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1Academic Journal
المؤلفون: Natalie Holmberg-Douglas (7254830), Younggi Choi (2531542), Brian Aquila (1414042), Hoan Huynh (1738915), David A. Nicewicz (1336134)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Evolutionary Biology, Marine Biology, Cancer, Computational Biology, Saturated Aza-Heterocycles Enabled, photoredox catalysis approach, photoredox-catalyzed copper-mediate., β- functionalization, ene-carbamate, aza-heterocycle, Organic Photoredox Catalysis, heteroatom-containing nucleophiles .
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2
المصدر: ACS Catal
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Photoredox catalysis, Surface modification, Dehydrogenation, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Article, Catalysis, 0104 chemical sciences
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3
المؤلفون: Ingo Muegge, Brian Aquila, Choi Younggi, Lewis D. Pennington, Valiulin Roman A
المصدر: Journal of medicinal chemistry. 63(17)
مصطلحات موضوعية: Drug, Nitrogen, media_common.quotation_subject, Heteroatom, 01 natural sciences, Hydrocarbons, Aromatic, 03 medical and health sciences, Structure-Activity Relationship, Heterocyclic Compounds, Microsomes, Drug Discovery, Structure–activity relationship, Animals, Humans, 030304 developmental biology, media_common, 0303 health sciences, Chemistry, Fluorine, Combinatorial chemistry, Matrix Metalloproteinases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Hydrophobic and Hydrophilic Interactions
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4
المؤلفون: Nancy Su, Brian Aquila, Gareth P. Gregory, Stephen Fawell, J. Adam Hendricks, Ammar Adam, Lawrence H. Boise, Jeffrey W. Johannes, Kevin J. Embrey, Edwin Clark, Philip B. Rawlins, Justin Cidado, Francis D. Gibbons, Ricky W. Johnstone, Qing Ye, Elisabetta Chiarparin, Steven L. Kazmirski, Michelle Lamb, J. Paul Secrist, Wenzhan Yang, Alexander Hird, Daniel W. Robbins, Adriana E. Tron, Alwin Schuller, Martin J. Packer, David J. Hargreaves, Xiaolan Zheng, Matthew A. Belmonte, Eric Gangl, Ajay K. Nooka, Shannon M. Matulis, Jason Grant Kettle, Bo Peng, David Matthew Wilson
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Myeloid, General Physics and Astronomy, Apoptosis, Mice, SCID, medicine.disease_cause, Crystallography, X-Ray, Bortezomib, chemistry.chemical_compound, Mice, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, lcsh:Science, Multiple myeloma, Sulfonamides, Multidisciplinary, Myeloid leukemia, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Multiple Myeloma, medicine.drug, Science, Antineoplastic Agents, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Rats, Nude, Cell Line, Tumor, medicine, Animals, Humans, neoplasms, Venetoclax, business.industry, General Chemistry, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Xenograft Model Antitumor Assays, Rats, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Cancer cell, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, lcsh:Q, Carcinogenesis, business
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5
المؤلفون: James E. Dowling, J. Breed, Adrian Whitty, J. Debreczeni, Herschel Mukherjee, Sharon Tentarelli, Neil P. Grimster, Brian Aquila
المصدر: Organic & Biomolecular Chemistry. 15:9685-9695
مصطلحات موضوعية: musculoskeletal diseases, chemistry.chemical_classification, Sulfonyl, Steric effects, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Rational design, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Amino acid, chemistry, Nucleophile, Covalent bond, Molecule, Physical and Theoretical Chemistry, Cysteine
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6
المؤلفون: Mathieu Frenette, Natalie H. Jones, Daniel W. Robbins, Sharon Tentarelli, Antoine Juneau, Jeffrey W. Johannes, Brian Aquila, Martins S. Oderinde
المصدر: Angewandte Chemie International Edition. 55:13219-13223
مصطلحات موضوعية: Steric effects, 010405 organic chemistry, Aryl, chemistry.chemical_element, Halide, General Medicine, General Chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, Coupling reaction, 0104 chemical sciences, chemistry.chemical_compound, Nickel, chemistry, Electrophile, Iridium
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7
المؤلفون: Martins S. Oderinde, Jeffrey W. Johannes, Daniel W. Robbins, Brian Aquila, Adrián Varela-Álvarez
المصدر: The Journal of Organic Chemistry. 80:7642-7651
مصطلحات موضوعية: Light, Molecular Structure, Organic Chemistry, Reproducibility of Results, chemistry.chemical_element, Iridium, Photochemical Processes, Photochemistry, Carbon, Catalysis, Coupling reaction, Oxygen, Solvent, Nickel, chemistry, Solvents, Reaction system, Irradiation, Molecular oxygen, Oxidation-Reduction
