المؤلفون: Grzegorz A. Czapski, Marta Matuszewska, Magdalena Cieślik, Joanna B. Strosznajder

المصدر: Folia Neuropathologica, Vol 62, Iss 2, Pp 127-135 (2024)

مصطلحات موضوعية: alzheimer’s disease, systemic inflammatory response, endotoxin, bromodomain and extraterminal domain proteins, hippocampus, microglia, Medicine

وصف الملف: electronic resource

Relation: https://www.termedia.pl/Inhibitor-of-bromodomain-and-extraterminal-domain-proteins-decreases-transcription-of-Cd33-in-the-brain-of-mice-subjected-to-systemic-inflammation-a-promising-strategy-r-nfor-neuroprotection,20,53626,1,1.html; https://doaj.org/toc/1641-4640; https://doaj.org/toc/1509-572X

URL الوصول: https://doaj.org/article/62011e42640a4bb9963f78cda100833b

المؤلفون: Borthakur, Gautam, Odenike, Olatoyosi, Aldoss, Ibrahim, Rizzieri, David A, Prebet, Thomas, Chen, Chris, Popovic, Relja, Modi, Dimple A, Joshi, Rujuta H, Wolff, Johannes E, Jonas, Brian A

المصدر: Cancer. 127(16)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Orphan Drug, Pediatric Cancer, Hematology, Pediatric, Rare Diseases, Childhood Leukemia, 6.1 Pharmaceuticals, 5.1 Pharmaceuticals, Good Health and Well Being, Antineoplastic Combined Chemotherapy Protocols, Bridged Bicyclo Compounds, Heterocyclic, Humans, Leukemia, Myeloid, Acute, Pyridones, Sulfonamides, ABBV‐, 075, acute myeloid leukemia, bromodomain and extraterminal domain protein, mivebresib, phase 1 clinical trial, ABBV-075, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1kf2n130
https://escholarship.org/content/qt1kf2n130/qt1kf2n130.pdf

المؤلفون: Goldin, Amanda N, Singh, Alok, Joshi, Shweta, Jamieson, Christina, Durden, Donald L

المصدر: Journal of Pediatric Hematology/Oncology. 43(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric Research Initiative, Pediatric, Pediatric Cancer, Stem Cell Research, Rare Diseases, Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Cell Cycle Proteins, Cell Line, Tumor, Cell Survival, Chromones, Humans, Mice, Morpholines, Oligopeptides, Phosphoinositide-3 Kinase Inhibitors, Phosphorylation, Pyrans, Sarcoma, Ewing, Transcription Factors, Ewing sarcoma, dual inhibition, phosphoinositide-3 kinase (PI3K) pathway, bromodomain and extraterminal domain (BET) proteins, SF1126, SF2523, Cardiorespiratory Medicine and Haematology, Oncology & Carcinogenesis, Cardiovascular medicine and haematology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/5vm2r5rx

المؤلفون: Martin V. Nguyen, Lydia Loof, Gerald S. Falchook

المصدر: Journal of Immunotherapy and Precision Oncology, Pp 16-22 (2020)

مصطلحات موضوعية: bromodomain and extraterminal domain, bromodomain and extraterminal inhibitor, cancer, clinical trial, review, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2666-2345; https://doaj.org/toc/2590-017X

URL الوصول: https://doaj.org/article/953c704e02074f5595cc1efcdade115b

المؤلفون: Hu, Xiao, Schewitz-Bowers, Lauren, Lait, Philippa, Copland, Dave, Stimpson, Madeleine, Li, Jing Jing, Liu, Yizhi, Dick, Andrew, Lee, Richard, Wei, Lai

المصدر: Hu , X , Schewitz-Bowers , L , Lait , P , Copland , D , Stimpson , M , Li , J J , Liu , Y , Dick , A , Lee , R & Wei , L 2019 , ' The Bromodomain and Extra-Terminal Protein Inhibitor OTX015 Suppresses T Helper Cell Proliferation and Differentiation ' , Current Molecular Medicine , vol. 18 , no. 9 , pp. 594-601 . https://doi.org/10.2174/1566524019666190126112238

