المؤلفون: Oscar Mammoliti (1923286), Koen Jansen (1822096), Sandy El Bkassiny (10740138), Adeline Palisse (10740135), Nicolas Triballeau (1400671), Denis Bucher (352807), Brigitte Allart (2944395), Alex Jaunet (1863439), Giovanni Tricarico (9941678), Maxim De Wachter (11494630), Christel Menet (9941675), Javier Blanc (1714399), Vatroslav Letfus (11494633), Renata Rupčić (2115004), Mario Šmehil (11494636), Tanja Poljak (11494639), Beatrice Coornaert (10740141), Kathleen Sonck (5898149), Inge Duys (10740144), Ludovic Waeckel (11494642), Lola Lecru (332155), Florence Marsais (11494645), Catherine Jagerschmidt (753692), Marielle Auberval (3989720), Philippe Pujuguet (11494648), Line Oste (1705675), Monica Borgonovi (4747311), Emanuelle Wakselman (1705648), Thierry Christophe (242276), Nicolas Houvenaghel (10740147), Mia Jans (4376776), Bertrand Heckmann (632958), Laurent Sanière (10740150), Reginald Brys (1705672)

مصطلحات موضوعية: Biochemistry, Medicine, Pharmacology, Biotechnology, Ecology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, potent phthalazone series, orally bioavailable phthalazone, increasing evidence suggests, chemical enablement strategy, progressive lung disease, s1p2 antagonists could, 6 , s1p2 antagonists, disease progression, vivo <, vitro <, s1p2 activity, three different, therapeutic setting, suboptimal pharmacokinetics, scaffold hopping, rapid exploration, position adjacent, mouse models, kg bid, homology model, good pharmacokinetics

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Optimization_of_Orally_Bioavailable_Phthalazone_and_Cinnolone_Carboxylic_Acid_Derivatives_as_S1P2_Antagonists_against_Fibrotic_Diseases/16692334

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01066.s001

المؤلفون: Oscar Mammoliti (1923286), Adeline Palisse (10740135), Caroline Joannesse (2191360), Sandy El Bkassiny (10740138), Brigitte Allart (2944395), Alex Jaunet (1863439), Christel Menet (9941675), Beatrice Coornaert (10740141), Kathleen Sonck (5898149), Inge Duys (10740144), Philippe Clément-Lacroix (2035135), Line Oste (1705675), Monica Borgonovi (4747311), Emanuelle Wakselman (1705648), Thierry Christophe (242276), Nicolas Houvenaghel (10740147), Mia Jans (4376776), Bertrand Heckmann (632958), Laurent Sanière (10740150), Reginald Brys (1705672)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Cancer, Infectious Diseases, Plant Biology, Chemical Sciences not elsewhere classified, bleomycin-induced model, phenotypic IL 8 release assay, CYP inhibition liability, S 1PR, Idiopathic Pulmonary Fibrosis Mount., fibrosis, pyridazine series, Preclinical Candidate, GLPG, lipophilic efficiency, chemical enablement strategy, IPF, antagonist activity, S 1P receptor, pyridine series

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_the_S1P2_Antagonist_GLPG2938_1-_2-Ethoxy-6-_trifluoromethyl_-4-pyridyl_-3-_5-methyl-6-_1-methyl-3-_trifluoromethyl_pyrazol-4-yl_pyridazin-3-yl_methyl_urea_a_Preclinical_Candidate_for_the_Treatment_of_Idiopathic_Pulmonary_Fibros/14531544

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00138.s001

المؤلفون: Nicolas Triballeau, Bertrand Heckmann, Nicolas Houvenaghel, Tanja Poljak, F. Marsais, Adeline Marie Elise Palisse, Emanuelle Wakselman, Mario Smehil, Mia Jans, Kathleen Sonck, Monica Borgonovi, Denis Bucher, Sandy El Bkassiny, Javier Blanc, Beatrice Coornaert, Thierry Christophe, Philippe Pujuguet, Vatroslav Letfus, M. Auberval, Lola Lecru, Laurent Saniere, Inge Duys, Reginald Brys, Line Oste, Brigitte Allart, Alex Jaunet, Maxim De Wachter, Catherine Jagerschmidt, Koen Karel Jansen, Oscar Mammoliti, Ludovic Waeckel, Giovanni Tricarico, Christel Jeanne Marie Menet, Renata Rupčić

المصدر: Journal of medicinal chemistry. 64(19)

