المؤلفون: Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer

المصدر: Frontiers in Neurology, Vol 12 (2021)

مصطلحات موضوعية: Huntington's disease, neurodegenerative, biomarkers, neuroimaging, volumetric MRI, C-Path, Neurology. Diseases of the nervous system, RC346-429

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2021.712555/full; https://doaj.org/toc/1664-2295

URL الوصول: https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75

المؤلفون: Jessica E. Garb, Brian Bettencourt, Sara J. Dunaj, Robert M. Brucker

المصدر: BMC Evolutionary Biology
BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-17 (2020)

مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Hologenome, Evolution, Zoology, Context (language use), Biology, complex mixtures, 010603 evolutionary biology, 01 natural sciences, Phylosymbiosis, 03 medical and health sciences, Arthropod evolution, Phylogenetics, RNA, Ribosomal, 16S, QH359-425, Animals, Microbiome, Cephalothorax, Symbiosis, Phylogeny, Ecology, Evolution, Behavior and Systematics, Metatranscriptomics, Spider, Common house spider, Phylogenetic tree, Host (biology), Microbiota, Host-microbe interactions, Black widow spiders, Spiders, Biological Evolution, 030104 developmental biology, Hologenome theory of evolution, Female, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fc65c811cc61911a27e1ccf29f640e
https://doi.org/10.1186/s12862-020-01664-x

المؤلفون: Akshay Vaishnaw, Peter L.J. Wijngaard, Amy Simon, Brian Bettencourt, Kevin Fitzgerald, Jay D. Horton, Chamikara Fernando, Jorg Taubel, Anna Borodovsky, Ashley Brooks, Valerie A. Clausen, Andrew Strahs, Robert S. Kauffman, David Kallend, Suellen White

المصدر: New England Journal of Medicine. 376:41-51

مصطلحات موضوعية: 0301 basic medicine, business.industry, Cholesterol, PCSK9, General Medicine, 030204 cardiovascular system & hematology, Pharmacology, Placebo, law.invention, 03 medical and health sciences, Subcutaneous injection, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Randomized controlled trial, chemistry, law, Pharmacodynamics, Medicine, lipids (amino acids, peptides, and proteins), business, Adverse effect, Lipoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::785b9837d364de10753887f8881d7c1a
https://doi.org/10.1056/nejmoa1609243

المؤلفون: Jared Gollob, Verena Karsten, Brian Bettencourt, Malcolm Boyce, Akshay Vaishnaw, Joseph Chiesa, Tracy Zimmermann, Saraswathy V. Nochur, Renta Hutabarat, Amy Chan

المصدر: Molecular Therapy. 25:71-78

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Small interfering RNA, Acetylgalactosamine, Asialoglycoprotein Receptor, Pharmacology, Young Adult, 03 medical and health sciences, Pharmacokinetics, RNA interference, Drug Discovery, Genetics, Humans, Prealbumin, Medicine, Gene silencing, Gene Silencing, RNA, Small Interfering, Molecular Biology, biology, business.industry, Middle Aged, Healthy Volunteers, Transthyretin, 030104 developmental biology, Tolerability, Pharmacodynamics, Hepatocytes, biology.protein, Molecular Medicine, Female, Original Article, Asialoglycoprotein receptor, Drug Monitoring, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ce51f9dee2f966f951d04fb89269d
https://doi.org/10.1016/j.ymthe.2016.10.019

المؤلفون: Patrick Haslett, Timothy Racie, William Querbes, David Erbe, Abigail Liebow, Julia Hettinger, Brian Bettencourt, John Knight, Xingsheng Li, Ross P. Holmes, Kevin Fitzgerald, Nader Najafian

