المؤلفون: Abacha, Yabalu Z., Forkuo, A.D., Gbedema, S.Y., Mittal, N., Ottilie, S., Rocamora, F., Winzeler, E.A., van Schalkwyk, D.A., Kelly, J.M., Taylor, M.C., Reader, J., Birkholtz, L-M., Lisgarten, D.R., Cockcroft, J.K., Lisgarten, J.N., Palmer, R.A., Talbert, R.C., Shnyder, Steven, Wright, Colin W.

مصطلحات موضوعية: Sustainable pharmaceuticals, Halogenation of cryptolepine, Plasmodium falciparum, Plasmodium knowlesi, Trypanosoma brucei, Ovarian cancer, Malaria, African trypanosomiasis

الاتاحة: http://hdl.handle.net/10454/18930

المؤلفون: Birkholtz, L. -M., Bastien, O., Wells, G., Grando, D., Joubert, F., Kasam, V., Zimmermann, M., Ortet, P., Jacq, N., Roy, S., Hoffmann-Apitius, M., Breton, V., Louw, A. I., Maréchal, E.

المصدر: Malaria Journal 5 (2006) 1-24

مصطلحات موضوعية: Quantitative Biology - Quantitative Methods, Computer Science - Distributed, Parallel, and Cluster Computing, Quantitative Biology - Genomics

URL الوصول: http://arxiv.org/abs/q-bio/0611053

المؤلفون: Morahan, BJ, Abrie, C, Al-Hasani, K, Batty, MB, Corey, V, Cowell, AN, Niemand, J, Winzeler, EA, Birkholtz, L-M, Doerig, C, Garcia-Bustos, JF

Relation: pii: 10.1038/s42003-020-01424-z; Morahan, B. J., Abrie, C., Al-Hasani, K., Batty, M. B., Corey, V., Cowell, A. N., Niemand, J., Winzeler, E. A., Birkholtz, L. -M., Doerig, C. & Garcia-Bustos, J. F. (2020). Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases. Commun Biol, 3 (1), pp.701-. https://doi.org/10.1038/s42003-020-01424-z.; http://hdl.handle.net/11343/272130

الاتاحة: http://hdl.handle.net/11343/272130

المؤلفون: Horatscheck, A, Andrijevic, A, Nchinda, AT, Le Manach, C, Paquet, T, Khonde, LP, Dam, J, Pawar, K, Taylor, D, Lawrence, N, Brunschwig, C, Gibhard, L, Njoroge, M, Reader, J, van der Watt, M, Wicht, K, de Sousa, ACC, Okombo, J, Maepa, K, Egan, TJ, Birkholtz, L-M, Basarab, GS, Wittlin, S, Fish, PV, Street, LJ, Duffy, J, Chibale, K

المصدر: Journal of Medicinal Chemistry , 63 (21) pp. 13013-13030. (2020)

مصطلحات موضوعية: Parasites, Substituents, Assays, Rodent models, Toxicity

وصف الملف: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10113807/1/jm-2020-014118_final_manuscript.pdf; https://discovery.ucl.ac.uk/id/eprint/10113807/

الاتاحة: https://discovery.ucl.ac.uk/id/eprint/10113807/1/jm-2020-014118_final_manuscript.pdf
https://discovery.ucl.ac.uk/id/eprint/10113807/

المؤلفون: Coertzen D., Reader J., Van Der Watt M., Nondaba S. H., Gibhard L., Wiesner L., Smith P., D'Alessandro S., Taramelli D., Wong H. N., Du Preez J. L., Wu R. W. K., Birkholtz L. -M., Haynes R. K.

المساهمون: D. Coertzen, J. Reader, M. Van Der Watt, S.H. Nondaba, L. Gibhard, L. Wiesner, P. Smith, S. D'Alessandro, D. Taramelli, H.N. Wong, J.L. Du Preez, R.W.K. Wu, L.-. Birkholtz, R.K. Haynes

مصطلحات موضوعية: Artemisinin, Gametocyte, Oxidative stre, Plasmodium falciparum, Reactive oxygen specie, Synergism, Settore MED/04 - Patologia Generale, Settore MED/07 - Microbiologia e Microbiologia Clinica

Relation: info:eu-repo/semantics/altIdentifier/pmid/29866868; info:eu-repo/semantics/altIdentifier/wos/WOS:000440008400066; volume:62; issue:8; firstpage:1; lastpage:17; numberofpages:17; journal:ANTIMICROBIAL AGENTS AND CHEMOTHERAPY; http://hdl.handle.net/2434/658186; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85052022980

