المؤلفون: Matthew E. Paolella, Daniel S. Honeycutt, Bradley M. Lipka, Jacob M. Goldberg, Fang Wang

المصدر: Beilstein Journal of Organic Chemistry, Vol 21, Iss 1, Pp 189-199 (2025)

مصطلحات موضوعية: bioisostere, difluoromethyl (cf2h), fluorine, hydrogen bond donors, hydrogen bond strength, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/22ffda80f23749feb5eb99cc81ed52b3

المؤلفون: Jens Frackenpohl, David M. Barber, Guido Bojack, Birgit Bollenbach-Wahl, Ralf Braun, Rahel Getachew, Sabine Hohmann, Kwang-Yoon Ko, Karoline Kurowski, Bernd Laber, Rebecca L. Mattison, Thomas Müller, Anna M. Reingruber, Dirk Schmutzler, Andrea Svejda

المصدر: Beilstein Journal of Organic Chemistry, Vol 20, Iss 1, Pp 540-551 (2024)

مصطلحات موضوعية: 2,3-dihydro[1,3]thiazolo[4,5-b]pyridine, acyl-acp thioesterase, bioisostere, herbicide, heterocycle, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/6054080d522941d3aa12d30eab93302d

المؤلفون: Livesley, Sarah, Sterling, Alistair J, Robertson, Craig M, Goundry, William RF, Morris, James A, Duarte, Fernanda, Aïssa, Christophe

المصدر: Angewandte Chemie International Edition. 61(2)

مصطلحات موضوعية: [1, 1, 1]propellane, amination, bicyclo[1, 1]pentane, bioisostere, halogen bond, [1.1.1]propellane, bicyclo[1.1.1]pentane, Chemical Sciences, Organic Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0v33v6h8
https://escholarship.org/content/qt0v33v6h8/qt0v33v6h8.pdf

المؤلفون: Francisco, Karol R, Varricchio, Carmine, Paniak, Thomas J, Kozlowski, Marisa C, Brancale, Andrea, Ballatore, Carlo

مصطلحات موضوعية: Generic health relevance, Hydrogen Bonding, Models, Molecular, Molecular Structure, Sulfonamides, N-Acylsulfonamide isostere, Bioisostere, Isosteric replacement, Physicochemical properties, Structure property relationship, Oxetane, Thietane, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3k75582x

المؤلفون: Nathan Long, Adam Le Gresley, Arran Solomonsz, Antony Wozniak, Steve Brough, Stephen P. Wren

المصدر: SynOpen, Vol 07, Iss 03, Pp 401-407 (2023)

مصطلحات موضوعية: squaric acid, squaramide, bioisostere, carboxylic acid, compound library, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2509-9396

URL الوصول: https://doaj.org/article/2cabfebc41af4399a6b0179a660de13c

المؤلفون: La Spada, Gabriella, Miniero, Daniela Valeria, Rullo, Mariagrazia, Cipolloni, Marco, Delre, Pietro, Colliva, Carolina, Colella, Marco, Leonetti, Francesco, Liuzzi, Grazia Maria, Mangiatordi, Giuseppe Felice, Giacchè, Nicola, Pisani, Leonardo

المساهمون: La Spada, Gabriella, Miniero, Daniela Valeria, Rullo, Mariagrazia, Cipolloni, Marco, Delre, Pietro, Colliva, Carolina, Colella, Marco, Leonetti, Francesco, Liuzzi, Grazia Maria, Mangiatordi, Giuseppe Felice, Giacchè, Nicola, Pisani, Leonardo

مصطلحات موضوعية: Multitarget, monoamine oxidases, acetylcholinesterase, butyrylcholinesterase, bioisostere, structure-based

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001249456700001; volume:274; journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; https://hdl.handle.net/11586/479540

الاتاحة: https://hdl.handle.net/11586/479540
https://doi.org/10.1016/j.ejmech.2024.116511

