المؤلفون: Zhongtang Li, Fan Fang, Yiyan Li, Xuehui Lv, Ruqiu Zheng, Peili Jiao, Yuxi Wang, Guiwang Zhu, Zefang Jin, Xiangqing Xu, Yinli Qiu, Guisen Zhang, Zhongjun Li, Zhenming Liu, Liangren Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4553-4577 (2023)

مصطلحات موضوعية: Dopamine D3 receptor, Carbazole derivatives, Tetrahydro-carboline, Bitopic ligand, Antipsychotic, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523002861; https://doaj.org/toc/2211-3835

URL الوصول: https://doaj.org/article/08553c6ed9fd4efaa867b3079b9ecb63

المؤلفون: Gianferrara, Teresa, Pavan, Matteo, Bassani, Davide, Vincenzi, Fabrizio, Pasquini, Silvia, Bolcato, Giovanni, Varani, Katia, Spalluto, Giampiero, Federico, Stephanie, Moro, Stefano

المساهمون: Gianferrara, Teresa, Pavan, Matteo, Bassani, Davide, Vincenzi, Fabrizio, Pasquini, Silvia, Bolcato, Giovanni, Varani, Katia, Spalluto, Giampiero, Federico, Stephanie, Moro, Stefano

مصطلحات موضوعية: adenosine, adenosine receptor, bis-ribosyl-adenosine, bitopic ligand, receptor activation, receptor recognition

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/37114338; info:eu-repo/semantics/altIdentifier/wos/WOS:000985016500001; volume:18/2023; issue:14; firstpage:1; lastpage:14; numberofpages:14; journal:CHEMMEDCHEM; https://hdl.handle.net/11368/3067478; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85159106769

الاتاحة: https://hdl.handle.net/11368/3067478
https://doi.org/10.1002/cmdc.202300109
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202300109

المؤلفون: Kim, Ho Young, Lee, Ji Youn, Hsieh, Chia-Ju, Taylor, Michelle, Luedtke, Robert R., Mach, Robert H.

المصدر: International Journal of Molecular Sciences

مصطلحات موضوعية: D3 receptor antagonists, bitopic ligand, computational chemistry, metoclopramide, beta-arrestin recruitment assay, Ligands, Receptors, Dopamine D2 / metabolism, Dopamine D3 / metabolism, Dopamine, Structure-Activity Relationship, Benzamides / chemistry

وصف الملف: application/pdf

Relation: https://doi.org/10.3390/ijms24010432; Kim, H. Y., Lee, J. Y., Hsieh, C. J., Taylor, M., Luedtke, R. R., & Mach, R. H. (2022). Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D3-Selective Antagonists. International journal of molecular sciences, 24(1), 432. https://doi.org/10.3390/ijms24010432; https://hdl.handle.net/20.500.12503/32013; 24

الاتاحة: https://hdl.handle.net/20.500.12503/32013

المؤلفون: Ho Young Kim, Ji Youn Lee, Chia-Ju Hsieh, Michelle Taylor, Robert R. Luedtke, Robert H. Mach

المصدر: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 432

مصطلحات موضوعية: D 3 receptor antagonists, metoclopramide, bitopic ligand, β-arrestin recruitment assay, computational chemistry

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Neurobiology; https://dx.doi.org/10.3390/ijms24010432

الاتاحة: https://doi.org/10.3390/ijms24010432

المؤلفون: Egyed, Attila, Kelemen, Ádám A., Vass, Márton, Visegrády, András, Thee, Stephanie A., Wang, Zhiyong, de Graaf, Chris, Brea, Jose, Loza, Maria Isabel, Leurs, Rob, Keserű, György M.

المصدر: Egyed , A , Kelemen , Á A , Vass , M , Visegrády , A , Thee , S A , Wang , Z , de Graaf , C , Brea , J , Loza , M I , Leurs , R & Keserű , G M 2021 , ' Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule ' , Bioorganic Chemistry , vol. 111 , 104832 , pp. 1-11 . https://doi.org/10.1016/j.bioorg.2021.104832

مصطلحات موضوعية: Bitopic ligand, Fragment linking, GPCR, Secondary binding pocket, Selectivity, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الاتاحة: https://research.vu.nl/en/publications/a2a77a32-da33-49ad-b455-6e7f15c2f882
https://doi.org/10.1016/j.bioorg.2021.104832
https://hdl.handle.net/1871.1/a2a77a32-da33-49ad-b455-6e7f15c2f882
http://www.scopus.com/inward/record.url?scp=85103953318&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85103953318&partnerID=8YFLogxK

المؤلفون: Bonifazi A., Newman A. H., Keck T. M., Gervasoni S., Vistoli G., Del Bello F., Giorgioni G., Pavletic P., Quaglia W., Piergentili A.

