المؤلفون: Kendra A. Sirak (Department of Genetics, Harvard Medical School), Daniel M. Fernandes (Department of Evolutionary Anthropology, Faculty of Life Sciences, University of Vienna), Mark Lipson (Department of Genetics, Harvard Medical School), Swapan Mallick (Department of Genetics, Harvard Medical School), Matthew Mah (Department of Genetics, Harvard Medical School), Iñigo Olalde (Department of Genetics, Harvard Medical School), Harald Ringbauer (Department of Genetics, Harvard Medical School), Nadin Rohland (Department of Genetics, Harvard Medical School), Carla S. Hadden (Center for Applied Isotope Studies, University of Georgia), Éadaoin Harney (Department of Genetics, Harvard Medical School), Nicole Adamski (Department of Genetics, Harvard Medical School), Rebecca Bernardos (Department of Genetics, Harvard Medical School), Nasreen Broomandkhoshbacht (Department of Anthropology, University of California, Santa Cruz), Kimberly Callan (Department of Genetics, Harvard Medical School), Matthew Ferry (Department of Genetics, Harvard Medical School), Ann Marie Lawson (Department of Human Genetics, University of Michigan Medical School), Megan Michel (Department of Human Evolutionary Biology, Harvard University), Jonas Oppenheimer (Department of Biomolecular Engineering, University of California, Santa Cruz), Kristin Stewardson (Department of Genetics, Harvard Medical School), Fatma Zalzala (Department of Genetics, Harvard Medical School), Nick Patterson (Broad Institute of Harvard and MIT), Ron Pinhasi (Department of Evolutionary Anthropology, Faculty of Life Sciences, University of Vienna), Jessica C. Thompson (Department of Anthropology, Emory University), Dennis Van Gerven (Department of Anthropology, University of Colorado at Boulder), David Reich (Department of Genetics, Harvard Medical School)

المصدر: Nature Communications ; issn:2041-1723

مصطلحات موضوعية: Genomics, Population genetics

وصف الملف: application/pdf

Relation: hdl:11353/10.1610845; https://phaidra.univie.ac.at/o:1610845

الاتاحة: https://doi.org/10.1101/2021.02.17.431423
https://phaidra.univie.ac.at/o:1610845

المؤلفون: Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, Novartis Institutes for BioMedical Research

المصدر: Science, 2007 Jun 01. 316(5829), 1331-1336.

URL الوصول: https://www.jstor.org/stable/20036394

المؤلفون: de Vries, Ronald P. Westerdijk Fungal Biodiversity Institute, Utrecht, Utrecht University, Utrecht . Fungal Molecular Physiology, Riley, Robert USDOE Joint Genome Institute , Walnut Creek, CA, Wiebenga, Ad Westerdijk Fungal Biodiversity Institute, Utrecht, Aguilar-Osorio, Guillermo National University of Mexico, Ciudad Universitaria, D.F. C.P. 04510 . Dept. of Food Science and Biotechnology, Faculty of Chemistry, Amillis, Sotiris Univ. of Athens . Dept. of Biology,National and Kapodistrian, Uchima, Cristiane Akemi Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, VTTBrasil, Alameda Inajá, 123, CEP 06460-055 Barueri, São Paulo, Anderluh, Gregor National Institute of Chemistry, Ljubljana . Laboratory for Molecular Biology and Nanobiotechnology, Asadollahi, Mojtaba Univ. of Debrecen,4032 Debrecen Dept. of Biochemical Engineering, Faculty of Science and Technology, Askin, Marion Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, CSIRO Publishing, Clayton, VIC 3168, Barry, Kerrie USDOE Joint Genome Institute , Walnut Creek, CA, Battaglia, Evy Westerdijk Fungal Biodiversity Institute, Utrecht, Bayram, Özgür Georg August University, Göttingen . Dept. of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, Maynooth University, Maynooth, Co. Kildare . Department of Biology, Benocci, Tiziano Westerdijk Fungal Biodiversity Institute, Utrecht, Braus-Stromeyer, Susanna A. Georg August University, Göttingen . Dept. of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, Caldana, Camila Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Brazilian Bioethanol Science and Technology Laboratory, Sao Paulo . Max Planck Partner Group, Cánovas, David Univ. of Seville, Sevilla . Dept. of Genetics, Faculty of Biology, Univ. of Natural Resources and Life Sciences Vienna, . Fungal Genetics and Genomics Unit, Department of Applied Genetics and Cell Biology, Cerqueira, Gustavo C. Broad Institute of Harvard and MIT, Cambridge, MA, Chen, Fusheng Huazhong Agricultural University, Wuhan . College of Food Science and Technology, Chen, Wanping Huazhong Agricultural University, Wuhan . College of Food Science and Technology, Choi, Cindy USDOE Joint Genome Institute , Walnut Creek, CA, Clum, Alicia USDOE Joint Genome Institute , Walnut Creek, CA, dos Santos, Renato Augusto Corrêa Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Damásio, André Ricardo de Lima Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, University of Campinas, CEP13083-862 Campinas, SP, . Dept. of Biochemistry and Tissue Biology, Institute of Biology University of Campinas, CEP13083-862 Campinas, SP, Brazi, Diallinas, George Univ. of Athens . Dept. of Biology,National and Kapodistrian, Emri, Tamás Univ. of Debrecen,Egyetem tér 1, 4032 Debrecen . Dept. of Biotechnology and Microbiology, Faculty of Science and Technology, Fekete, Erzsébet Univ. of Debrecen,4032 Debrecen Dept. of Biochemical Engineering, Faculty of Science and Technology, Flipphi, Michel Univ. of Debrecen,4032 Debrecen Dept. of Biochemical Engineering, Faculty of Science and Technology, Freyberg, Susanne Georg August University, Göttingen . Dept. of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, Gallo, Antonia Institute of Sciences of Food Production , National Research Council , via Provinciale Lecce-Monteroni, Lecce ., Gournas, Christos Institute of Biosciences and Applications, Microbial Molecular Genetics Laboratory, National Center for Scientific Research, Demokritos , Athens, Université Libre de BruxellesInstitute of Molecular Biology and Medicine , Brussels, Habgood, Rob Univ. of Nottingham, University Park, Nottingham . School of Life Sciences, Hainaut, Matthieu CNRS, Aix-Marseille Université, Marseille, Harispe, María Laura Institut Pasteur de Montevideo, Unidad Mixta INIA-IPMont, Mataojo 2020, CP11400 Montevideo, Instituto de Profesores Artigas, Consejo de Formación en Educación, ANEP, CP 11800Av. del Libertador 2025, Montevideo, Henrissat, Bernard CNRS, Aix-Marseille Université, Marseille, INRA, USC 1408 AFMB, 13288 Marseille, King Abdulaziz University, Jeddah . Dept. of Biological Sciences, Hildén, Kristiina S. Univ. of Helsinki,Viikinkaari 9, Helsinki . Dept. of Food and Environmental Sciences, Hope, Ryan Univ. of Nottingham, University Park, Nottingham . School of Life Sciences, Hossain, Abeer Dutch DNA Biotech BV, Utrechtseweg 48,3703AJ Zeist, Univ. of Amsterdam, Amsterdam, . Swammerdam Institute for Life Sciences, Karabika, Eugenia Univ. of St. Andrews, St. Andrews . School of Biology, Univ. of Ioannina . Dept. of Chemistry, Karaffa, Levente Univ. of Debrecen,4032 Debrecen Dept. of Biochemical Engineering, Faculty of Science and Technology, Karányi, Zsolt Univ. of Debrecen, Debrecen . Dept. of Medicine, Faculty of Medicine, Kraševec, Nada National Institute of Chemistry, Ljubljana . Laboratory for Molecular Biology and Nanobiotechnology, Kuo, Alan USDOE Joint Genome Institute , Walnut Creek, CA, Kusch, Harald Georg August University, Göttingen . Dept. of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, University Medical Centre, Göttingen . Dept. of Medical Informatics, Universitätsmedizin Göttingen, Göttingen . Dept. of Molecular Biology, LaButti, Kurt USDOE Joint Genome Institute , Walnut Creek, CA, Lagendijk, Ellen L. Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Lapidus, Alla USDOE Joint Genome Institute , Walnut Creek, CA, St.Petersburg State University, St. Petersburg . Center for Algorithmic Biotechnology, Levasseur, Anthony INRA, Aix-Marseille Univ,BBF, Biodiversité et Biotechnologie Fongiques, Marseille, Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses etTropicales Emergentes , UM63, CNRS 7278, IRD 198, INSERM U1095,IHU Méditerranée Infection, Pôle des Maladies Infectieuses, AssistancePublique-Hôpitaux de Marseille, Faculté de Médecine, 27 Bd Jean Moulin,13005 Marseille, Lindquist, Erika USDOE Joint Genome Institute , Walnut Creek, CA, Lipzen, Anna USDOE Joint Genome Institute , Walnut Creek, CA, Logrieco, Antonio F. Institute of Sciences of Food Production , National Research Council , Bari, MacCabe, Andrew Departamento de Biotecnología,Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior deInvestigaciones Científicas , Paterna, Valencia, Mäkelä, Miia R. Univ. of Helsinki,Viikinkaari 9, Helsinki . Dept. of Food and Environmental Sciences, Malavazi, Iran Departamentode Genética e Evolução, Centro de Ciências Biológicas e da Saúde,Universidade Federal de São Carlos, São Carlos, São Paulo, Melin, Petter Swedish University of Agricultural Sciences, Uppsala, . Uppsala Bio Center, Department of Microbiology, Swedish Chemicals Agency, Sundbyberg, Meyer, Vera Berlin University of Technology, Berlin . Institute of Biotechnology, Department Applied and Molecular Microbiology, Mielnichuk, Natalia Univ. of Seville, Sevilla . Dept. of Genetics, Faculty of Biology, Instituto de Ciencia yTecnología Dr. César Milstein, Fundación Pablo Cassará, CONICET, Saladillo2468 C1440FFX, Ciudad de Buenos Aires, Miskei, Márton Univ. of Debrecen,Egyetem tér 1, 4032 Debrecen . Dept. of Biotechnology and Microbiology, Faculty of Science and Technology, University of Debrecen, Nagyerdei krt.98., 4032 Debrecen . MTA-DEMomentum, Laboratory of Protein Dynamics, Department of Biochemistry and Molecular Biology, Molnár, Ákos P. Univ. of Debrecen,4032 Debrecen Dept. of Biochemical Engineering, Faculty of Science and Technology, Mulé, Giuseppina Institute of Sciences of Food Production , National Research Council , Bari, Ngan, Chew Yee USDOE Joint Genome Institute , Walnut Creek, CA, Orejas, Margarita Departamento de Biotecnología,Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior deInvestigaciones Científicas , Paterna, Valencia, Orosz, Erzsébet Westerdijk Fungal Biodiversity Institute, Utrecht, Univ. of Debrecen,Egyetem tér 1, 4032 Debrecen . Dept. of Biotechnology and Microbiology, Faculty of Science and Technology, Ouedraogo, Jean Paul Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Concordia University, Montreal, . Centre for Structural and Functional Genomics, Overkamp, Karin M. Dutch DNA Biotech BV, Utrechtseweg 48,3703AJ Zeist, Park, Hee-Soo Kyungpook National Univ., Daegu . School of Food Science and Biotechnology, Perrone, Giancarlo Institute of Sciences of Food Production , National Research Council , Bari, Piumi, Francois INRA, Aix-Marseille Univ,BBF, Biodiversité et Biotechnologie Fongiques, Marseille, INRA UMR1198 Biologie du Développement et de la Reproduction -Domaine de Vilvert, Jouy en Josas 78352, Cedex, Punt, Peter J. Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Dutch DNA Biotech BV, Utrechtseweg 48,3703AJ Zeist, Ram, Arthur F. J. Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Ramón, Ana Universidad de la República, Montevideo . Sección Bioquímica, Departamento de Biología Celular y Molecular, Facultad deCiencias, Rauscher, Stefan Karlsruhe Inst. of Technology . Dept. of Microbiology, Institute for Applied Biosciences, Record, Eric INRA, Aix-Marseille Univ,BBF, Biodiversité et Biotechnologie Fongiques, Marseille, Riaño-Pachón, Diego Mauricio Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Robert, Vincent Westerdijk Fungal Biodiversity Institute, Utrecht, Röhrig, Julian Karlsruhe Inst. of Technology . Dept. of Microbiology, Institute for Applied Biosciences, Ruller, Roberto Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Salamov, Asaf USDOE Joint Genome Institute , Walnut Creek, CA, Salih, Nadhira S. Univ. of Nottingham, University Park, Nottingham . School of Life Sciences, Univ. of Sulaimani, Al Sulaymaneyah . Dept. of Biology, School of Science, Samson, Rob A. Westerdijk Fungal Biodiversity Institute, Utrecht, Sándor, Erzsébet University of Debrecen, Debrecen . Institute of Food Science, Faculty of Agricultural and Food Sciences and Environmental Management, Sanguinetti, Manuel Universidad de la República, Montevideo . Sección Bioquímica, Departamento de Biología Celular y Molecular, Facultad deCiencias, Schütze, Tabea Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Berlin University of Technology, Berlin . Department Applied and Molecular Microbiology, Institute of Biotechnology, Sepčić, Kristina Univ. of Ljubljana, Ljubljana . Dept. of Biology, Biotechnical Faculty, Shelest, Ekaterina Leibniz Inst. for Natural Product Research and Infection Biology, Hans Knoell Institute , Jena . Systems Biology/Bioinformatics group, Sherlock, Gavin Stanford Univ., CA . Dept. of Genetics, Sophianopoulou, Vicky Institute of Biosciences and Applications, Microbial Molecular Genetics Laboratory, National Center for Scientific Research, Demokritos , Athens, Squina, Fabio M. Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Sun, Hui USDOE Joint Genome Institute , Walnut Creek, CA, Susca, Antonia Institute of Sciences of Food Production , National Research Council , Bari, Todd, Richard B. Kansas State Univ., Manhattan, KS . Dept. of Plant Pathology, Tsang, Adrian Concordia University, Montreal . Centre for Structural and Functional Genomics, Unkles, Shiela E. Univ. of St. Andrews, St. Andrews . School of Biology, van de Wiele, Nathalie Westerdijk Fungal Biodiversity Institute, Utrecht, van Rossen-Uffink, Diana Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, BaseClear B.V., Einsteinweg 5, 2333, CC, Leiden, Oliveira, Juliana Velasco de Castro Laboratório Nacional de Ciência e Tecnologia do Bioetanol, Centro Nacional de Pesquisa em Energia e Materiais , CaixaPostal 6192CEP 13083-970, Campinas, São Paulo, Vesth, Tammi C. Technical Univ. of Denmark, Lyngby . Dept. of Biotechnology and Biomedicine, Visser, Jaap Westerdijk Fungal Biodiversity Institute, Utrecht, Yu, Jae-Hyuk Univ. of Wisconsin, Madison, WI . Departments of Bacteriology and Genetics, Zhou, Miaomiao Westerdijk Fungal Biodiversity Institute, Utrecht, Andersen, Mikael R. Technical Univ. of Denmark, Lyngby . Dept. of Biotechnology and Biomedicine, Archer, David B. Univ. of Nottingham, University Park, Nottingham . School of Life Sciences, Baker, Scott E. Pacific Northwest National Lab. , Richland, WA . Fungal Biotechnology Team, Benoit, Isabelle Westerdijk Fungal Biodiversity Institute, Utrecht, Concordia University, Montreal . Centre of Functional and Structure Genomics Biology Department, Brakhage, Axel A. Friedrich Schiller Univ., Jena . Dept. of Molecular and Applied Microbiology, Leibniz-Institute for Natural Product Research and Infection Biology - Hans Knoell Institute and Institute for Microbiology, Braus, Gerhard H. Georg August University, Göttingen . Dept. of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, Fischer, Reinhard Karlsruhe Inst. of Technology . Dept. of Microbiology, Institute for Applied Biosciences, Frisvad, Jens C. Technical Univ. of Denmark, Lyngby . Dept. of Biotechnology and Biomedicine, Goldman, Gustavo H. Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade deSão Paulo, Av. do Café S/N, CEP 14040-903 Ribeirão Preto, São Paulo, Houbraken, Jos Westerdijk Fungal Biodiversity Institute, Utrecht, Oakley, Berl Univ. of Kansas, Lawrence, KS . Dept. of Molecular Biosciences, Pócsi, István Univ. of Debrecen,Egyetem tér 1, 4032 Debrecen . Dept. of Biotechnology and Microbiology, Faculty of Science and Technology, Scazzocchio, Claudio Imperial College . Dept. of Microbiology, Université Paris‐Saclay, 91198 Gif‐sur‐Yvette cedex,. Institute for Integrative Biology of the Cell , CEA, CNRS,University Paris‐Sud, Seiboth, Bernhard Institute of Chemical Engineering, Vienna . Research Division Biochemical Technology, Institute of Chemical Engineering, vanKuyk, Patricia A. Westerdijk Fungal Biodiversity Institute, Utrecht, Leiden Univ. . Institute of Biology Leiden, Molecular Microbiology and Biotechnology, Wortman, Jennifer Broad Institute, St, Cambridge, MA, Seres Therapeutics, St,Cambridge, MA, Dyer, Paul S. Univ. of Nottingham, University Park, Nottingham . School of Life Sciences, Grigoriev, Igor V. USDOE Joint Genome Institute , Walnut Creek, CA

