المؤلفون: Kenneth Down (1523722), Augustin Amour (1523692), Niall A. Anderson (4590892), Nick Barton (363978), Sebastien Campos (3847891), Edward P. Cannons (1840267), Cole Clissold (10498431), Maire A. Convery (1840459), John J. Coward (11422026), Kevin Doyle (2324602), Birgit Duempelfeld (4174972), Christopher D. Edwards (2342788), Michael D. Goldsmith (11422029), Jana Krause (2885033), David N. Mallett (1494217), Grant A. McGonagle (1330743), Vipulkumar K. Patel (2342794), James Rowedder (6112244), Paul Rowland (1523731), Andrew Sharpe (3575186), Srividya Sriskantharajah (9261425), Daniel A. Thomas (1932538), Douglas W. Thomson (1266420), Sorif Uddin (2891561), J. Nicole Hamblin (1523686), Edith M. Hessel (8267715)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, positive heteroaromatic amine, orally bioavailable inhibitor, avoid glutathione trapping, clinical candidate compound, 31 , highly selective compound, highly selective, highly potent, trp760 led, sulfonamide followed, enhance potency, embedded ames, 45 mg

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_GSK251_A_Highly_Potent_Highly_Selective_Orally_Bioavailable_Inhibitor_of_PI3K_with_a_Novel_Binding_Mode/16607748

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01102.s001

المؤلفون: Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe

المصدر: Journal of Medicinal Chemistry. 65:633-664

مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Binding Sites, Aldehyde Oxidase, Molecular Docking Simulation, Mice, Structure-Activity Relationship, Drug Delivery Systems, Liver, Drug Discovery, Quinazolines, Animals, Humans, Janus Kinase Inhibitors, Molecular Medicine, Administration, Intravenous, Female, Lung, Administration, Intranasal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765

المؤلفون: Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell

المصدر: Journal of Medicinal Chemistry. 63:638-655

مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Cell membrane permeability, Class I Phosphatidylinositol 3-Kinases, Biological Availability, Class iii, Crystallography, X-Ray, Binding, Competitive, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Drug discovery, Chemistry, Class III Phosphatidylinositol 3-Kinases, Combinatorial chemistry, Rats, Bioavailability, Isoenzymes, Molecular Docking Simulation, Toxicity, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee509ec4ce8051c7f53718e7e95b2637
https://doi.org/10.1021/acs.jmedchem.9b01585

المؤلفون: Carsten, Hopf, Dirk, Eberhard, Markus, Boesche, Sonja, Bastuck, Birgit, Dümpelfeld, Marcus, Bantscheff

المصدر: Methods in molecular biology (Clifton, N.J.). 803

مصطلحات موضوعية: Cell Extracts, Proteomics, Staining and Labeling, Statistics as Topic, Cell Fractionation, Staurosporine, Binding, Competitive, Chromatography, Affinity, Mass Spectrometry, Molecular Weight, Inhibitory Concentration 50, Biological Assay, Trypsin, Protein Kinase Inhibitors, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::3344fd6f61a86877b50728be6e5ee913
https://pubmed.ncbi.nlm.nih.gov/22065223

المؤلفون: Carsten Hopf, Markus Boesche, Marcus Bantscheff, Dirk Eberhard, Sonja Bastuck, Birgit Dümpelfeld

المصدر: Methods in Molecular Biology ISBN: 9781617793639

مصطلحات موضوعية: Matrix (chemical analysis), medicine.anatomical_structure, Biochemistry, Chemistry, Kinase, Cell, medicine, Biophysics, Isobaric process, Mass spectrometry, Proteomics, Small molecule, Function (biology)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5cc1517e907266939ceb899f5b0acfb6
https://doi.org/10.1007/978-1-61779-364-6_10

المؤلفون: Isabelle Becher, Valerie Reader, Giovanna Bergamini, Gavain Sweetman, Carola Huthmacher, Nigel Ramsden, Katja Strunk, Dirk Eberhard, Markus Boesche, Antje Dittmann, Marcus Bantscheff, Mikhail M. Savitski, Ulrich Kruse, Daniel Poeckel, Birgit Dümpelfeld, Gitte Neubauer, Judith Schlegl, Anne-Marie Michon, Gerard Drewes, Paola Grandi, Toby Mathieson, Carsten Hopf, Yann Abraham, Manja Delling

