المؤلفون: Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J. M. Zweemer, Bircan Coban, Mjriam Capula, Giulia Mantini, Asia Botto, Francesco Finamore, Ingrid Garajova, Liam A. McDonnell, Thomas Schmidt, Elisa Giovannetti, Erik H. J. Danen

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)

مصطلحات موضوعية: Pancreatic cancer, Paclitaxel resistance, ABCB1, Kinase-inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-9966

URL الوصول: https://doaj.org/article/178d9e5136a64abeb42daf0ec279d03d

المؤلفون: Rohola Hosseini, Matthijs Vlasveld, Joost Willemse, Bob van de Water, Sylvia E. Le Dévédec, Katherine J. Wolstencroft

المصدر: Scientific Data, Vol 10, Iss 1, Pp 1-5 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2052-4463

URL الوصول: https://doaj.org/article/c9f35a39edfa43a98125407bc5d1f226

المؤلفون: Cecilia Bergonzini, Alessandro Gregori, Tessa M. S. Hagens, Vera E. van der Noord, Bob van de Water, Annelien J. M. Zweemer, Bircan Coban, Mjriam Capula, Giulia Mantini, Asia Botto, Francesco Finamore, Ingrid Garajova, Liam A. McDonnell, Thomas Schmidt, Elisa Giovannetti, Erik H. J. Danen

مصطلحات موضوعية: Biochemistry, Genetics, Ecology, Cancer, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Pancreatic cancer, Paclitaxel resistance, ABCB1, Kinase-inhibitors

Relation: https://figshare.com/articles/journal_contribution/Additional_file_1_of_ABCB1_overexpression_through_locus_amplification_represents_an_actionable_target_to_combat_paclitaxel_resistance_in_pancreatic_cancer_cells/24923728

الاتاحة: https://doi.org/10.6084/m9.figshare.24923728.v1
https://figshare.com/articles/journal_contribution/Additional_file_1_of_ABCB1_overexpression_through_locus_amplification_represents_an_actionable_target_to_combat_paclitaxel_resistance_in_pancreatic_cancer_cells/24923728

المؤلفون: Vera E. van der Noord, Wanda van der Stel, Gijs Louwerens, Danielle Verhoeven, Hendrik J. Kuiken, Cor Lieftink, Melanie Grandits, Gerhard F. Ecker, Roderick L. Beijersbergen, Peter Bouwman, Sylvia E. Le Dévédec, Bob van de Water

المصدر: Breast Cancer Research, Vol 25, Iss 1, Pp 1-20 (2023)

مصطلحات موضوعية: Triple-negative breast cancer, Transcriptional cyclin-dependent kinases, CDK12/13, THZ531, ABCG2, Drug resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1465-542X

URL الوصول: https://doaj.org/article/3cd3539eec0948958a3e708b71d4da89

المؤلفون: Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Wibke Busch, Christian Desaintes, Anne Gourmelon, Roland Grafström, Joshua Harrill, Thomas Hartung, Matthias Herzler, George E.N. Kass, Nicole Kleinstreuer, Marcel Leist, Mirjam Luijten, Philip Marx-Stoelting, Oliver Poetz, Bennard van Ravenzwaay, Rob Roggeband, Vera Rogiers, Adrian Roth, Pascal Sanders, Russell S. Thomas, Anne Marie Vinggaard, Mathieu Vinken, Bob van de Water, Andreas Luch, Tewes Tralau

المصدر: Environment International, Vol 178, Iss , Pp 108082- (2023)

مصطلحات موضوعية: New approach methodologies, Chemical safety, Human health protection, Regulatory risk assessment, Next generation risk assessment, Regulatory toxicology, Environmental sciences, GE1-350

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412023003550; https://doaj.org/toc/0160-4120