مصطلحات موضوعية: antiproliferation, Autoimmune disease, bromodomain and extraterminal domain (BET) inhibitors, CD4+ T cells, epigenetics, immunosuppression., OTX015

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/1983/04683b91-2893-448a-b201-173d44468e33
https://research-information.bris.ac.uk/en/publications/04683b91-2893-448a-b201-173d44468e33
https://doi.org/10.2174/1566524019666190126112238
https://research-information.bris.ac.uk/ws/files/186880601/Lai_MS_text_RL.pdf
https://research-information.bris.ac.uk/ws/files/186880602/Lai_supple_figures.pdf
https://research-information.bris.ac.uk/ws/files/186880603/Lai_figures.pdf
http://www.scopus.com/inward/record.url?scp=85062195212&partnerID=8YFLogxK

المؤلفون: Thao N.D. Pham, Sophie Stempel, Mario A. Shields, Christina Spaulding, Krishan Kumar, David J. Bentrem, Maria Matsangou, Hidayatullah G. Munshi

المصدر: International Journal of Molecular Sciences; Volume 20; Issue 17; Pages: 4293

مصطلحات موضوعية: flavonoids, quercetin, bromodomain and extraterminal domain (BET) inhibitors, combination therapy, pancreatic cancer, thyroid cancer, heterogeneous nuclear nucleoprotein A1 (hnRNPA1), survivin

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Bioactives and Nutraceuticals; https://dx.doi.org/10.3390/ijms20174293

الاتاحة: https://doi.org/10.3390/ijms20174293

المؤلفون: Jaydeep Bhat, Léonce Kouakanou, Christian Peters, Zhinan Yin, Dieter Kabelitz

المصدر: Frontiers in Immunology, Vol 9 (2018)

مصطلحات موضوعية: Bromodomain and ExtraTerminal domain, checkpoint inhibitors, DNA methylation, gamma delta T cells, histone acetylation, immunotherapy, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2018.00512/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/1e7112c05d814756a1c87538cc9c87c1

المؤلفون: Hu, X, Schewitz-Bowers, LP, Lait, PJP, Copland, DA, Stimpson, ML, Li, JJ, Liu, Y, Dick, AD, Lee, RWJ, Wei, L

المصدر: Current Molecular Medicine , 18 (9) pp. 594-601. (2018)

مصطلحات موضوعية: Autoimmune disease, CD4+ T cells, OTX015, antiproliferation, bromodomain and extraterminal domain (BET) inhibitors, epigenetics, immunosuppression

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10068127/1/Dick%20Lai%20MS%20text_RL.pdf; https://discovery.ucl.ac.uk/id/eprint/10068127/7/Dick%20Lai%20supple%20figures.pdf; https://discovery.ucl.ac.uk/id/eprint/10068127/13/Dick%20Lai%20figures.pdf; https://discovery.ucl.ac.uk/id/eprint/10068127/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10068127/1/Dick%20Lai%20MS%20text_RL.pdf
https://discovery.ucl.ac.uk/id/eprint/10068127/7/Dick%20Lai%20supple%20figures.pdf
https://discovery.ucl.ac.uk/id/eprint/10068127/13/Dick%20Lai%20figures.pdf
https://discovery.ucl.ac.uk/id/eprint/10068127/

المؤلفون: Peiqing Liu, Zhuoming Li, Junjian Wang, Sidong Cai, Rui Lan, Zhirong Lin, Zhen Guo, Jingyan Li, Zhenzhen Li