المساهمون: A. Bonifazi, A.H. Newman, T.M. Keck, S. Gervasoni, G. Vistoli, F. Del Bello, G. Giorgioni, P. Pavletic, W. Quaglia, A. Piergentili

مصطلحات موضوعية: bitopic ligand, central nervous system disorder, docking studie, dopamine D, receptor, multitarget compound, Settore CHIM/08 - Chimica Farmaceutica

Time: 3

Relation: info:eu-repo/semantics/altIdentifier/pmid/34529404; info:eu-repo/semantics/altIdentifier/wos/WOS:000706182800013; volume:12; issue:19; firstpage:3638; lastpage:3649; numberofpages:12; journal:ACS CHEMICAL NEUROSCIENCE; http://hdl.handle.net/2434/875879; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115993131

الاتاحة: http://hdl.handle.net/2434/875879
https://doi.org/10.1021/acschemneuro.1c00368

المؤلفون: Pramisha Adhikari, Bing Xie, Ana Semeano, Alessandro Bonifazi, Francisco O. Battiti, Amy H. Newman, Hideaki Yano, Lei Shi

المصدر: Biomolecules; Volume 11; Issue 4; Pages: 570

مصطلحات موضوعية: dopamine D3 receptor, dopamine D2 receptor, bitopic ligand, biased agonism, functional selectivity, subtype selectivity, subtype affinity, chirality

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Chemical Biology; https://dx.doi.org/10.3390/biom11040570

الاتاحة: https://doi.org/10.3390/biom11040570

المؤلفون: Maspero M., Volpato D., Cirillo D., Yuan Chen N., Messerer R., Sotriffer C., De Amici M., Holzgrabe U., Dallanoce C.

المساهمون: M. Maspero, D. Volpato, D. Cirillo, N. Yuan Chen, R. Messerer, C. Sotriffer, M. De Amici, U. Holzgrabe, C. Dallanoce

مصطلحات موضوعية: Multitarget compound, Bitopic ligand, Allosteric modulation, M-1 muscarinic acetylcholine receptor, Ellman's assay, Inositol monophosphate, Phospholipase C, Iperoxo, Tacrine, Xanomeline, Settore CHIM/08 - Chimica Farmaceutica, Settore BIO/14 - Farmacologia

Relation: info:eu-repo/semantics/altIdentifier/pmid/32032848; info:eu-repo/semantics/altIdentifier/wos/WOS:000516796900074; volume:96; numberofpages:13; journal:BIOORGANIC CHEMISTRY; http://hdl.handle.net/2434/719169; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078881070

الاتاحة: http://hdl.handle.net/2434/719169
https://doi.org/10.1016/j.bioorg.2020.103633

المؤلفون: Morales, Paula, Navarro, Gemma, Gómez-Autet, Marc, Redondo, Laura, Fernández-Ruiz, Javier, Pérez-Benito, Laura, Cordomí, Arnau, Pardo, Leonardo, Franco, Rafael, Jagerovic, Nadine

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Superior de Investigaciones Científicas (España)

مصطلحات موضوعية: GPCR, CB2 cannabinoid, Bitopic ligand, Site-directed mutagenesis, Molecular dynamics

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095544-B-I00; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109240RB-I00; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-84117-R; http://dx.doi.org/10.1002/chem.202003389; Sí; e-issn: 1521-3765; Chemistry - A European Journal 26: 15839-15842 (2020); http://hdl.handle.net/10261/230658; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100003339

الاتاحة: http://hdl.handle.net/10261/230658
https://doi.org/10.1002/chem.202003389
https://doi.org/10.13039/501100000780
https://doi.org/10.13039/501100003339

المؤلفون: Elizaveta Lider, Taisiya Sukhikh, Anton Smolentsev, Evgeny Semitut, Evgeny Filatov, Andrei Potapov

المصدر: Crystals; Volume 9; Issue 4; Pages: 222

مصطلحات موضوعية: 1,1,2,2-tetrakis(pyrazol-1-yl)ethane, copper(II) chloride, bitopic ligand, thermogravimetric analysis, binuclear complexes, crystal structure

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cryst9040222

الاتاحة: https://doi.org/10.3390/cryst9040222

المؤلفون: Daniela Volpato, Ulrike Holzgrabe

المصدر: Molecules; Volume 23; Issue 12; Pages: 3230

مصطلحات موضوعية: AChE inhibitor, Alzheimer’s disease, bitopic ligand, cholinergic system, hybrid molecules, muscarinic receptors, nicotinic receptors