URL الوصول: https://doaj.org/article/f976f541aefc4b4e8d0e30fa3b873d98

المؤلفون: Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Sylvie Bortoli, Peter Bouwman, Albert Braeuning, Tanja Burgdorf, Xavier Coumoul, Kloé Debizet, Maria Dusinska, Norman Ertych, Jörg Fahrer, Verena Fetz, Ludovic Le Hégarat, Adela López de Cerain, Harm J. Heusinkveld, Kevin Hogeveen, Miriam N. Jacobs, Mirjam Luijten, Giuseppa Raitano, Cynthia Recoules, Elise Rundén-Pran, Mariam Saleh, Iva Sovadinová, Martina Stampar, Lea Thibol, Céline Tomkiewicz, Ariane Vettorazzi, Bob Van de Water, Naouale El Yamani, Bojana Zegura, Michael Oelgeschläger

المصدر: Frontiers in Toxicology, Vol 5 (2023)

مصطلحات موضوعية: non-genotoxic carcinogens, NGTxC, new approach methodologies, NAM, PARC, Toxicology. Poisons, RA1190-1270

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/ftox.2023.1220998/full; https://doaj.org/toc/2673-3080

URL الوصول: https://doaj.org/article/bb67b7cd857c45a58747146a121d489d

المؤلفون: Steven Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, Jeroen Esselink, Allard van Egmond, Jornt Mos, Joost B. Beltman, Jens Timmer, Bob van de Water, Daniel Kaschek

المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/15080c2445a249f3aa5307f2274fe4e7

المؤلفون: Giulia Callegaro, Johannes P. Schimming, Janet Piñero González, Steven J. Kunnen, Lukas Wijaya, Panuwat Trairatphisan, Linda van den Berk, Kim Beetsma, Laura I. Furlong, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens, Bob van de Water

المصدر: iScience, Vol 26, Iss 3, Pp 106094- (2023)

مصطلحات موضوعية: Gene network, Bioinformatics, Transcriptomics, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223001712; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/c1ec17ac979040d09bc96f5bae7f9e91

المؤلفون: Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A. Burger, Bram Herpers, Kuan Yan, Leo S. Price, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/57418be9999441f5885dc1b1785fe4d6

المؤلفون: Esmee Koedoot, Eline van Steijn, Marjolein Vermeer, Román González-Prieto, Alfred C. O. Vertegaal, John W. M. Martens, Sylvia E. Le Dévédec, Bob van de Water

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)

مصطلحات موضوعية: Triple-negative breast cancer, Mitosis, Sister chromatid cohesion, RNA splicing, Splicing factors, Proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1756-9966

URL الوصول: https://doaj.org/article/965c99b87fb3412fb4c7057176e1ddb5

المؤلفون: Muriel M Heldring, Lukas S Wijaya, Marije Niemeijer, Huan Yang, Talel Lakhal, Sylvia E Le Dévédec, Bob van de Water, Joost B Beltman

المصدر: PLoS Computational Biology, Vol 18, Iss 7, p e1010264 (2022)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358

URL الوصول: https://doaj.org/article/bd05827ec19846e2a4c97f9f4699496c

المؤلفون: Gerhard A. Burger, Bob van de Water, Sylvia E. Le Dévédec, Joost B. Beltman

المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

مصطلحات موضوعية: cell migration, single-cell analysis, pseudopods, computational modeling, cellular Potts model, breast cancer, Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.854721/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/08c079f564034d1fae82a1949b50fd4e

المؤلفون: Vera E. van der Noord, Bob van de Water, Sylvia E. Le Dévédec

المصدر: Cancers; Volume 14; Issue 18; Pages: 4353

مصطلحات موضوعية: triple-negative breast cancer, transcriptional machinery, transcription-associated cyclin-dependent kinases (CDKs), bromodomain and extra-terminal (BET) proteins

