المؤلفون: Cuffaro, Doretta, Nuti, Elisa, Gifford, Valentina, Ito, Noriko, Camodeca, Caterina, Tuccinardi, Tiziano, Nencetti, Susanna, Orlandini, Elisabetta, Itoh, Yoshifumi, Rossello, Armando

المساهمون: Cuffaro, Doretta, Nuti, Elisa, Gifford, Valentina, Ito, Noriko, Camodeca, Caterina, Tuccinardi, Tiziano, Nencetti, Susanna, Orlandini, Elisabetta, Itoh, Yoshifumi, Rossello, Armando

مصطلحات موضوعية: Arylsulfonamide hydroxamate, Bifunctional inhibitor, MMP inhibitor, MT1-MMP homodimerization, Biochemistry, Molecular Medicine, Molecular Biology, Drug Discovery3003 Pharmaceutical Science, Clinical Biochemistry, Organic Chemistry

Time: 3003

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/30522899; info:eu-repo/semantics/altIdentifier/wos/WOS:000453233300020; volume:27; issue:1; firstpage:196; lastpage:207; numberofpages:12; journal:BIOORGANIC & MEDICINAL CHEMISTRY; http://hdl.handle.net/11568/938174; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85057829887; http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/

الاتاحة: http://hdl.handle.net/11568/938174
https://doi.org/10.1016/j.bmc.2018.11.041
http://www.journals.elsevier.com/bioorganic-and-medicinal-chemistry/

المؤلفون: NUTI, ELISA, ROSALIA, LEA, CUFFARO, DORETTA, CAMODECA, CATERINA, GIACOMELLI, CHIARA, DA POZZO, ELEONORA, TUCCINARDI, TIZIANO, COSTA, BARBARA, Antoni, Claudia, Vera, Laura, CICCONE, LIDIA, ORLANDINI, ELISABETTA, NENCETTI, SUSANNA, Dive, Vincent, MARTINI, CLAUDIA, Stura, Enrico A., ROSSELLO, ARMANDO

المساهمون: Nuti, Elisa, Rosalia, Lea, Cuffaro, Doretta, Camodeca, Caterina, Giacomelli, Chiara, DA POZZO, Eleonora, Tuccinardi, Tiziano, Costa, Barbara, Antoni, Claudia, Vera, Laura, Ciccone, Lidia, Orlandini, Elisabetta, Nencetti, Susanna, Dive, Vincent, Martini, Claudia, Stura, Enrico A., Rossello, Armando

مصطلحات موضوعية: Bifunctional inhibitor, glioblastoma multiforme, MMP-9 homodimerization, X-ray crystallography

وصف الملف: ELETTRONICO

Relation: info:eu-repo/semantics/altIdentifier/pmid/28337319; info:eu-repo/semantics/altIdentifier/wos/WOS:000396297700007; volume:8; issue:3; firstpage:293; lastpage:298; numberofpages:6; journal:ACS MEDICINAL CHEMISTRY LETTERS; http://hdl.handle.net/11568/850358; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85014955912

الاتاحة: http://hdl.handle.net/11568/850358
https://doi.org/10.1021/acsmedchemlett.6b00446
https://pubs.acs.org/doi/10.1021/acsmedchemlett.6b00446

المؤلفون: Fang Fang, Can Zhao, Jingtai Liang, Qiangqiang Tao, Xiaodong Ma, Yong Wang, Hao Wang, Jiaming Li

المصدر: Medicinal Chemistry Research

مصطلحات موضوعية: MAPK/ERK pathway, 010405 organic chemistry, Chemistry, Kinase, MEK inhibitor, Organic Chemistry, Allosteric regulation, Cross talk, 01 natural sciences, 0104 chemical sciences, mTOR/MEK bifunctional inhibitor, Allosteric MEK inhibitor, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Cell culture, Drug resistance, Cancer research, General Pharmacology, Toxicology and Pharmaceutics, Bifunctional, Protein kinase B, mTOR kinase inhibitor, PI3K/AKT/mTOR pathway, Original Research

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed8f77cc89d438c9b23d440854e7cde
http://europepmc.org/articles/PMC7223898

المؤلفون: Giuseppina Laganà, Ersilia Bellocco, Antonella Calderaro, Davide Barreca

