المؤلفون: Pidot, Sacha, Klatt, Stephan, Ates, Louis, Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian, Porter, Jessica, Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory, West, Nicholas, Tobias, Nicholas, Fuerst, John, Stutz, Michael, Pellegrini, Marc, Mcconville, Malcolm, Brosch, Roland, Stinear, Timothy

المساهمون: University of Melbourne, Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), The University of Queensland (UQ All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations ), UK Health Security Agency London (UKHSA), University of Otago Dunedin, Nouvelle-Zélande, The Walter and Eliza Hall Institute of Medical Research (WEHI), This project was supported by a National Health and Medical Research Council (NHMRC) Ideas grant (GNT2021638) to S.J.P, a NHMRC L2 Fellowship to T.P.S., and NHMRC Project Grant (GNT1105522) to T.P.S. and S.J.P., an Agence Nationale pour la Recherche grant (ANR-10-LABX-62-IBEID) to RB and an Australian Research Council (ARC) Linkage project (LP0882233) to J.A.F. H.I. was supported by a University of Queensland Research Scholarship (UQRS) and University of Queensland International Research Tuition Award (UQIRTA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010)

المصدر: ISSN: 1553-7366.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio], [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology

Relation: info:eu-repo/semantics/altIdentifier/pmid/39207937; PUBMED: 39207937; PUBMEDCENTRAL: PMC11361433

الاتاحة: https://hal.science/hal-04684147
https://hal.science/hal-04684147v1/document
https://hal.science/hal-04684147v1/file/journal.ppat.1012440.pdf
https://doi.org/10.1371/journal.ppat.1012440

المؤلفون: Maure, Alexandra, Lawarée, Emeline, Fiorentino, Francesco, Pawlik, Alexandre, Gona, Saideep, Giraud-Gatineau, Alexandre, Eldridge, Matthew, Danckaert, Anne, Hardy, David, Frigui, Wafa, Keck, Camille, Gutierrez, Claude, Neyrolles, Olivier, Aulner, Nathalie, Mai, Antonello, Hamon, Mélanie, Barreiro, Luis, Brodin, Priscille, Brosch, Roland, Rotili, Dante, Tailleux, Ludovic

المساهمون: Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma "La Sapienza" = Sapienza University Rome (UNIROMA), University of Chicago, Biologie des Spirochètes / Biology of Spirochetes, Chromatine et Infection - Chromatin and Infection, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), BioImagerie Photonique – Photonic BioImaging (UTechS PBI), Plate-Forme d’Histopathologie / Histopathology Platform, Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), This research project was funded by the Institut Pasteur (grant to RB), the Georges, Jacques and Elias Canetti Award (grant to LT) and the French National Research Agency (grant ANR Mustart 20-PAMR-0005 to RB and LT). We gratefully acknowledge the UTechS Cytometry and Biomarkers and the UTechS Photonic BioImaging (PBI) /C2RT of Institut Pasteur (Paris, France). PBI, part of the France–BioImaging infrastructure network (ANR-10–INSB–04, Investments for the Future) kindly acknowledge the support of the Région Île-de-France (DIM1 Health) for the use of the Opera Phenix. AM was supported by the Fondation pour la Recherche Médicale (FRM FDM201806006250). DR acknowledges Sapienza Ateneo Project 2021 RM12117A61C811CE and Regione Lazio PROGETTI DI GRUPPI DI RICERCA 2020, project ID: A0375-2020-36597. AnM acknowledges the project FISR2019_00374 MeDyCa., ANR-20-PAMR-0005,Mustart,Multiparametric Strategies against Antibiotic Resistance in Tuberculosis(2020), ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010)

المصدر: ISSN: 1544-9173.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/38683873; PUBMED: 38683873; PUBMEDCENTRAL: PMC11081512

الاتاحة: https://pasteur.hal.science/pasteur-04609945
https://pasteur.hal.science/pasteur-04609945v1/document
https://pasteur.hal.science/pasteur-04609945v1/file/journal.pbio.3002259.pdf
https://doi.org/10.1371/journal.pbio.3002259