وصف الملف: application/pdf

Relation: Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers14184353

الاتاحة: https://doi.org/10.3390/cancers14184353

المؤلفون: Sebastiaan T. A. Koenders, Lukas S. Wijaya, Martje N. Erkelens, Alexander T. Bakker, Vera E. van der Noord, Eva J. van Rooden, Lindsey Burggraaff, Pasquale C. Putter, Else Botter, Kim Wals, Hans van den Elst, Hans den Dulk, Bogdan I. Florea, Bob van de Water, Gerard J. P. van Westen, Reina E. Mebius, Herman S. Overkleeft, Sylvia E. Le Dévédec, Mario van der Stelt

المصدر: ACS Central Science, Vol 5, Iss 12, Pp 1965-1974 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2374-7951

URL الوصول: https://doaj.org/article/989e2de45d314bdeb9af0694f21eb017

المؤلفون: Ronan P. McLaughlin, Jichao He, Vera E. van der Noord, Jevin Redel, John A. Foekens, John W. M. Martens, Marcel Smid, Yinghui Zhang, Bob van de Water

المصدر: Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: CDK9/Cdc7 inhibition, EGFR-targeted therapy, Drug resistance, Triple-negative breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13058-019-1161-9; https://doaj.org/toc/1465-542X

URL الوصول: https://doaj.org/article/d7a9858eb35e4f8bbbf909c779d15779

المؤلفون: Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec

المؤلفون: Huan Yang, Wanda van der Stel, Randy Lee, Caroline Bauch, Sam Bevan, Paul Walker, Bob van de Water, Erik H. J. Danen, Joost B. Beltman

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: mitochondrial respiration, mitochondrial membrane potential, dynamic modeling, parameter identifiability, high-throughput microscopy imaging, uncertainty quantification, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.679407/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/fee3a32d499742bb887a718282353d47

المؤلفون: Wanda van der Stel (Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University), Giada Carta (Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam), Julie Eakins (Cyprotex Discovery Ltd.), Johannes Delp (In vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz), Ilinca Suciu (In vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz), Anna Forsby (Department of Biochemistry and Biophysics, Stockholm University), Andrea Cediel-Ulloa (Department of Organismal Biology, Uppsala University), Kristina Attoff (Department of Biochemistry and Biophysics, Stockholm University), Florentina Troger (Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna), Hennicke Kamp (BASF), Iain Gardner (Certara UK Limited), Barbara Zdrazil (Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna), Martijn J. Moné (Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University), Gerhard F. Ecker (Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna), Manuel Pastor (Department of Experimental and Health Sciences, Universitat Pompeu Fabra), Jose Carlos Gómez-Tamayo (Department of Experimental and Health Sciences, Universitat Pompeu Fabra), Andrew White (Unilever), Erik H. J. Danen (Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University), Marcel Leist (In vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz), Paul Walker (Cyprotex Discovery Ltd.), Paul Jennings (Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam), Susanne Hougaard (Bennekou National Food Institute, Technical University of Denmark (DTU)), Bob van de Water (Division of Drug Discovery and Safety, Leiden Academic Centre of Drug Research, Leiden University)

المصدر: ALTEX ; issn:1868-596X

مصطلحات موضوعية: in vitro, mitochondrial toxicity, neurotoxicity, PBK-modelling, uncertainty analysis

وصف الملف: application/pdf

Relation: hdl:11353/10.1604356; https://phaidra.univie.ac.at/o:1604356

الاتاحة: https://doi.org/10.14573/altex.2103051
https://phaidra.univie.ac.at/o:1604356

المؤلفون: François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella-Gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel Angel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez-Anguita, Francesco Ronzano, Philip Rowell, Josep Saüch-Pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, Ferran Sanz

المصدر: Pharmaceuticals; Volume 14; Issue 3; Pages: 237

مصطلحات موضوعية: toxicology, drug safety, translational safety assessment, data sharing, integrative knowledge management, data mining, read across, predictive modelling

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/ph14030237

الاتاحة: https://doi.org/10.3390/ph14030237

المؤلفون: Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules

المصدر: Bioinformatics and Biology Insights, Vol 14 (2020)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1177-9322

URL الوصول: https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4