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1
المؤلفون: Ashish Kalra, Jeffrey D. Kearns, Adnan O. Abu-Yousif, Gavin MacBeath, Alexey Lugovskoy, Maria Håkansson, Derek T. Logan, Birgit Schoeberl, Martin Welin, Melissa Geddie, Ulrik B. Nielsen, Neeraj Kohli, Tim Maiwald, Jessica B. Casaletto, Aaron Fulgham, Brian Harms, Shrikanta Chattopadhyay, Stephen Su, Maja Razlog, Antoine Boudot, Kristina Masson, Andreas Raue
المصدر: Proceedings of the National Academy of Sciences. 116:7533-7542
مصطلحات موضوعية: medicine.drug_class, Monoclonal antibody, Mice, chemistry.chemical_compound, Antineoplastic Agents, Immunological, Antigen, Cell Line, Tumor, Antibodies, Bispecific, medicine, Animals, Humans, Binding site, Receptor, Multidisciplinary, biology, Hepatocyte Growth Factor, Chemistry, Epithelial cell adhesion molecule, Neoplasms, Experimental, Proto-Oncogene Proteins c-met, Epithelial Cell Adhesion Molecule, Xenograft Model Antitumor Assays, PNAS Plus, Cancer cell, Cancer research, biology.protein, Hepatocyte growth factor, Antibody, Signal Transduction, medicine.drug
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2
المؤلفون: Victoria Rimkunas, Jian Tang, Alexey Lugovskoy, Rachel Rennard, Kenneth J. Olivier, Lihui Xu, Sergio Iadevaia, Birgit Schoeberl, Bryan Johnson, Jonathan Fitzgerald, Neeraj Kohli, Brian Harms, Jason Baum, Yang Jiao, Sharlene Adams, Ulrik B. Nielsen, Maja Razlog
المصدر: Molecular Cancer Therapeutics. 13:410-425
مصطلحات موضوعية: Cancer Research, Receptor, ErbB-3, Blotting, Western, Mice, Nude, Docetaxel, Mice, SCID, Biology, Pharmacology, Antibodies, Monoclonal, Humanized, Deoxycytidine, Receptor, IGF Type 1, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Mice, Inbred NOD, Cell Line, Tumor, Neoplasms, Antibodies, Bispecific, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, ERBB3, Everolimus, Receptor, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Gemcitabine, Tumor Burden, Oncology, chemistry, Cancer cell, Female, Taxoids, Signal transduction, Growth inhibition, Proto-Oncogene Proteins c-akt, Signal Transduction, medicine.drug
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3
المؤلفون: Alexey Lugovskoy, Brian Harms, Jeffrey D. Kearns, Sergio Iadevaia
المصدر: Methods. 65:95-104
مصطلحات موضوعية: Receptor, ErbB-3, Receptor, ErbB-2, Computational biology, Biology, Protein Engineering, General Biochemistry, Genetics and Molecular Biology, Cell Line, Receptor, IGF Type 1, Inhibitory Concentration 50, Immune system, Binding efficiency, Antigen, Antibody Specificity, Antibodies, Bispecific, Animals, Humans, Avidity, Molecular Biology, Effector, Antibodies, Monoclonal, Acquired immune system, Immunoglobulin G, Monoclonal, Immunology, biology.protein, Antibody, Proto-Oncogene Proteins c-akt, Protein Binding
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4
المؤلفون: Jonathan Fitzgerald, Gavin MacBeath, Aaron Fulgham, Victor Moyo, Brian Harms, Emily Pace, Art Kudla, Gregory J. Finn, Viara P. Grantcharova, Jeff Kearns, Kristina Masson, Bambang Adiwijaya, Michael D. Curley, Gabriela Garcia, Ulrik B. Nielsen, Birgit Schoeberl, Bill Kubasek, Jaeyeon Kim, Olga Burenkova, Rachel Nering, Marisa Wainszelbaum, Sara Mathews, Ashish Kalra, Defne Yarar, Violette Paragas, Akos Czibere, Kip A. West
المصدر: NPJ Systems Biology and Applications
مصطلحات موضوعية: 0301 basic medicine, Review Article, Pharmacology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, ErbB, Drug Discovery, Medicine, ERBB3, Epidermal growth factor receptor, biology, business.industry, Applied Mathematics, Seribantumab, Cancer, medicine.disease, Computer Science Applications, 030104 developmental biology, 030220 oncology & carcinogenesis, Modeling and Simulation, Cancer research, biology.protein, Neuregulin, business, Ovarian cancer
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5
المؤلفون: Violette Paragas, Matt Wallace, Stephanie Nguyen, Ryan Overland, Michael Feldhaus, Neeraj Kohli, Lia Luus, Brian Harms, Birgit Schoeberl, Bo Zhang, Aruthur J Kudla, Sharlene Adams, Ulrik B. Nielsen, Charlotte Mcdonagh, Shinji Oyama, Jinming Gu, Alexandra Huhalov