المؤلفون: Knippenberg, Niels, Lowdon, Joseph W, Frigoli, Margaux, Cleij, Thomas J, Eersels, Kasper, van Grinsven, Bart, Diliën, Hanne

المصدر: Knippenberg , N , Lowdon , J W , Frigoli , M , Cleij , T J , Eersels , K , van Grinsven , B & Diliën , H 2024 , ' Development towards a novel screening method for nipecotic acid bioisosteres using molecular imprinted polymers (MIPs) as alternative to in vitro cellular uptake assays ' , Talanta , vol. 278 , 126500 , pp. 126500 . https://doi.org/10.1016/j.talanta.2024.126500

مصطلحات موضوعية: Bioisostere, In vitro screening, Molecular imprinted polymer, Nipecotic acid

الاتاحة: https://cris.maastrichtuniversity.nl/en/publications/fabb71de-03b5-4189-acdc-98c246e77738
https://doi.org/10.1016/j.talanta.2024.126500

المؤلفون: Giulia Bononi, Chiara Lonzi, Tiziano Tuccinardi, Filippo Minutolo, Carlotta Granchi

المصدر: Molecules, Vol 29, Iss 9, p 1930 (2024)

مصطلحات موضوعية: benzoylpiperidine, phenyl(piperidin-4-yl)methanone, benzoylpiperidine-based small molecules, privileged structure, medicinal chemistry, bioisostere, Organic chemistry, QD241-441

Relation: https://www.mdpi.com/1420-3049/29/9/1930; https://doaj.org/toc/1420-3049; https://doaj.org/article/6816455dde564c90b93b21d9b672a53a

الاتاحة: https://doi.org/10.3390/molecules29091930
https://doaj.org/article/6816455dde564c90b93b21d9b672a53a

المؤلفون: Choy, Alison Pui Ki

المساهمون: Glen, Robert

مصطلحات موضوعية: 615.7, Sites of metabolism prediction, QSAR, Bioisostere, Bioavailability, Cytochrome P450 3A4, P-Glycoprotein

URL الوصول: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753416

المؤلفون: Jian, Jie, Hammink, Roel, Tinnemans, Paul, Bickelhaupt, F. Matthias, Poater, Jordi, Mecinović, Jasmin

المصدر: Jian , J , Hammink , R , Tinnemans , P , Bickelhaupt , F M , Poater , J & Mecinović , J 2023 , ' Probing Polar-π Interactions Between Tetrazoles and Aromatic Rings ' , Chemistry - An Asian Journal , vol. 18 , no. 10 , e202300192 , pp. 1-9 . https://doi.org/10.1002/asia.202300192

مصطلحات موضوعية: aromatic ring, bioisostere, noncovalent interactions, substituent effect, tetrazole

الاتاحة: https://research.vu.nl/en/publications/afc720d7-4537-43a5-8fcc-5a2907197644
https://doi.org/10.1002/asia.202300192
https://hdl.handle.net/1871.1/afc720d7-4537-43a5-8fcc-5a2907197644
http://www.scopus.com/inward/record.url?scp=85153330757&partnerID=8YFLogxK
http://www.scopus.com/inward/citedby.url?scp=85153330757&partnerID=8YFLogxK

المؤلفون: Vadim Markovtsov, Matthew A. J. Duncton, Art Bagos, Sothy Yi, Sylvia Braselmann, Somasekhar Bhamidipati, Ihab S. Darwish, Jiaxin Yu, Alexander M. Owyang, Beth Fernandez, Bhushan Samant, Gary Park, Esteban S. Masuda, Simon J. Shaw

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Ecology, Immunology, Hematology, Infectious Diseases, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, vinyl sulfone series, triazolone bioisostere approach, shows little inhibition, low plasma stability, highly electrophilic molecules, eae model similar, 17 , 1 , efficacy dimethyl fumarate, target nrf2 activation, target activation, vivo <, target receptors, target potency, pk properties, niacin receptor, multiple sclerosis