المؤلفون: Sous, Camille, Frigui, Wafa, Pawlik, Alexandre, Sayes, Fadel, Ma, Laurence, Cokelaer, Thomas, Brosch, Roland

المساهمون: Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Biomics (plateforme technologique), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Support by grants from the Agence National de Recherche (ANR-10-LABX-62-IBEID and ANR-20-CE15-0013) is gratefully acknowledged. The project leading to this publication has also received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No. 853989. The JU receives support from the European Union’s Horizon 2020 Research and Innovation Programme and EFPIA and Global Alliance for TB Drug Development Non-Profit Organisation, Bill & Melinda Gates Foundation, University of Dundee. This communication reflects the author’s view, and neither IMI nor the European Union or EFPIA is responsible for any use that may be made of the information contained therein. The Biomics Platform, C2RT, at the Institut Pasteur, Paris, France is supported by France Génomique (ANR-10-INBS-09) and IBISA. The LABGeM (CEA/Genoscope and CNRS UMR8030), the France Génomique, and French Bioinformatics Institute national infrastructures (funded as part of Investissement d'Avenir program managed by Agence Nationale pour la Recherche, contracts ANR-10-INBS-09 and ANR-11-INBS-0013) are acknowledged for support within the MicroScope annotation platform., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-20-CE15-0013,MTB-Spread,PhoPR et transmission de la tuberculose(2020), ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-11-INBS-0013,IFB (ex Renabi-IFB),Institut français de bioinformatique(2011), European Project: 853989,H2020-JTI-IMI2-2018-15-two-stage,ERA4TB(2020)

المصدر: ISSN: 2165-0497 ; Microbiology Spectrum ; https://pasteur.hal.science/pasteur-04609394 ; Microbiology Spectrum, 2024, 12 (6), pp.1235-1248. ⟨10.1128/spectrum.04126-23⟩.

مصطلحات موضوعية: Mycobacterium tuberculosis, mycobacterial model, virulence, phylotype, evolution, ESX-1, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/38700329; info:eu-repo/grantAgreement//853989/EU/EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS/ERA4TB; pasteur-04609394; https://pasteur.hal.science/pasteur-04609394; https://pasteur.hal.science/pasteur-04609394/document; https://pasteur.hal.science/pasteur-04609394/file/sous-et-al-2024-genomic-and-phenotypic-characterization-of-mycobacterium-tuberculosis-closest-related-non-tuberculous.pdf; PUBMED: 38700329

الاتاحة: https://pasteur.hal.science/pasteur-04609394
https://pasteur.hal.science/pasteur-04609394/document
https://pasteur.hal.science/pasteur-04609394/file/sous-et-al-2024-genomic-and-phenotypic-characterization-of-mycobacterium-tuberculosis-closest-related-non-tuberculous.pdf
https://doi.org/10.1128/spectrum.04126-23

المؤلفون: Orgeur, Mickael, Sous, Camille, Madacki, Jan, Brosch, Roland

المساهمون: Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Support by grants from the Agence National de Recherche ANR-10-LABX-62-IBEID and ANR-20-CE15-0013 is gratefully acknowledged. The project leading to this publication has also received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 853989. The JU receives support from the European Union’s Horizon 2020 Research and Innovation Programme and EFPIA and Global Alliance for TB Drug Development Non-Profit Organisation, Bill & Melinda Gates Foundation, University of Dundee., ANR-20-CE15-0013,MTB-Spread,PhoPR et transmission de la tuberculose(2020), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 853989,JU

المصدر: ISSN: 0168-6445.

