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1Academic Journal
المؤلفون: Goldsteen, Pien, Sabogal Guaqueta, Angelica, Mulder, Patty, Bos, I. Sophie T., Eggens, Manon, van der Koog, Luke, Soeiro, J.T., Halayko, A.J., Mathwig, Klaus, Kistemaker, Loes, Verpoorte, Elisabeth, Dolga, Amalia, Gosens, Reinoud
المصدر: Goldsteen , P , Sabogal Guaqueta , A , Mulder , P , Bos , I S T , Eggens , M , van der Koog , L , Soeiro , J T , Halayko , A J , Mathwig , K , Kistemaker , L , Verpoorte , E , Dolga , A & Gosens , R 2022 , ' Differentiation and on axon-guidance chip culture of human pluripotent stem cell-derived peripheral cholinergic neurons for airway neurobiology studies ' , Frontiers in Pharmacology , vol. 13 , 991072 . https://doi.org/10.3389/fphar.2022.991072
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2Academic Journal
المؤلفون: Rahmawati, Siti Farah, Vos, Rémon, Bos, I. Sophie T., Kerstjens, Huib A.M., Kistemaker, Loes E.M., Gosens, Reinoud
المصدر: Rahmawati , S F , Vos , R , Bos , I S T , Kerstjens , H A M , Kistemaker , L E M & Gosens , R 2022 , ' Function-specific IL-17A and dexamethasone interactions in primary human airway epithelial cells ' , Scientific Reports , vol. 12 , 11110 . https://doi.org/10.1038/s41598-022-15393-2
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3Academic Journal
المؤلفون: Wu, Xinhui, Ciminieri, Chiara, Bos, I Sophie T, Woest, Manon E, D'Ambrosi, Angela, Wardenaar, René, Spierings, Diana C J, Königshoff, Melanie, Schmidt, Martina, Kistemaker, Loes E M, Gosens, Reinoud
المصدر: Wu , X , Ciminieri , C , Bos , I S T , Woest , M E , D'Ambrosi , A , Wardenaar , R , Spierings , D C J , Königshoff , M , Schmidt , M , Kistemaker , L E M & Gosens , R 2022 , ' Diesel exhaust particles distort lung epithelial progenitors and their fibroblast niche ' , Environmental Pollution , vol. 305 , 119292 . https://doi.org/10.1016/j.envpol.2022.119292
مصطلحات موضوعية: Air pollution, Lung repair, Organoids, Oxidative stress, WNT signaling, CYTOCHROMES P450 1A1, ACUTE EXACERBATION, AIRWAY-RESISTANCE, DNA-DAMAGE, INFLAMMATION, ACTIVATION, EXPRESSION, POLLUTION, PATHWAY
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4Academic Journal
المؤلفون: Wu, Xinhui, Bos, I Sophie T, Conlon, Thomas M, Ansari, Meshal, Verschut, Vicky, van der Koog, Luke, Verkleij, Lars A, D'Ambrosi, Angela, Matveyenko, Aleksey, Schiller, Herbert B, Königshoff, Melanie, Schmidt, Martina, Kistemaker, Loes E M, Yildirim, Ali Önder, Gosens, Reinoud
المصدر: Wu , X , Bos , I S T , Conlon , T M , Ansari , M , Verschut , V , van der Koog , L , Verkleij , L A , D'Ambrosi , A , Matveyenko , A , Schiller , H B , Königshoff , M , Schmidt , M , Kistemaker , L E M , Yildirim , A Ö & Gosens , R 2022 , ' A transcriptomics-guided drug target discovery strategy identifies receptor ligands for lung regeneration ' , Science Advances , vol. 8 , no. 12 , eabj9949 . https://doi.org/10.1126/sciadv.abj9949
وصف الملف: application/pdf
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5Academic Journal
المؤلفون: van den Berg, Mariska P. M., Nijboer-Brinksma, Susan, Bos, I. Sophie T., van den Berge, Maarten, Lamb, David, van Faassen, Martijn, Kema, Ido P., Gosens, Reinoud, Kistemaker, Loes E. M.