Relation: https://figshare.com/articles/journal_contribution/Tuning_the_Reactivity_of_Nuclear_Factor_Erythroid_2_Related_Factor_2_Nrf2_Activators_for_Optimal_i_in_Vivo_i_Efficacy/24602042

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00336.s001
https://figshare.com/articles/journal_contribution/Tuning_the_Reactivity_of_Nuclear_Factor_Erythroid_2_Related_Factor_2_Nrf2_Activators_for_Optimal_i_in_Vivo_i_Efficacy/24602042

المؤلفون: Jeffrey J. Jackson, Aaron C. Siegmund, Wen-Ju Bai, Anthony B. Reed, Adam B. Birkholz, Iain D. G. Campuzano, Amandine Créquer-Grandhomme, Ruozhen Hu, Rucha V. Modak, Athena Sudom, Noelle Javier, Christiana Sanders, Mei-Chu Lo, Fang Xie, Victor J. Cee, Paolo Manzanillo, John G. Allen

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Immunology, Developmental Biology, Mental Health, Hematology, Chemical Sciences not elsewhere classified, β ‑ 1, ray cocrystal structures, cell surface long, based drug design, >‑ acetylglucosaminyltransferase 2, vivo <, successfully serve, pk properties, pharmacokinetic properties, n <, isoform selectivity, improved potency, immune response, chain polylactosamine, certain physicochemical, attractive target, amide bond, amide bioisosteres, amide bioisostere, 3 ‑<

Relation: https://figshare.com/articles/journal_contribution/Imidazolone_as_an_Amide_Bioisostere_in_the_Development_of_1_3_i_N_i_Acetylglucosaminyltransferase_2_B3GNT2_Inhibitors/24602242

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01517.s001
https://figshare.com/articles/journal_contribution/Imidazolone_as_an_Amide_Bioisostere_in_the_Development_of_1_3_i_N_i_Acetylglucosaminyltransferase_2_B3GNT2_Inhibitors/24602242

المؤلفون: Jarvis Hill, Robert M. Jones, David Crich

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, key polar interactions, improved drug efflux, beneficial properties conferred, matched molecular pair, >‑ noralkoxy switch, lesser substituted hydroxylamines, atypical amine bioisostere, approved dual csrc, >- alkyl groups, 9 , dual csrc, >‑ alkyl, >- alkyl, molecular weight, vivo <, n <, well tolerated, upon incorporation, trisubstituted hydroxylamines, trisubstituted hydroxylamine, piperazine unit, often ascribed, medicinal chemistry

Relation: https://figshare.com/articles/journal_contribution/Atypical_i_N_i_Alkyl_to_i_N_i_Noralkoxy_Switch_in_a_Dual_cSRC_BCR-ABL1_Kinase_Inhibitor_Improves_Drug_Efflux_and_hERG_Affinity/24747391

الاتاحة: https://doi.org/10.1021/acsmedchemlett.3c00479.s001
https://figshare.com/articles/journal_contribution/Atypical_i_N_i_Alkyl_to_i_N_i_Noralkoxy_Switch_in_a_Dual_cSRC_BCR-ABL1_Kinase_Inhibitor_Improves_Drug_Efflux_and_hERG_Affinity/24747391

المؤلفون: Chu Wang, Xiao Liu, Qian Wang, Wei-Hai Fang, Xuebo Chen

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, unveiling mechanistic insights, underlying mechanisms involved, reactions remains limited, potential aniline bioisostere, kinetic data contribute, intricate mechanisms regulating, critical control factors, 2 )- cycloaddition, two paradigmatic single, photoredox catalysis signifies, photoredox catalysis, particularly single, thereby guiding, sustainable chemistry, state theory, remarkable breakthrough, radical cascades, photocatalytic advancements, pharmaceutical chemistry, organic chemistry, models combined, investigations delve, innovatively introduce, employ high