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1286-1299 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Hypertrophic genes, ISO, isoproterenol, PARP1, poly(ADP-ribose)polymerase-1, TSS, transcription start sites, RNA polymerase II, LVAW, left ventricular anterior wall thickness, LVPW, left ventricular posterior wall thickness, PARP1, TL, tibia length, NS, normal saline, NC, negative control, BET, bromodomain and extraterminal domain, 0302 clinical medicine, HATs, histone acetyltransferases, Gene expression, Transcription activation, co-IP, co-immunoprecipitation, General Pharmacology, Toxicology and Pharmaceutics, HW, heart weight, 0303 health sciences, siRNA, small-interfering RNA, PSR, picrosirius red, biology, FS, fractional shortening, Chemistry, BW, body weight, Chromatin, Cell biology, Cardiac hypertrophy, 030220 oncology & carcinogenesis, PBS, phosphate buffer solution, Phosphorylation, BRD4, Original Article, WGA, wheat germ agglutinin, RM1-950, 03 medical and health sciences, FBS, fetal bovine serum, HE, hematoxylin-eosin, RNA Pol II, RNA polymerases II, RNA Pol II, Gene silencing, EF, ejection fraction, IF, immunofluorescence, ANP, atrial natriuretic peptide, CDK9, cyclin-dependent kinase 9, 030304 developmental biology, LVID, left ventricular internal diameter, BNP, brain natriuretic polypeptide, NRCMs, neonatal rat cardiomyocytes, β-AR, β-adrenergic receptor, Isoproterenol, HDACs, histone deacetylases, Bromodomain, PARylation, biology.protein, SD, Sprague–Dawley, β-MHC, β-myosin heavy chain, Therapeutics. Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fde96e7c9d22c0d4144a0bf59c2cb8
http://www.sciencedirect.com/science/article/pii/S2211383520308455

المؤلفون: Ksenija Bernau, Melissa Skibba, Jonathan P. Leet, Sierra Furey, Carson Gehl, Yi Li, Jia Zhou, Nathan Sandbo, Allan R. Brasier

مصطلحات موضوعية: Molecular Biology, Bioinformatics, Diseases, Pathology (excl. Oral Pathology), Molecular Medicine, idiopathic pulmonarry fibrosis, myofibroblast, epigenetics, bromodomain and extraterminal domain (BET), bromodomain-containing protein 4

Relation: https://figshare.com/articles/dataset/DataSheet1_Selective_Inhibition_of_Bromodomain-Containing_Protein_4_Reduces_Myofibroblast_Transdifferentiation_and_Pulmonary_Fibrosis_PDF/19359146

الاتاحة: https://doi.org/10.3389/fmmed.2022.842558.s001
https://figshare.com/articles/dataset/DataSheet1_Selective_Inhibition_of_Bromodomain-Containing_Protein_4_Reduces_Myofibroblast_Transdifferentiation_and_Pulmonary_Fibrosis_PDF/19359146

المؤلفون: Pengda Sun, Zhiming Ma, Jianfeng Mu, Pengfei Sun

المصدر: Journal of Cellular and Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Male, Cell Cycle Proteins, gastrointestinal stromal tumour, Transactivation, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Phosphorylation, Caspase, Gastrointestinal Neoplasms, biology, GiST, Chemistry, TOR Serine-Threonine Kinases, Middle Aged, bromodomain and extraterminal domain, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-kit, 030220 oncology & carcinogenesis, Imatinib Mesylate, Molecular Medicine, BRD4, Original Article, Female, medicine.drug, Signal Transduction, Gastrointestinal Stromal Tumors, JQ1, Mice, Nude, Antineoplastic Agents, Disease-Free Survival, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Protein kinase B, neoplasms, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Cell growth, Imatinib, Cell Biology, Original Articles, 030104 developmental biology, Drug Resistance, Neoplasm, biology.protein, Cancer research, imatinib resistance, Proto-Oncogene Proteins c-akt, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1473a07e86ac90abbcbb7221e63053e2
http://europepmc.org/articles/PMC7028844

المؤلفون: Alok R. Singh, Christina Jamieson, Amanda N Goldin, Donald L. Durden, Shweta Joshi