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8
المؤلفون: Joe Patel, Matthew A. Belmonte, Neil P. Grimster, Brian Aquila, Herschel Mukherjee, Sharon Tentarelli, David J. Hargreaves, Nancy Su
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:126682
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, bcl-X Protein, Pharmaceutical Science, Bcl-xL, 01 natural sciences, Biochemistry, Protein–protein interaction, Drug Discovery, Humans, Molecule, Tyrosine, Molecular Biology, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Antiapoptotic protein, Covalent bond, biology.protein, Molecular Medicine, Protein Binding, Cysteine, Conjugate
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9
المؤلفون: Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Naomi Laing, Vibha Oza, David Whitston, Victor Kamhi, Jamal Carlos Saeh, Lillian Castriotta, Li Sha, Troy Patterson, Christopher Huntington, Danyang Li, Haiyun Wang, Charles A. Omer, Alexander Hird, Melissa Vasbinder, Donald J. Cook, Michael T. Rooney, Galina Repik, Maureen Hattersley, Ammar Adam
المصدر: Journal of Medicinal Chemistry. 56:9897-9919
مصطلحات موضوعية: Molecular Conformation, Antineoplastic Agents, Pharmacology, Inhibitor of apoptosis, Inhibitor of Apoptosis Proteins, Mice, Structure-Activity Relationship, Biomimetic Materials, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, IC50, Cell Proliferation, Dose-Response Relationship, Drug, Chemistry, Xenograft Model Antitumor Assays, In vitro, XIAP, Apoptosis, Cell culture, Alkynes, Molecular Medicine, Drug Screening Assays, Antitumor, Dimerization, Oligopeptides
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10
المؤلفون: Mathieu Frenette, Jeffrey W. Johannes, Martins S. Oderinde, Brian Aquila, Daniel W. Robbins
المصدر: ChemInform. 47
مصطلحات موضوعية: chemistry.chemical_classification, Radical, Aryl, chemistry.chemical_element, General Medicine, Medicinal chemistry, Catalysis, chemistry.chemical_compound, Nickel, chemistry, Functional group, Molecular oxygen, Thiyl radicals, Alkyl
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11
المؤلفون: Naomi Laing, Nicholas A. Larsen, Jamal Carlos Saeh, Charles A. Omer, Haiyun Wang, Andrew D. Ferguson, Terry MacIntyre, Brian Aquila, Edward J. Hennessy, Li Sha
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1690-1694
مصطلحات موضوعية: Models, Molecular, Steric effects, Clinical Biochemistry, Pharmaceutical Science, Inhibitor of apoptosis, Biochemistry, Inhibitor of Apoptosis Proteins, Protein–protein interaction, Mitochondrial Proteins, Inhibitory Concentration 50, Structure-Activity Relationship, Piperidines, Biomimetics, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Amines, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, XIAP, Cell culture, Apoptosis, Drug Design, Cancer cell, Molecular Medicine, biological phenomena, cell phenomena, and immunity, Apoptosis Regulatory Proteins, Protein Binding
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12
المؤلفون: Ellen Freed, Lucienne Ronco, Timothy Pontz, Patrick Brassil, Haiqing Hu, Xiaolan Zheng, Muthusamy Jayaraman, Davies Audrey, Lillian Castriotta, Dennis Huszar, Maria-Elena Theoclitou, Murali V P Nadella, Daniel John Russell, Brian Aquila, Michael Collins, Vibha Oza, David Whitston, Tracy L. Deegan, Michael Howard Block, Deborah Lawson, Sandra Filla, Maniyan Padmanilayam, Erin Code, Paula Lewis, Jayachandran Ezhuthachan
المصدر: Journal of Medicinal Chemistry. 54:6734-6750
مصطلحات موضوعية: Cell Survival, Stereochemistry, Kinesins, Mice, Nude, Antineoplastic Agents, Stereoisomerism, Pyrimidinones, Plasma protein binding, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Rats, Wistar, Mitosis, Cell Proliferation, Chemistry, Blood Proteins, Rats, Solubility, Cell culture, Benzamides, Hepatocytes, Microsomes, Liver, Microsome, M Phase Cell Cycle Checkpoints, Molecular Medicine, Kinesin, Drug Screening Assays, Antitumor, Protein Binding
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13
المؤلفون: Charles A. Omer, Tracy L. Deegan, Minwei Ye, Les A. Dakin, Paul Lyne, Maureen Hattersley, Donald J. Cook, Xiaolan Zheng, Stephanos Ioannidis, Brian Aquila, Geraldine Bebernitz, Scott David
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:4794-4797
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mice, Nude, Pharmaceutical Science, Antineoplastic Agents, Receptor, Macrophage Colony-Stimulating Factor, Carboxamide, Biochemistry, Chemical synthesis, Mice, chemistry.chemical_compound, In vivo, Neoplasms, Drug Discovery, medicine, Animals, Humans, Thiazole, Molecular Biology, chemistry.chemical_classification, Kinase, Chemistry, Organic Chemistry, Cancer, 3T3 Cells, medicine.disease, Amides, In vitro, Rats, Thiazoles, Enzyme, Molecular Medicine, Female
