المؤلفون: Michael H. Reutershan (2470597), Michelle R. Machacek (2639716), Michael D. Altman (1302795), Stephane Bogen (2519965), Mingmei Cai (9470078), Carolyn Cammarano (11624110), Dapeng Chen (528941), Matthew Christopher (9661265), John Cryan (3485639), Pierre Daublain (1625986), Xavier Fradera (2585029), Prasanthi Geda (1412485), Peter Goldenblatt (4640101), Armetta D. Hill (11624113), Raymond A. Kemper (2317396), Victoria Kutilek (5741171), Chaomin Li (1976134), Michelle Martinez (642014), Mark McCoy (2600125), Latha Nair (2299723), Weidong Pan (1427614), Christopher F. Thompson (1706539), Giovanna Scapin (1427611), Manami Shizuka (2650621), Marianne L. Spatz (11624116), Dietrich Steinhuebel (1586218), Binyuan Sun (1648267), Matthew E. Voss (2354965), Xiao Wang (19312), Liping Yang (156318), Tammie C. Yeh (2653399), Isabelle Dussault (1638010), C. Gary Marshall (163727), B. Wesley Trotter (2517580)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, overall favorable pharmacokinetic, efficiency metrics led, conformationally constrained analogs, 4688 , projected dose inhibitors, weight inhibitor suitable, like inhibitors, efficient inhibitor, derived inhibitor, therapeutic potential, strategy focused, recent success, ppi inhibition, physical properties, highly potent, describe herein, clinical investigation, biostructural information

Relation: https://figshare.com/articles/dataset/Discovery_of_b_MK-4688_b_an_Efficient_Inhibitor_of_the_HDM2_p53_Protein_Protein_Interaction/16903996

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01524.s002