المصدر: van den Berg , M P M , Nijboer-Brinksma , S , Bos , I S T , van den Berge , M , Lamb , D , van Faassen , M , Kema , I P , Gosens , R & Kistemaker , L E M 2021 , ' The novel TRPA1 antagonist BI01305834 inhibits ovalbumin-induced bronchoconstriction in guinea pigs ' , Respiratory Research , vol. 22 , no. 1 , 48 . https://doi.org/10.1186/s12931-021-01638-7
وصف الملف: application/pdf
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6Academic Journal
المؤلفون: Wu, Xinhui, van Dijk, Eline M, Ng-Blichfeldt, John-Poul, Bos, I Sophie T, Ciminieri, Chiara, Königshoff, Melanie, Kistemaker, Loes E M, Gosens, Reinoud
المصدر: Wu , X , van Dijk , E M , Ng-Blichfeldt , J-P , Bos , I S T , Ciminieri , C , Königshoff , M , Kistemaker , L E M & Gosens , R 2019 , ' Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors ' , Cells , vol. 8 , no. 10 . https://doi.org/10.3390/cells8101147
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7Academic Journal
المؤلفون: Liu, Yun, Bos, I. Sophie T., Oenema, Tjitske A., Meurs, Herman, Maarsingh, Harm, Hirsch, Anna K. H.
المصدر: Liu , Y , Bos , I S T , Oenema , T A , Meurs , H , Maarsingh , H & Hirsch , A K H 2018 , ' Delivery system for budesonide based on lipid-DNA ' , European Journal of Pharmaceutics and Biopharmaceutics , vol. 130 , pp. 123-127 . https://doi.org/10.1016/j.ejpb.2018.06.012
مصطلحات موضوعية: Drug delivery, Anti-inflammatory, Budesonide, Lipid-DNA, Solubility, AIRWAY SMOOTH-MUSCLE, DRUG-DELIVERY, RHEUMATOID-ARTHRITIS, ULCERATIVE-COLITIS, POLYMERIC MICELLES, CROHNS-DISEASE, ASTHMA, THERAPY, PHARMACOKINETICS, CORTICOSTEROIDS
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/b0933bf2-0412-419b-aad6-a1370e7537b3
https://research.rug.nl/en/publications/b0933bf2-0412-419b-aad6-a1370e7537b3
https://doi.org/10.1016/j.ejpb.2018.06.012
https://pure.rug.nl/ws/files/65102219/1_s2.0_S0939641118303126_main.pdf
https://repository.helmholtz-hzi.de/bitstream/handle/10033/621489/Liu%20et%20al.pdf;jsessionid=B6F3593D8ECEE5841488065E77665AB5?sequence=1 -
8Academic Journal
المؤلفون: Kistemaker, Loes E M, Oenema, Tjitske A, Baarsma, Hoeke A, Bos, I. Sophie T., Schmidt, Martina, Facchinetti, Fabrizio, Civelli, Maurizio, Villetti, Gino, Gosens, Reinoud
المصدر: Kistemaker , L E M , Oenema , T A , Baarsma , H A , Bos , I S T , Schmidt , M , Facchinetti , F , Civelli , M , Villetti , G & Gosens , R 2017 , ' The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodeling in lung slices ' , American Journal of Physiology - Lung Cellular and Molecular Physiology , vol. 313 , no. 3 , pp. L507-L515 . https://doi.org/10.1152/ajplung.00069.2017
مصطلحات موضوعية: phosphodiesterase-4, long-acting anticholinergics, OBSTRUCTIVE PULMONARY-DISEASE, PHOSPHODIESTERASE-4 INHIBITOR, IN-VITRO, ROFLUMILAST, TIOTROPIUM, ASTHMA, INFLAMMATION
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9Academic Journal
المؤلفون: Tania, Navessa P, Maarsingh, Harm, Bos, I. Sophie T., Mattiotti, Andrea, Prakash, Stuti, Timens, Wim, Gunst, Quinn D, Jimenez-Borreguero, Luis J, Schmidt, Martina, van den Hoff, Maurice J B, Gosens, Reinoud