مصطلحات موضوعية: Mycobacterium tuberculosis, evolution, genetic diversity, population dynamics, virulence, host-pathogen relationship, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.BID]Life Sciences [q-bio]/Biodiversity, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]

Relation: info:eu-repo/semantics/altIdentifier/pmid/38365982; info:eu-repo/grantAgreement//853989/EU/ Innovative Medicines Initiative 2 Joint Undertaking/JU; hal-04566137; https://hal.science/hal-04566137; https://hal.science/hal-04566137/document; https://hal.science/hal-04566137/file/fuae006.pdf; PUBMED: 38365982; PUBMEDCENTRAL: PMC10906988

الاتاحة: https://hal.science/hal-04566137
https://hal.science/hal-04566137/document
https://hal.science/hal-04566137/file/fuae006.pdf
https://doi.org/10.1093/femsre/fuae006

المؤلفون: Osman, Morwan M., Shanahan, Jonathan K., Chu, Frances, Takaki, Kevin K., Pinckert, Malte L., Pagán, Antonio J., Brosch, Roland, Conrad, William H., Ramakrishnan, Lalita

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2022 Mar . 119(11), 1-9.

URL الوصول: https://www.jstor.org/stable/27150990

المؤلفون: Malaga, Wladimir, Payros, Delphine, Meunier, Eva, Frigui, Wafa, Sayes, Fadel, Pawlik, Alexandre, Orgeur, Mickael, Berrone, Céline, Moreau, Flavie, Mazères, Serge, Gonzalo-Asensio, Jesus, Rengel, David, Martin, Carlos, Astarie-Dequeker, Catherine, Mourey, Lionel, Brosch, Roland, Guilhot, Christophe

وصف الملف: application/pdf

Relation: http://zaguan.unizar.es/record/127090

الاتاحة: http://zaguan.unizar.es/record/127090
https://doi.org/10.1371/journal.ppat.1011437

المؤلفون: Sathkumara, Harindra D., Muruganandah, Visai, Cooper, Martha M., Field, Matt A., Alim, Md Abdul, Brosch, Roland, Ketheesan, Natkunam, Govan, Brenda, Rush, Catherine M., Henning, Lars, Kupz, Andreas

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug . 117(34), 20848-20859.

URL الوصول: https://www.jstor.org/stable/26969056

المؤلفون: Osman, Morwan M, Shanahan, Jonathan K, Chu, Frances, Takaki, Kevin K, Pinckert, Malte L, Pagán, Antonio J, Brosch, Roland, Conrad, William H, Ramakrishnan, Lalita

وصف الملف: text

Relation: https://eprints.whiterose.ac.uk/216798/1/osman-et-al-2022-the-c-terminus-of-the-mycobacterium-esx-1-secretion-system-substrate-esat-6-is-required-for-phagosomal.pdf; Osman, Morwan M, Shanahan, Jonathan K, Chu, Frances et al. (6 more authors) (2022) The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. Proceedings of the National Academy of Sciences of the United States of America. e2122161119. ISSN 1091-6490

الاتاحة: https://eprints.whiterose.ac.uk/216798/
https://doi.org/10.1073/pnas.2122161119

المؤلفون: Comín, Jessica, Madacki, Jan, Rabanaque, Isabel, Zúñiga-Antón, María, Ibarz, Daniel, Cebollada, Alberto, Viñuelas, Jesús, Torres, Luis, Sahagún, Juan, Klopp, Christophe, Gonzalo-Asensio, Jesús, Brosch, Roland, Iglesias, María-José, Samper, Sofía

وصف الملف: application/pdf

Relation: http://zaguan.unizar.es/record/117254

الاتاحة: http://zaguan.unizar.es/record/117254
https://doi.org/10.3389/fcimb.2022.887134

المؤلفون: Anna, François, Lopez, Jodie, Moncoq, Fanny, Blanc, Catherine, Authié, Pierre, Noirat, Amandine, Fert, Ingrid, Souque, Philippe, Nevo, Fabien, Pawlik, Alexandre, Hardy, David, Goyard, Sophie, Hudrisier, Denis, Brosch, Roland, Guinet, Françoise, Neyrolles, Olivier, Charneau, Pierre, Majlessi, Laleh