وصف الملف: application/pdf

Relation: http://www.osti.gov/servlets/purl/1626939; https://www.osti.gov/biblio/1626939; https://doi.org/10.1186/s13059-017-1151-0

الاتاحة: http://www.osti.gov/servlets/purl/1626939
https://www.osti.gov/biblio/1626939
https://doi.org/10.1186/s13059-017-1151-0

المؤلفون: Sadler, Jessica B. A., Wenzel, Dawn M., Williams, Lauren K. Univ. of Utah, School of Medicine, Salt Lake City, UT . Dept. of Biochemistry, Univ. of Utah, Salt Lake City, UT . Dept. of Oncological Sciences, Huntsman Cancer Institute, Guindo-Martínez, Marta Barcelona Supercomputing Center, Alam, Steven L. Univ. of Utah, School of Medicine, Salt Lake City, UT . Dept. of Biochemistry, Mercader, Josep M. Barcelona Supercomputing Center, Broad Institute of Harvard and MIT, Cambridge, MA, Massachusetts General Hospital, Boston, MA, Torrents, David Barcelona Supercomputing Center, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Ullman, Katharine S. Univ. of Utah, Salt Lake City, UT . Dept. of Oncological Sciences, Huntsman Cancer Institute, Sundquist, Wesley I. Univ. of Utah, School of Medicine, Salt Lake City, UT . Dept. of Biochemistry, Martin-Serrano, Juan King's College London . Dept. of Infectious Diseases, Faculty of Life Sciences and Medicine

مصطلحات موضوعية: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY, 59 BASIC BIOLOGICAL SCIENCES

وصف الملف: application/pdf

Relation: http://www.osti.gov/servlets/purl/1625022; https://www.osti.gov/biblio/1625022; https://doi.org/10.1073/pnas.1805504115

الاتاحة: http://www.osti.gov/servlets/purl/1625022
https://www.osti.gov/biblio/1625022
https://doi.org/10.1073/pnas.1805504115

المؤلفون: Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA, Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA ; SP and PW contributed equally to this study and should both be considered first authors., Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA, Institute of Surgical Pathology, Department of Pathology, University Hospital of Zurich, Zurich, Switzerland, Department of Medical Oncology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA ; Broad Institute of Harvard and M.I.T, Cambridge, MA, USA, Division of Thoracic Surgery, University Hospital of Zurich, Zurich, Switzerland, Department of Medical Oncology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA ; Broad Institute of Harvard and M.I.T, Cambridge, MA, USA ; Department of Pathology, Harvard Medical School, Boston, MA, USA, Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA ; Department of Pathology and Laboratory Medicine, Weill Cornell Medical Center, New York, NY, USA., Perner, S., Wagner, P. L., Soltermann, A., LaFargue, C., Tischler, V., Weir, B. A., Weder, W., Meyerson, M., Giordano, T. J., Moch, H., Rubin, M. A.

URL: http://hdl.handle.net/2027.42/61439
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18932182&dopt=citation

المؤلفون: Ley, Timothy, Miller, Christopher, Ding, Li, Raphael, Benjamin J., Mungall, Andrew J., Robertson, A. Gordon, Hoadley, Katherine, Triche, Timothy J., Laird, Peter W., Baty, Jack D., Fulton, Lucinda L., Fulton, Robert, Heath, Sharon E., Kalicki Veizer, Joelle, Kandoth, Cyriac, Klco, Jeffery M., Koboldt, Daniel C., Kanchi, Krishna Latha, Shashikant Kulkarni, M. S. , P.h. D., F. A. C. M. G., Tamara L. Lamprecht, B. S., Washington University, S.t. Louis, David E. Larson, P.h. D., Ling Lin, M. S., Charles Lu, Michael D. McLellan, Joshua F. McMichael, the Genome Institute at Washington University, Jacqueline Payton, M. D. , P.h. D., Heather Schmidt, David H. Spencer, Michael H. Tomasson, M. D., Siteman Cancer Center, S.t. Louis, John W. Wallis, Lukas D. Wartman, Mark A. Watson, John Welch, Michael C. Wendl, Adrian Ally, B. S.c., Miruna Balasundaram, B. A. S.c., Inanc Birol, Yaron Butterfield, Readman Chiu, M. S.c., Andy Chu, Eric Chuah, Hye Jung Chun, Richard Corbett, Noreen Dhalla, Ranabir Guin, An He, Carrie Hirst, Martin Hirst, Robert A. Holt, Steven Jones, Aly Karsan, Darlene Lee, Haiyan I. Li, Marco A. Marra, Michael Mayo, Richard A. Moore, Karen Mungall, Jeremy Parker, Erin Pleasance, Patrick Plettner, Jacquie Schein, Dominik Stoll, Lucas Swanson, Angela Tam, Nina Thiessen, Richard Varhol, Natasja Wye, Yongjun Zhao, M. S.c. , D. V. M., British Columbia Cancer Agency's Genome Sciences Centre, Vancouver, Canada, Stacey Gabriel, Gad Getz, Carrie Sougnez, Lihua Zou, Broad Institute of Harvard, Massachusetts Institute of Technology, Cambridge, MA, Mark D. M. Leiserson, B. A., Hsin Ta Wu, Brown University, Center for Computational Molecular Biology, Providence, RI, Frederick Applebaum, Fred Hutchinson Cancer Research Center, Division of Medical Oncology, Seattle Cancer Care Alliance, Seattle, Stephen B. Baylin, Johns Hopkins University, Baltimore, Rehan Akbani, Bradley M. Broom, Ken Chen, Thomas C. Motter, B. A., Khanh Nguyen, John N. Weinstein, Nianziang Zhang, University of Texas M. D. Anderson Cancer Center, Houston, Martin L. Ferguson, MLF Consulting, Biotechnology Consultant, Boston, Christopher Adams, Aaron Black, Jay Bowen, Julie Gastier Foster, Thomas Grossman, Tara Lichtenberg, Lisa Wise, the Research Institute at Nationwide Children's Hospital, Columbus, OH, Tanja Davidsen, John A. Demchok, Kenna R. Mills Shaw, Margi Sheth, National Cancer Institute, Bethesda, MD, Heidi J. Sofia, P.h. D. , M. P. H., National Human Genome Research Institute, Liming Yang, James R. Downing, S.t. Jude Children's Research Hospital, Memphis, Greg Eley, Sciementis LLC, Statham, GA, Shelley Alonso, Brenda Ayala, Julien Baboud, Mark Backus, Sean P. Barletta, Dominique L. Berton, M. S. C. S., Anna L. Chu, Stanley Girshik, Mark A. Jensen, Ari Kahn, Prachi Kothiyal, Matthew C. Nicholls, Todd D. Pihl, David A. Pot, Rohini Raman, B. E., Rashmi N. Sanbhadti, Eric E. Snyder, Deepak Srinivasan, Jessica Walton, Yunhu Wan, Zhining Wang, SRA International, Fairfax, VA, Jean Pierre J. Issa, Temple University, Philadelphia, Michelle Le Beau, University of Chicago, Chicago, Martin Carroll, University of Pennsylvania, Hagop Kantarjian, M. D., Steven Kornblau, Moiz S. Bootwalla, B. S.c. , M. S., Phillip H. Lai, Hui Shen, David J. Van Den Berg, Daniel J. Weisenberger, University of Southern California, Epigenome Center, Los Angeles, Daniel C. Link, M. D., Matthew J. Walter, Bradley A. Ozenberger, Elaine R. Mardis, Peter Westervelt, Timothy A. Graubert, John F. DiPersio, Richard K. Wilson, VANDIN, FABIO

المساهمون: Ley, Timothy, Miller, Christopher, Ding, Li, Raphael, Benjamin J., Mungall, Andrew J., Robertson, A. Gordon, Hoadley, Katherine, Triche, Timothy J., Laird, Peter W., Baty, Jack D., Fulton, Lucinda L., Fulton, Robert, Heath, Sharon E., Kalicki Veizer, Joelle, Kandoth, Cyriac, Klco, Jeffery M., Koboldt, Daniel C., Kanchi, Krishna Latha, Shashikant, Kulkarni, M. S., P. h. D., F. A. C. M., G., Tamara L., Lamprecht, B., S., Washington, University, Louis, S. t., David E., Larson, P. h., D., Ling, Lin, M., S., Charles, Lu, Michael D., Mclellan, Joshua F., Mcmichael, the Genome Institute at Washington, University, Jacqueline, Payton, M. D., P. h. D., Heather, Schmidt, David H., Spencer, Michael H., Tomasson, M., D., Siteman Cancer Center, S. t. Loui, John W., Walli, Lukas D., Wartman, Mark A., Watson, John, Welch, Michael C., Wendl, Adrian, Ally, B. S., C., Miruna, Balasundaram, B. A. S., C., Inanc, Birol, Yaron, Butterfield, Readman, Chiu, M. S., C., Andy, Chu, Eric, Chuah, Hye Jung, Chun, Richard, Corbett, Noreen, Dhalla, Ranabir, Guin, An, He, Carrie, Hirst, Martin, Hirst, Robert A., Holt, Steven, Jone

مصطلحات موضوعية: Adult, CpG Island, DNA Methylation, Epigenomic, Female, Gene Expression, Gene Fusion, Genome, Human, Leukemia, Myeloid, Acute, Male, MicroRNA, Middle Aged, Sequence Analysis, DNA, Mutation