الاتاحة: http://hdl.handle.net/2434/658186
https://doi.org/10.1128/AAC.02214-17

المؤلفون: Brunschwig, C, Lawrence, N, Taylor, D, Abay, E, Njoroge, M, Basarab, GS, Le Manach, C, Paquet, T, Cabrera, D, Nchinda, AT, de Kock, C, Wiesner, L, Denti, P, Waterson, D, Blasco, B, Leroy, D, Witty, MJ, Donini, C, Duffy, J, Wittlin, S, White, KL, Charman, SA, Jiménez-Díaz, MB, Angulo-Barturen, I, Herreros, E, Gamo, FJ, Rochford, R, Mancama, D, Coetzer, TL, van der Watt, ME, Reader, J, Birkholtz, L-M, Marsh, KC, Solapure, SM, Vanaerschot, M, Fidock, DA, Fish, PV, Siegl, P, Smith, DA, Wirjanata, G, Noviyanti, R, Price, RN, Marfurt, J, Silue, KD, Street, LJ, Chibale, K

Relation: https://ora.ox.ac.uk/objects/uuid:14edbcdb-ccd5-434f-ac7a-4c93ad57a0d7; https://doi.org/10.1128/aac.00012-18

الاتاحة: https://doi.org/10.1128/aac.00012-18
https://ora.ox.ac.uk/objects/uuid:14edbcdb-ccd5-434f-ac7a-4c93ad57a0d7

المؤلفون: Le Manach, C., Dam, J., Woodland, J. G., Kaur, G., Khonde, L. P., Brunschwig, C., Njoroge, M., Wicht, K. J., Horatscheck, A., Paquet, T., Boyle, G. A., Gibhard, L., Taylor, D., Lawrence, N., Yeo, T., Mok, S., Eastman, R. T., Dorjsuren, D., Talley, D. C., Guo, H., Simeonov, A., Reader, J., van der Watt, M., Erlank, E., Venter, N., Zawada, J. W., Aswat, A., Nardini, L., Coetzer, T. L., Lauterbach, S. B., Bezuidenhout, B. C., Theron, A., Mancama, D., Koekemoer, L. L., Birkholtz, L. M., Wittlin, S., Delves, M., Ottilie, S., Winzeler, E. A., von Geldern, T. W., Smith, D., Fidock, D. A., Street, L. J., Basarab, G. S., Duffy, J., Chibale, K.

Relation: Le Manach, C. and Dam, J. and Woodland, J. G. and Kaur, G. and Khonde, L. P. and Brunschwig, C. and Njoroge, M. and Wicht, K. J. and Horatscheck, A. and Paquet, T. and Boyle, G. A. and Gibhard, L. and Taylor, D. and Lawrence, N. and Yeo, T. and Mok, S. and Eastman, R. T. and Dorjsuren, D. and Talley, D. C. and Guo, H. and Simeonov, A. and Reader, J. and van der Watt, M. and Erlank, E. and Venter, N. and Zawada, J. W. and Aswat, A. and Nardini, L. and Coetzer, T. L. and Lauterbach, S. B. and Bezuidenhout, B. C. and Theron, A. and Mancama, D. and Koekemoer, L. L. and Birkholtz, L. M. and Wittlin, S. and Delves, M. and Ottilie, S. and Winzeler, E. A. and von Geldern, T. W. and Smith, D. and Fidock, D. A. and Street, L. J. and Basarab, G. S. and Duffy, J. and Chibale, K. (2021) Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts. Journal of medicinal chemistry, 64 (4). pp. 2291-2309.; info:pmid/33573376; urn:ISSN:0022-2623

الاتاحة: https://edoc.unibas.ch/89177/
https://doi.org/10.1021/acs.jmedchem.1c00034

المؤلفون: Dziwornu, G. A., Coertzen, D., Leshabane, M., Korkor, C. M., Cloete, C. K., Njoroge, M., Gibhard, L., Lawrence, N., Reader, J., van der Watt, M., Wittlin, S., Birkholtz, L. M., Chibale, K.

Relation: Dziwornu, G. A. and Coertzen, D. and Leshabane, M. and Korkor, C. M. and Cloete, C. K. and Njoroge, M. and Gibhard, L. and Lawrence, N. and Reader, J. and van der Watt, M. and Wittlin, S. and Birkholtz, L. M. and Chibale, K. (2021) Antimalarial benzimidazole derivatives incorporating phenolic mannich base side chains inhibit microtubule and hemozoin formation: structure-activity relationship and in vivo oral efficacy studies. Journal of medicinal chemistry, 64 (8). pp. 5198-5215.; info:pmid/33844521; urn:ISSN:0022-2623

الاتاحة: https://edoc.unibas.ch/89033/
https://doi.org/10.1021/acs.jmedchem.1c00354

المؤلفون: Horatscheck, A., Andrijevic, A., Nchinda, A. T., Le Manach, C., Paquet, T., Khonde, L. P., Dam, J., Pawar, K., Taylor, D., Lawrence, N., Brunschwig, C., Gibhard, L., Njoroge, M., Reader, J., van der Watt, M., Wicht, K., de Sousa, A. C. C., Okombo, J., Maepa, K., Egan, T. J., Birkholtz, L. M., Basarab, G. S., Wittlin, S., Fish, P. V., Street, L. J., Duffy, J., Chibale, K.