المصدر: Nature biotechnology. 29(3)

مصطلحات موضوعية: Proteomics, SIN3 Complex, medicine.drug_class, Chemistry, HDAC10, Histone deacetylase inhibitor, Biomedical Engineering, Bioengineering, HDAC6, Applied Microbiology and Biotechnology, Small molecule, Peptide Mapping, Histone Deacetylases, Mass Spectrometry, Biochemistry, Protein Interaction Mapping, medicine, Molecular Medicine, Chemoproteomics, Histone deacetylase, Mitosis, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858112a78ab434e3f673b402df393db3
https://pubmed.ncbi.nlm.nih.gov/21390028

المؤلفون: Thomas Luebbers, Harald Steiner, Birgit Dümpelfeld, Scott Hobson, Edith Winkler, Carsten Hopf, Karlheinz Baumann, Christian Haass, Akio Fukumori

المصدر: Biochemistry. 48(6)

مصطلحات موضوعية: medicine.medical_treatment, Protein subunit, Nicastrin, Peptide, Biology, Tandem mass spectrometry, Biochemistry, Presenilin, Chromatography, Affinity, Cell Line, Substrate Specificity, Tandem Mass Spectrometry, mental disorders, medicine, Humans, Biotinylation, Enzyme Inhibitors, chemistry.chemical_classification, Protease, Molecular mass, Molecular Weight, Protein Subunits, Membrane protein, chemistry, Multiprotein Complexes, biology.protein, Electrophoresis, Polyacrylamide Gel, Mutant Proteins, Amyloid Precursor Protein Secretases, Chromatography, Liquid, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e60763f0e63395d10bb415ff009cc7a
https://pubmed.ncbi.nlm.nih.gov/19159235

المؤلفون: Paola Grandi, Georg Casari, Roland Krause, Marie-Anne Heurtier, Lars Juhl Jensen, Anne-Marie Michon, Gerard Drewes, Martina Marzioch, Angela Edelmann, Andreas Bauer, Christian Hoefert, Christina Rau, Verena Hoffman, Tatjana Rudi, Marita Remor, Giulio Superti-Furga, Karin Klein, Bernhard Kuster, Tewis Bouwmeester, Patrick Aloy, Robert B. Russell, Manuela Hudak, Sonja Bastuck, Birgit Dümpelfeld, Jens Rick, Markus Schirle, Markus Boesche, Peer Bork, Sean D. Hooper, Malgorzata Schelder, Gitte Neubauer, Anne-Claude Gavin

المصدر: Nature, Vol. 440, No 7084 (2006) pp. 631-636

مصطلحات موضوعية: Proteomics, Biological data, Saccharomyces cerevisiae Proteins, Multidisciplinary, Proteome, Systems biology, Saccharomyces cerevisiae, Computational biology, Biology, biology.organism_classification, Cell biology, Open Reading Frames, Phenotype, Protein structure, Structural biology, Multiprotein Complexes, ddc:610, Genome, Fungal, Functional genomics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d8009f07f8203f6ed2e3505bdf3e5b
https://archive-ouverte.unige.ch/unige:156899

المؤلفون: Marcus Bantscheff, Birgit Dümpelfeld, Bernhard Kuster

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Chromatography, Chemistry, Microchemistry, Sample (material), Absolute quantification, Organic Chemistry, Proteins, Reproducibility of Results, Computational biology, Oxygen Isotopes, Composition (combinatorics), Mass spectrometry, Sensitivity and Specificity, Analytical Chemistry, Label-free quantification, Isotope Labeling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Nanotechnology, Protein identification, Sensitivity (control systems), Spectroscopy, Chemical labeling

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e325cd6a96612d6e593ebd37f093d12
http://www.scopus.com/inward/record.url?eid=2-s2.0-1942502792&partnerID=MN8TOARS