المصدر: Journal of pediatric hematology/oncology, vol 43, iss 3

مصطلحات موضوعية: Cell Cycle Proteins, Cardiorespiratory Medicine and Haematology, Mice, 0302 clinical medicine, Phosphorylation, Phosphoinositide-3 Kinase Inhibitors, Cancer, Pediatric, Tumor, Kinase, Bone cancer, Sarcoma, Hematology, phosphoinositide-3 kinase (PI3K) pathway, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Oligopeptides, Pediatric Research Initiative, Cell Survival, Pediatric Cancer, Morpholines, bromodomain and extraterminal domain (BET) proteins, Antineoplastic Agents, Sarcoma, Ewing, SF2523, Cell Line, 03 medical and health sciences, Rare Diseases, Cell Line, Tumor, Ewing, medicine, Animals, Humans, Viability assay, Oncology & Carcinogenesis, Protein kinase B, PI3K/AKT/mTOR pathway, Pyrans, business.industry, dual inhibition, SF1126, medicine.disease, Stem Cell Research, Bromodomain, Chromones, Pediatrics, Perinatology and Child Health, Cancer research, business, Ewing sarcoma, 030215 immunology, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7852b900fca7868c19b10690bb05b777
https://escholarship.org/uc/item/5vm2r5rx

المؤلفون: Gautam Borthakur, Brian A. Jonas, Ibrahim Aldoss, David A. Rizzieri, Thomas Prebet, Olatoyosi Odenike, Chris Chen, Rujuta Joshi, Dimple A. Modi, Relja Popovic, Johannes E. A. Wolff

المصدر: Cancer
Cancer, vol 127, iss 16

مصطلحات موضوعية: Oncology, Myeloid, Cancer Research, phase 1 clinical trial, Phases of clinical research, mivebresib, chemistry.chemical_compound, ABBV-075, Antineoplastic Combined Chemotherapy Protocols, bromodomain and extraterminal domain protein, Cancer, Pediatric, Sulfonamides, Leukemia, Heterocyclic, Myeloid leukemia, Hematology, Leukemia, Myeloid, Acute, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, Public Health and Health Services, Original Article, medicine.symptom, Development of treatments and therapeutic interventions, medicine.medical_specialty, Combination therapy, Pediatric Cancer, Childhood Leukemia, Pyridones, Oncology and Carcinogenesis, Acute, acute myeloid leukemia, Discipline, Bridged Bicyclo Compounds, Rare Diseases, Clinical Research, ABBV‐075, Internal medicine, medicine, Genetics, Humans, Clinical Trials, Oncology & Carcinogenesis, Adverse effect, Venetoclax, business.industry, Evaluation of treatments and therapeutic interventions, Original Articles, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Dysgeusia, Good Health and Well Being, chemistry, Pharmacodynamics, ABBV‐, business

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579d30c12cedca3c99ef7390b7cdb7c
https://pubmed.ncbi.nlm.nih.gov/33934351

المؤلفون: Yue Song, Yaping Wu, Laikui Liu, Wei Zhang, Hongbing Jiang, Jie Cheng, Zhongwu Li, Han Ge, Dongmiao Wang, Pengfei Diao, Jin Li, Yanling Wang

المصدر: Theranostics

مصطلحات موضوعية: 0301 basic medicine, BRD4, JQ1, Transplantation, Heterologous, Medicine (miscellaneous), Cell Cycle Proteins, Mice, SCID, medicine.disease_cause, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Mediator, Downregulation and upregulation, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, Gene silencing, Epigenetics, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Oncogene, business.industry, Gene Expression Profiling, Azepines, Triazoles, medicine.disease, head neck squamous cell carcinoma, Immunohistochemistry, bromodomain and extraterminal domain, Disease Models, Animal, stomatognathic diseases, Treatment Outcome, 030104 developmental biology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Cancer research, Carcinogenesis, business, Research Paper, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08eb81e85e4fa7a32a48c30fe022013
https://doi.org/10.7150/thno.31581