المصدر: Tania , N P , Maarsingh , H , Bos , I S T , Mattiotti , A , Prakash , S , Timens , W , Gunst , Q D , Jimenez-Borreguero , L J , Schmidt , M , van den Hoff , M J B & Gosens , R 2017 , ' Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling ' , Pulmonary circulation , vol. 7 , no. 1 , pp. 219-231 . https://doi.org/10.1177/2045893217702340
مصطلحات موضوعية: bone morphogenetic protein, endothelium, Endothelin-1, Jagged1, Endoglin, HEREDITARY HEMORRHAGIC TELANGIECTASIA, GLA PROTEIN-DEFICIENCY, ARTERIAL-HYPERTENSION, ARTERIOVENOUS-MALFORMATIONS, BINDING-PROTEIN, GENE-EXPRESSION, KINASE-1 GENE, MICE LACKING, II RECEPTOR
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10Academic Journal
المؤلفون: Han, Bing, Poppinga, Wilfred J., Zuo, Haoxiao, Zuidhof, Annet B., Bos, I. Sophie T., Smit, Marieke, Vogelaar, Pieter, Krenning, Guido, Henning, Robert H., Maarsingh, Harm, Halayko, Andrew J., van Vliet, Bernard, Stienstra, Stef, van der Graaf, Adrianus Cornelis, Meurs, Herman, Schmidt, Martina
المصدر: Han , B , Poppinga , W J , Zuo , H , Zuidhof , A B , Bos , I S T , Smit , M , Vogelaar , P , Krenning , G , Henning , R H , Maarsingh , H , Halayko , A J , van Vliet , B , Stienstra , S , van der Graaf , A C , Meurs , H & Schmidt , M 2016 , ' The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease ' , Scientific Reports , vol. ....
مصطلحات موضوعية: GUINEA-PIG MODEL, SMOOTH-MUSCLE-CELLS, ACUTE LUNG INJURY, NF-KAPPA-B, OXIDATIVE STRESS, HYDROGEN-SULFIDE, CIGARETTE-SMOKE, EPITHELIAL BARRIER, REDOX REGULATION, GENE-TRANSCRIPTION
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11Academic Journal
المؤلفون: Kistemaker, Loes E. M., Bos, I. Sophie T., Menzen, Mark H., Maarsingh, Harm, Meurs, Herman, Gosens, Reinoud
المصدر: Kistemaker , L E M , Bos , I S T , Menzen , M H , Maarsingh , H , Meurs , H & Gosens , R 2016 , ' Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma ' , Respiratory Research , vol. 17 , no. 1 , 13 . https://doi.org/10.1186/s12931-016-0327-6
مصطلحات موضوعية: Anticholinergics, Inhaled corticosteroids, Interaction, RECEPTORS MEDIATE STIMULATION, SMOOTH-MUSCLE PROLIFERATION, HUMAN LUNG FIBROBLAST, MUSCARINIC RECEPTORS, EPITHELIAL-CELLS, ALLERGIC-ASTHMA, BRONCHOCONSTRICTION, BROMIDE, MICE, RELEASE
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12Academic Journal
المؤلفون: Kistemaker, Loes E. M., van Os, Ronald P., Dethmers-Ausema, Albertina, Bos, I. Sophie T., Hylkema, Machteld N., van den Berge, Maarten, Hiemstra, Pieter S, Wess, Jürgen, Meurs, Herman, Kerstjens, Huib A. M., Gosens, Reinoud
المصدر: Kistemaker , L E M , van Os , R P , Dethmers-Ausema , A , Bos , I S T , Hylkema , M N , van den Berge , M , Hiemstra , P S , Wess , J , Meurs , H , Kerstjens , H A M & Gosens , R 2015 , ' Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice ' , American Journal of Physiology - Lung Cellular and Molecular Physiology , vol. 308 , no. 1 , pp. L96-L103 . https://doi.org/10.1152/ajplung.00259.2014