Relation: info:eu-repo/semantics/altIdentifier/pmid/23634996; info:eu-repo/semantics/altIdentifier/wos/WOS:000319574200004; volume:368; issue:22; firstpage:2059-74; lastpage:2074; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11577/3194446; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84878372012

الاتاحة: http://hdl.handle.net/11577/3194446
https://doi.org/10.1056/NEJMoa1301689

المؤلفون: Sadler, Jessica B., A. King's College London . Dept. of Infectious Diseases, Faculty of Life Sciences, Medicine, Wenzel, Dawn M., Univ. of Utah, School of Medicine, Salt Lake City, UT . Dept. of Biochemistry, Williams, Lauren K. Univ. of Utah, School of Medicine, Salt Lake City, UT . Dept. of Biochemistry, Univ. of Utah, Salt Lake City, UT . Dept. of Oncological Sciences, Huntsman Cancer Institute, Guindo-Martínez, Marta Barcelona Supercomputing Center, Alam, Steven L., Mercader, Josep M. Barcelona Supercomputing Center, Broad Institute of Harvard, MIT, Cambridge, MA, Massachusetts General Hospital, Boston, MA, Torrents, David Barcelona Supercomputing Center, Institució Catalana de Recerca i Estudis Avançats, Barcelona, Ullman, Katharine S., Sundquist, Wesley I., Martin-Serrano, Juan King's College London . Dept. of Infectious Diseases, Faculty of Life Sciences

مصطلحات موضوعية: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY, 59 BASIC BIOLOGICAL SCIENCES, socio, envir

Relation: http://www.osti.gov/servlets/purl/1625022

الاتاحة: http://www.osti.gov/servlets/purl/1625022

المؤلفون: Zhou, Wei, Brumpton, Ben, Kabil, Omer, Gudmundsson, Julius, Thorleifsson, Gudmar, Weinstock, Josh, Zawistowski, Matthew, Nielsen, Jonas B, Chaker, Layal, Medici, Marco, Teumer, Alexander, Naitza, Silvia, Sanna, Serena, Schultheiss, Ulla T, Cappola, Anne, Karjalainen, Juha, Kurki, Mitja, Oneka, Morgan, Taylor, Peter, Fritsche, Lars G, Graham, Sarah E, Wolford, Brooke N, Overton, William, Rasheed, Humaira, Haug, Eirin B, Gabrielsen, Maiken E, Skogholt, Anne Heidi, Surakka, Ida, Davey Smith, George, Pandit, Anita, Roychowdhury, Tanmoy, Hornsby, Whitney E, Jonasson, Jon G, Senter, Leigha, Liyanarachchi, Sandya, Ringel, Matthew D, Xu, Li, Kiemeney, Lambertus A, He, Huiling, Netea-Maier, Romana T, Mayordomo, Jose I, Plantinga, Theo S, Hrafnkelsson, Jon, Hjartarson, Hannes, Sturgis, Erich M, Palotie, Aarno, Daly, Mark, Citterio, Cintia E, Arvan, Peter, Brummett, Chad M, Boehnke, Michael, de la Chapelle, Albert, Stefansson, Kari, Hveem, Kristian, Willer, Cristen J, Åsvold, Bjørn Olav

المساهمون: 1Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. wzhou@broadinstitute.org. 2Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. wzhou@broadinstitute.org. 3Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. wzhou@broadinstitute.org. 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. wzhou@broadinstitute.org. 5K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. 6Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK. 7Department of Thoracic Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 8Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA. 9Division of Metabolism Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA. 10deCODE genetics/AMGEN, 101, Reykjavik, Iceland. 11Center for Statistical Genetics and Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA. 12Department of Internal Medicine, Division of Cardiology, University of Michigan Medical School, Ann Arbor, Michigan, USA. 13Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark. 14Erasmus MC Academic Center for Thyroid Diseases, Rotterdam, The Netherlands. 15Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. 16Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. 17Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Centre, Radboud Institute for Molecular Life Sciences, 6500HB, Nijmegen, The Netherlands. 18Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 19DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 20Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche Monserrato, Monserrato, Italy. 21Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 22Faculty of Medicine and Medical Center, Institute of Genetic Epidemiology, University of Freiburg, Freiburg, Germany. 23Faculty of Medicine and Medical Center, Department of Medicine IV-Nephrology and Primary Care, University of Freiburg, Freiburg, Germany. 24Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. 25Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. 26Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. 27Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. 28Institute for Molecular Medicine Finland, Helsinki Institute of Life Sciences, University of Helsinki, Helsinki, 00014, Finland. 29Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. 30Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK. 31Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. 32Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. 33Landspitali-University Hospital, 101, Reykjavik, Iceland. 34Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. 35The Icelandic Cancer Registry, 105, Reykjavik, Iceland. 36Division of Human Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, USA. 37Department of Cancer Biology and Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, 43210, USA. 38Division of Endocrinology, Diabetes, and Metabolism, The Ohio State University, Columbus, Ohio, 43210, USA. 39Department of Head and Neck Surgery, and Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA. 40Radboud University Medical Centre, Radboud Institute for Health Sciences, 6500HB, Nijmegen, The Netherlands. 41University of Colorado Hospital, Aurora, Colorado, 80045, USA. 42Department of Pathology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, 6500HB, Nijmegen, The Netherlands. 43Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología/Cátedra de Genética, Buenos Aires, C1113AAD, Argentina. 44CONICET-Universidad de Buenos Aires, Instituto de Inmunología, Genética y Metabolismo (INIGEM), C1120AAR, Buenos Aires, Argentina. 45Division of Pain Medicine, Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA. 46HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway. 47Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, 7600, Norway. 48Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. 49K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. bjorn.o.asvold@ntnu.no. 50HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway. bjorn.o.asvold@ntnu.no. 51Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. bjorn.o.asvold@ntnu.no.

المصدر: Nature communications ; 11 ; 1 ; 3981 ; United States ; United Kingdom ; England

مصطلحات موضوعية: Thyroid stimulating hormone, TSH, Thyroid cancer, Skjaldkirtilssjúkdómar, Skjaldkirtill, Thyrotropin, Thyroid Neoplasms

Relation: https://www.nature.com/articles/s41467-020-17718-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414135/; Zhou W, Brumpton B, Kabil O, et al. GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer. Nat Commun. 2020;11(1):3981. Published 2020 Aug 7. doi:10.1038/s41467-020-17718-z; http://hdl.handle.net/2336/621522; Nature communications

الاتاحة: http://hdl.handle.net/2336/621522
https://doi.org/10.1038/s41467-020-17718-z

المؤلفون: AstraZeneca

المساهمون: Pradeep Natarajan, Director, Preventive Cardiology, Assistant Professor of Medicine, Harvard Medical School, Associate Member of the Broad Institute of Harvard and MIT

المصدر: A Novel Disease Management Platform Delivered Via Smartphone Application for the Management of Patients With Heart Failure: Pilot Study

المؤلفون: The Psychiatric Genomics Consortium, The Autism Spectrum Disorders Working Group Of, Anney, Richard J L, Ripke, Stephan, Anttila, Verneri, Grove, Jakob, Holmans, Peter, Huang, Hailiang, Klei, Lambertus, Lee, Phil H, Medland, Sarah E, Neale, Benjamin, Robinson, Elise, Weiss, Lauren A, Zwaigenbaum, Lonnie, Yu, Timothy W, Wittemeyer, Kerstin, Willsey, a Jeremy, Wijsman, Ellen M, Werge, Thomas, Wassink, Thomas H, Waltes, Regina, Walsh, Christopher A, Wallace, Simon, Vorstman, Jacob a S, Vieland, Veronica J, Vicente, Astrid M, Vanengeland, Herman, Tsang, Kathryn, Thompson, Ann P, Szatmari, Peter, Svantesson, Oscar, Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, State, Matthew W, Soorya, Latha, Silagadze, Teimuraz, Scherer, Stephen W, Schellenberg, Gerard D, Sandin, Sven, Sanders, Stephan J, Saemundsen, Evald, Rouleau, Guy A, Rogé, Bernadette, Roeder, Kathryn, Roberts, Wendy, Reichert, Jennifer, Reichenberg, Abraham, Rehnström, Karola, Regan, Regina, Poustka, Fritz, Poultney, Christopher S, Piven, Joseph, Pinto, Dalila, Pericak-Vance, Margaret A, Pejovic-Milovancevic, Milica, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Paterson, Andrew D, Parr, Jeremy R, Pagnamenta, Alistair T, Oliveira, Guiomar, Nurnberger, John I, Nordentoft, Merete, Murtha, Michael T, Mouga, Susana, Mortensen, Preben Bo, Mors, Ole, Morrow, Eric M, Moreno-De-Luca, Daniel, Monaco, Anthony P, Minshew, Nancy, Merikangas, Alison, Mcmahon, William M, Mcgrew, Susan G, Mattheisen, Manuel, Martsenkovsky, Igor, Martin, Donna M, Mane, Shrikant M, Magnusson, Pall, Magalhaes, Tiago, Maestrini, Elena, Lowe, Jennifer K, Lord, Catherine, Levitt, Pat, Martin, Christa Lese, Ledbetter, David H, Leboyer, Marion, Lecouteur, Ann S, Ladd-Acosta, Christine, Kolevzon, Alexander, Klauck, Sabine M, Jacob, Suma, Iliadou, Bozenna, Hultman, Christina M, Hougaard, David M, Hertz-Picciotto, Irva, Hendren, Robert, Hansen, Christine Søholm, Haines, Jonathan L, Guter, Stephen J, Grice, Dorothy E, Green, Jonathan M, Green, Andrew, Goldberg, Arthur P, Gillberg, Christopher, Gilbert, John, Gallagher, Louise, Freitag, Christine M, Fombonne, Eric, Folstein, Susan E, Fernandez, Bridget, Fallin, M Daniele, Ercan-Sencicek, a Gulhan, Ennis, Sean, Duque, Frederico, Duketis, Eftichia, Delorme, Richard, De Rubeis, Silvia, Dejonge, Maretha V, Dawson, Geraldine, Cuccaro, Michael L, Correia, Catarina T, Conroy, Judith, Conceição, Ines C, Chiocchetti, Andreas G, Celestino-Soper, Patrícia B S, Casey, Jillian, Cantor, Rita M, Café, Cátia, Bybjerg-Grauholm, Jonas, Brennan, Sean, Bourgeron, Thomas, Bolton, Patrick F, Bölte, Sven, Bolshakova, Nadia, Betancur, Catalina, Bernier, Raphael, Beaudet, Arthur L, Battaglia, Agatino, Bal, Vanessa H, Baird, Gillian, Bailey, Anthony J, Bækvad-Hansen, Marie, Bader, Joel S, Bacchelli, Elena, Anagnostou, Evdokia, Amaral, David, Almeida, Joana, Børglum, Anders D, Buxbaum, Joseph D, Chakravarti, Aravinda, Cook, Edwin H, Coon, Hilary, Geschwind, Daniel H, Gill, Michael, Hallmayer, Joachim, Palotie, Aarno, Santangelo, Susan, Sutcliffe, James S, Arking, Dan E, Devlin, Bernie, Daly, Mark J