Relation: https://figshare.com/articles/journal_contribution/Unveiling_Mechanistic_Insights_and_Photocatalytic_Advancements_in_Intramolecular_Photo-_3_2_-Cycloaddition_A_Comparative_Assessment_of_Two_Paradigmatic_Single-Electron-Transfer_Models/24808579

الاتاحة: https://doi.org/10.1021/jacsau.3c00542.s001
https://figshare.com/articles/journal_contribution/Unveiling_Mechanistic_Insights_and_Photocatalytic_Advancements_in_Intramolecular_Photo-_3_2_-Cycloaddition_A_Comparative_Assessment_of_Two_Paradigmatic_Single-Electron-Transfer_Models/24808579

المؤلفون: Cuadros, Sara, Goti, Giulio, Barison, Giorgia, Raulli, Alfredo, Bortolato, Tommaso, Pelosi, Giorgio, Costa, Paolo, Dell'Amico, Luca

المساهمون: Cuadros, Sara, Goti, Giulio, Barison, Giorgia, Raulli, Alfredo, Bortolato, Tommaso, Pelosi, Giorgio, Costa, Paolo, Dell'Amico, Luca

مصطلحات موضوعية: Fluorine Chemistry, Hybrid Bioisostere, Photoredox Catalysi, Propellane, Sustainable Synthesis, Settore CHEM-05/A - Chimica organica

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:001014501700001; journal:ANGEWANDTE CHEMIE. INTERNATIONAL EDITION; https://hdl.handle.net/11381/2968633

الاتاحة: https://hdl.handle.net/11381/2968633
https://doi.org/10.1002/anie.202303585

المؤلفون: Philipp Rühl, Franz Bracher

المصدر: Molecules, Vol 28, Iss 21, p 7428 (2023)

مصطلحات موضوعية: cation channels, TRPML1, bioisostere, steroids, estrogens, ring cleavage, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/21/7428; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/b1d4b91a9d984ff4ad60261614d2cdad

المؤلفون: Lassalas, Pierrik, Oukoloff, Killian, Makani, Vishruti, James, Michael, Tran, Van, Yao, Yuemang, Huang, Longchuan, Vijayendran, Krishna, Monti, Ludovica, Trojanowski, John Q, Lee, Virginia M-Y, Kozlowski, Marisa C, Smith, Amos B, Brunden, Kurt R, Ballatore, Carlo

المصدر: ACS Medicinal Chemistry Letters. 8(8)

مصطلحات موضوعية: Oxetan-3-ol, thietan-3-ol, carboxylic acid bioisostere, cyclooxygenase, lipoxygenase, dual inhibitors, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/41r604kc

المؤلفون: Hiroyuki Kagechika, Shuichi Mori, 影近 弘之, 森 修一

المصدر: YAKUGAKU ZASSHI. 2023, 143(5):429

المؤلفون: Yuvixza Lizarme-Salas, Alexandra Daryl Ariawan, Ranjala Ratnayake, Hendrik Luesch, Angela Finch, Luke Hunter

المصدر: Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2663-2670 (2020)

مصطلحات موضوعية: alzheimer's disease, bioisostere, conformational analysis, gauche effect, stereoselective synthesis, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/42e3bb5aa4d2484d8ce4736cb8375a10

المؤلفون: Huang, Guang, Cierpicki, Tomasz, Grembecka, Jolanta

المصدر: Future Med Chem ; ISSN:1756-8927 ; Volume:17 ; Issue:1

مصطلحات موضوعية: Thioamides, bioisostere, chelator, drug design, drug discovery, hydrogen sulfide donor, metal complexes, prodrug

Relation: https://doi.org/10.1080/17568919.2024.2435245; https://pubmed.ncbi.nlm.nih.gov/39623876

الاتاحة: https://doi.org/10.1080/17568919.2024.2435245
https://pubmed.ncbi.nlm.nih.gov/39623876