المؤلفون: Pasquale Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Véronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcântara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi

المصدر: ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/5c64fcc1dcb6440098320d12bd53e394

المؤلفون: Daniel Stoessel, Jan-Patrick Stellmann, Anne Willing, Birte Behrens, Sina C. Rosenkranz, Sibylle C. Hodecker, Klarissa H. Stürner, Stefanie Reinhardt, Sabine Fleischer, Christian Deuschle, Walter Maetzler, Daniela Berg, Christoph Heesen, Dirk Walther, Nicolas Schauer, Manuel A. Friese, Ole Pless

المصدر: Frontiers in Human Neuroscience, Vol 12 (2018)

مصطلحات موضوعية: untargeted metabolomics, biomarker, PPMS, MS neurodegeneration, LysoPC(20:0), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnhum.2018.00226/full; https://doaj.org/toc/1662-5161

URL الوصول: https://doaj.org/article/6e3fe203b67340c084d0541f37c9575e

المؤلفون: Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Chiara Borsari, Stefania Ferrari, Matteo Santucci, Nuno Santarem, Anabela Cordeiro-da-Silva, Carolina Moraes, Laura Alcantara, Vanessa Fontana, Lucio Freitas-Junior, Sheraz Gul, Maria Kuzikov, Birte Behrens, Ina Pöhner, Rebecca Wade, Maria Costi, Stefano Mangani

المصدر: Molecules; Volume 22; Issue 3; Pages: 426

مصطلحات موضوعية: pteridine reductase 1, Trypanosoma brucei, Leishmania spp., chroman-4-one, chromen-4-one, crystallographic studies

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules22030426

الاتاحة: https://doi.org/10.3390/molecules22030426

المؤلفون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul

المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul

مصطلحات موضوعية: anti-infective drug, cell-based assay, compound repositorie, enzyme assays or enzyme kinetic, liquid handling

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/30784368; info:eu-repo/semantics/altIdentifier/wos/WOS:000459287100013; volume:24; issue:3; firstpage:346; lastpage:361; numberofpages:16; journal:SLAS DISCOVERY; info:eu-repo/grantAgreement/EC/FP7/603240; http://hdl.handle.net/11585/700003; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85061859197; https://journals.sagepub.com/home/jbx

الاتاحة: http://hdl.handle.net/11585/700003
https://doi.org/10.1177/2472555218823171
https://journals.sagepub.com/home/jbx

المؤلفون: Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt

المساهمون: Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Pöhner, Wolfgang Müller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, José María Alunda, María Jesús Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul, Publica

المصدر: Slas Discovery

مصطلحات موضوعية: Chagas disease, cell-based assays, Antiparasitic, medicine.drug_class, cell-based assay, Computational biology, liquid handling, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Trypanosomiasis, anti-infective drugs, Drug Discovery, parasitic diseases, medicine, Humans, compound repositories, enzyme assays or enzyme kinetics, Biotechnology, Molecular Medicine, 030304 developmental biology, 0303 health sciences, Biological Products, Natural product, biology, Drug discovery, Leishmaniasis, biology.organism_classification, medicine.disease, Trypanocidal Agents, anti-infective drug, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, chemistry, compound repositorie, Neglected tropical diseases, enzyme assays or enzyme kinetic

وصف الملف: ELETTRONICO

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165

المؤلفون: Paloma Tejera Nevado, Anabela Cordeiro-da-Silva, María Jesús Corral, Gesa Witt, Catarina Baptista, Rebecca C. Wade, G. Landi, José Mª Alunda, Juan J. Torrado, Bernhard Ellinger, Maria Kuzikov, Maria Paola Costi, Julia Eick, Stefano Mangani, Jeanette Reinshagen, Eugenia Bifeld, Nuno Santarém, Sheraz Gul, Manfred Kohler, Stefania Ferrari, Joachim Clos, María Dolores Jiménez-Antón, Lucia Dello Iacono, Birte Behrens, Philip Gribbon, Cecilia Pozzi, Oliver Keminer, Markus Wolf, Luca Costantino, Stefan Henrich, Matteo Trande, Rosaria Luciani, Ina Poehner, Flavio Di Pisa, Annalisa Tait, Federica Pellati, Chiara Borsari

المساهمون: Publica

المصدر: 'Journal of Medicinal Chemistry ', vol: 59, pages: 7598-7616 (2016)

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Flavonols, Stereochemistry, Phenotypic screening, Trypanosoma brucei brucei, Trypanosoma brucei, 01 natural sciences, Flavonol Derivatives, Drug Development, Antitrypanosomatidic Drugs, enzyme inhibition, x-ray crystallography, drug delivery, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Drug Discovery, Animals, Humans, Structure–activity relationship, EC50, chemistry.chemical_classification, Biological Products, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, biology, Macrophages, Drug Discovery3003 Pharmaceutical Science, biology.organism_classification, Trypanocidal Agents, In vitro, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, chemistry, Biochemistry, Molecular Medicine, Docking (molecular), Toxicity

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a889fd44ef2bdd1456774dc95d126ca2
https://doi.org/10.1021/acs.jmedchem.6b00698