مصطلحات موضوعية: nonneuronal acetylcholine, anticholinergics, neutrophil adhesion, NONNEURONAL CHOLINERGIC SYSTEM, OBSTRUCTIVE PULMONARY-DISEASE, TIOTROPIUM BROMIDE, COPD, ACETYLCHOLINE, RELEASE, MODEL, MIGRATION, ASTHMA, CD177
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/6231ac40-3560-4418-9239-15753d3a9064
https://research.rug.nl/en/publications/6231ac40-3560-4418-9239-15753d3a9064
https://doi.org/10.1152/ajplung.00259.2014
https://pure.rug.nl/ws/files/84456066/Muscarinic_M3_receptors_on_structural_cells_regulate_cigarette_smoke_induced.pdf -
13Academic Journal
المؤلفون: Kistemaker, Loes E. M., Hiemstra, Pieter S., Bos, I. Sophie T., Bouwman, Susanne, van den Berge, Maarten, Hylkema, Machteld N., Meurs, Herman, Kerstjens, Huib A. M., Gosens, Reinoud
المصدر: Kistemaker , L E M , Hiemstra , P S , Bos , I S T , Bouwman , S , van den Berge , M , Hylkema , M N , Meurs , H , Kerstjens , H A M & Gosens , R 2015 , ' Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells ' , Thorax , vol. 70 , no. 7 , pp. 668-676 . https://doi.org/10.1136/thoraxjnl-2014-205731
مصطلحات موضوعية: MUCOCILIARY DIFFERENTIATION, NONNEURONAL ACETYLCHOLINE, CHOLINERGIC SYSTEM, RELEASE MACHINERY, MUCIN SECRETION, ASTHMA, MUCUS, RAT, EXPRESSION, BROMIDE
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/cc7c53d7-554d-41de-9f1c-f2c3733288a7
https://research.rug.nl/en/publications/cc7c53d7-554d-41de-9f1c-f2c3733288a7
https://doi.org/10.1136/thoraxjnl-2014-205731
https://pure.rug.nl/ws/files/86306691/Tiotropium_attenuates_IL_13_induced_goblet_cell_metaplasia_of_human_airway.pdf -
14Academic Journal
المؤلفون: Dekkers, Bart G J, Naeimi, Saeideh, Bos, I. Sophie T., Menzen, Mark H, Halayko, Andrew John, Sadeghi Hashjin, Goudarz, Meurs, Herman
المصدر: Dekkers , B G J , Naeimi , S , Bos , I S T , Menzen , M H , Halayko , A J , Sadeghi Hashjin , G & Meurs , H 2015 , ' L-Thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1 ' , American Journal of Physiology - Lung Cellular and Molecular Physiology , vol. 308 , no. 3 , pp. L301-L306 . https://doi.org/10.1152/ajplung.00071.2014
مصطلحات موضوعية: airway smooth muscle proliferation, airway smooth muscle contractile protein expression, L-thyroxine, triiodothyronine, transforming growth factor-beta 1, TRIIODOTHYRONINE-INDUCED THYROTOXICOSIS, OBSTRUCTIVE PULMONARY-DISEASE, THYROID-HORMONE, EXTRACELLULAR-MATRIX, MEDIATE ENHANCEMENT, ASTHMA, HYPERRESPONSIVENESS, RECEPTOR, FIBRONECTIN, INFLAMMATION
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/de65d99d-a58b-46f4-840f-a210ac8264ad
https://research.rug.nl/en/publications/de65d99d-a58b-46f4-840f-a210ac8264ad
https://doi.org/10.1152/ajplung.00071.2014
https://pure.rug.nl/ws/files/84300702/L_Thyroxine_promotes_a_proliferative_airway_smooth_muscle_phenotype.pdf -
15Academic Journal
المؤلفون: Dekkers, Bart G.J., Pehlić, Adnan, Mariani, Raissa, Bos, I. Sophie T., Meurs, Herman, Zaagsma, Johan
المصدر: The Journal of Pharmacology and Experimental Therapeutics ; volume 342, issue 3, page 780-787 ; ISSN 0022-3565
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16Academic Journal
