المؤلفون: Ryan E Feaver, M Scott Bowers, Banumathi K Cole, Steve Hoang, Mark J Lawson, Justin Taylor, Brian D LaMoreaux, Lin Zhao, Brad R Henke, Brian A Johns, Andrew C Nyborg, Brian R Wamhoff, Robert A Figler

المصدر: PLoS ONE, Vol 18, Iss 9, p e0291330 (2023)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0291330&type=printable; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/73653be581c742099685677071b70e9b

المؤلفون: Allison J. Armstrong (10639004), Brad R. Henke (1453429), Maria Sol Collado (10639007), Justin M. Taylor (10639010), Taylor D. Pourtaheri (10639013), John E. Dillberger (10639016), Thomas D. Roper (2718895), Brian R. Wamhoff (199470), Matthew W. Olson (10639019), Robert A. Figler (10639022), Stephen A. Hoang (10639025), John E. Reardon (6829922), Brian A. Johns (1833643)

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, methylmalonic acidemia, Methylmalonic Acidemia Propionic ac., HST 5040, Propionic Acidemia, enzymes P-CoA carboxylase, organ dysfunction, metabolites results, short-chain carboxylic acids, intermediary metabolism, PA, identification, intramitochondrial accumulation, M-CoA, vivo absorption, excretion profile, disease-related metabolites, hepatocyte disease models, autosomal recessive disorders

Relation: https://figshare.com/articles/journal_contribution/Identification_of_2_2-Dimethylbutanoic_Acid_HST5040_a_Clinical_Development_Candidate_for_the_Treatment_of_Propionic_Acidemia_and_Methylmalonic_Acidemia/14410565

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00124.s002

المؤلفون: Brian A. Johns, Christin A. Hamilton, Allison J. Armstrong, Robert A. Figler, Maria Sol Collado, Taylor D. Pourtaheri, Brad R. Henke, Marshall M. Summar, Stephen A. Hoang, Kimberly A. Chapman, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson

المصدر: Mol Genet Metab

مصطلحات موضوعية: 0301 basic medicine, Methylmalonyl-CoA Decarboxylase, Propionic Acidemia, Endocrinology, Diabetes and Metabolism, Methylmalonic acidemia, Methylmalonic acid, 030105 genetics & heredity, Biochemistry, Article, Cell Line, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Valine, Carnitine, Genetics, medicine, Humans, Citrates, Propionic acidemia, Amino Acid Metabolism, Inborn Errors, Molecular Biology, Methionine, Catabolism, Liver cell, Methylmalonyl-CoA Mutase, food and beverages, medicine.disease, chemistry, Hepatocytes, Acyl Coenzyme A, Isoleucine, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2d2bba59a2136c64aeca4cb4d67b68
https://doi.org/10.1016/j.ymgme.2021.03.001

المؤلفون: Olivia Burns, Jianjun Gan, Mark Johnson, Brian A. Johns, Etienne Dumont, Roxanne C. Jewell

المصدر: Clinical Pharmacology in Drug Development. 9:972-977

مصطلحات موضوعية: Adult, Male, Anti-HIV Agents, Drug Compounding, Cmax, Administration, Oral, Biological Availability, Pharmaceutical Science, HIV Infections, Pharmacology, 030226 pharmacology & pharmacy, Drug Administration Schedule, Food-Drug Interactions, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Pharmacology (medical), Ritonavir, Dose-Response Relationship, Drug, business.industry, Cobicistat, Capsule, Fasting, Middle Aged, Healthy Volunteers, Bioavailability, Regimen, Area Under Curve, 030220 oncology & carcinogenesis, Drug Therapy, Combination, Female, Safety, Geometric mean, Pentacyclic Triterpenes, business, Tablets, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd92487194df339d90e1e6ca694650b2
https://doi.org/10.1002/cpdd.820

المؤلفون: John E Dillberger, Thomas D Roper, Allison J. Armstrong, Brian R. Wamhoff, Stephen A. Hoang, Matthew W. Olson, Justin M. Taylor, Brad R. Henke, John E. Reardon, Maria Sol Collado, Brian A. Johns, Robert A. Figler, Taylor D. Pourtaheri

المصدر: Journal of medicinal chemistry. 64(8)