المساهمون: MRC Centre for Neuropsychiatric Genetics and Genomics Cardiff, UK, Cardiff University, Génétique Humaine et Fonctions Cognitives, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Fondation FondaMental Créteil, Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), The Autism Working Group of the Psychiatric Genomics Consortium was supported by National Institutes of Mental Health (NIMH, USA) grant MH109539, MH094432 and MH094421 to M.J.D. The ACE Network was supported by MH081754 and MH100027 to D.H.G. The Autism Genetic Resource Exchange (AGRE) is a program of Autism Speaks (USA) and was supported by grant MH081810. The Autism Genome Project (AGP) was supported by grants from Autism Speaks, the Canadian Institutes of Health Research (CIHR), Genome Canada, the Health Research Board (Ireland, AUT/ 2006/1, AUT/2006/2, PD/2006/48), the Hilibrand Foundation (USA), the Medical Research Council (UK), the National Institutes of Health (USA, the National Institute of Child Health and Human Development and the National Institute of Mental Health), the Ontario Genomics Institute, and the University of Toronto McLaughlin Centre. The Simons Simplex Collection (SSC) was supported by a grant from the Simons Foundation (SFARI 124827 to the investigators of the Simons Simplex Collection Genetic Consortium), approved researchers can obtain the SSC population dataset described in this study (http://sfari.org/resources/sfari-base) by applying at https://base.sfari.org. The Gene Discovery Project of Johns Hopkins was funded by MH060007, MH081754, and the Simons Foundation. The MonBos Collection study was funded in part through a grant from the Autism Consortium of Boston. Support for the Extreme Discordant Sib-Pair (EDSP) family sample (part of the MonBos collection) was provided by the NLM Family foundation. Support for the Massachusetts General Hospital (MGH)–Finnish collaborative sample was provided by NARSAD. The PAGES collection was funded by NIMH grant MH097849. The collection of data and biomaterials that participated in the NIMH Autism Genetics Initiative has been supported by National Institute of Health grants MH52708, MH39437, MH00219, and MH00980, National Health Medical Research Council grant 0034328, and by grants from the Scottish Rite, the Spunk Fund, Inc., the Rebecca and Solomon Baker Fund, the APEX Foundation, the National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), the endowment fund of the Nancy Pritzker Laboratory (Stanford), and by gifts from the Autism Society of America, the Janet M. Grace Pervasive Developmental Disorders Fund, and families and friends of individuals with autism. The iPSYCH project is funded by The Lundbeck Foundation and the universities and university hospitals of Aarhus and Copenhagen. In addition, the genotyping of iPSYCH samples was supported by grants from the Stanley Foundation, the Simons Foundation (SFARI 311789 to MJD), and NIMH (5U01MH094432-02 to MJD). The Study to Explore Early Development (SEED) was funded by the Centers for Disease Control and Prevention (CDC) grants U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, and U10DD000498. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and financially supported by the Netherlands Scientific Organization (NWO 480-05-003), along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Additional statistical analyses were performed and supported by the Trinity Centre for High Performance Computing (http://www.tchpc.tcd.ie/) funded through Science Foundation Ireland. Computational support for the PAGES collection was provided in part through the computational resources and staff expertise of the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai (https://hpc.mssm.edu). Data QC and statistical analyses of the iPSYCH samples were performed at the high-performance computing cluster GenomeDK (http://genome.au.dk) at the Center for Integrative Sequencing, iSEQ, Aarhus University. iSEQ provided computed time, data storage, and technical support for the study., Richard JL Anney, Email: anneyr@cardiff.ac.uk, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK, Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Stephan Ripke, Email: ripke@atgu.mgh.harvard.edu, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany. Verneri Anttila, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Jakob Grove, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK-8000, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. Peter Holmans, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK. Hailiang Huang, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lambertus Klei, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Phil H Lee, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA. Sarah E Medland, Affiliation/s: Queensland Institute of Medical Research Brisbane, QLD, 4006, Australia. Benjamin Neale, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Elise Robinson, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lauren A Weiss, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Lonnie Zwaigenbaum, Affiliation/s: Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 1C9, Canada. Timothy W Yu, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Kerstin Wittemeyer, Affiliation/s: School of Education, University of Birmingham, Birmingham, B15 2TT, UK. A.Jeremy Willsey, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Ellen M Wijsman, Affiliation/s: Department of Medicine, University of Washington, Seattle, WA 98195, USA, Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Thomas Werge, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Institute of Biological Psychiatry, MHC Sct Hans, Mental Health Services Copenhagen, Roskilde, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark. Thomas H Wassink, Affiliation/s: Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242, USA. Regina Waltes, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher A Walsh, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA, Program in Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA, Simon Wallace, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK. Jacob AS Vorstman, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Veronica J Vieland, Affiliation/s: Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children ’ s Hospital, Columbus, OH 43205, USA. Astrid M Vicente, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Herman vanEngeland, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Kathryn Tsang, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Ann P Thompson, Affiliation/s: Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, L8S 4L8, Canada. Peter Szatmari, Affiliation/s: Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada. Oscar Svantesson, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stacy Steinberg, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Kari Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Hreinn Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Matthew W State, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Latha Soorya, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, USA. Teimuraz Silagadze, Affiliation/s: Department of Psychiatry and Drug Addiction, Tbilisi State Medical University, Tbilisi, 0186, Georgia. Stephen W Scherer, Affiliation/s: The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, McLaughlin Centre, University of Toronto, Toronto, ON, M5G 0A4, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. Gerard D Schellenberg, Affiliation/s: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102, USA. Sven Sandin, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stephan J Sanders, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Evald Saemundsen, Affiliation/s: State Diagnostic and Counseling Centre, Kopavogur, IS-201, Iceland. Guy A Rouleau, Affiliation/s: Montreal Neurological Institute, Dept of Neurology and Neurosurgery, McGill University, Montreal, QC, H3A 2B4, Canada. Bernadette Rogé, Affiliation/s: Centre d ’ Etudes et de Recherches en Psychopathologie, Toulouse University, Toulouse, 31058, France. Kathryn Roeder, Affiliation/s: Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Wendy Roberts, Affiliation/s: Autism Research Unit, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada. Jennifer Reichert, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Abraham Reichenberg, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Karola Rehnström, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK. Regina Regan, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Fritz Poustka, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher S Poultney, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Joseph Piven, Affiliation/s: University of North Carolina, Chapel Hill, NC 27599, USA. Dalila Pinto, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Margaret A Pericak-Vance, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Milica Pejovic-Milovancevic, Affiliation/s: Institute of Mental Health and Medical Faculty, University of Belgrade, Belgrade, 11 000, Serbia. Marianne Giørtz Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Carsten Bøcker Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Andrew D Paterson, Affiliation/s: Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, Dalla Lana School of Public Health, Toronto, ON, M5T 3M7, Canada. Jeremy R Parr, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Alistair T Pagnamenta, Affiliation/s: Wellcome Trust Centre for Human Genetics, OxfordUniversity,Oxford,OX37BN,UK. Guiomar Oliveira, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. John I Nurnberger, Affiliation/s: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Merete Nordentoft, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. Michael T Murtha, Affiliation/s: Programs on Neurogenetics, Yale University School of Medicine, New Haven, CT 06520, USA. Susana Mouga, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Preben Bo Mortensen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Na- tional Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark, Ole Mors, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark. Eric M Morrow, Affiliation/s: Department of Psychiatry and Human Behaviour, Brown University, Providence, RI 02912, USA. Daniel Moreno-De-Luca, Affiliation/s: Department of Psychiatry and Hu- man Behaviour, Brown University, Providence, RI 02912, USA. Anthony P Monaco, Affiliation/s: Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK, Tufts University, Boston, MA 02155?, USA. Nancy Minshew, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Alison Merikangas, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. William M McMahon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Susan G McGrew, Affiliation/s: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. Manuel Mattheisen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Igor Martsenkovsky, Affiliation/s: Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social Fo- rensic Psychiatry and Drug Abuse, Kyiv, 04080, Ukraine. Donna M Martin, Affiliation/s: Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Shrikant M Mane, Affiliation/s: Yale Center for Genomic Analysis, Yale University School of Medicine, New Haven, CT 06516, USA. Pall Magnusson, Affiliation/s: Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, IS-101, Iceland. Tiago Magalhaes, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Elena Maestrini, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Jennifer K Lowe, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Catherine Lord, Affiliation/s: Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Pat Levitt, Affiliation/s: Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. Christa LeseMartin, Affiliation/s: Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA 17837, USA. David H Ledbetter, Affiliation/s: Chief Scientific Officer, Geisinger Health System, Danville, PA 17837, USA. Marion Leboyer, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, INSERM U955, Paris, 94010, France, Faculté de Médecine, Université Paris Est, Créteil, 94000, France, Department of Psychiatry, Henri Mondor-Albert Chene- vier Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, 94000, France, Ann S LeCouteur, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Christine Ladd-Acosta, Affiliation/s: Department of Epidemiology, Johns Hop- kins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Alexander Kolevzon, Affiliation/s: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Sabine M Klauck, Affiliation/s: Division of Molecular Genome Analysis and Working Group Cancer Genome Research, Deutsches Krebsforschungszentrum, Heidelberg, D-69120, Germany. Suma Jacob, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA, Institute of Translational Neuroscience and Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA. Bozenna Iliadou, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Christina M Hultman, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. David M Hougaard, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Irva Hertz-Picciotto, Affiliation/s: Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA 95616, USA, The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA. Robert Hendren, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Christine Søholm Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Jonathan L Haines, Affiliation/s: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Stephen J Guter, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Dorothy E Grice, Affiliation/s: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Jonathan M Green, Affiliation/s: Manchester Academic Health Sciences Centre, Manchester, M13 9NT, UK, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PT, UK. Andrew Green, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Arthur P Goldberg, Affiliation/s: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Christopher Gillberg, Affiliation/s: Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, S-405 30, Sweden. John Gilbert, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Louise Gallagher, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Christine M Freitag, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Eric Fombonne, Affiliation/s: Department of Psychiatry and Institute for Development and Disability, Oregon Health and Science University, Portland, OR 97239, USA. Susan E Folstein, Affiliation/s: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Bridget Fernandez, Affiliation/s: Memorial University of Newfoundland, St John ’ s, NL, A1B 3X9, Canada. M.Daniele Fallin, Affiliation/s: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. A.Gulhan Ercan-Sencicek, Affiliation/s: Programs on Neurogenetics, Yale Uni- versity School of Medicine, New Haven, CT 06520, USA. Sean Ennis, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Frederico Duque, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Eftichia Duketis, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Richard Delorme, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, Human Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, 75015, France, Centre National de la Recherche Scientifique URA 2182 Institut Pasteur, Paris, 75724, France, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Assistance Publique – Hôpitaux de Paris, Paris, 75019, France, Silvia DeRubeis, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Maretha V DeJonge, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Geraldine Dawson, Affiliation/s: Duke Center for Autism and Brain Developments, Duke University School of Medicine, Durham, NC 27705, USA, Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC 27708, USA. Michael L Cuccaro, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Catarina T Correia, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Judith Conroy, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Temple Street Children ’ s University Hospital, Dublin, D1, Ireland. Ines C Conceição, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Andreas G Chiocchetti, Affiliation/s: Depar tment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goe the University Frankfurt, Frankfurt am Main, 60528, Germany. Patrícia BS Celestino-Soper, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indian- apolis, IN 46202, USA. Jillian Casey, Affiliation/s: Temple Street Children ’ s University Hospital, Dublin, D1, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Rita M Cantor, Affiliation/s: Department of Psychiatry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA. Cátia Café, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Jonas Bybjerg-Grauholm, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Sean Brennan, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Thomas Bourgeron, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, University Paris Diderot, Sorbonne Paris Cité, Paris, 75013, France, Patrick F Bolton, Affiliation/s: Institute of Psychiatry, Kings College London, London, SE5 8AF, UK, South London and Maudsley Biomedical Research Centre for Mental Health, London, SE5 8AF, UK. Sven Bölte, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany, Department of Women ’ s and Children ’ s Health, Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, SE- 113 30, Sweden, Child and Adolescent Psychiatry, Center for Psychiatry Re- search, Stockholm County Council, Stockholm, SE-171 77, Sweden. Nadia Bolshakova, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Catalina Betancur, Affiliation/s: INSERM U1130, Paris, 75005, France, CNRS UMR 8246, Paris, 75005, France, Sorbonne Universités, UPMC Univ Paris 6, Neuroscience Paris Seine, Paris, 75005, France. Raphael Bernier, Affiliation/s: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. Arthur L Beaudet, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Agatino Battaglia, Affiliation/s: Stella Maris Institute for Child and Adolescent Neuropsychiatr, Pisa, 56018, Italy. Vanessa H Bal, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Gillian Baird, Affiliation/s: Paediatric Neurodisability, King ’ s Health Partners, Kings College London, London, SE1 7EH, UK. Anthony J Bailey, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK, Mental Health and Addictions Research Unit, University of British Colombia, Vancouver, BC, V5Z 4H4, Canada. Marie Bækvad-Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Joel S Bader, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Elena Bacchelli, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Evdokia Anagnostou, Affiliation/s: Bloorview Research Institute, University of Toronto, Toronto, ON, M4G 1R8, Canada. David Amaral, Affiliation/s: The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Psychiatry, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Behavioural Sciences, School of Medicine, University of California Davis, Davis, CA 95817, USA. Joana Almeida, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Anders D Børglum, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Joseph D Buxbaum, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Aravinda Chakravarti, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Edwin H Cook, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Hilary Coon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Daniel H Geschwind, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Michael Gill, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Hakon Hakonarson, Affiliation/s: The Center for Applied Genomics and Division of Human Genetics, Children ’ s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Dept of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. Joachim Hallmayer, Affiliation/s: Department of Psychiatry, Stanford University, Stanford, CA 94305, USA. Aarno Palotie, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK.

المصدر: ISSN: 2040-2392 ; Molecular Autism ; https://inserm.hal.science/inserm-01535717 ; Molecular Autism, 2017, 8, pp.21. ⟨10.1186/s13229-017-0137-9⟩.