المصدر: Dekkers , B G J , Bos , I S T , Halayko , A J , Zaagsma , J & Meurs , H 2010 , ' The laminin beta 1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma ' , Respiratory Research , vol. 11 , 170 . https://doi.org/10.1186/1465-9921-11-170
مصطلحات موضوعية: EXTRACELLULAR-MATRIX PROTEINS, MAP KINASE ACTIVATION, GUINEA-PIG MODEL, CELL-ADHESION, EXPRESSION, RECEPTOR, LUNG, PROLIFERATION, CHAIN, DISEASE
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/35cf16bd-5f63-4540-ba32-6b4070041db2
https://research.rug.nl/en/publications/35cf16bd-5f63-4540-ba32-6b4070041db2
https://doi.org/10.1186/1465-9921-11-170
https://pure.rug.nl/ws/files/61205551/The_laminin_1_competing_peptide_YIGSR_induces_a_hypercontractile_hypoproliferative_airway_smooth_muscle_phenotype_in_an_animal_model_of_allergic_asthma.pdf -
17Academic Journal
المؤلفون: Van Eck, Miranda, Hoekstra, Menno, Out, Ruud, Bos, I. Sophie T., Kruijt, J. Kar, Hildebrand, Reeni B., Van Berkel, Theo J.C.
المصدر: Journal of Lipid Research ; volume 49, issue 1, page 136-146 ; ISSN 0022-2275
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18Book
المصدر: Wu , X , van Dijk , E M , Bos , I S T , Kistemaker , L E M & Gosens , R 2019 , Mouse Lung Tissue Slice Culture . in Mouse cell culture . Methods in Molecular Biology , vol. 1940 , Humana Press , New York , pp. 297-311 . https://doi.org/10.1007/978-1-4939-9086-3_21
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19Academic Journal
المصدر: Schaafsma , D , Bos , I S T , Zuidhof , A B , Zaagsma , J & Meurs , H 2006 , ' Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction ' , Respiratory Research , vol. 7 , 121 . https://doi.org/10.1186/1465-9921-7-121
مصطلحات موضوعية: SMOOTH-MUSCLE CONTRACTION, MEDIATED CA2+ SENSITIZATION, RESPONSIVENESS, PROSTAGLANDINS, CELLS, MICE
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/ccbc1162-2045-4bf9-b888-e64800460a9c
https://research.rug.nl/en/publications/ccbc1162-2045-4bf9-b888-e64800460a9c
https://doi.org/10.1186/1465-9921-7-121
https://pure.rug.nl/ws/files/61207937/Inhalation_of_the_Rho_kinase_inhibitor_Y_27632_reverses_allergen_induced_airway_hyperresponsiveness_after_the_early_and_late_asthmatic_reaction.pdf -
20Academic Journal
المؤلفون: Maarsingh, H, Leusink, J, Bos, I Sophie T, Zaagsma, J, Meurs, H
المصدر: Maarsingh , H , Leusink , J , Bos , I S T , Zaagsma , J & Meurs , H 2006 , ' Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma ' , Respiratory Research , vol. 7 , 6 . https://doi.org/10.1186/1465-9921-7-6
مصطلحات موضوعية: UNRESTRAINED GUINEA-PIGS, L-ARGININE UTILIZATION, BRONCHIAL HYPERRESPONSIVENESS, ALVEOLAR MACROPHAGES, HYPERREACTIVITY, DEFICIENCY, INFLAMMATION, INHIBITION, EXPRESSION, RESPONSES
وصف الملف: application/pdf
الاتاحة: https://hdl.handle.net/11370/1b0851ba-0b88-44e5-bf03-e03094e4ee8c
https://research.rug.nl/en/publications/1b0851ba-0b88-44e5-bf03-e03094e4ee8c
https://doi.org/10.1186/1465-9921-7-6
https://pure.rug.nl/ws/files/61236198/Arginase_strongly_impairs_neuronal_nitric_oxide_mediated_airway_smooth_muscle_relaxation_in_allergic_asthma.pdf