المصدر: Journal of the American Society of Nephrology. 28:494-503

مصطلحات موضوعية: Male, Primates, 0301 basic medicine, Calcium oxalate, Pharmacology, Oxalate, End stage renal disease, RNAi Therapeutics, Primary hyperoxaluria, Mice, 03 medical and health sciences, chemistry.chemical_compound, RNA interference, Primary Hyperoxaluria Type I, medicine, Animals, Gene Silencing, RNA, Messenger, Oxalates, Kidney, General Medicine, medicine.disease, Rats, Alcohol Oxidoreductases, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Liver, chemistry, Biochemistry, Nephrology, Hyperoxaluria, Primary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed87ff05ad92abfa79a372a3429b2ba
https://doi.org/10.1681/asn.2016030338

المؤلفون: Paula Gonçalves, Susete Costelha, Jennifer L. S. Willoughby, Shannon Fishman, Dinah W.Y. Sah, Rachel Meyers, James Butler, Kallanthottathil G. Rajeev, Rene Alvarez, Qingmin Chen, Tracy Zimmermann, Brian Bettencourt, Todd Borland, June Qin, Kevin Fitzgerald, Maria João Saraiva, Muthiah Manoharan, Stuart Milstein, Amy Chan, Donald Foster, Saraswathy V. Nochur

المصدر: Amyloid

مصطلحات موضوعية: Male, 0301 basic medicine, Tafamidis, Pathology, Small interfering RNA, Drug Evaluation, Preclinical, Gene Expression, Mice, gene silencing, chemistry.chemical_compound, 0302 clinical medicine, RNA interference, Prealbumin, RNA, Small Interfering, Benzoxazoles, Gene knockdown, biology, Amyloidosis, Anti-Inflammatory Agents, Non-Steroidal, lipid nanoparticle, Liver, Female, RNA Interference, Original Article, endocrine system, medicine.medical_specialty, Amyloid, Mice, Transgenic, Article, 03 medical and health sciences, Internal Medicine, medicine, Animals, Humans, Gene silencing, RNA, Messenger, Amyloid Neuropathies, Familial, nutritional and metabolic diseases, medicine.disease, GalNAc, Disease Models, Animal, Macaca fascicularis, therapeutic, Transthyretin, 030104 developmental biology, chemistry, siRNA, biology.protein, Cancer research, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a684c021114a93d3a2a719c981318402
https://doi.org/10.3109/13506129.2016.1160882

المؤلفون: William S. Blaner, John Vest, Altaf Pirmohamed, Codruta Chiuzan, Mathew S. Maurer, Adam Castano, Richard Weinberg, Verena Karsten, Sabahat Bokhari, Albert DeLuca, Brian Bettencourt, Ted Pozniakoff, Jared Gollob

المصدر: Journal of Nuclear Cardiology. 23:1355-1363

مصطلحات موضوعية: Noninvasive imaging, Pathology, medicine.medical_specialty, chemistry.chemical_element, 030204 cardiovascular system & hematology, Technetium, Scintigraphy, Pyrophosphate, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Serial scanning, Medicine, Radiology, Nuclear Medicine and imaging, biology, medicine.diagnostic_test, business.industry, Amyloidosis, medicine.disease, Transthyretin, chemistry, Cardiac amyloidosis, biology.protein, Cardiology and Cardiovascular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06a11026e9d744fa40706b65178f659f
https://doi.org/10.1007/s12350-015-0261-x

المؤلفون: Zoia Mincheva, William J. Litchy, Jared Gollob, Brian Bettencourt, Pritesh Gandhi, Peter J. Dyck, David H. Adams, Narupat Suanprasert, Laura Obici, Giampaolo Merlini, Teresa Coelho

المصدر: Neurology. 85:675-682

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Cross-sectional study, Population, Severity of Illness Index, Article, Internal medicine, Severity of illness, Humans, Medicine, Age of Onset, education, health care economics and organizations, Aged, Amyloid Neuropathies, Familial, education.field_of_study, Portugal, biology, business.industry, Middle Aged, medicine.disease, United States, Amyloid Neuropathy, Transthyretin, Cross-Sectional Studies, Italy, Disease Progression, biology.protein, Female, France, Neurology (clinical), Age of onset, business, Polyneuropathy, Natural history study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5165a76499a7ad3eda6415c4bb12c3
https://doi.org/10.1212/wnl.0000000000001870