مصطلحات موضوعية: Autism spectrum disorder, Genome-wide association study, Meta-analysis, Genetic correlation, Heritability, Gene-set analysis, Schizophrenia, Neurodevelopment, [SDV.GEN]Life Sciences [q-bio]/Genetics

Relation: info:eu-repo/semantics/altIdentifier/pmid/28540026; inserm-01535717; https://inserm.hal.science/inserm-01535717; https://inserm.hal.science/inserm-01535717/document; https://inserm.hal.science/inserm-01535717/file/ASD%20Working%20Group%20of%20the%20Psychiatric%20Genomics%20Consortium%20Mol%20Autism%202017.pdf; PUBMED: 28540026; PUBMEDCENTRAL: PMC5441062

الاتاحة: https://inserm.hal.science/inserm-01535717
https://inserm.hal.science/inserm-01535717/document
https://inserm.hal.science/inserm-01535717/file/ASD%20Working%20Group%20of%20the%20Psychiatric%20Genomics%20Consortium%20Mol%20Autism%202017.pdf
https://doi.org/10.1186/s13229-017-0137-9

المؤلفون: Yu Chen, Hao, Dina, Christian, Small, Aeron M, Shaffer, Christian M, Levinson, Rebecca T, Helgadóttir, Anna, Capoulade, Romain, Munter, Hans Markus, Martinsson, Andreas, Cairns, Benjamin J, Trudsø, Linea C, Hoekstra, Mary, Burr, Hannah A, Marsh, Thomas W, Damrauer, Scott M, Dufresne, Line, Le Scouarnec, Solena, Messika-Zeitoun, David, Ranatunga, Dilrini K, Whitmer, Rachel A, Bonnefond, Amélie, Sveinbjornsson, Garðar, Daníelsen, Ragnar, Arnar, David O, Thorgeirsson, Gudmundur, Thorsteinsdottir, Unnur, Gudbjartsson, Daníel F, Hólm, Hilma, Ghouse, Jonas, Olesen, Morten Salling, Christensen, Alex H, Mikkelsen, Susan, Jacobsen, Rikke Louise, Dowsett, Joseph, Pedersen, Ole Birger Vesterager, Erikstrup, Christian, Ostrowski, Sisse R, O’Donnell, Christopher J, Budoff, Matthew J, Gudnason, Vilmundur, Post, Wendy S, Rotter, Jerome I, Lathrop, Mark, Bundgaard, Henning, Johansson, Bengt, Ljungberg, Johan, Näslund, Ulf, Le Tourneau, Thierry, Smith, J Gustav, Wells, Quinn S

المساهمون: Fonds de Recherche du Québec—Santé, US Government or the US Department of Veterans Affairs, Swedish Heart–Lung Foundation, County Council of Västerbotten, Umeå University, Heart Foundation of Northern Sweden, grants from the Swedish Heart-Lung Foundation, Swedish Research Council, European Research Council, Crafoord Foundation, Skåne University Hospital, Swedish National Health Service, Knut and Alice Wallenberg foundation, Wallenberg Center for Molecular Medicine in Lund, Swedish Foundation for Strategic Research, Lund University Diabetes Center, Canadian Institutes for Health Research, Heart and Stroke Foundation of Canada, Heart and Stroke Foundation, National Institutes of Health, Ellison Medical Foundation, Robert Wood Johnson, Wayne and Gladys Valley Foundation, Kaiser Permanente Northern California, Kaiser Permanente National and Regional Community Benefit Programs, Health Research Unit, Medical Research Council and the University of Oxford, British Heart Foundation, NHLBI, Broad Institute of Harvard, National Center for Advancing Translational Sciences, National Institute of Diabetes and Digestive, Disease Diabetes Research Center, Southern California Diabetes Endocrinology Research Center, National Institute of Health, National Institutes of Health-funded Shared Instrumentation, Clinical and Translational Science Award, ANR & FRM, Fédération Française de Cardiologie, French Regional Council of Pays-de-la-Loire, Novartis Pharma and Sanofi-Aventis, Fondation de France, ALFEDIAM, Société francophone du diabète, ONIVINS, Abbott, Ardix Medical, Bayer Diagnostics, Becton Dickinson, Cardionics, Merck Santé, Novo Nordisk, Pierre Fabre, Roche, Topcon, General practitioners of the Region, Assistance Publique—Hôpitaux, Département de la Recherche Clinique et du Développemen, Novo Nordisk Foundation, Innovation Fund Denmark, Capital Regions Research Council

المصدر: European Heart Journal ; volume 44, issue 21, page 1927-1939 ; ISSN 0195-668X 1522-9645

الاتاحة: http://dx.doi.org/10.1093/eurheartj/ehad142
https://academic.oup.com/eurheartj/article-pdf/44/21/1927/50486951/ehad142.pdf

المؤلفون: Reeskamp, Laurens F., Shim, Injeong, Dron, Jacqueline S., Ibrahim, Shirin, Tromp, Tycho R., Fahed, Akl C., Patel, Aniruddh P., Hutten, Barbara A., Stroes, Erik S.G., Hovingh, G. Kees, Khera, Amit V.

المساهمون: National Human Genome Research Institute, Eli and Edythe L Broad Institute of Harvard and MIT

المصدر: JACC: Advances ; volume 2, issue 9, page 100662 ; ISSN 2772-963X

الاتاحة: http://dx.doi.org/10.1016/j.jacadv.2023.100662
https://api.elsevier.com/content/article/PII:S2772963X23006531?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2772963X23006531?httpAccept=text/plain

المؤلفون: Gesuita, Lorenzo, Cavaccini, Anna, Argunsah, Ali Özgür, Favuzzi, Emilia, Ibrahim, Leena Ali, Stachniak, Tevye Jason, De Gennaro, Martina, Utz, Sebastian, Greter, Melanie, Karayannis, Theofanis

المساهمون: Biological and Environmental Science and Engineering (BESE) Division, Bioscience Program, Laboratory of Neural Circuit Assembly, Brain Research Institute, University of Zurich, Zurich 8057, Switzerland, Neuroscience Center Zurich (ZNZ), Zurich 8057, Switzerland, Department of Neurobiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Institute of Experimental Immunology, University of Zurich, Zurich 8057, Switzerland

وصف الملف: application/pdf; application/zip; image/jpeg

Relation: https://linkinghub.elsevier.com/retrieve/pii/S2211124722010269; Gesuita, L., Cavaccini, A., Argunsah, A. Ö., Favuzzi, E., Ibrahim, L. A., Stachniak, T. J., De Gennaro, M., Utz, S., Greter, M., & Karayannis, T. (2022). Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity. Cell Reports, 40(7), 111209. https://doi.org/10.1016/j.celrep.2022.111209; Cell Reports; 111209; http://hdl.handle.net/10754/680432; 40

الاتاحة: http://hdl.handle.net/10754/680432
https://doi.org/10.1016/j.celrep.2022.111209

المؤلفون: Noel, Maxence, Chasman, Daniel I, Mora, Samia, Otvos, James D, Palmer, Christopher D, Parsons, Patrick J, Smoller, Jordan W, Cummings, Richard D, Mealer, Robert G

المساهمون: Broad Institute of Harvard/MIT, Glycomics-related studies, WHS, WGHS, National Heart, Lung, and Blood Institute, National Cancer Institute, Amgen, R.G. Mealer, P.J. Parsons, NIH

المصدر: Clinical Chemistry ; volume 69, issue 1, page 80-87 ; ISSN 0009-9147 1530-8561

الاتاحة: https://doi.org/10.1093/clinchem/hvac160
https://academic.oup.com/clinchem/article-pdf/69/1/80/48447158/hvac160.pdf

المؤلفون: Geraldine Dawson, Sven Sandin, Frederico Duque, Peter Holmans, Marion Leboyer, Aarno Palotie, Fritz Poustka, Richard Delorme, Stephen Sanders, Alistair T. Pagnamenta, Lonnie Zwaigenbaum, Bridget A. Fernandez, A. Jeremy Willsey, Christine M. Freitag, Christa Lese Martin, Elena Maestrini, Elena Bacchelli, Guiomar Oliveira, Jeremy R. Parr, Guy A. Rouleau, Jonas Bybjerg-Grauholm, Joseph Piven, Latha Soorya, Lauren A. Weiss, Jonathan Green, Carsten Bøcker Pedersen, Louise Gallagher, Regina Regan, Stephan Ripke, Thomas Werge, Pat Levitt, Aravinda Chakravarti, Joana Almeida, Kathryn Roeder, Catalina Betancur, Bernie Devlin, Benjamin M. Neale, Gillian Baird, Jakob Grove, Thomas Bourgeron, David H. Ledbetter, Eftichia Duketis, Karola Rehnström, Gerard D. Schellenberg, Jillian P. Casey, Preben Bo Mortensen, Patrick Bolton, Igor Martsenkovsky, Elise Robinson, Hakon Hakonarson, Vanessa H. Bal, Stacy Steinberg, Christopher Gillberg, Kathryn Tsang, Jacob A. S. Vorstman, Verneri Anttila, Suma Jacob, Judith Conroy, J. Haines, William M. McMahon, Edwin H. Cook, Ann P. Thompson, Inês C. Conceição, Mark J. Daly, Arthur P. Goldberg, Sarah E. Medland, Milica Pejovic-Milovancevic, David M. Hougaard, Shrikant Mane, Christina M. Hultman, Susana Mouga, Hreinn Stefansson, Ellen M. Wijsman, Andreas G. Chiocchetti, Ole Mors, Phil Lee, Richard Anney, Astrid M. Vicente, Veronica J. Vieland, K. Stefansson, Stephen W. Scherer, Teimuraz Silagadze, Pall Magnusson, Donna M. Martin, Merete Nordentoft, Peter Szatmari, Patrícia B. S. Celestino-Soper, Ann S Le-Couteur, Cátia Café, Arthur L. Beaudet, Kerstin Wittemeyer, Anders D. Børglum, Joel S. Bader, Christopher S. Poultney, Hailiang Huang, Alexander Kolevzon, Margaret A. Pericak-Vance, Joachim Hallmayer, Rita M. Cantor, Eric Fombonne, Andrew Green, Dan E. Arking, M. Daniele Fallin, Matthew W. State, Christine Ladd-Acosta, Silvia Derubeis, Raphael Bernier, Regina Waltes, David G. Amaral, Manuel Mattheisen, Abraham Reichenberg, Lambertus Klei, Daniel Moreno-De-Luca, Marie Bækvad-Hansen, Maretha V. Dejonge, Susan G. McGrew, Joseph D. Buxbaum, Hilary Coon, Jennifer Reichert, Michael Gill, Herman Vanengeland, Christine Søholm Hansen, Anthony P. Monaco, Nadia Bolshakova, John I. Nurnberger, Nancy J. Minshew, Michael T. Murtha, Thomas H. Wassink, Evald Saemundsen, Simon Wallace, Sean Brennan, Sean Ennis, A. Gulhan Ercan-Sencicek, Sven Bölte, Oscar Svantesson, Susan L. Santangelo, Andrew D. Paterson, Robert L. Hendren, Timothy W. Yu, Dalila Pinto, D.E. Grice, Alison Merikangas, Stephen J. Guter, Anthony J. Bailey, Bernadette Rogé, Christopher A. Walsh, Susan E. Folstein, Wendy Roberts, Sabine M. Klauck, Marianne Giørtz Pedersen, Tiago R. Magalhaes, John R. Gilbert, Irva Hertz-Picciotto, James S. Sutcliffe, Evdokia Anagnostou, Catarina Correia, Eric M. Morrow, Daniel H. Geschwind, Jennifer K. Lowe, Agatino Battaglia, Bozenna Iliadou, Michael L. Cuccaro, Catherine Lord

