة: http://dx.doi.org/10.1159/000479114
https://www.karger.com/Article/Pdf/479114

المؤلفون: Brouwer, Niels J., Luyten, Gregorius P.M., van Duinen, Sjoerd G., Jager, Martine J., Marinkovic, Marina

المصدر: Ocular Oncology and Pathology ; volume 3, issue 2, page 113-116 ; ISSN 2296-4681 2296-4657

الاتاحة: http://dx.doi.org/10.1159/000452447
https://www.karger.com/Article/Pdf/452447