المؤلفون: Ryota Takahashi, Keisuke Tateishi, Yasuo Tanaka, Yousuke Nakai, Kiyoshi Hasegawa, Yoshihiro Sakamoto, Yotaro Kudo, Mariko Tanaka, Takuma Nakatsuka, Hideaki Ijichi, Hiroaki Fujiwara, Hiroyuki Isayama, Koji Miyabayashi, Taku Aoki, Kazuhiko Koike, Keisuke Yamamoto, Yasuyuki Morishita, Norihiro Kokudo, Masashi Fukayama, Mayumi Hoshikawa

المصدر: Oncotarget

مصطلحات موضوعية: 0301 basic medicine, Male, Pathology, endocrine system diseases, Transcription, Genetic, Mice, SCID, pancreatic ductal adenocarcinoma (PDAC), Epigenesis, Genetic, cancer-associated fibroblast (CAF), Mice, Cancer-Associated Fibroblasts, Mice, Inbred NOD, Transforming Growth Factor beta, Medicine, STAT3, biology, Molecular pathology, Azepines, Immunohistochemistry, Oncology, Disease Progression, Cytokines, Research Paper, Carcinoma, Pancreatic Ductal, Signal Transduction, STAT3 Transcription Factor, medicine.medical_specialty, Chromatin Immunoprecipitation, Stromal cell, bromodomain and extraterminal domain (BET) proteins, JQ1, Primary Cell Culture, BET inhibitor, 03 medical and health sciences, Pancreatic cancer, Cell Line, Tumor, Animals, Humans, Hedgehog Proteins, Protein kinase B, Pancreas, Cell Proliferation, epigenetics, business.industry, Proteins, Triazoles, medicine.disease, Xenograft Model Antitumor Assays, Actins, Bromodomain, Pancreatic Neoplasms, 030104 developmental biology, Cancer research, biology.protein, business, Chromatin immunoprecipitation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06f7cd82820d583d2b054ab4c551873
http://europepmc.org/articles/PMC5308665

المؤلفون: Villar-Prados, Alejandro

المصدر: Dissertations and Theses (Open Access)

مصطلحات موضوعية: ovarian cancer, targeted therapies, BRD4, Notch3, Bromodomain and extraterminal domain inhibitors, Medicine and Health Sciences

وصف الملف: application/pdf

Relation: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/840; https://digitalcommons.library.tmc.edu/context/utgsbs_dissertations/article/1885/viewcontent/Identifying_molecular_targets_and_validating_novel_therapies_for_ovarian_cancer.pdf

الاتاحة: https://digitalcommons.library.tmc.edu/utgsbs_dissertations/840
https://digitalcommons.library.tmc.edu/context/utgsbs_dissertations/article/1885/viewcontent/Identifying_molecular_targets_and_validating_novel_therapies_for_ovarian_cancer.pdf

المؤلفون: Bikash R. Pattnaik, Pawan K Shahi, Jun Li, Mengxue Zhang, Jonathan N. Ouellette, Jyoti J. Watters, Yingmei Fu, Lei Zhao, Wai T. Wong, Lian-Wang Guo, Bowen Wang

المصدر: Journal of Neuroinflammation

مصطلحات موضوعية: 0301 basic medicine, Retinal degeneration, Bromodomain and extraterminal domain (BET) proteins, JQ1, Immunology, Mice, Transgenic, Nerve Tissue Proteins, Receptors, Cell Surface, Biology, Epigenetic readers, Proinflammatory cytokine, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, Mice, Cellular and Molecular Neuroscience, PDE6B, Retinitis pigmentosa, rd10 mice, medicine, Animals, Microglial activation, Photoreceptor Cells, Retina, General Neuroscience, Research, Neurodegeneration, Retinal Degeneration, Retinal, medicine.disease, Bromodomain, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Neurology, Retinitis Pigmentosa

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde1898ab828335a7aaa233be03bb7aa