مصطلحات موضوعية: Propionic Acidemia, Methylmalonic acidemia, Drug Evaluation, Preclinical, Pharmacology, 01 natural sciences, Models, Biological, 03 medical and health sciences, Mice, Structure-Activity Relationship, Mutase, Dogs, Drug Discovery, medicine, Animals, Humans, Propionic acidemia, Amino Acid Metabolism, Inborn Errors, Cells, Cultured, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemistry, Catabolism, Organ dysfunction, Metabolism, medicine.disease, 0104 chemical sciences, Pyruvate carboxylase, Rats, 010404 medicinal & biomolecular chemistry, Butyrates, Enzyme, ROC Curve, Area Under Curve, Hepatocytes, Molecular Medicine, Acyl Coenzyme A, medicine.symptom, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254da545beecc6f429bfbe4bad4afc4f
https://pubmed.ncbi.nlm.nih.gov/33848153

المؤلفون: Brian Douglas Johns, Brian Douglas "the Creation

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://ir.uiowa.edu/cgi/viewcontent.cgi?article%3D5173%26context%3Detd.

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.682.6756; http://ir.uiowa.edu/cgi/viewcontent.cgi?article%3D5173%26context%3Detd

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.682.6756
http://ir.uiowa.edu/cgi/viewcontent.cgi?article%3D5173%26context%3Detd

المؤلفون: P. Garvey, Steven J. Novick, Karen E. Chiswell, L. Golden, Scott A. Foster, Brian A. Johns, Jason G, Christine Goffinet, Ina Allespach, Lena Oberbremer, Inhibitor On Human Immunodeficiency

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jvi.asm.org/content/83/15/7706.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.616.4173; http://jvi.asm.org/content/83/15/7706.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.616.4173
http://jvi.asm.org/content/83/15/7706.full.pdf

المؤلفون: Jianfeng Xu, Anita Scribner, Brian A. Johns, Mark Johnson, Jerry Jeffrey, Viviana Wilches, Moti Ramgopal, Edwin DeJesus, Franco Felizarta, Christine L. Talarico, Jianjun Gan, Paul M. Benson, Roxanne C. Jewell, Etienne Dumont, Fiona Halliday, Sara Duckworth Harward

المصدر: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 71(5)

مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), Maturation inhibitor, business.industry, Anti-HIV Agents, Cobicistat, 030106 microbiology, Cmax, Half-life, HIV Infections, Pharmacology, Viral Load, Clinical trial, 03 medical and health sciences, 030104 developmental biology, Infectious Diseases, Pharmacokinetics, HIV-1, Medicine, Humans, Adverse effect, business, Pentacyclic Triterpenes, Viral load

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379ba8f6e89f8981a98d23226af0f9ce
https://pubmed.ncbi.nlm.nih.gov/31769793

المؤلفون: Susan Danehower, David Temelkoff, Emile Johann Velthuisen, Kevin W. Brown, Brian A. Johns

المصدر: European Journal of Medicinal Chemistry. 117:99-112

مصطلحات موضوعية: 0301 basic medicine, Lactams, Anti-HIV Agents, Stereochemistry, Integrase inhibitor, HIV Integrase, medicine.disease_cause, 01 natural sciences, Cell Line, Strand transfer, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Viral, Drug Discovery, medicine, Humans, HIV Integrase Inhibitors, ADME, Pharmacology, Mutation, biology, 010405 organic chemistry, Organic Chemistry, Quinoline, 8-Hydroxyquinoline, General Medicine, 0104 chemical sciences, Integrase, 030104 developmental biology, chemistry, Drug Design, HIV-1, biology.protein, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06644c82bc4476e5604c544b81e2660
https://doi.org/10.1016/j.ejmech.2016.03.038

المؤلفون: Brian D. Johns

مصطلحات موضوعية: Pointwise, Identification (information), Membrane, Materials science, Biological system

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4c3d2abb631f324af141c21649d6653f
https://doi.org/10.17077/etd.st5j1yg7

المؤلفون: Brian D. Johns

مصطلحات موضوعية: Engineering, business.industry, Augmented reality, business, Surgical training, Simulation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::df24ea561a996721a02b8a0984b826b3
https://doi.org/10.17077/etd.x8t4uged

المؤلفون: Sandra J. Baldwin, Jianfeng Xu, Matt Davies, Jerry Jeffrey, Matthew Burke, Allan R Tenorio, Brian A. Johns, Elizabeth Gould, Amanda Peppercorn, Roxanne C. Jewell, Mark Johnson, Yu Lou