المساهمون: MRC Centre for Neuropsychiatric Genetics and Genomics [Cardiff, UK], Cardiff University, The Autism Working Group of the Psychiatric Genomics Consortium was supported by National Institutes of Mental Health (NIMH, USA) grant MH109539, MH094432 and MH094421 to M.J.D. The ACE Network was supported by MH081754 and MH100027 to D.H.G. The Autism Genetic Resource Exchange (AGRE) is a program of Autism Speaks (USA) and was supported by grant MH081810. The Autism Genome Project (AGP) was supported by grants from Autism Speaks, the Canadian Institutes of Health Research (CIHR), Genome Canada, the Health Research Board (Ireland, AUT/ 2006/1, AUT/2006/2, PD/2006/48), the Hilibrand Foundation (USA), the Medical Research Council (UK), the National Institutes of Health (USA, the National Institute of Child Health and Human Development and the National Institute of Mental Health), the Ontario Genomics Institute, and the University of Toronto McLaughlin Centre. The Simons Simplex Collection (SSC) was supported by a grant from the Simons Foundation (SFARI 124827 to the investigators of the Simons Simplex Collection Genetic Consortium), approved researchers can obtain the SSC population dataset described in this study (http://sfari.org/resources/sfari-base) by applying at https://base.sfari.org. The Gene Discovery Project of Johns Hopkins was funded by MH060007, MH081754, and the Simons Foundation. The MonBos Collection study was funded in part through a grant from the Autism Consortium of Boston. Support for the Extreme Discordant Sib-Pair (EDSP) family sample (part of the MonBos collection) was provided by the NLM Family foundation. Support for the Massachusetts General Hospital (MGH)–Finnish collaborative sample was provided by NARSAD. The PAGES collection was funded by NIMH grant MH097849. The collection of data and biomaterials that participated in the NIMH Autism Genetics Initiative has been supported by National Institute of Health grants MH52708, MH39437, MH00219, and MH00980, National Health Medical Research Council grant 0034328, and by grants from the Scottish Rite, the Spunk Fund, Inc., the Rebecca and Solomon Baker Fund, the APEX Foundation, the National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), the endowment fund of the Nancy Pritzker Laboratory (Stanford), and by gifts from the Autism Society of America, the Janet M. Grace Pervasive Developmental Disorders Fund, and families and friends of individuals with autism. The iPSYCH project is funded by The Lundbeck Foundation and the universities and university hospitals of Aarhus and Copenhagen. In addition, the genotyping of iPSYCH samples was supported by grants from the Stanley Foundation, the Simons Foundation (SFARI 311789 to MJD), and NIMH (5U01MH094432-02 to MJD). The Study to Explore Early Development (SEED) was funded by the Centers for Disease Control and Prevention (CDC) grants U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, and U10DD000498. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and financially supported by the Netherlands Scientific Organization (NWO 480-05-003), along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Additional statistical analyses were performed and supported by the Trinity Centre for High Performance Computing (http://www.tchpc.tcd.ie/) funded through Science Foundation Ireland. Computational support for the PAGES collection was provided in part through the computational resources and staff expertise of the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai (https://hpc.mssm.edu). Data QC and statistical analyses of the iPSYCH samples were performed at the high-performance computing cluster GenomeDK (http://genome.au.dk) at the Center for Integrative Sequencing, iSEQ, Aarhus University. iSEQ provided computed time, data storage, and technical support for the study., Richard JL Anney, Email: anneyr@cardiff.ac.uk, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK, Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Stephan Ripke, Email: ripke@atgu.mgh.harvard.edu, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany. Verneri Anttila, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Jakob Grove, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK-8000, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. Peter Holmans, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK. Hailiang Huang, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lambertus Klei, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Phil H Lee, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA. Sarah E Medland, Affiliation/s: Queensland Institute of Medical Research Brisbane, QLD, 4006, Australia. Benjamin Neale, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Elise Robinson, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lauren A Weiss, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Lonnie Zwaigenbaum, Affiliation/s: Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 1C9, Canada. Timothy W Yu, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Kerstin Wittemeyer, Affiliation/s: School of Education, University of Birmingham, Birmingham, B15 2TT, UK. A.Jeremy Willsey, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Ellen M Wijsman, Affiliation/s: Department of Medicine, University of Washington, Seattle, WA 98195, USA, Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Thomas Werge, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Institute of Biological Psychiatry, MHC Sct Hans, Mental Health Services Copenhagen, Roskilde, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark. Thomas H Wassink, Affiliation/s: Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242, USA. Regina Waltes, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher A Walsh, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA, Program in Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA, Simon Wallace, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK. Jacob AS Vorstman, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Veronica J Vieland, Affiliation/s: Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children ’ s Hospital, Columbus, OH 43205, USA. Astrid M Vicente, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Herman vanEngeland, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Kathryn Tsang, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Ann P Thompson, Affiliation/s: Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, L8S 4L8, Canada. Peter Szatmari, Affiliation/s: Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada. Oscar Svantesson, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stacy Steinberg, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Kari Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Hreinn Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Matthew W State, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Latha Soorya, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, USA. Teimuraz Silagadze, Affiliation/s: Department of Psychiatry and Drug Addiction, Tbilisi State Medical University, Tbilisi, 0186, Georgia. Stephen W Scherer, Affiliation/s: The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, McLaughlin Centre, University of Toronto, Toronto, ON, M5G 0A4, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. Gerard D Schellenberg, Affiliation/s: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102, USA. Sven Sandin, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stephan J Sanders, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Evald Saemundsen, Affiliation/s: State Diagnostic and Counseling Centre, Kopavogur, IS-201, Iceland. Guy A Rouleau, Affiliation/s: Montreal Neurological Institute, Dept of Neurology and Neurosurgery, McGill University, Montreal, QC, H3A 2B4, Canada. Bernadette Rogé, Affiliation/s: Centre d ’ Etudes et de Recherches en Psychopathologie, Toulouse University, Toulouse, 31058, France. Kathryn Roeder, Affiliation/s: Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Wendy Roberts, Affiliation/s: Autism Research Unit, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada. Jennifer Reichert, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Abraham Reichenberg, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Karola Rehnström, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK. Regina Regan, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Fritz Poustka, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher S Poultney, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Joseph Piven, Affiliation/s: University of North Carolina, Chapel Hill, NC 27599, USA. Dalila Pinto, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Margaret A Pericak-Vance, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Milica Pejovic-Milovancevic, Affiliation/s: Institute of Mental Health and Medical Faculty, University of Belgrade, Belgrade, 11 000, Serbia. Marianne Giørtz Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Carsten Bøcker Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Andrew D Paterson, Affiliation/s: Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, Dalla Lana School of Public Health, Toronto, ON, M5T 3M7, Canada. Jeremy R Parr, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Alistair T Pagnamenta, Affiliation/s: Wellcome Trust Centre for Human Genetics, OxfordUniversity,Oxford,OX37BN,UK. Guiomar Oliveira, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. John I Nurnberger, Affiliation/s: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Merete Nordentoft, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. Michael T Murtha, Affiliation/s: Programs on Neurogenetics, Yale University School of Medicine, New Haven, CT 06520, USA. Susana Mouga, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Preben Bo Mortensen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Na- tional Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark, Ole Mors, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark. Eric M Morrow, Affiliation/s: Department of Psychiatry and Human Behaviour, Brown University, Providence, RI 02912, USA. Daniel Moreno-De-Luca, Affiliation/s: Department of Psychiatry and Hu- man Behaviour, Brown University, Providence, RI 02912, USA. Anthony P Monaco, Affiliation/s: Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK, Tufts University, Boston, MA 02155?, USA. Nancy Minshew, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Alison Merikangas, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. William M McMahon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Susan G McGrew, Affiliation/s: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. Manuel Mattheisen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Igor Martsenkovsky, Affiliation/s: Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social Fo- rensic Psychiatry and Drug Abuse, Kyiv, 04080, Ukraine. Donna M Martin, Affiliation/s: Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Shrikant M Mane, Affiliation/s: Yale Center for Genomic Analysis, Yale University School of Medicine, New Haven, CT 06516, USA. Pall Magnusson, Affiliation/s: Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, IS-101, Iceland. Tiago Magalhaes, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Elena Maestrini, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Jennifer K Lowe, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Catherine Lord, Affiliation/s: Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Pat Levitt, Affiliation/s: Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. Christa LeseMartin, Affiliation/s: Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA 17837, USA. David H Ledbetter, Affiliation/s: Chief Scientific Officer, Geisinger Health System, Danville, PA 17837, USA. Marion Leboyer, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, INSERM U955, Paris, 94010, France, Faculté de Médecine, Université Paris Est, Créteil, 94000, France, Department of Psychiatry, Henri Mondor-Albert Chene- vier Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, 94000, France, Ann S LeCouteur, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Christine Ladd-Acosta, Affiliation/s: Department of Epidemiology, Johns Hop- kins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Alexander Kolevzon, Affiliation/s: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Sabine M Klauck, Affiliation/s: Division of Molecular Genome Analysis and Working Group Cancer Genome Research, Deutsches Krebsforschungszentrum, Heidelberg, D-69120, Germany. Suma Jacob, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA, Institute of Translational Neuroscience and Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA. Bozenna Iliadou, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Christina M Hultman, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. David M Hougaard, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Irva Hertz-Picciotto, Affiliation/s: Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA 95616, USA, The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA. Robert Hendren, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Christine Søholm Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Jonathan L Haines, Affiliation/s: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Stephen J Guter, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Dorothy E Grice, Affiliation/s: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Jonathan M Green, Affiliation/s: Manchester Academic Health Sciences Centre, Manchester, M13 9NT, UK, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PT, UK. Andrew Green, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Arthur P Goldberg, Affiliation/s: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Christopher Gillberg, Affiliation/s: Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, S-405 30, Sweden. John Gilbert, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Louise Gallagher, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Christine M Freitag, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Eric Fombonne, Affiliation/s: Department of Psychiatry and Institute for Development and Disability, Oregon Health and Science University, Portland, OR 97239, USA. Susan E Folstein, Affiliation/s: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Bridget Fernandez, Affiliation/s: Memorial University of Newfoundland, St John ’ s, NL, A1B 3X9, Canada. M.Daniele Fallin, Affiliation/s: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. A.Gulhan Ercan-Sencicek, Affiliation/s: Programs on Neurogenetics, Yale Uni- versity School of Medicine, New Haven, CT 06520, USA. Sean Ennis, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Frederico Duque, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Eftichia Duketis, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Richard Delorme, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, Human Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, 75015, France, Centre National de la Recherche Scientifique URA 2182 Institut Pasteur, Paris, 75724, France, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Assistance Publique – Hôpitaux de Paris, Paris, 75019, France, Silvia DeRubeis, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Maretha V DeJonge, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Geraldine Dawson, Affiliation/s: Duke Center for Autism and Brain Developments, Duke University School of Medicine, Durham, NC 27705, USA, Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC 27708, USA. Michael L Cuccaro, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Catarina T Correia, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Judith Conroy, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Temple Street Children ’ s University Hospital, Dublin, D1, Ireland. Ines C Conceição, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Andreas G Chiocchetti, Affiliation/s: Depar tment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goe the University Frankfurt, Frankfurt am Main, 60528, Germany. Patrícia BS Celestino-Soper, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indian- apolis, IN 46202, USA. Jillian Casey, Affiliation/s: Temple Street Children ’ s University Hospital, Dublin, D1, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Rita M Cantor, Affiliation/s: Department of Psychiatry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA. Cátia Café, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Jonas Bybjerg-Grauholm, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Sean Brennan, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Thomas Bourgeron, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, University Paris Diderot, Sorbonne Paris Cité, Paris, 75013, France, Patrick F Bolton, Affiliation/s: Institute of Psychiatry, Kings College London, London, SE5 8AF, UK, South London and Maudsley Biomedical Research Centre for Mental Health, London, SE5 8AF, UK. Sven Bölte, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany, Department of Women ’ s and Children ’ s Health, Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, SE- 113 30, Sweden, Child and Adolescent Psychiatry, Center for Psychiatry Re- search, Stockholm County Council, Stockholm, SE-171 77, Sweden. Nadia Bolshakova, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Catalina Betancur, Affiliation/s: INSERM U1130, Paris, 75005, France, CNRS UMR 8246, Paris, 75005, France, Sorbonne Universités, UPMC Univ Paris 6, Neuroscience Paris Seine, Paris, 75005, France. Raphael Bernier, Affiliation/s: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. Arthur L Beaudet, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Agatino Battaglia, Affiliation/s: Stella Maris Institute for Child and Adolescent Neuropsychiatr, Pisa, 56018, Italy. Vanessa H Bal, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Gillian Baird, Affiliation/s: Paediatric Neurodisability, King ’ s Health Partners, Kings College London, London, SE1 7EH, UK. Anthony J Bailey, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK, Mental Health and Addictions Research Unit, University of British Colombia, Vancouver, BC, V5Z 4H4, Canada. Marie Bækvad-Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Joel S Bader, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Elena Bacchelli, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Evdokia Anagnostou, Affiliation/s: Bloorview Research Institute, University of Toronto, Toronto, ON, M4G 1R8, Canada. David Amaral, Affiliation/s: The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Psychiatry, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Behavioural Sciences, School of Medicine, University of California Davis, Davis, CA 95817, USA. Joana Almeida, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Anders D Børglum, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Joseph D Buxbaum, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Aravinda Chakravarti, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Edwin H Cook, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Hilary Coon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Daniel H Geschwind, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Michael Gill, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Hakon Hakonarson, Affiliation/s: The Center for Applied Genomics and Division of Human Genetics, Children ’ s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Dept of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. Joachim Hallmayer, Affiliation/s: Department of Psychiatry, Stanford University, Stanford, CA 94305, USA. Aarno Palotie, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK., Anney, Richard J. L., Ripke, Stephan, Anttila, Verneri, Grove, Jakob, Holmans, Peter, Huang, Hailiang, Klei, Lambertu, Lee, Phil H., Medland, Sarah E., Neale, Benjamin, Robinson, Elise, Weiss, Lauren A., Zwaigenbaum, Lonnie, Yu, Timothy W., Wittemeyer, Kerstin, Willsey, A. Jeremy, Wijsman, Ellen M., Werge, Thoma, Wassink, Thomas H., Waltes, Regina, Walsh, Christopher A., Wallace, Simon, Vorstman, Jacob A. S., Vieland, Veronica J., Vicente, Astrid M., Vanengeland, Herman, Tsang, Kathryn, Thompson, Ann P., Szatmari, Peter, Svantesson, Oscar, Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, State, Matthew W., Soorya, Latha, Silagadze, Teimuraz, Scherer, Stephen W., Schellenberg, Gerard D., Sandin, Sven, Sanders, Stephan J., Saemundsen, Evald, Rouleau, Guy A., Rogã©, Bernadette, Roeder, Kathryn, Roberts, Wendy, Reichert, Jennifer, Reichenberg, Abraham, Rehnstrã¶m, Karola, Regan, Regina, Poustka, Fritz, Poultney, Christopher S., Piven, Joseph, Pinto, Dalila, Pericak-Vance, Margaret A., Pejovic-Milovancevic, Milica, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Paterson, Andrew D., Parr, Jeremy R., Pagnamenta, Alistair T., Oliveira, Guiomar, Nurnberger, John I., Nordentoft, Merete, Murtha, Michael T., Mouga, Susana, Mortensen, Preben Bo, Mors, Ole, Morrow, Eric M., Moreno-De-Luca, Daniel, Monaco, Anthony P., Minshew, Nancy, Merikangas, Alison, Mcmahon, William M., Mcgrew, Susan G., Mattheisen, Manuel, Martsenkovsky, Igor, Martin, Donna M., Mane, Shrikant M., Magnusson, Pall, Magalhaes, Tiago, Maestrini, Elena, Lowe, Jennifer K., Lord, Catherine, Levitt, Pat, Martin, Christa Lese, Ledbetter, David H., Leboyer, Marion, Lecouteur, Ann S., Ladd-Acosta, Christine, Kolevzon, Alexander, Klauck, Sabine M., Jacob, Suma, Iliadou, Bozenna, Hultman, Christina M., Hougaard, David M., Hertz-Picciotto, Irva, Hendren, Robert, Hansen, Christine Søholm, Haines, Jonathan L., Guter, Stephen J., Grice, Dorothy E., Green, Jonathan M., Green, Andrew, Goldberg, Arthur P., Gillberg, Christopher, Gilbert, John, Gallagher, Louise, Freitag, Christine M., Fombonne, Eric, Folstein, Susan E., Fernandez, Bridget, Fallin, M. Daniele, Ercan-Sencicek, A. Gulhan, Ennis, Sean, Duque, Frederico, Duketis, Eftichia, Delorme, Richard, Derubeis, Silvia, Dejonge, Maretha V., Dawson, Geraldine, Cuccaro, Michael L., Correia, Catarina T., Conroy, Judith, Conceiã§ã£o, Ines C., Chiocchetti, Andreas G., Celestino-Soper, Patrícia B. S., Casey, Jillian, Cantor, Rita M., Cafã©, Cã¡tia, Bybjerg-Grauholm, Jona, Brennan, Sean, Bourgeron, Thoma, Bolton, Patrick F., Bã¶lte, Sven, Bolshakova, Nadia, Betancur, Catalina, Bernier, Raphael, Beaudet, Arthur L., Battaglia, Agatino, Bal, Vanessa H., Baird, Gillian, Bailey, Anthony J., Bækvad-Hansen, Marie, Bader, Joel S., Bacchelli, Elena, Anagnostou, Evdokia, Amaral, David, Almeida, Joana, Bã¸rglum, Anders D., Buxbaum, Joseph D., Chakravarti, Aravinda, Cook, Edwin H., Coon, Hilary, Geschwind, Daniel H., Gill, Michael, Hallmayer, Joachim, Palotie, Aarno, Santangelo, Susan, Sutcliffe, James S., Arking, Dan E., Devlin, Bernie, Daly, Mark J., Hakonarson, Hakon, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Fondation FondaMental [Créteil], Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Molecular Autism
Molecular Autism, BioMed Central, 2017, 8, pp.21. ⟨10.1186/s13229-017-0137-9⟩
Anney, R J L, Ripke, S, Anttila, V, Grove, J, Holmans, P, Huang, H, Klei, L, Lee, P H, Medland, S E, Neale, B, Robinson, E, Weiss, L A, Zwaigenbaum, L, Yu, T W, Wittemeyer, K, Willsey, A J, Wijsman, E M, Werge, T, Wassink, T H, Waltes, R, Walsh, C A, Wallace, S, Vorstman, J A S, Vieland, V J, Vicente, A M, Vanengeland, H, Tsang, K, Thompson, A P, Szatmari, P, Svantesson, O, Steinberg, S, Stefansson, K, Stefansson, H, State, M W, Soorya, L, Silagadze, T, Scherer, S W, Schellenberg, G D, Sandin, S, Sanders, S J, Saemundsen, E, Rouleau, G A, Rogé, B, Roeder, K, Roberts, W, Reichert, J, Reichenberg, A, Rehnström, K, Regan, R, Poustka, F, Poultney, C S, Piven, J, Pinto, D, Pericak-Vance, M A, Pejovic-Milovancevic, M, Pedersen, M G, Pedersen, C B, Paterson, A D, Parr, J R, Pagnamenta, A T, Oliveira, G, Nurnberger, J I, Nordentoft, M, Murtha, M T, Mouga, S, Mortensen, P B, Mors, O, Morrow, E M, Moreno-De-Luca, D, Monaco, A P, Minshew, N, Merikangas, A, McMahon, W M, McGrew, S G, Mattheisen, M, Martsenkovsky, I, Martin, D M, Mane, S M, Magnusson, P, Magalhaes, T, Maestrini, E, Lowe, J K, Lord, C, Levitt, P, Martin, C L, Ledbetter, D H, Leboyer, M, Lecouteur, A S, Ladd-Acosta, C, Kolevzon, A, Klauck, S M, Jacob, S, Iliadou, B, Hultman, C M, Hougaard, D M, Hertz-Picciotto, I, Hendren, R, Hansen, C S, Haines, J L, Guter, S J, Grice, D E, Green, J M, Green, A, Goldberg, A P, Gillberg, C, Gilbert, J, Gallagher, L, Freitag, C M, Fombonne, E, Folstein, S E, Fernandez, B, Fallin, M D, Ercan-Sencicek, A G, Ennis, S, Duque, F, Duketis, E, Delorme, R, Derubeis, S, Dejonge, M V, Dawson, G, Cuccaro, M L, Correia, C T, Conroy, J, Conceição, I C, Chiocchetti, A G, Celestino-Soper, P B S, Casey, J, Cantor, R M, Café, C, Bybjerg-Grauholm, J, Brennan, S, Bourgeron, T, Bolton, P F, Bölte, S, Bolshakova, N, Betancur, C, Bernier, R, Beaudet, A L, Battaglia, A, Bal, V H, Baird, G, Bailey, A J, Bækvad-Hansen, M, Bader, J S, Bacchelli, E, Anagnostou, E, Amaral, D, Almeida, J, Børglum, A D, Buxbaum, J D, Chakravarti, A, Cook, E H, Coon, H, Geschwind, D H, Gill, M, Hakonarson, H, Hallmayer, J, Palotie, A, Santangelo, S, Sutcliffe, J S, Arking, D E, Devlin, B & Daly, M J 2017, ' Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia ', Molecular Autism, vol. 8, 21 . https://doi.org/10.1186/s13229-017-0137-9
Molecular Autism, 2017, 8, pp.21. ⟨10.1186/s13229-017-0137-9⟩
Bolton, P F 2017, ' Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia ', Molecular Autism, vol. 8, pp. 21 . https://doi.org/10.1186/s13229-017-0137-9
Molecular Autism, Vol 8, Iss 1, Pp 1-17 (2017)
Molecular autism, vol 8, iss 1
The Autism Spectrum Disorders Working Group of the Psychiatric Genomics Consortium 2017, ' Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia ', Autism, vol. 8, no. 21, 21 . https://doi.org/10.1186/s13229-017-0137-9