المصدر: Molecular Cancer Therapeutics. 11:582-593
مصطلحات موضوعية: Cancer Research, Receptor, ErbB-3, Receptor, ErbB-2, medicine.drug_class, Neuregulin-1, Blotting, Western, Mice, Nude, Antineoplastic Agents, Mice, SCID, Pharmacology, Lapatinib, Monoclonal antibody, Inhibitory Concentration 50, Mice, Phosphatidylinositol 3-Kinases, Mice, Inbred NOD, Trastuzumab, Cell Line, Tumor, Neoplasms, Antibodies, Bispecific, medicine, Animals, Humans, Cyclin D1, ERBB3, skin and connective tissue diseases, Receptor, neoplasms, Cell Proliferation, biology, Chemistry, Kinase, Xenograft Model Antitumor Assays, Fusion protein, Oncology, Drug Design, Multiprotein Complexes, biology.protein, Female, Antibody, Protein Binding, Signal Transduction, medicine.drug
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6
المؤلفون: Ilse Y. Guzman-Jimenez, Joseph L. Stark, ‡ and Jean-François Halet, Jean-Yves Saillard, Brian Harms, Régis Gautier, Kenton H. Whitmire
المصدر: Journal of the American Chemical Society. 121:4409-4418
مصطلحات موضوعية: Hypervalent molecule, chemistry.chemical_element, General Chemistry, Electronic structure, Biochemistry, Catalysis, Metal, Crystallography, chemistry.chemical_compound, Colloid and Surface Chemistry, chemistry, Bromide, Cubane, Computational chemistry, visual_art, Cluster (physics), visual_art.visual_art_medium, Electron counting, Palladium
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7
المؤلفون: Alexey Kamyshny, David T. Adams, John B. Cliff, James Farquhar, Brian Harms, Mark Claire, Aubrey L. Zerkle, Simon W. Poulton
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 110(44)
مصطلحات موضوعية: Geological Phenomena, Multidisciplinary, Isotope, Hydrogen sulfide, Iron, Geochemistry, chemistry.chemical_element, engineering.material, Isotopes of sulfur, Sulfides, Sulfur, chemistry.chemical_compound, South Africa, δ34S, chemistry, Chemistry and Applications in Nature of Mass Independent Isotope Effects Special Feature, Sulfur Isotopes, engineering, Sedimentary rock, Pyrite, Sulfate, Geology, History, Ancient, Electron Probe Microanalysis
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8
المؤلفون: Hao Zou, Ulrik B. Nielsen, Fraser Conrad, Yu Zhou, Brian Harms, Anne Laure Goenaga, Gregory P. Adams, Jianlong Lou, James D. Marks, Birgit Schoeberl
المصدر: Molecular cancer therapeutics. 11(7)
مصطلحات موضوعية: Cancer Research, Antibody Affinity, Gene Expression, Plasma protein binding, Epitope, Article, Epidermal growth factor, Cell Line, Tumor, Neoplasms, Potency, Humans, Avidity, Phosphorylation, Receptor, Cell Proliferation, biology, Epidermal Growth Factor, Antibodies, Monoclonal, Molecular biology, ErbB Receptors, Oncology, Biochemistry, biology.protein, Antibody, Protein Binding
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9
المؤلفون: Neeraj Kohli, Stephen Su, Brian Harms, Ulrik B. Nielsen, Jeffrey D. Kearns, Birgit Schoeberl
مصطلحات موضوعية: Computational model, biology, medicine.diagnostic_test, medicine.drug_class, Chemistry, Monoclonal antibody, Molecular biology, Receptor tyrosine kinase, Flow cytometry, Antigen, biology.protein, medicine, Biophysics, Potency, Avidity, Antibody
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10
المؤلفون: Harry Oduro, George D. Cody, Herman O. Sintim, Brian Harms, Alan J. Kaufman, James Farquhar
مصطلحات موضوعية: Multidisciplinary, Hot Temperature, Isotope, Sulfates, Inorganic chemistry, Electron Spin Resonance Spectroscopy, chemistry.chemical_element, Isotopes of sulfur, Early Earth, Sulfur, chemistry.chemical_compound, Magnetics, Isotope fractionation, chemistry, Models, Chemical, Kinetic isotope effect, Physical Sciences, Sulfur Isotopes, Sulfate, Amino Acids, Magnetic isotope effect, Oxidation-Reduction
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11
المؤلفون: Bryan Linggi, Violette Paragas, Ashish Kalra, Jonathan Fitzgerald, Magdalena Leszczyniecka, Viara P. Grantcharova, Lihui Xu, Neeraj Kohli, Raghida Bukhalid, Lin Nie, Ulrik B. Nielsen, Kip A. West, Brian Harms, Arthur J. Kudla, Birgit Schoeberl, Michael Feldhaus, Emily Pace