المساهمون: Laboratoire commun Pasteur-TheraVectys, Institut Pasteur Paris (IP)-TheraVectys-Université Paris Cité (UPCité), Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Plate-Forme d’Histopathologie / Histopathology Platform, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Plateforme d'Innovation et de Développement de Tests Diagnostiques / Diagnostic Test Innovation and Development Core Facility, Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Lymphocytes et Immunité - Lymphocytes and Immunity, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), This work was also supported by the Programmes Transversaux de Recherche (PTR # 52-17 from Institut Pasteur to L.M. and P.C.), the EU program TBVAC2020 (contract n°643381 to P.C.), CNRS, University of Toulouse, Agence Nationale de la Recherche/Program d’Investissements d’Avenir (ANR-11-EQUIPEX-0003 to O.N.), the Fondation pour la Recherche Médicale (DEQ20160334902 to O.N.), the Bettencourt Schueller Foundation (Grants Coup d’Élan pour la Recherche Française and Explore-TB to O.N.)., ANR-11-EQPX-0003,ANINFIMIP,Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées(2011), European Project: 643381,H2020,H2020-PHC-2014-single-stage,TBVAC2020(2015)

المصدر: ISSN: 1933-0219.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/36104497; info:eu-repo/grantAgreement//643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020; pasteur-03909615; https://pasteur.hal.science/pasteur-03909615; https://pasteur.hal.science/pasteur-03909615/document; https://pasteur.hal.science/pasteur-03909615/file/s41385-022-00566-z.pdf; PUBMED: 36104497; PUBMEDCENTRAL: PMC9473479

الاتاحة: https://pasteur.hal.science/pasteur-03909615
https://pasteur.hal.science/pasteur-03909615/document
https://pasteur.hal.science/pasteur-03909615/file/s41385-022-00566-z.pdf
https://doi.org/10.1038/s41385-022-00566-z

المؤلفون: Pérez, Irene, Campos-Pardos, Elena, Díaz, Caridad, Uranga, Santiago, Sayes, Fadel, Vicente, Francisca, Aguiló, Nacho, Brosch, Roland, Martín, Carlos, Gonzalo-Asensio, Jesús

المساهمون: Universidad de Zaragoza = University of Zaragoza Saragossa University = Université de Saragosse, Instituto de Salud Carlos III Madrid (ISC), Fundación MEDINA Granada, Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Hospital Universitario Miguel Servet, Instituto de Biocomputación y Física de Sistemas Complejos = Institute for Biocomputation and Physics of Complex Systems (BIFI), This work was supported by a grant from the Spanish Ministry of Science and Innovation to J.G.-A. (reference PID2019-104690RB-I00). I.P. was a recipient of a “DGA-Fondo Social Europeo” grant. I.P. also was a recipient of a “Programa CAI-Ibercaja Estancias de Investigación” grant (CM3/18) and a “FEMS Research and Training” grant (FEMS-GO-2018-118) to perform an internship at the Integrated Mycobacterial Pathogenomics Unit at the Institut Pasteur of Paris. MEDINA authors disclosed the receipt of financial support from Fundación MEDINA, a public–private partnership of Merck Sharp & Dohme de España S.A./Universidad de Granada/Junta de Andalucía (PIN-0474-2016).

المصدر: ISSN: 2162-2531 ; Molecular Therapy - Nucleic Acids ; https://pasteur.hal.science/pasteur-03648358 ; Molecular Therapy - Nucleic Acids, 2022, 27, pp.1235-1248. ⟨10.1016/j.omtn.2022.02.011⟩.

مصطلحات موضوعية: BCG, IFN, MT:therapies and applications, MTBVAC, PhoPR, cyclic dinucleotides, innate immunity, live vaccines, tuberculosis, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]

Relation: info:eu-repo/semantics/altIdentifier/pmid/35282413; PUBMED: 35282413; PUBMEDCENTRAL: PMC8894143

الاتاحة: https://pasteur.hal.science/pasteur-03648358
https://pasteur.hal.science/pasteur-03648358v1/document
https://pasteur.hal.science/pasteur-03648358v1/file/1-s2.0-S2162253122000397-main.pdf
https://doi.org/10.1016/j.omtn.2022.02.011