المصدر: Pharmacology researchperspectives. 6(4)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Anti-HIV Agents, Cmax, Biological Availability, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Chrysenes, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Double-Blind Method, medicine, Humans, Drug Interactions, General Pharmacology, Toxicology and Pharmaceutics, Adverse effect, Ritonavir, business.industry, Middle Aged, Healthy Volunteers, Bioavailability, Regimen, Butyrates, 030104 developmental biology, Neurology, Tolerability, Area Under Curve, Female, business, Pentacyclic Triterpenes, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4413391e38d9e7f99b7279ba5b19681d
https://pubmed.ncbi.nlm.nih.gov/29930812

المؤلفون: Brian D. Johns, Donald D. Anderson, Jenniefer Y. Kho, Geb Thomas

المصدر: IEEE Transactions on Human-Machine Systems. 45:119-125

مصطلحات موضوعية: Computer Networks and Communications, Computer science, business.industry, Validity, Construct validity, Human Factors and Ergonomics, Tracking system, Mixed reality, Computer Science Applications, Task (project management), Human-Computer Interaction, Artificial Intelligence, Control and Systems Engineering, Signal Processing, Graphics, business, Simulation, ComputingMethodologies_COMPUTERGRAPHICS, Face validity, Haptic technology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83d72f4934b1c02e012b2c8e43d1afcc
https://doi.org/10.1109/thms.2014.2339324

المؤلفون: Jun Tang, Erjuan Wang, Zhimin Jin, Kevin W. Brown, David M. Irlbeck, Jerry L. Jeffery, Rui Li, Heping Yang, Cristin M. Galardi, Sonia R. Miranda, Bin Shen, Charlene B. McDanal, Yajun Yu, Daxin Gao, Brian A. Johns, Chunyu Liu, Yongyong Wu, Yufei Sun, Caiming Xi, Nianhe Han, Stacey A. Jones

المصدر: The Open Medicinal Chemistry Journal

مصطلحات موضوعية: Betulin derivative, Pharmacology, Anti hiv 1, Betulin, macrocyclization, Chemistry, Maturation inhibitor, Drug discovery, HIV, Pharmaceutical Science, Bioinformatics, Combinatorial chemistry, Article, Chemical space, chemistry.chemical_compound, maturation inhibitor, Drug Discovery, Molecular Medicine, Structural class, Bevirimat, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b3d6198adabb5714b9d267efd4805
https://doi.org/10.2174/1874104501408010023

المؤلفون: Greg L. Beilhartz, Peter Gerondelis, Felix Deanda, Brian A. Johns, Marianne Ngure, Matthias Götte

المصدر: Journal of Biological Chemistry. 289:16270-16277

مصطلحات موضوعية: Pyridines, RNase P, Ribonuclease H, Pyrimidinones, Biology, Biochemistry, Ribonuclease, RNase H, Molecular Biology, chemistry.chemical_classification, Base Sequence, virus diseases, Active site, Cell Biology, Molecular biology, HIV Reverse Transcriptase, Reverse transcriptase, Dissociation constant, Kinetics, Enzyme, Oligodeoxyribonucleotides, chemistry, Enzyme inhibitor, Enzymology, biology.protein, Reverse Transcriptase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700f961467c7bda2583a69220caa2cfd
https://doi.org/10.1074/jbc.m114.569707

المؤلفون: Richard D. Cummings, Hong Ju, David F. Smith, Xuezheng Song, Brian A. Johns, Yi Lasanajak, Chunmei Zhao

المصدر: ACS Chemical Biology. 8:2478-2483

مصطلحات موضوعية: Glycan, Cleavage (embryo), Biochemistry, Reductive amination, Article, chemistry.chemical_compound, Polysaccharides, Cleave, Functional studies, Chromatography, High Pressure Liquid, Amination, Fluorescent Dyes, Molecular Structure, biology, food and beverages, Succinates, General Medicine, Amides, Combinatorial chemistry, chemistry, biology.protein, Molecular Medicine, N-Bromosuccinimide, Glycoconjugates, Oxidation-Reduction, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8486dc3153ab3553aadfbbfb6c1fe6
https://doi.org/10.1021/cb400513k