المصدر: Science Signaling. 2
مصطلحات موضوعية: Receptor, ErbB-3, Transplantation, Heterologous, Biology, Antibodies, Monoclonal, Humanized, Ligands, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, ErbB, Animals, Humans, ERBB3, Epidermal growth factor receptor, Phosphorylation, Receptor, Molecular Biology, PI3K/AKT/mTOR pathway, Antibodies, Monoclonal, Cell Biology, ErbB Receptors, Transplantation, Cancer research, biology.protein, Signal transduction, Protein Binding, Signal Transduction
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12Applications of sensitivity analysis for drug discovery and development in the ErbB receptor network
المؤلفون: Ricardo E. Paxson, Ulrik B. Nielsen, Brian Harms, Birgit Schoeberl, Allen Lee
المصدر: BMC Systems Biology, Vol 1, Iss Suppl 1, p P74 (2007)
مصطلحات موضوعية: MAPK/ERK pathway, Drug discovery, Systems biology, In silico, Applied Mathematics, Computational biology, Biology, Computer Science Applications, lcsh:Biology (General), ErbB, Structural Biology, Modeling and Simulation, Modelling and Simulation, Akt phosphorylation, Receptor, Molecular Biology, lcsh:QH301-705.5, Intracellular
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13
المؤلفون: Brian Harms, Neil Kumar, Douglas A. Lauffenburger, Sarah Sheppard, Raffi Afeyan
المصدر: Biochemical and biophysical research communications. 354(1)
مصطلحات موضوعية: Biophysics, Gene Expression, Biology, Mitogen-activated protein kinase kinase, Biochemistry, Article, MAP2K7, Humans, Insulin, Kinase activity, Phosphorylation, Molecular Biology, Protein kinase B, MAP kinase kinase kinase, Dose-Response Relationship, Drug, Epidermal Growth Factor, Akt/PKB signaling pathway, Cyclin-dependent kinase 2, Cell Biology, Molecular biology, Enzyme Activation, biology.protein, Cyclin-dependent kinase 9, HT29 Cells, Proto-Oncogene Proteins c-akt, Signal Transduction
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14
المؤلفون: Alan, Wells, Brian, Harms, Akihiro, Iwabu, Lily, Koo, Kirsty, Smith, Linda, Griffith, Douglas A, Lauffenburger
المصدر: Methods in molecular biology (Clifton, N.J.). 327
مصطلحات موضوعية: ErbB Receptors, Mice, Wound Healing, Cell Movement, Cell Adhesion, Animals, Pseudopodia, Signal Transduction
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15Academic Journal
المؤلفون: Jonathan Fitzgerald, Lucia Wille, Birgit Schoeberl, Brian Harms, Emily Pace, Art Kudla, Ulrik Nielsen
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: computational modeling, drug
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.590.63; http://cnls.lanl.gov/q-bio/wiki/images/a/ac/Poster08-fitzgerald.pdf
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16
المؤلفون: Carlos M. Ferregut, Roberto A Osegueda, David Meza, Cesar J. Carrasco, Brian Harms, Mike Grygier
المصدر: Engineering, Construction, and Operations in Space V.
مصطلحات موضوعية: Vibration, Modal, Data collection, Computer science, business.industry, Truss, Structural engineering, business, Space (mathematics), Scale model, Three dimensional model
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17
المؤلفون: Birgit Schoeberl, V. Grantcharova, Ulrik B. Nielsen, E. Stewart, Brian Harms
المصدر: European Journal of Cancer Supplements. 4:196
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, Colorectal cancer, Internal medicine, medicine.medical_treatment, medicine, business, medicine.disease, Targeted therapy
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18
المصدر: Biophysical Journal. (2):1479-1488
مصطلحات موضوعية: Biophysics, Motility, CHO Cells, Biology, Cricetulus, Cell Movement, Epidermal growth factor, Cricetinae, Cell Adhesion, Animals, Pseudopodia, Cell adhesion, Dose-Response Relationship, Drug, Epidermal Growth Factor, Chinese hamster ovary cell, Cell migration, Adhesion, Recombinant Proteins, Fibronectins, Cell biology, ErbB Receptors, Fibronectin, Cell Biophysics, biology.protein, Oligopeptides