المؤلفون: Lopez, Jodie, Anna, François, Authié, Pierre, Pawlik, Alexandre, Ku, Min-Wen, Blanc, Catherine, Souque, Philippe, Moncoq, Fanny, Noirat, Amandine, Hardy, David, Sougakoff, Wladimir, Brosch, Roland, Guinet, Françoise, Charneau, Pierre, Majlessi, Laleh

المساهمون: Laboratoire commun Pasteur-TheraVectys, Institut Pasteur Paris (IP)-TheraVectys-Université Paris Cité (UPCité), Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Plate-Forme d’Histopathologie / Histopathology Platform, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Lymphocytes et Immunité - Lymphocytes and Immunity, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), This project received funding from the European Union's Horizon 2020 research and innovation program (TBVAC2020 643381) and the Marie Sklodowska-Curie grant agreement 665807. The work was also supported by the Programmes Transversaux de Recherche (PTR) 52-17 from the Institut Pasteur and in part by the French National Research Council ANR (ANR-10-LABX-62-IBEID) and the Institut Carnot Pasteur Microbes & Santé. M.-W.K. is a participant of the Pasteur-Paris University (PPU) International PhD Program., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 643381,H2020,H2020-PHC-2014-single-stage,TBVAC2020(2015)

المصدر: ISSN: 2211-1247.

مصطلحات موضوعية: lentiviral vectors, MHC-II antigenic presentation, CD4+ T cell response, intranasal immunization, mucosal immunity, tuberculosis, mycobacteria, polyantigen, antigen routing, polyfunctional T cells, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/35905717; info:eu-repo/grantAgreement//643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020; pasteur-03909608; https://pasteur.hal.science/pasteur-03909608; https://pasteur.hal.science/pasteur-03909608/document; https://pasteur.hal.science/pasteur-03909608/file/1-s2.0-S2211124722009512-main.pdf; PUBMED: 35905717

الاتاحة: https://pasteur.hal.science/pasteur-03909608
https://pasteur.hal.science/pasteur-03909608/document
https://pasteur.hal.science/pasteur-03909608/file/1-s2.0-S2211124722009512-main.pdf
https://doi.org/10.1016/j.celrep.2022.111142

المؤلفون: Osman, Morwan, Shanahan, jonathan, Chu, Frances, Takaki, Kevin K, Pinckert, Malte L, Pagan Velez, AJ, Brosch, Roland, Conrad, William H, Ramakrishnan, Lalita

المصدر: nlmid: 7505876 ; essn: 1091-6490

مصطلحات موضوعية: ESAT-6, ESX-1, phagosomal damage, virulence, Antigens, Bacterial, Bacterial Proteins, Humans, Mycobacterium marinum, Mycobacterium tuberculosis, Phagosomes, Protein Conformation, Tuberculoma, Type VII Secretion Systems

وصف الملف: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/335970

الاتاحة: https://www.repository.cam.ac.uk/handle/1810/335970
https://doi.org/10.17863/CAM.83404

المؤلفون: Chitale, Poonam, Lemenze, Alexander D., Fogarty, Emily C., Shah, Avi, Grady, Courtney, Odom-Mabey, Aubrey R., Johnson, W. Evan, Yang, Jason H., Eren, A. Murat, Brosch, Roland, Kumar, Pradeep, Alland, David

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

المصدر: Nature Communications ; volume 13, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-022-34853-x
https://www.nature.com/articles/s41467-022-34853-x.pdf
https://www.nature.com/articles/s41467-022-34853-x

المؤلفون: Gharbi, Reem, Khanna, Varun, Frigui, Wafa, Mhenni, Besma, Brosch, Roland, Mardassi, Helmi

المساهمون: Laboratoire de Microbiologie Moléculaire, Vaccinologie et Développement Biotechnologique (LR11IPT01), Institut Pasteur de Tunis, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur), Université de Tunis El Manar (UTM), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, This study was funded by the Tunisian Ministry of Higher Education and Scientific Research (LR16IPT01)., We thank Christiane Bouchier and Laurence Ma, from the Biomics platform of the Institut Pasteur, Paris, for library construction and genome sequencing, and Sinda Zarouk from Institut Pasteur, Tunis, for sample logistics., ANR-11-INBS-0013,IFB (ex Renabi-IFB),Institut français de bioinformatique(2011)

المصدر: ISSN: 2045-2322.