مصطلحات موضوعية: 0301 basic medicine, Male, INTELLECTUAL DISABILITY, Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium, Autism, Neurodevelopment, Gene Expression, Genome-wide association study, [SDV.GEN] Life Sciences [q-bio]/Genetics, lcsh:RC346-429, 0302 clinical medicine, 2.1 Biological and endogenous factors, Pair 10, Copy-number variation, Aetiology, Autism spectrum disorder, Genetics, Adaptor Proteins, Forkhead Transcription Factors, Serious Mental Illness, 3. Good health, Mental Health, Psychiatry and Mental Health, Meta-analysis, Female, Biotechnology, Human, Autismo, Genetic correlation, Intellectual and Developmental Disabilities (IDD), Clinical Sciences, Gene-set analysi, Genomics, Locus (genetics), FOXP1, Biology, Chromosomes, Heritability, 03 medical and health sciences, Plasma Membrane Calcium-Transporting ATPases, Developmental Neuroscience, REVEALS, mental disorders, LINKAGE, medicine, Journal Article, Humans, Genetic Predisposition to Disease, Meta-analysi, GENOME-WIDE ASSOCIATION, COMMON, Genotyping, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, COPY NUMBER VARIATION, Genetic association, Adaptor Proteins, Signal Transducing, Homeodomain Proteins, [SDV.GEN]Life Sciences [q-bio]/Genetics, Chromosomes, Human, Pair 10, Research, Human Genome, Signal Transducing, Neurosciences, Membrane Proteins, medicine.disease, RISK LOCI, R1, Brain Disorders, Repressor Proteins, 030104 developmental biology, Genetic Loci, Case-Control Studies, Perturbações do Desenvolvimento Infantil e Saúde Mental, Schizophrenia, Carrier Proteins, Gene-set analysis, MENTAL-RETARDATION, SCAN, 030217 neurology & neurosurgery, Transcription Factors, Developmental Biology

وصف الملف: application/pdf; STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efa92826829f7f870799b08a5c31e5
https://www.hal.inserm.fr/inserm-01535717

المؤلفون: Taylor, Hannah B., Klaeger, Susan, Clauser, Karl R., Sarkizova, Siranush, Weingarten-Gabbay, Shira, Graham, Daniel B., Carr, Steven A., Abelin, Jennifer G.

المساهمون: Eli and Edythe L. Broad Institute of Harvard and MIT, National Institutes of Health, National Cancer Institute

المصدر: Molecular & Cellular Proteomics ; volume 20, page 100116 ; ISSN 1535-9476

الاتاحة: http://dx.doi.org/10.1016/j.mcpro.2021.100116
https://api.elsevier.com/content/article/PII:S1535947621000888?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1535947621000888?httpAccept=text/plain

المؤلفون: Teumer, Alexander, Li, Yong, Ghasemi, Sahar, Prins, Bram P, Wuttke, Matthias, Hermle, Tobias, Giri, Ayush, Sieber, Karsten B, Qiu, Chengxiang, Kirsten, Holger, Tin, Adrienne, Chu, Audrey Y, Bansal, Nisha, Feitosa, Mary F, Wang, Lihua, Chai, Jin-Fang, Cocca, Massimiliano, Fuchsberger, Christian, Gorski, Mathias, Hoppmann, Anselm, Horn, Katrin, Li, Man, Marten, Jonathan, Noce, Damia, Nutile, Teresa, Sedaghat, Sanaz, Sveinbjornsson, Gardar, Tayo, Bamidele O, van der Most, Peter J, Xu, Yizhe, Yu, Zhi, Gerstner, Lea, Ärnlöv, Johan, Bakker, Stephan J L, Baptista, Daniela, Biggs, Mary L, Boerwinkle, Eric, Brenner, Hermann, Burkhardt, Ralph, Carroll, Robert J, Chee, Miao-Li, Chee, Miao-Ling, Chen, Mengmeng, Cheng, Ching-Yu, Cook, James P, Coresh, Josef, Corre, Tanguy, Danesh, John, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Dittrich, Katalin, Divers, Jasmin, Eckardt, Kai-Uwe, Ehret, Georg, Endlich, Karlhans, Felix, Janine F, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Gansevoort, Ron T, Giedraitis, Vilmantas, Gögele, Martin, Grundner-Culemann, Franziska, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Hamet, Pavel, Harris, Tamara B, Hicks, Andrew A, Holm, Hilma, Foo, Valencia Hui Xian, Hwang, Shih-Jen, Ikram, M Arfan, Ingelsson, Erik, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Khor, Chiea-Chuen, Kiess, Wieland, Koenig, Wolfgang, Körner, Antje, Kovacs, Peter, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jianjun, Loeffler, Markus, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Maranville, Joseph C, Mascalzoni, Deborah, McMullen, Barbara, Meisinger, Christa, Meitinger, Thomas, Miliku, Kozeta, Mook-Kanamori, Dennis O, Müller-Nurasyid, Martina, Mychaleckyj, Josyf C, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Noordam, Raymond, Connell, Jeffrey O', Olafsson, Isleifur, Palmer, Nicholette D, Peters, Annette, Podgornaia, Anna I, Ponte, Belen, Poulain, Tanja, Pramstaller, Peter P, Rabelink, Ton J, Raffield, Laura M, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rivadeneira, Fernando, Runz, Heiko, Ryan, Kathleen A, Sabanayagam, Charumathi, Saum, Kai-Uwe, Schöttker, Ben, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Strauch, Konstantin, Stumvoll, Michael, Sun, Benjamin B, Szymczak, Silke, Tai, E-Shyong, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorsteinsdottir, Unnur, Tönjes, Anke, Tremblay, Johanne, Uitterlinden, André G, van der Harst, Pim, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Waldenberger, Melanie, Wang, Chaolong, Wilson, Otis D, Wong, Charlene, Wong, Tien-Yin, Yang, Qiong, Yasuda, Masayuki, Akilesh, Shreeram, Bochud, Murielle, Böger, Carsten A, Devuyst, Olivier, Edwards, Todd L, Ho, Kevin, Morris, Andrew P, Parsa, Afshin, Pendergrass, Sarah A, Psaty, Bruce M, Rotter, Jerome I, Stefansson, Kari, Wilson, James G, Susztak, Katalin, Snieder, Harold, Heid, Iris M, Scholz, Markus, Butterworth, Adam S, Hung, Adriana M, Pattaro, Cristian, Köttgen, Anna