المؤلفون: Brian Bettencourt, Noah D. Charney, Andrea T. Ireland

المصدر: Journal of Herpetology. 48:210-219

مصطلحات موضوعية: Host (biology), Zoology, Vertebrate, Biology, Disjunct, biology.organism_classification, Genome, Ambystoma jeffersonianum, biology.animal, Genotype, Microsatellite, Animal Science and Zoology, Evolutionary dynamics, Ecology, Evolution, Behavior and Systematics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2228140200632bd090cdc38483657a95
https://doi.org/10.1670/12-212

المؤلفون: Joseph Chiesa, Amy Simon, Jeffrey Cehelsky, Brian Bettencourt, Kevin Fitzgerald, Valerie A. Clausen, Jessica E. Sutherland, Maria Frank-Kamenetsky, Renta Hutabarat, Jay D. Horton, JM Ritter, Timothy Mant, Svetlana Shulga-Morskaya, Verena Karsten, Malathy Munisamy, Abigail Liebow, Akshay Vaishnaw, Jared Gollob, Victor Kotelianski, Saraswathy V. Nochur

المصدر: The Lancet. 383:60-68

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Bococizumab, Placebo, Article, chemistry.chemical_compound, Internal medicine, medicine, Humans, Single-Blind Method, RNA, Small Interfering, Dose-Response Relationship, Drug, Cholesterol, business.industry, PCSK9, Serine Endopeptidases, Area under the curve, Cholesterol, LDL, Genetic Therapy, General Medicine, Middle Aged, Healthy Volunteers, Endocrinology, chemistry, Tolerability, Pharmacodynamics, LDL receptor, RNA Interference, Female, Proprotein Convertases, Proprotein Convertase 9, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8c11c6c882cccf5c09317e25602966
https://doi.org/10.1016/s0140-6736(13)61914-5

المؤلفون: Robert Brian Bettencourt, Michael M. Linder

المصدر: Primary Care: Clinics in Office Practice. 40:259-269

مصطلحات موضوعية: medicine.medical_specialty, Stinger (medicine), biology, business.industry, Athletes, Spinal stenosis, Cervical spinal stenosis, Disease, medicine.disease, biology.organism_classification, Spinal cord, Neck Injuries, Sports Equipment, medicine.anatomical_structure, Peripheral Nerve Injuries, Preparedness, Athletic Injuries, Cervical Nerve, Cervical Vertebrae, Physical therapy, Humans, Medicine, Pharmacology (medical), business, Spinal Cord Injuries

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6077e82292c9b3e5794103a4079cf4
https://doi.org/10.1016/j.pop.2013.02.012

المؤلفون: Stuart Pollard, Chen Li, Zoltan Szabo, David Kocisko, Klaus Charisse, Barry L. Karger, Shiaw Lin Wu, Rachel Meyers, Seshu Tummala, András Guttman, Brian Bettencourt, Chunhua Wang, Greg Thill, Michael Titus, Stuart Milstein, Donald Foster, Carlo Ciatto, Anthony Rossomando, Satya Kuchimanchi, Jack Deroot, Muthuswamy Jayaraman, Lee Wilson, Greg Hinkle

المصدر: Biotechnology Progress. 29:415-424

مصطلحات موضوعية: Small interfering RNA, Antibody-Dependent Cell Cytotoxicity, Antibodies, Monoclonal, Context (language use), Transfection, Biology, Fucosyltransferases, Article, Cell Line, Small hairpin RNA, Metabolic engineering, Metabolic Engineering, Biochemistry, RNA interference, Cell culture, Animals, Humans, Gene silencing, Gene Silencing, RNA, Small Interfering, Protein Processing, Post-Translational, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df122f18fc10a1b505e18de4f572b7a
https://doi.org/10.1002/btpr.1667