مصطلحات موضوعية: Indole test, chemistry.chemical_classification, Benzimidazole, Carboxylic acid, Carboxylic Acids, Administration, Oral, Biological Availability, Transporter, Pharmacology, medicine.disease, In vitro, Idiopathic Pulmonary Fibrosis, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Disease Models, Animal, Mice, chemistry, Pharmacokinetics, In vivo, Drug Discovery, medicine, Molecular Medicine, Animals, Humans, Sphingosine-1-Phosphate Receptors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045dde34db98ae7f215ad12e45f175db
https://pubmed.ncbi.nlm.nih.gov/34581584

المؤلفون: Thierry Christophe, Nicolas Houvenaghel, Philippe Clément-Lacroix, Reginald Brys, Line Oste, Inge Duys, Emanuelle Wakselman, Bertrand Heckmann, Caroline Joannesse, Alex Jaunet, Adeline Marie Elise Palisse, Brigitte Allart, Laurent Saniere, Mia Jans, Monica Borgonovi, Sandy El Bkassiny, Oscar Mammoliti, Beatrice Coornaert, Christel Jeanne Marie Menet, Kathleen Sonck

المصدر: Journal of medicinal chemistry. 64(9)

مصطلحات موضوعية: Male, Stereochemistry, CHO Cells, 01 natural sciences, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, Idiopathic pulmonary fibrosis, Mice, Structure-Activity Relationship, Cricetulus, Drug Discovery, Pulmonary fibrosis, medicine, Structure–activity relationship, Animals, Humans, Tissue Distribution, Sphingosine-1-Phosphate Receptors, 030304 developmental biology, S1PR2, 0303 health sciences, Trifluoromethyl, Interleukin-8, Antagonist, medicine.disease, Idiopathic Pulmonary Fibrosis, 0104 chemical sciences, Pyridazines, 010404 medicinal & biomolecular chemistry, chemistry, Lipophilic efficiency, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf77a662664d4953efc380b9590624
https://pubmed.ncbi.nlm.nih.gov/33939425

المؤلفون: Galina Dragneva, Tanja Karppinen, Minna U. Kaikkonen, Ann-Marie Määttä, Brigitte Allart, David L. Selwood, Pauliina Lehtolainen-Dalkilic, Jukka Mönkkönen, Marika Ruponen, Tiina Puustinen, Marjo Jauhiainen, Thomas Wirth, Hanna P. Lesch, Seppo Ylä-Herttuala, Suvi K. Soininen

المصدر: European Journal of Pharmaceutical Sciences. 47:848-856

مصطلحات موضوعية: Biodistribution, Recombinant Fusion Proteins, Receptor expression, Biotin, Mice, Nude, Pharmaceutical Science, Biology, Mice, chemistry.chemical_compound, Cell Line, Tumor, polycyclic compounds, Animals, Humans, Biotinylation, Tissue Distribution, Liposome, Antibiotics, Antineoplastic, Avidin, Fusion protein, Rats, Kinetics, chemistry, Biochemistry, Doxorubicin, Liposomes, Biophysics, biology.protein, Drug carrier

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b9dae63bf4d4898b51ba2343ec4cf3
https://doi.org/10.1016/j.ejps.2012.09.001

المؤلفون: Seppo Ylä-Herttuala, David L. Selwood, Pauliina Lehtolainen, John Martin, Brigitte Allart

المصدر: Bioconjugate Chemistry. 14:187-194

مصطلحات موضوعية: Streptavidin, Alkylation, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Aldehyde, chemistry.chemical_compound, Biotin, Organic chemistry, Biotinylation, Pharmacology, chemistry.chemical_classification, Aldehydes, biology, Sodium cyanoborohydride, Organic Chemistry, Affinity Labels, Combinatorial chemistry, DNA Topoisomerases, Type II, chemistry, Doxorubicin, biology.protein, Derivative (chemistry), Biotechnology, Avidin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e51b08f5215fa746e650a3b41436fb2
https://doi.org/10.1021/bc0255992

المؤلفون: Piet Herdewijn, Berthold Wroblowski, Mattheus Froeyen, Eveline Lescrinier, Robert Esnouf, Hans De Winter, Brigitte Allart

المصدر: Helvetica Chimica Acta. 83:2153-2182

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Oligonucleotide, Organic Chemistry, RNA, Nuclear magnetic resonance spectroscopy, Biochemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Ribose, Nucleic acid, Oligoribonucleotides, A-DNA, Nucleotide, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c56a94580e997dff43324c1c2f12f
https://doi.org/10.1002/1522-2675(20000906)83:9<2153::aid-hlca2153>3.0.co;2-i

المؤلفون: Arthur Van Aerschot, K. Khan, Frank Seela, Chris Hendrix, Piet Herdewijn, Helmut Rosemeyer, Guy Schepers, K. Rothenbacher, Brigitte Allart