مصطلحات موضوعية: MESH: Computational Biology, MESH: Gene Transfer, Horizontal, MESH: Virulence Factors, MESH: Genome, Bacterial, MESH: Genomics, MESH: Humans, MESH: Molecular Sequence Annotation, MESH: Mycobacterium Infections, Nontuberculous, MESH: Mycobacterium fortuitum, MESH: Phenotype, MESH: Phylogeny, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/34155223; PUBMED: 34155223; PUBMEDCENTRAL: PMC8217490

الاتاحة: https://riip.hal.science/pasteur-03547033
https://riip.hal.science/pasteur-03547033v1/document
https://riip.hal.science/pasteur-03547033v1/file/had4.pdf
https://doi.org/10.1038/s41598-021-91737-8

المؤلفون: van der Niet, Sanne, van Zon, Maaike, de Punder, Karin, Grootemaat, Anita, Rutten, Sofie, Moorlag, Simone J. C. F. M., Houben, Diane, van der Sar, Astrid M., Bitter, Wilbert, Brosch, Roland, Hernandez Pando, Rogelio, Pena, Maria T., Peters, Peter J., Reits, Eric A., Mayer-Barber, Katrin D., van der Wel, Nicole N.

المصدر: van der Niet , S , van Zon , M , de Punder , K , Grootemaat , A , Rutten , S , Moorlag , S J C F M , Houben , D , van der Sar , A M , Bitter , W , Brosch , R , Hernandez Pando , R , Pena , M T , Peters , P J , Reits , E A , Mayer-Barber , K D & van der Wel , N N 2021 , ' IL-1R1-Dependent Signals Improve Control of Cytosolic Virulent Mycobacteria In Vivo ' , mSphere , ....

الاتاحة: https://research.vumc.nl/en/publications/a1159099-dd6e-4a24-8d3d-64b7a4484786
https://doi.org/10.1128/mSphere.00153-21
http://www.scopus.com/inward/record.url?scp=85105501727&partnerID=8YFLogxK

المؤلفون: Allen, Aideen, C, Malaga, Wladimir, Gaudin, Cyril, Volle, Arnaud, Moreau, Flavie, Hassan, Ali, Astarie-Dequeker, Catherine, Peixoto, Antonio, Antoine, Rudy, Pawlik, Alexandre, Frigui, Wafa, Berrone, Céline, Brosch, Roland, Supply, Philip, Guilhot, Christophe

المساهمون: Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Genoscreen Lille, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), This project received funding from the European Respiratory Society and the European Union’s H2020 research and innovation programme under the Marie Sklodowska–Curie grant agreement no. 713406 awarded to A.C.A. This work was also supported by grants from the French National Research Agency (TBemerg contract no. ANR-16-CE35-0009 awarded to R.B., P.S. and C. Guilhot, Equipex ANINFIMIP ANR-11-EQUIPEX-0003 to C. Guilhot, Labex ANR-10-LABX-62-IBEID awarded to R.B.), the European Union (PathoNgenTrace contract no. FP7-278864 awarded to P.S.), and the Fondation pour la Recherche Médicale (Equipe FRM 2016 DEQ20160334879), the Fondation Bettencourt Schueller and the Fondation MSDAvenir (Fight-TB project) to C. Guilhot., ANR-16-CE35-0009,TBemerg,Naissance d'un tueur: facteurs génétiques et adaptations métaboliques impliquées dans l'émergence des bacilles tuberculeux épidémiques(2016), ANR-11-EQPX-0003,ANINFIMIP,Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées(2011), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 713406,H2020,H2020-MSCA-COFUND-2015,RESPIRE 3(2016), European Project: 278864,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,PATHONGEN-TRACE(2012)

المصدر: ISSN: 2058-5276.