المؤلفون: Juan Buades, Hartmut Schmidt, Akshay Vaishnaw, Josep M. Campistol, David Adams, Jean Pouget, Jared Gollob, Brian Bettencourt, Ole B. Suhr, Isabel Conceição, Teresa Coelho, John L. Berk, Márcia Waddington-Cruz

المساهمون: Department of Public Health & Clinical Medicine, Section for Medicine, Umeå University Hospital Sweden, Hospital de Santo António, Centro Hospitalar do Porto, Servicio de Medicina Interna, Hospital Son Llatzer, Hôpital de la Timone [CHU - APHM] (TIMONE), Centro Hospitalar Lisboa Norte-Hospital de Santa Maria, Boston University [Boston] (BU), Universitätsklinikum Münster, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Hospital Clinic, University of Barcelona, Alnylam Pharmaceuticals, National Reference Center for FAP (NNERF)/ APHP/ INSERM U 1191, Hôpital de Bicêtre, HAL AMU, Administrateur

المصدر: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, BioMed Central, 2015, 10 (109 ), ⟨10.1186/s13023-015-0326-6⟩
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

مصطلحات موضوعية: Male, neuropatías amiloideas, humanos, Transthyretin-mediated familial amyloidotic polyneuropathy, Genetic mutation, Amyloid Neuropathies, Gastroenterology, 0302 clinical medicine, RNA interference, Genetics(clinical), Pharmacology (medical), RNA, Small Interfering, mediana edad, Genetics (clinical), Medicine(all), anciano, 0303 health sciences, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, Amyloidosis, General Medicine, Middle Aged, RNA interferenc, Phase II, 3. Good health, ARN, Clinical trial, Tolerability, Vomiting, Patisiran, Female, medicine.symptom, Polyneuropathy, medicine.medical_specialty, Population, Hereditary disease, 03 medical and health sciences, Pharmacokinetics, Internal medicine, medicine, Humans, education, 030304 developmental biology, Aged, Amyloid Neuropathies, Familial, Dose-Response Relationship, Drug, business.industry, Research, medicine.disease, Transthyretin, Endocrinology, Pharmacodynamics, biology.protein, RNA, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d843bffbb5a94fb26b80776a45cbe3cb
http://europepmc.org/articles/PMC4559363

المؤلفون: Adam, Castaño, Albert, DeLuca, Richard, Weinberg, Ted, Pozniakoff, William S, Blaner, Altaf, Pirmohamed, Brian, Bettencourt, Jared, Gollob, Verena, Karsten, John A, Vest, Codruta, Chiuzan, Mathew S, Maurer, Sabahat, Bokhari

المصدر: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 23(6)

مصطلحات موضوعية: Male, Technetium Tc 99m Pyrophosphate, Reproducibility of Results, Amyloidosis, Image Enhancement, Sensitivity and Specificity, Subtraction Technique, Humans, Female, Single-Blind Method, Longitudinal Studies, Radiopharmaceuticals, Cardiomyopathies, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::b6c5a2dcb95df921f513858d9c53038c
https://pubmed.ncbi.nlm.nih.gov/26542989

المؤلفون: A. Plaisted, Saraswathy V. Nochur, R. De Frutos, Jared Gollob, Akshay Vaishnaw, David H. Adams, Jeffrey Cehelsky, Brian Bettencourt, R. N. Denoncourt, O. Amitay, Lindsey White, T. Coelho, Jamie Harrop, Rick Falzone

المصدر: Value in Health. 18(3)

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, business.industry, Health Policy, Disease progression, medicine, Public Health, Environmental and Occupational Health, medicine.disease, business, Polyneuropathy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b4e315c5831e8c78ba51b1751bfeefb