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14
المؤلفون: Daniel W. Robbins, Mathieu Frenette, Martins S. Oderinde, Jeffrey W. Johannes, Brian Aquila
المصدر: Journal of the American Chemical Society. 138(6)
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Aryl, Radical, chemistry.chemical_element, General Chemistry, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, Catalysis, 0104 chemical sciences, chemistry.chemical_compound, Nickel, Colloid and Surface Chemistry, chemistry, Functional group, Molecular oxygen, Thiyl radicals, Alkyl
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15
المؤلفون: Matthew A. Belmonte, Nancy Su, Sharon Tentarelli, Claudio Chuaqui, Philip B. Rawlins, Alexander Hird, Michelle Lamb, Qibin Su, Gizem Akçay, Neil P. Grimster, Brian Aquila
المصدر: Nature chemical biology. 12(11)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Lysine, 01 natural sciences, 03 medical and health sciences, Residue (chemistry), chemistry.chemical_compound, Structure-Activity Relationship, Structure–activity relationship, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Cell Biology, Hydrogen-Ion Concentration, Small molecule, Boronic Acids, 0104 chemical sciences, 030104 developmental biology, Covalent bond, Myeloid Cell Leukemia Sequence 1 Protein, Boronic acid, Cysteine
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16
المؤلفون: Charles A. Omer, Donald N. Cook, Jeffrey W. Johannes, Lisa Drew, Timothy Pontz, Minwei Ye, Paul Lyne, Benjamin Fauber, Brian Aquila, Edward J. Hennessy, Martin Augustin, Haixia Wang, Sangeetha Palakurthi, Steve C. Glossop, Huawei Chen, Stephen Lee, Mario Mörtl, Melissa Vasbinder, Michael Grondine, Tony Cheung, Li Sha, Allan Wu, Jon Read, Minhui Shen, Stefan Steinbacher
المصدر: Journal of medicinal chemistry. 56(5)
مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, Chemistry, Kinase, Mutant, Small molecule, In vitro, Rats, Mice, Structure-Activity Relationship, Biochemistry, In vivo, Cell culture, Drug Discovery, Quinazolines, Molecular Medicine, Structure–activity relationship, Animals, Humans, Kinase activity, Melanoma, Protein Kinase Inhibitors
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17
المؤلفون: Jeffrey W. Johannes, Brian Aquila, Mathieu Frenette, Natalie H. Jones, Martins S. Oderinde, Sharon Tentarelli, Antoine Juneau, Daniel W. Robbins
المصدر: Angewandte Chemie International Edition. 55:13350-13350
مصطلحات موضوعية: chemistry.chemical_compound, Nickel, Primary (chemistry), chemistry, Aryl, Polymer chemistry, Halide, chemistry.chemical_element, General Chemistry, Iridium, Photochemistry, Catalysis
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18
المؤلفون: Brian Aquila, Mathieu Frenette, Jeffrey W. Johannes, Martins S. Oderinde, Daniel W. Robbins, Natalie H. Jones, Sharon Tentarelli, Antoine Juneau
المصدر: Angewandte Chemie. 128:13546-13546
مصطلحات موضوعية: chemistry.chemical_compound, Nickel, Primary (chemistry), chemistry, Aryl, Polymer chemistry, chemistry.chemical_element, Halide, General Medicine, Iridium, Photochemistry, Catalysis
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19
المؤلفون: Brian Aquila, Rebecca Ellston, Barry R. Davies, Helen Musgrove, Stephanie Klein, Dawn Trueman, Elizabeth Janet Pease, Linette Ruston, Leigh J. Williams
المصدر: Cancer Research. 76:3769-3769
مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Bladder cancer, business.industry, Neutropenia, medicine.disease, medicine.anatomical_structure, Oncology, Urothelial cell carcinoma, Apoptosis, Cancer research, Medicine, Dosing, Bone marrow, Urothelium, business, Mitosis
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20
المؤلفون: Dominique Custeau, Srinivasu Poondru, Qing Ye, Minhui Shen, Donald J. Cook, Jay Ezhuthachan, Michael Howard Block, Lee John W, Paul Lyne, Scott David, Allan Wu, Mei Su, Lisa Drew, Timothy Pontz, Les A. Dakin, Stephanos Ioannidis, Tracy L. Deegan, Scott Cowen, Brian Aquila, Xiaolan Zheng
المصدر: Bioorganicmedicinal chemistry letters. 19(3)
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Chemistry, Pharmaceutical, Clinical Biochemistry, Mutant, Pharmaceutical Science, Administration, Oral, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Cytotoxicity, Mode of action, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Chemistry, Organic Chemistry, Rats, Enzyme, Models, Chemical, Enzyme inhibitor, Mitogen-activated protein kinase, Drug Design, Mutation, biology.protein, ras Proteins, Molecular Medicine, raf Kinases