مصطلحات موضوعية: [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.GEN]Life Sciences [q-bio]/Genetics

Relation: info:eu-repo/semantics/altIdentifier/pmid/34294904; info:eu-repo/grantAgreement//713406/EU/REspiratory Science Promoted by International Research Exchanges 3/RESPIRE 3; info:eu-repo/grantAgreement/EC/FP7/278864/EU/Next Generation Genome Based High Resolution Tracing of Pathogens/PATHONGEN-TRACE; hal-03318178; https://hal.science/hal-03318178; https://hal.science/hal-03318178/document; https://hal.science/hal-03318178/file/Allen_NatMicrobiol_HAL.pdf; PUBMED: 34294904

الاتاحة: https://hal.science/hal-03318178
https://hal.science/hal-03318178/document
https://hal.science/hal-03318178/file/Allen_NatMicrobiol_HAL.pdf
https://doi.org/10.1038/s41564-021-00938-4

المؤلفون: Orgeur, Mickael, Frigui, Wafa, Pawlik, Alexandre, Clark, Simon, Williams, Ann, Ates, Louis, S, Ma, Laurence, Bouchier, Christiane, Parkhill, Julian, Brodin, Priscille, Brosch, Roland

المساهمون: Pathogénomique mycobactérienne intégrée - Integrated Mycobacterial Pathogenomics, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Public Health England Salisbury (PHE), University of Amsterdam Amsterdam = Universiteit van Amsterdam (UvA), Pôle Biomics (C2RT), Centre de Ressources et de Recherche Technologique - Center for Technological Resources and Research (C2RT), Institut Pasteur Paris (IP)-Institut Pasteur Paris (IP), University of Cambridge UK (CAM), The Wellcome Trust Sanger Institute Cambridge, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the European Commission (TBVAC2020, grant 260872) and the Agence Nationale de la Recherche (grants ANR-16-CE35-0009 and ANR-10-LABX-62-IBEID). M. O. was supported by the Fondation pour la Recherche Médicale (SPF20160936136) and the Institut Pasteur (Pasteur-Roux-Cantarini postdoctoral fellowship program). The Biomics platform is supported by France Génomique (ANR-10-INBS-09–09) and IBISA., We thank the pathology team (Public Health England, Porton, Salisbury, UK) for the generation of histopathology data and images, the staff of the Biological Investigations Group (Public Health England, Porton, Salisbury, UK) for their assistance in conducting the guinea pig study, and the core Sequencing and Informatic groups (Sanger Institute, Hinxton, UK) for processing the Illumina whole-genome sequencing. We also thank Julien Guglielmini, Thomas Bigot and Varun Khanna (C3BI, HUB Bioinformatics and Biostatistics, Institut Pasteur, Paris, France) for their help in data analysis and phylogenetic reconstruction, as well as Laleh Majlessi, Fadel Sayes (Institut Pasteur, Paris, France) and Anzaan Dippenaar (Stellenbosch University, Cape Town, South Africa) for advice and fruitful discussions., ANR-16-CE35-0009,TBemerg,Naissance d'un tueur: facteurs génétiques et adaptations métaboliques impliquées dans l'émergence des bacilles tuberculeux épidémiques(2016), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), European Project: 260872,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,MM4TB(2011)

المصدر: ISSN: 2057-5858.

مصطلحات موضوعية: ESX-1, Mycobacterium microti, mouse and guinea pig models, protective efficacy, virulence evaluation, whole-genome sequencing, [SDV]Life Sciences [q-bio]

Relation: info:eu-repo/semantics/altIdentifier/pmid/33529148; info:eu-repo/grantAgreement/EC/FP7/260872/EU/More Medicines for Tuberculosis/MM4TB; PUBMED: 33529148

الاتاحة: https://pasteur.hal.science/pasteur-03255655
https://pasteur.hal.science/pasteur-03255655v1/document
https://pasteur.hal.science/pasteur-03255655v1/file/mgen000505%281%29.pdf
https://doi.org/10.1099/mgen.0.000505