Relation: Horatscheck, A. and Andrijevic, A. and Nchinda, A. T. and Le Manach, C. and Paquet, T. and Khonde, L. P. and Dam, J. and Pawar, K. and Taylor, D. and Lawrence, N. and Brunschwig, C. and Gibhard, L. and Njoroge, M. and Reader, J. and van der Watt, M. and Wicht, K. and de Sousa, A. C. C. and Okombo, J. and Maepa, K. and Egan, T. J. and Birkholtz, L. M. and Basarab, G. S. and Wittlin, S. and Fish, P. V. and Street, L. J. and Duffy, J. and Chibale, K. (2020) Identification of 2,4-disubstituted imidazopyridines as hemozoin formation inhibitors with fast-killing kinetics and in vivo efficacy in the Plasmodium falciparum NSG mouse model. Journal of medicinal chemistry, 63 (21). pp. 13013-13030.; info:pmid/33103428; urn:ISSN:0022-2623

الاتاحة: https://edoc.unibas.ch/91161/
https://doi.org/10.1021/acs.jmedchem.0c01411

المؤلفون: Ahenkorah, S., Coertzen, D., Tong, J. X., Fridianto, K., Wittlin, S., Birkholtz, L. M., Tan, K. S. W., Lam, Y., Go, M. L., Haynes, R. K.

Relation: Ahenkorah, S. and Coertzen, D. and Tong, J. X. and Fridianto, K. and Wittlin, S. and Birkholtz, L. M. and Tan, K. S. W. and Lam, Y. and Go, M. L. and Haynes, R. K. (2020) Antimalarial N1,N3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships. ACS medicinal chemistry letters, 11. pp. 49-55.; info:pmid/31938463; urn:ISSN:1948-5875

الاتاحة: https://edoc.unibas.ch/75569/
https://doi.org/10.1021/acsmedchemlett.9b00457

المؤلفون: Paquet, T, Le Manach, C, Cabrera, DG, Younis, Y, Henrich, PP, Abraham, TS, Lee, MCS, Basak, R, Ghidelli-Disse, S, Lafuente-Monasterio, MJ, Bantscheff, M, Ruecker, A, Blagborough, AM, Zakutansky, SE, Zeeman, A-M, White, KL, Shackleford, DM, Mannila, J, Morizzi, J, Scheurer, C, Angulo-Barturen, I, Martinez, MS, Ferrer, S, Sanz, LM, Gamo, FJ, Reader, J, Botha, M, Dechering, KJ, Sauerwein, RW, Tungtaeng, A, Vanachayangkul, P, Lim, CS, Burrows, J, Witty, MJ, Marsh, KC, Bodenreider, C, Rochford, R, Solapure, SM, Jimenez-Diaz, MB, Wittlin, S, Charman, SA, Donini, C, Campo, B, Birkholtz, L-M, Hanson, KK, Drewes, G, Kocken, CHM, Delves, MJ, Leroy, D, Fidock, DA, Waterson, D, Street, LJ, Chibale, K

المساهمون: Medical Research Council (MRC), Bill & Melinda Gates Foundation

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Cell Biology, Medicine, Research & Experimental, Research & Experimental Medicine, DNA-SEQUENCING DATA, SINGLE-DOSE CURE, IN-VITRO, DRUG DISCOVERY, NEXT-GENERATION, KINASE INHIBITORS, MALARIA PARASITES, FALCIPARUM, TRANSMISSION, QUANTIFICATION, 11 Medical And Health Sciences, 06 Biological Sciences

Relation: Science Translational Medicine; http://hdl.handle.net/10044/1/53195; https://dx.doi.org/10.1126/scitranslmed.aad9735; MR/N00227X/1; n/a

الاتاحة: http://hdl.handle.net/10044/1/53195
https://doi.org/10.1126/scitranslmed.aad9735

المؤلفون: Rossouw, CL, Chetty, A, Moolman, FS, Birkholtz, L-M, Hoppe, H, Mancama, Dalubuhle T

مصطلحات موضوعية: Poly(N-isopropylacrylamide), Poly(propylene), Cell proliferation, Hepatocyte, Non-woven fabrics

وصف الملف: application/pdf

Relation: Workflow;9930; Rossouw CL, Chetty A, Moolman FS, Birkholtz L-M, Hoppe H and Mancama DT. 2012. Thermo-Responsive non-woven scaffolds for ‘‘smart’’ 3D cell culture. Biotechnology & Bioengineering, Vol. 109(8), pp 2147-2158; http://hdl.handle.net/10204/6406

الاتاحة: http://hdl.handle.net/10204/6406
http://onlinelibrary.wiley.com/doi/10.1002/bit.24469/abstract;jsessionid=01608DA574DDD9CD670971127F9D9762.d04t04