المصدر: Chemistry - A European Journal. 5:2424-2431

مصطلحات موضوعية: chemistry.chemical_compound, Biochemistry, Oligonucleotide, Chemistry, D-altritol, Organic Chemistry, Nucleic acid, Oligoribonucleotides, Moiety, Antisense Agents, General Chemistry, Catalysis, DNA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3877262ef432ec8cdfcdf7a6d02fba53
https://doi.org/10.1002/(sici)1521-3765(19990802)5:8<2424::aid-chem2424>3.0.co;2-w

المؤلفون: Piet Herdewijn, Brigitte Allart, Arthur Van Aerschot

المصدر: Scopus-Elsevier

مصطلحات موضوعية: chemistry.chemical_compound, Stereochemistry, Chemistry, Oligonucleotide, Guanine, Genetics, Nucleic acid, RNA, Moiety, Uracil, Biochemistry, Nucleoside, Cytosine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabd6ce8a36fb71af11371b6f7ced779
https://doi.org/10.1080/07328319808004682

المؤلفون: Paul J, Edwards, Brigitte, Allart, Martin J I, Andrews, J Andrew, Clase, Christel, Menet

المصدر: Current opinion in drug discoverydevelopment. 9(4)

مصطلحات موضوعية: Pharmaceutical Preparations, Chemistry, Pharmaceutical, Animals, Humans, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::833c534fb809bd751937e8b7c7a42de6
https://pubmed.ncbi.nlm.nih.gov/16889227

المؤلفون: Piet Herdewijn, Hans De Winter, Mattheus Froeyen, Eveline Lescrinier, Robert Esnouf, Brigitte Allart, Berthold Wroblowski

المصدر: ChemInform. 31

مصطلحات موضوعية: chemistry.chemical_classification, Molecular dynamics, chemistry.chemical_compound, Aqueous solution, chemistry, Stereochemistry, Oligonucleotide, Ribose, Nucleic acid, Solvation, RNA, Nucleotide, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::827ddaea9cf13aa7ba734ff9dfd176ec
https://doi.org/10.1002/chin.200052195

المؤلفون: Roger Busson, Leslie E. Orgel, Igor A. Kozlov, Luc Kerremans, Piet Herdewijn, Magdalene Zielinski, Arthur Van Aerschot, Brigitte Allart

المصدر: Scopus-Elsevier

مصطلحات موضوعية: musculoskeletal diseases, Stereochemistry, Guanosine Monophosphate, Oligonucleotides, Catalysis, Nucleobase, chemistry.chemical_compound, Sugar Alcohols, immune system diseases, Nucleic Acids, skin and connective tissue diseases, Oligonucleotide, Chemistry, Organic Chemistry, RNA, General Chemistry, DNA, Templates, Genetic, Template synthesis, Carbohydrate moiety, stomatognathic diseases, Monomer, Nucleic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21bd161be492baf3922c0e42bf754f2d
https://pubmed.ncbi.nlm.nih.gov/10747399

المؤلفون: Brigitte Allart, Georges Guillerm, Danielle Guillerm

المصدر: Nucleosidesnucleotides. 18(4-5)

مصطلحات موضوعية: Stereochemistry, Chemistry, medicine.disease_cause, Biochemistry, Catalysis, Substrate Specificity, Kinetics, Methylthioadenosine nucleosidase, Genetics, medicine, Escherichia coli, Substrate specificity, N-Glycosyl Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11de15d16d4ee7b2e426947147da903
https://pubmed.ncbi.nlm.nih.gov/10432695

المؤلفون: Marie Gatel, Georges Guillerm, Danielle Guillerm, Brigitte Allart

المصدر: European journal of biochemistry. 256(1)

مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Oxocarbenium, Active site, Substrate (chemistry), Glycosidic bond, Hydrogen-Ion Concentration, Deuterium, Biochemistry, Catalysis, Substrate Specificity, Adenosylhomocysteine nucleosidase, Nucleophile, Methylthioadenosine nucleosidase, chemistry, Models, Chemical, Purine-Nucleoside Phosphorylase, biology.protein, Escherichia coli, N-Glycosyl Hydrolases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d73bb3201bb360c1a2efd045250a5bf
https://pubmed.ncbi.nlm.nih.gov/9746359

المؤلفون: C. Hendrix, B. De Bouvere, N. Hossain, H. L. De Winter, Berthold Wroblowski, Piet Herdewijn, I. Verheggen, Guy Schepers, Brigitte Allart, A. Van Aerschot

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Base (group theory), chemistry.chemical_compound, Oligonucleotide, Stereochemistry, Chemistry, Group (periodic table), Genetics, Moiety, Hydroxymethyl, Carbohydrate, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d15153c25fb1001cbf3913e34f8e36
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032780789&partnerID=MN8TOARS