المؤلفون: Andrew Maynard, Renae M. Crosby, Byron Ellis, Robert Hamatake, Zhi Hong, Brian A. Johns, Kirsten M. Kahler, Cecilia Koble, Anna Leivers, Martin R. Leivers, Amanda Mathis, Andrew J. Peat, Jeffrey J. Pouliot, Christopher D. Roberts, Vicente Samano, Rachel M. Schmidt, Gary K. Smith, Andrew Spaltenstein, Eugene L. Stewart, Pia Thommes, Elizabeth M. Turner, Christian Voitenleitner, Jill T. Walker, Greg Waitt, Jason Weatherhead, Kurt Weaver, Shawn Williams, Lois Wright, Zhiping Z. Xiong, David Haigh, J. Brad Shotwell

المصدر: Journal of Medicinal Chemistry. 57:1902-1913

مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Hepacivirus, Viral Nonstructural Proteins, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Resistance, Viral, Drug Discovery, Structure–activity relationship, Replicon, Enzyme Inhibitors, NS5B, Subgenomic mRNA, Drug discovery, virus diseases, RNA-Dependent RNA Polymerase, Boronic Acids, Virology, Molecular biology, digestive system diseases, In vitro, chemistry, Molecular Medicine, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ce7599d644e69b47104c8ac1a7db2e
https://doi.org/10.1021/jm400317w

المؤلفون: Emile J. Velthuisen, Todd M. Baughman, Brian A. Johns, David P. Temelkoff, Jason G. Weatherhead

المصدر: European Journal of Medicinal Chemistry. 63:202-212

مصطلحات موضوعية: Metabolic Clearance Rate, Stereochemistry, Bond breaking, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, Kinetic isotope effect, medicine, Animals, Humans, Benzodioxoles, Pharmacology, Molecular Structure, Organic Chemistry, HIV Protease Inhibitors, General Medicine, Metabolic stability, Deuterium, Rate-determining step, Combinatorial chemistry, Protease inhibitor (biology), Rats, Models, Chemical, chemistry, Area Under Curve, Hepatocytes, Brecanavir, Administration, Intravenous, Carbamates, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde19bdf8d4f57e51906010406251085
https://doi.org/10.1016/j.ejmech.2013.02.001

المؤلفون: Jun Tang, Kevin W. Brown, Jerry Jeffrey, Charlene B. McDanal, Brian A. Johns, Sonia R. Miranda, Stacey A. Jones, David M. Irlbeck, Cristin M. Galardi

المصدر: Bioorganicmedicinal chemistry letters. 27(12)

مصطلحات موضوعية: 0301 basic medicine, Anti hiv 1, Anti-HIV Agents, 030106 microbiology, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Biology, Cleavage (embryo), Biochemistry, Peripheral blood mononuclear cell, gag Gene Products, Human Immunodeficiency Virus, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Genotype, Drug Discovery, medicine, Molecular Biology, Polymorphism, Genetic, Dose-Response Relationship, Drug, Molecular Structure, Maturation inhibitor, Organic Chemistry, Wild type, Virology, Molecular biology, Amides, Triterpenes, 030104 developmental biology, chemistry, Mechanism of action, HIV-1, Molecular Medicine, medicine.symptom, Bevirimat

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218669177b08ef6a1fe9d91139f48e57
https://pubmed.ncbi.nlm.nih.gov/28454672

المؤلفون: Takashi Kawasuji, Brian A. Johns, Hiroshi Yoshida, Jason G. Weatherhead, Toshiyuki Akiyama, Teruhiko Taishi, Yoshiyuki Taoda, Minako Mikamiyama-Iwata, Hitoshi Murai, Ryuichi Kiyama, Masahiro Fuji, Norihiko Tanimoto, Tomokazu Yoshinaga, Takahiro Seki, Masanori Kobayashi, Akihiko Sato, Edward P. Garvey, Tamio Fujiwara

المصدر: Journal of Medicinal Chemistry. 56:1124-1135

مصطلحات موضوعية: chemistry.chemical_classification, Magnetic Resonance Spectroscopy, Bicyclic molecule, Pyridones, Stereochemistry, Late stage, Substituent, Integrase inhibitor, HIV Integrase, Mass Spectrometry, Rats, chemistry.chemical_compound, Pharmacokinetics, chemistry, Drug Discovery, Dolutegravir, Hiv 1 integrase, Animals, Molecular Medicine, HIV Integrase Inhibitors, Chromatography, Liquid, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1167fb02558e33f61b588c3a9fb8ae3c
https://doi.org/10.1021/jm301550c