المساهمون: 1 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 2 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 3 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 4 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 5 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 6 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 7 Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 8 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 9 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 10 Target Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA. 11 Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 12 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 13 LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 14 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 15 Epidemiology and Clinical Research, Welch Centre for Prevention, Baltimore, MD, USA. 16 Genetics, Merck & Co., Inc., Kenilworth, NJ, USA. 17 Division of Nephrology, University of Washington, Seattle, WA, USA. 18 Kidney Research Institute, University of Washington, Seattle, WA, USA. 19 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 20 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 21 Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy. 22 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. 23 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 24 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 25 Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. 26 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 27 Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy. 28 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 29 deCODE Genetics, Amgen Inc., Reykjavik, Iceland. 30 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 31 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 32 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 33 Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Falun, Sweden. 35 Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 36 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 37 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 38 Department of Biostatistics, University of Washington, Seattle, WA, USA. 39 Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. 40 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 41 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 42 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 43 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 44 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 45 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 46 Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 47 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 48 Department of Biostatistics, University of Liverpool, Liverpool, UK. 49 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. 50 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 51 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 52 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 53 Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. 54 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 55 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 56 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 57 Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. 58 Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. 59 Intensive Care Medicine, Charité, Berlin, Germany. 60 Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany. 61 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 62 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 63 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 64 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 65 Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA. 66 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA. 67 Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. 68 Icelandic Heart Association, Kopavogur, Iceland. 69 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 70 Montreal University Hospital Research Centre, CHUM, Montreal, QC, Canada. 71 Medpharmgene, Montreal, QC, Canada. 72 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. 73 NHLBI's Framingham Heart Study, Framingham, MA, USA. 74 The Centre for Population Studies, NHLBI, Framingham, MA, USA. 75 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. 76 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 77 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 78 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 79 Icelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland. 80 The Centre of Public Health Sciences, University of Iceland, Sturlugata 8, Reykjavík, IS-101, Iceland. 81 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 82 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 83 Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 84 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 85 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 86 DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 87 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 88 Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. 89 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 90 5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 91 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 92 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA. 93 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 94 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 95 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 96 Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Singapore. 97 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 98 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 99 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 100 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 101 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. 102 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 103 MRL, Merck & Co., Inc., Kenilworth, NJ, USA. 104 Celgene Inc., Cambridge, MA, USA. 105 Vanderbilt University School of Medicine, Nashville, TN, USA. 106 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. 107 Chair of Epidemiology Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 108 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 109 Institute of Human Genetics, Technische Universität München, Munich, Germany. 110 Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands. 111 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 112 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. 113 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. 114 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. 115 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 116 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 117 Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 118 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 119 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 120 University of Maryland School of Medicine, Baltimore, MD, USA. 121 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 122 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 123 Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 124 German Center for Diabetes Research (DZD), Neuherberg, Germany. 125 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 126 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, The Netherlands. 127 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 128 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 129 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 130 Biogen Inc., Cambridge, MA, USA. 131 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 132 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 133 Duke-NUS Medical School, Singapore, Singapore. 134 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 135 Heart Centre Leipzig, Leipzig, Germany. 136 Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 137 CRCHUM, Montreal, QC, Canada. 138 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 139 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 140 Durrer Centre for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, The Netherlands. 141 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 142 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 143 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 144 Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. 145 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. 146 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 147 Department of Nephrology, Diabetology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. 148 Institute of Physiology, University of Zurich, Zurich, Switzerland. 149 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. 150 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 151 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 152 Department of Nephrology, Geisinger, Danville, PA, USA. 153 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 154 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 155 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 156 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 157 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 158 Department of Pediatrics, Harbor-UCLA Medical Centre, Torrance, CA, USA. 159 Department of Medicine, Harbor-UCLA Medical Centre, Torrance, CA, USA. 160 Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. 161 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 162 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu. 163 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 164 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de

المصدر: Nature communications

مصطلحات موضوعية: Nýrnasjúkdómar, Prótín, Þvag, Albuminuria, Kidney Diseases

Relation: https://www.nature.com/articles/s41467-019-11576-0; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370/; Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 2019, 10(1):4130 Nat Commun; http://hdl.handle.net/2336/621103; Nature Communications

الاتاحة: http://hdl.handle.net/2336/621103
https://doi.org/10.1038/s41467-019-11576-0

المؤلفون: Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B, Feitosa, Mary F, Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y, Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O, Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J, Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S, Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J L, Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L, Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P, Boutin, Thibaud S, Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S, Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J, Catamo, Eulalia, Chambers, John C, Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Concas, Maria Pina, Cook, James P, Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E Warwick, de Borst, Martin H, De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P J, Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K, Felix, Janine F, Foo, Valencia Hui Xian, Franco, Oscar H, Franke, Andre, Freedman, Barry I, Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T, Gao, He, Gasparini, Paolo, Gaziano, J Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D, Gudbjartsson, Daniel F, Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B, Hartman, Catharina A, Hayward, Caroline, Hellwege, Jacklyn N, Heng, Chew-Kiat, Hicks, Andrew A, Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Indridason, Olafur S, Ingelsson, Erik, Ising, Marcus, Jaddoe, Vincent W V, Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K, Josyula, Navya Shilpa, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M, Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M, Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E, Koenig, Wolfgang, Kooner, Jaspal S, Körner, Antje, Kovacs, Peter, Kraja, Aldi T, Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K, Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A, Langefeld, Carl D, Lee, Jeannette Jen-Mai, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M, Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J F, Lucae, Susanne, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K E, Mahajan, Anubha, Martin, Nicholas G, Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K, Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P, Mohlke, Karen L, Mononen, Nina, Montgomery, Grant W, Mook-Kanamori, Dennis O, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nalls, Mike A, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, Noordam, Raymond, O'Connell, Jeffrey, O'Donoghue, Michelle L, Olafsson, Isleifur, Oldehinkel, Albertine J, Orho-Melander, Marju, Ouwehand, Willem H, Padmanabhan, Sandosh, Palmer, Nicholette D, Palsson, Runolfur, Penninx, Brenda W J H, Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I, Polasek, Ozren, Ponte, Belen, Porteous, David J, Poulain, Tanja, Pramstaller, Peter P, Preuss, Michael H, Prins, Bram P, Province, Michael A, Rabelink, Ton J, Raffield, Laura M, Raitakari, Olli T, Reilly, Dermot F, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Ridker, Paul M, Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J, Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A, Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M, Shi, Yuan, Smith, Albert V, Smith, Blair H, Soranzo, Nicole, Spracklen, Cassandra N, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Svensson, Per O, Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M, Tan, Nicholas Y Q, Taylor, Kent D, Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H L, Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G, Vaccargiu, Simona, van Dam, Rob M, van der Harst, Pim, van Duijn, Cornelia M, Velez Edward, Digna R, Verweij, Niek, Vogelezang, Suzanne, Völker, Uwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M, Bin Wei, Wen, White, Harvey, Whitfield, John B, Wild, Sarah H, Wilson, James F, Wojczynski, Mary K, Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M, Zhang, Weihua, Zonderman, Alan B, Rotter, Jerome I, Bochud, Murielle, Psaty, Bruce M, Vitart, Veronique, Wilson, James G, Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I, Ho, Kevin, Morris, Andrew P, Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A, Sim, Xueling, Böger, Carsten A, Okada, Yukinori, Edwards, Todd L, Snieder, Harold, Stefansson, Kari, Hung, Adriana M, Heid, Iris M, Scholz, Markus, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian

المساهمون: 1 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 2 Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. 3 Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA. 4 Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. 5 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 6 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 7 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 8 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 9 Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. 10 Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. 11 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 12 LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 13 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 14 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 15 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 16 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland. 17 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 18 Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. 19 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. 20 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 21 Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. 22 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 23 DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. 24 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 25 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 26 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 27 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. 28 Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 29 Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. 30 Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan. 31 Steno Diabetes Center Copenhagen, Gentofte, Denmark. 32 Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden. 33 Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Stockholm, Sweden. 35 Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 36 Division of Nephrology, University of Washington, Seattle, WA, USA. 37 Kidney Research Institute, University of Washington, Seattle, WA, USA. 38 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 39 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 40 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 41 Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa. 42 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 43 Department of Biostatistics, University of Washington, Seattle, WA, USA. 44 Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. 45 Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. 46 Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA. 47 CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. 48 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 49 Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany. 50 Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. 51 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 52 Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy. 53 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 54 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 55 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 56 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 57 Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 58 Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 59 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 60 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. 61 Department of Cardiology, Ealing Hospital, Middlesex, UK. 62 Imperial College Healthcare NHS Trust, Imperial College London, London, UK. 63 MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 64 Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. 65 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 66 Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 67 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 68 Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark. 69 Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic. 70 Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic. 71 IRCCS Neuromed, Pozzilli, Italy. 72 Department of Biostatistics, University of Liverpool, Liverpool, UK. 73 Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland. 74 San Raffaele Research Institute, Milan, Italy. 75 Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy. 76 Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy. 77 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 78 Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 79 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 80 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 81 Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 82 Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 83 NHS Blood and Transplant, Cambridge, UK. 84 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 85 Center for Pediatric Research, University of Leipzig, Leipzig, Germany. 86 Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA. 87 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 88 Intensive Care Medicine, Charité, Berlin, Germany. 89 Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany. 90 Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. 91 Imperial College NIHR Biomedical Research Center, Imperial College London, London, UK. 92 Dementia Research Institute, Imperial College London, London, UK. 93 Health Data Research UK-London, London, UK. 94 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 95 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA. 96 Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 97 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 98 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 99 Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. 100 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. 101 School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. 102 Department of Genomics of Common Disease, Imperial College London, London, UK. 103 Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. 104 Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 105 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 106 Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 107 German Center for Diabetes Research (DZD), Neuherberg, Germany. 108 Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. 109 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 110 Icelandic Heart Association, Kopavogur, Iceland. 111 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 112 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. 113 Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada. 114 Medpharmgene, Montreal, Quebec, Canada. 115 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA. 116 Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 117 Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 118 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. 119 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 120 Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 121 Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore. 122 Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. 123 Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. 124 Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China. 125 Shanghai Industrial Technology Institute, Shanghai, China. 126 Department of Pediatrics, Tampere University Hospital, Tampere, Finland. 127 Department of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 128 NHLBI's Framingham Heart Study, Framingham, MA, USA. 129 The Center for Population Studies, NHLBI, Framingham, MA, USA. 130 Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 131 Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. 132 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 133 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 134 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 135 Max Planck Institute of Psychiatry, Munich, Germany. 136 The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland. 137 Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. 138 Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 139 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 140 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 141 Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 142 Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 143 Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 144 Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. 145 Department of Medicine, Kuopio University Hospital, Kuopio, Finland. 146 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 147 DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 148 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 149 National Heart and Lung Institute, Imperial College London, London, UK. 150 Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. 151 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 152 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 153 RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan. 154 The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 155 Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland. 156 Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland. 157 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. 158 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 159 Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 160 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 161 Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore. 162 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 163 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 164 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 165 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 166 The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 167 Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA. 168 Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. 169 Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 170 Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. 171 Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. 172 Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. 173 Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 174 Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. 175 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. 176 Chair of Epidemiology, Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 177 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 178 Institute of Human Genetics, Technische Universität München, Munich, Germany. 179 Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden. 180 Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. 181 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 182 Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia. 183 Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. 184 Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA. 185 Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. 186 Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. 187 Data Tecnica International, Glen Echo, MD, USA. 188 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 189 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 190 Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, Tampere University, Tampere, Finland. 191 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 192 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. 193 University of Maryland School of Medicine, Baltimore, MD, USA. 194 Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. 195 TIMI Study Group, Boston, MA, USA. 196 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 197 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. 198 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 199 Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. 200 National Institute for Health and Welfare, Helsinki, Finland. 201 Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy. 202 Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. 203 Faculty of Medicine, University of Split, Split, Croatia. 204 Gen-info Ltd, Zagreb, Croatia. 205 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 206 Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. 207 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, the Netherlands. 208 Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. 209 Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. 210 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 211 Harvard Medical School, Boston, MA, USA. 212 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. 213 Department of Health Sciences, University of Milan, Milano, Italy. 214 ePhood Scientific Unit, ePhood SRL, Milano, Italy. 215 NHS Blood and Transplant, BRC Oxford Haematology Theme, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK. 216 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 217 Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. 218 Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy. 219 Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria. 220 Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. 221 Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA. 222 Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, USA. 223 Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. 224 Human Genetics, Wellcome Sanger Institute, Hinxton, UK. 225 Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. 226 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany. 227 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 228 Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. 229 Department of Cardiology, Södersjukhuset, Stockholm, Sweden. 230 Duke-NUS Medical School, Singapore, Singapore. 231 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 232 Heart Center Leipzig, Leipzig, Germany. 233 Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 234 CRCHUM, Montreal, Canada. 235 Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece. 236 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 237 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 238 Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands. 239 Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 240 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 241 Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. 242 Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 243 Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. 244 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 245 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 246 Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand. 247 Center for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. 248 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan. 249 Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. 250 Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA. 251 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 252 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 253 Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA. 254 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 255 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 256 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 257 Department of Nephrology, Geisinger, Danville, PA, USA. 258 Institute of Physiology, University of Zurich, Zurich, Switzerland. 259 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 260 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 261 Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany. 262 Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan. 263 Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. 264 Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA. 265 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 266 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de. 267 Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu

المصدر: Nature genetics

مصطلحات موضوعية: Nýrnasjúkdómar, Gen, Kidney Function Tests, Chromosome Mapping, Genome-Wide Association Study, Renal Insufficiency, Genetic Predisposition to Disease

Relation: https://www.nature.com/articles/s41588-019-0407-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888/; A catalog of genetic loci associated with kidney function from analyses of a million individuals. 2019, 51(6): 957-972 Nat Genet; http://hdl.handle.net/2336/621022; Nature Genetics

الاتاحة: http://hdl.handle.net/2336/621022
https://doi.org/10.1038/s41588-019-0407-x

المؤلفون: Murphy, Michael, Öngür, Dost

المساهمون: Broad Institute of Harvard, Harvard Medical School

المصدر: NeuroImage: Clinical ; volume 22, page 101693 ; ISSN 2213-1582

الاتاحة: http://dx.doi.org/10.1016/j.nicl.2019.101693
https://api.elsevier.com/content/article/PII:S2213158219300439?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2213158219300439?httpAccept=text/plain

المؤلفون: Fonteneau, Clara, Mondino, Marine, Arns, Martijn, Baeken, Chris, Bikson, Marom, Brunoni, Andre R., Burke, Matthew J., Neuvonen, Tuomas, Padberg, Frank, Pascual-Leone, Alvaro, Poulet, Emmanuel, Ruffini, Giulio, Santarnecchi, Emiliano, Sauvaget, Anne, Schellhorn, Klaus, Suaud-Chagny, Marie-Françoise, Palm, Ulrich, Brunelin, Jérome

المساهمون: neuroCare Group, Germany, Beneficent Association Alzira Denise Hertzog da Silva, CAPES/INCT program “National Institute of Biomarkers in Psychiatry” (INBioN), Brazil, BROAD Institute at Harvard-MIT, Defense Advanced Research Projects Agency (DARPA), USA, Beth Israel Deaconess Medical Center (BIDMC), USA

المصدر: Brain Stimulation ; volume 12, issue 3, page 668-673 ; ISSN 1935-861X

الاتاحة: http://dx.doi.org/10.1016/j.brs.2018.12.977
https://api.elsevier.com/content/article/PII:S1935861X18313962?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S1935861X18313962?httpAccept=text/plain