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules23123230

الاتاحة: https://doi.org/10.3390/molecules23123230

المؤلفون: Roman Marchenko, Andrei Potapov

المصدر: Molbank, Vol 2017, Iss 4, p M968 (2017)

مصطلحات موضوعية: 1,2,4-triazole, adamantane, alkylation, bitopic ligand, adamantylation, substitution reaction, Inorganic chemistry, QD146-197

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1422-8599/2017/4/M968; https://doaj.org/toc/1422-8599

URL الوصول: https://doaj.org/article/46bdeac625e8449fb71e4537cc8cb72b

المؤلفون: Evgeny Semitut, Taisiya Sukhikh, Evgeny Filatov, Alexey Ryadun, Andrei Potapov

المصدر: Crystals; Volume 7; Issue 12; Pages: 354

مصطلحات موضوعية: zinc, coordination polymer, bitopic ligand, crystal structure, thermal analysis, luminescence, 2,5-thiophenedicarboxylic acid, bis(1,2,4-triazol-1-yl)methane, 1,3-bis(1,2,4-triazol-1-yl)propane

وصف الملف: application/pdf

Relation: Inorganic Crystalline Materials; https://dx.doi.org/10.3390/cryst7120354

الاتاحة: https://doi.org/10.3390/cryst7120354

المؤلفون: A. De Min, U. Holzgrabe, K. Mohr, C. Matera, C. Dallanoce, M. De Amici

المساهمون: A. De Min, C. Matera, C. Dallanoce, U. Holzgrabe, M. De Amici, K. Mohr

مصطلحات موضوعية: muscarinic, dualsteric, allosteric, orthosteric, protean, acetylcholine, mAChR, dynamic binding, bitopic ligand, cholinergic, Settore BIO/10 - Biochimica, Settore BIO/11 - Biologia Molecolare, Settore BIO/14 - Farmacologia, Settore CHIM/08 - Chimica Farmaceutica

Relation: GPCRs: Beyond Structure Towards Therapy; http://hdl.handle.net/2434/329759; https://www.biochemistry.org/Events/tabid/379/View/Posters/Page/3/MeetingNo/SA173/Default.aspx

الاتاحة: http://hdl.handle.net/2434/329759
https://www.biochemistry.org/Events/tabid/379/View/Posters/Page/3/MeetingNo/SA173/Default.aspx

المؤلفون: Evgeny Semitut, Vladislav Komarov, Taisiya Sukhikh, Evgeny Filatov, Andrei Potapov

المصدر: Crystals; Volume 6; Issue 11; Pages: 138

مصطلحات موضوعية: silver, coordination polymer, bitopic ligand, pyrazole, crystal structure, thermal analysis, luminescence, silver nanoparticles

وصف الملف: application/pdf

Relation: Macromolecular Crystals; https://dx.doi.org/10.3390/cryst6110138

الاتاحة: https://doi.org/10.3390/cryst6110138

المؤلفون: C. Matera, M. De Amici, M. Quadri, C. Dallanoce, M. Di Bari, I. Cristofaro, A. M. Tata

المساهمون: C. Matera, M. De Amici, M. Quadri, M. Di Bari, I. Cristofaro, A.M. Tata, C. Dallanoce

مصطلحات موضوعية: glioma, glioblasoma, cancer, tumor, tumour, muscarinic receptor, acetylcholine, AChR, cholinergic system, dualsteric agonist, bitopic ligand, M2, cell line, cell proliferation, cell growth, anticancer activity, new therapy, Settore CHIM/08 - Chimica Farmaceutica, Settore BIO/14 - Farmacologia

Relation: info:eu-repo/semantics/altIdentifier/isbn/9789637067273; ispartofbook:GLISTEN Budapest 2014 Conference : book of abstracts; GLISTEN Conference; firstpage:51; lastpage:51; numberofpages:1; http://hdl.handle.net/2434/240825; http://glisten.ttk.mta.hu/GLISTEN_Budapest_2014_Conference_Booklet.pdf

الاتاحة: http://hdl.handle.net/2434/240825
http://glisten.ttk.mta.hu/GLISTEN_Budapest_2014_Conference_Booklet.pdf

المؤلفون: Javier Fernández-Ruiz, Laura Pérez-Benito, Arnau Cordomí, Rafael Franco, Marc Gómez-Autet, Nadine Jagerovic, Laura Redondo, Leonardo Pardo, Paula Morales, Gemma Navarro