المؤلفون: Juan J. Torrado, Stefania Ferrari, Maria Paola Costi, Birte Behrens, Luca Costantino, Rosaria Luciani, Sara Macedo, Maria Kuzikov, María Jesús Corral, Anabela Cordeiro-da-Silva, Bernhard Ellinger, Chiara Borsari, Sheraz Gul, Ana Isabel Olías-Molero, María Dolores Jiménez-Antón, Jeanette Reinshagen, Nuno Santarém, José María Alunda, Annalisa Tait, Glauco Ponterini

مصطلحات موضوعية: Stereochemistry, Phenotypic screening, hERG, Trypanosoma brucei, 01 natural sciences, Biochemistry, 03 medical and health sciences, In vivo, Drug Discovery, Moiety, Cytotoxicity, neglected tropical diseases, 030304 developmental biology, 0303 health sciences, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Cytochrome P450, ADME-tox properties, biology.organism_classification, In vitro, 0104 chemical sciences, 3. Good health, flavonol-like compounds, SAR studies, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455b808d33574d4d1e3e13d9c8209afd
https://hdl.handle.net/11380/1175170

المؤلفون: Chiara, Borsari, Nuno, Santarem, Sara, Macedo, María Dolores, Jiménez-Antón, Juan J, Torrado, Ana Isabel, Olías-Molero, María J, Corral, Annalisa, Tait, Stefania, Ferrari, Luca, Costantino, Rosaria, Luciani, Glauco, Ponterini, Sheraz, Gul, Maria, Kuzikov, Bernhard, Ellinger, Birte, Behrens, Jeanette, Reinshagen, José María, Alunda, Anabela, Cordeiro-da-Silva, Maria Paola, Costi

المصدر: ACS medicinal chemistry letters. 10(4)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::af097df47672b91955dfb91ef18ab11b
https://pubmed.ncbi.nlm.nih.gov/30996791

المؤلفون: Chiara Borsari, Flavio Di Pisa, Lucia Dello Iacono, Vanessa Fontana, Lucio H. Freitas-Junior, Anabela Cordeiro-da-Silva, Stefano Mangani, Sheraz Gul, Rebecca C. Wade, Carolina B. Moraes, Birte Behrens, Ina Pöhner, G. Landi, Stefania Ferrari, Matteo Santucci, Nuno Santarém, Maria Kuzikov, Cecilia Pozzi, Laura M. Alcantara, Maria Paola Costi

المساهمون: Publica

المصدر: MOLECULES
Molecules; Volume 22; Issue 3; Pages: 426
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

مصطلحات موضوعية: 0301 basic medicine, Anti parasitic, Molecular Conformation, Pharmaceutical Science, Leishmania spp, Analytical Chemistry, pteridine reductase 1, Drug Discovery, Trypanosoma brucei, Leishmania major, media_common, chemistry.chemical_classification, chromen-4-one, Antiparasitic Agents, Molecular Structure, biology, chroman-4-one, 3. Good health, Molecular Docking Simulation, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Leishmania infantum, Oxidoreductases, Protein Binding, Drug, crystallographic studies, Stereochemistry, media_common.quotation_subject, Trypanosoma brucei brucei, Molecular Dynamics Simulation, Article, Inhibitory Concentration 50, 03 medical and health sciences, parasitic diseases, Chromans, Physical and Theoretical Chemistry, Binding Sites, Organic Chemistry, biology.organism_classification, Leishmania, Antiparasitic agent, Enzyme Activation, Chroman-4-one, Chromen-4-one, Crystallographic studies, Pteridine reductase 1, 030104 developmental biology, Enzyme, chemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465b0d0594164ef59a549b16d64bf327
http://livrepository.liverpool.ac.uk/3019074/1/molecules_2017.pdf

المؤلفون: Daniel Stoessel, Jan-Patrick Stellmann, Anne Willing, Birte Behrens, Sina C. Rosenkranz, Sibylle C. Hodecker, Klarissa H. Stürner, Stefanie Reinhardt, Sabine Fleischer, Christian Deuschle, Walter Maetzler, Daniela Berg, Christoph Heesen, Dirk Walther, Nicolas Schauer, Manuel A. Friese, Ole Pless

مصطلحات موضوعية: Neuroscience, Exercise Physiology, Central Nervous System, Computer Perception, Memory and Attention, Decision Making, Neurocognitive Patterns and Neural Networks, Music Therapy, untargeted metabolomics, biomarker, PPMS, MS neurodegeneration, LysoPC(20:0)

Relation: https://figshare.com/articles/dataset/Data_Sheet_2_Metabolomic_Profiles_for_Primary_Progressive_Multiple_Sclerosis_Stratification_and_Disease_Course_Monitoring_xlsx/6427838

الاتاحة: https://doi.org/10.3389/fnhum.2018.00226.s002
https://figshare.com/articles/dataset/Data_Sheet_2_Metabolomic_Profiles_for_Primary_Progressive_Multiple_Sclerosis_Stratification_and_Disease_Course_Monitoring_xlsx/6427838