المؤلفون: David J. Calderwood, Wendy Waegell, Michelle Hart, Gavin C. Hirst, Annette Schwartz, Sheldon E. Ratnofsky, Brian Bettencourt, Robert F. Stachlewitz, Tegest Kebede

المصدر: Journal of Pharmacology and Experimental Therapeutics. 315:36-41

مصطلحات موضوعية: Graft Rejection, Male, Interleukin 2, T-Lymphocytes, T cell, Pharmacology, Lymphocyte Activation, In vivo, Rats, Inbred BN, Cyclosporin a, medicine, Animals, Transplantation, Homologous, Src family kinase, biology, Intracellular Signaling Peptides and Proteins, Rats, Transplantation, Pyrimidines, medicine.anatomical_structure, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Rats, Inbred Lew, Concanavalin A, Immunology, biology.protein, Heart Transplantation, Interleukin-2, Pyrazoles, Molecular Medicine, Tyrosine kinase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c3e81f6ec872f12ffe0a6183de4445
https://doi.org/10.1124/jpet.105.089169

المؤلفون: Martin Maier, Akin Akinc, Brian Bettencourt

المصدر: Gene and Cell Therapy ISBN: 9781466571990
Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, Fourth Edition

مصطلحات موضوعية: business.industry, Medicine, Computational biology, business, RNAi Therapeutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a8313cec0ac134946019218b6e757262
https://doi.org/10.1201/b18002-24

المؤلفون: Nadine Haase, Don Foster, Julia Bercher, Stuart Milstein, Michaela Golic, Klaus Charisse, Julianna Rugor, Satya Kuchimanchi, Lukasz Przybyl, Brian Bettencourt, Dominik N Müller, Greg Hinkle, Ralf Dechend

المصدر: Hypertension. 64

مصطلحات موضوعية: Internal Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ac3a7b4c9bd32a7faab281e20c9b48a0
https://doi.org/10.1161/hyp.64.suppl_1.666

المؤلفون: Una Mckeever, Sanjay S. Khandekar, Brian Bettencourt, Michael I. Jesson, Paul G. Gregory, John R. Newcomb, Jerome Naylor, Julian Banerji, Pamela P. Brauer, Barry Jones

المصدر: International Immunology. 10:27-35

مصطلحات موضوعية: Recombinant Fusion Proteins, T-Lymphocytes, T cell, Molecular Sequence Data, Immunology, Receptors, Antigen, T-Cell, Mice, Inbred Strains, chemical and pharmacologic phenomena, Biology, Lymphocyte Activation, Epitope, Mice, Immune system, Adjuvants, Immunologic, Antigen, parasitic diseases, medicine, Animals, Immunology and Allergy, Amino Acid Sequence, Vaccines, Immunogenicity, T-cell receptor, hemic and immune systems, General Medicine, Molecular biology, Recombinant Proteins, Tolerance induction, medicine.anatomical_structure, Solubility, Immunoglobulin G, Antibody Formation, biology.protein, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4779d4f98fa7f7ca53df817f2ad7d4e
https://doi.org/10.1093/intimm/10.1.27

المؤلفون: John L. Berk, Jared Gollob, Brian Bettencourt, Peter J. Dyck, Merrill D. Benson, Christopher J. Klein, Narupat Suanprasert, Verena Karsten

المصدر: Journal of the neurological sciences. 344(1-2)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Weakness, Neural Conduction, Neurophysiology, Sural nerve, Cohort Studies, Young Adult, Sensation, Medicine, Humans, Autonomic Pathways, Aged, Neurologic Examination, Amyloid Neuropathies, Familial, biology, business.industry, Middle Aged, Surgery, Compound muscle action potential, Sudomotor, Transthyretin, medicine.anatomical_structure, Neurology, Lower Extremity, Anesthesia, biology.protein, Female, Neurology (clinical), Protein stabilization, medicine.symptom, business, Sensory nerve

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427620ecf70956e864930ba090834ea6
https://pubmed.ncbi.nlm.nih.gov/25012480