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Superior de Investigaciones Científicas (España)

المصدر: Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Chemistry (Weinheim an Der Bergstrasse, Germany)

مصطلحات موضوعية: Cannabinoid receptor, Stereochemistry, medicine.medical_treatment, Proteïnes G, Molecular Dynamics Simulation, Molecular dynamics, Ligands, 010402 general chemistry, 01 natural sciences, Catalysis, Receptor, Cannabinoid, CB2, GPCR, G protein-coupled receptors, Cànnabis, medicine, Cannabinoid receptor type 2, Binding site, Receptor, Site-directed mutagenesis, G protein-coupled receptor, Cell receptors, Cannabis, Interacció cel·lular, Binding Sites, 010405 organic chemistry, Chemistry, Communication, Organic Chemistry, Mutagenesis, CB2 cannabinoid, General Chemistry, Communications, 0104 chemical sciences, Bitopic ligand, Cell interaction, Mutagenesis, Site-Directed, bitopic ligands, lipids (amino acids, peptides, and proteins), Receptors cel·lulars, Cannabinoid, G Proteins, Medicinal Chemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd90dd173de99ad0906d533b8a7da566
http://hdl.handle.net/2445/179068

المؤلفون: Anton I. Smolentsev, Andrei S. Potapov, Taisiya S. Sukhikh, Evgeny Yu. Semitut, Elizaveta V. Lider, Evgeny Filatov

المصدر: Crystals, Vol 9, Iss 4, p 222 (2019)
Crystals
Volume 9
Issue 4

مصطلحات موضوعية: crystal structure, copper(II) chloride, General Chemical Engineering, Supramolecular chemistry, Infrared spectroscopy, chemistry.chemical_element, 1,1,2,2-tetrakis(pyrazol-1-yl)ethane, Crystal structure, 010402 general chemistry, 01 natural sciences, Chloride, Coordination complex, Inorganic Chemistry, chemistry.chemical_compound, medicine, lcsh:QD901-999, General Materials Science, bitopic ligand, chemistry.chemical_classification, thermogravimetric analysis, 010405 organic chemistry, Chemistry, Hydrogen bond, Condensed Matter Physics, Copper, 0104 chemical sciences, Crystallography, Copper(II) chloride, lcsh:Crystallography, binuclear complexes, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9883dd55b961a5880d6d27cb06c49ff
https://www.mdpi.com/2073-4352/9/4/222

المؤلفون: Rossi, Mario, Fasciani, Irene, Marampon, Francesco, Maggio, Roberto, Scarselli, Marco

المساهمون: Rossi, Mario, Fasciani, Irene, Marampon, Francesco, Maggio, Roberto, Scarselli, Marco

مصطلحات موضوعية: protein-coupled receptor, single-molecule level, d3 receptor, functional-propertie, serotonin-receptor, bitopic ligand, d2, schizophrenia, antagonist, binding

Relation: info:eu-repo/semantics/altIdentifier/pmid/28265019; info:eu-repo/semantics/altIdentifier/wos/WOS:000401101800004; volume:91; issue:6; firstpage:586; lastpage:594; numberofpages:9; journal:MOLECULAR PHARMACOLOGY; http://hdl.handle.net/11573/1259207; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85019405272

الاتاحة: http://hdl.handle.net/11573/1259207
https://doi.org/10.1124/mol.116.107607

المؤلفون: Francesco Marampon, Roberto Maggio, Mario Rossi, Marco Scarselli, Irene Fasciani

مصطلحات موضوعية: 0301 basic medicine, binding, Allosteric modulator, Indoles, Dopamine, Allosteric regulation, Biology, d3 receptor, 03 medical and health sciences, d2, Anti-psychotics, Allosteric Regulation, Dopamine receptor D3, Dopamine receptor D2, Receptors, Dopamine D2, functional-properties, serotonin-receptors, Dopamine D3, Animals, Humans, bitopic ligand, G protein-coupled receptor, Pharmacology, Binding Sites, Receptors, Dopamine D2, Receptors, Dopamine D3, antagonist, Isoquinolines, Small molecule, Cell biology, protein-coupled receptors, single-molecule level, schizophrenia, Allosteric Site, Antipsychotic Agents, Dopamine D2 Receptor Antagonists, 030104 developmental biology, Allosteric enzyme, Biochemistry, Dopamine receptor, biology.protein, Molecular Medicine, Minireview

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e57b2bab31004b7a67126ca2b0f8e1
http://hdl.handle.net/11697/121538