المصدر: Current Medicinal Chemistry. 26:3242-3252

مصطلحات موضوعية: Azoles, Indoles, Plasmodium falciparum, Biochemistry, Antimalarials, 03 medical and health sciences, chemistry.chemical_compound, Lactate dehydrogenase, bifunctional inhibitor, enzyme inhibitor, galloflavin, miRNA and shRNAs, oxamate and derivatives, quinoline derivatives, 0302 clinical medicine, Functional importance, Lactate dehydrogenase, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Organic Chemicals, Peptide sequence, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, L-Lactate Dehydrogenase, biology, Organic Chemistry, Gossypol, biology.organism_classification, DNA metabolism, Enzyme, Isocoumarins, chemistry, Gluconeogenesis, 030220 oncology & carcinogenesis, Quinolines, Molecular Medicine, Anaerobic exercise

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c6149bb4b23a1d01ee1758f0b0e52e
https://doi.org/10.2174/0929867324666170209103444

المؤلفون: Cuccioloni M., Mozzicafreddo M., Ali I., Bonfili L., Cecarini V., Eleuteri A. M., Angeletti M.

المساهمون: Cuccioloni, M., Mozzicafreddo, M., Ali, I., Bonfili, L., Cecarini, V., Eleuteri, A. M., Angeletti, M.

مصطلحات موضوعية: Bifunctional inhibitor, Binding mode, Gluten sensitivity, Kinetic, Thermodynamic, Wheat

Relation: info:eu-repo/semantics/altIdentifier/wos/WOS:000380289900073; volume:213; firstpage:571; lastpage:578; numberofpages:8; journal:FOOD CHEMISTRY; http://hdl.handle.net/11566/299988; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84977620790

الاتاحة: http://hdl.handle.net/11566/299988
https://doi.org/10.1016/j.foodchem.2016.07.020

المؤلفون: Stefan Strobl, F. Xavier Gomis-Rüth, Robert Huber, Rudi Glockshuber, Klaus Maskos, Georg Wiegand

المصدر: Structure. 6:911-921

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Trypsin inhibitor, Molecular Sequence Data, yellow meal worm (Tenebrio molitor), Biology, Crystallography, X-Ray, Hydrolysis, Residue (chemistry), Structural Biology, medicine, Animals, Trypsin, Amino Acid Sequence, Amylase, Enzyme Inhibitors, Tenebrio, Pancreas, Molecular Biology, Ragi bifunctional inhibitor, Plant Proteins, chemistry.chemical_classification, Binding Sites, Sequence Homology, Amino Acid, Active site, N-terminus, α-amylase, Enzyme, Biochemistry, chemistry, biology.protein, X-ray structure, alpha-Amylases, Trypsin Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c05050876f13f0f124dcbe9a1bbe85
https://doi.org/10.1016/s0969-2126(98)00092-6

المؤلفون: Kees W. Rodenburg, Francois Vallée, Yves Bourne, Birte Svensson, Richard Haser, Anders Kadziola, Michel Juy

المصدر: Structure. 6:649-659

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Surface Properties, Trypsin inhibitor, Molecular Sequence Data, protein–interactions, Crystallography, X-Ray, Protein structure, Structural Biology, Amino Acid Sequence, Amylase, Molecular Biology, bifunctional inhibitor, Plant Proteins, X-ray crystallography, chemistry.chemical_classification, Sequence Homology, Amino Acid, biology, Kunitz STI protease inhibitor, Subtilisin, barley, food and beverages, Active site, Hordeum, Hydrogen Bonding, Starch, Amino acid, Isoenzymes, α-amylase, Biochemistry, chemistry, Amylases, Seeds, biology.protein, Insect Proteins, Calcium, Trypsin Inhibitor, Kunitz Soybean, alpha-Amylases, Alpha-amylase, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63858ba7cbc153ac55ba4c5f100f4ca4
https://doi.org/10.1016/s0969-2126(98)00066-5

المؤلفون: Connell, Bridgette Janine, Baleux, Françoise, Coic, Yves-Marie, Clayette, Pascal, Bonnaffé, David, Lortat-Jacob, Hugues

المساهمون: Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 )-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Chimie des biomolécules, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Chimie Organique, Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Pharmacologie des rétrovirus, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ANRS

المصدر: Chem Biol ; https://hal.science/hal-00664771 ; Chem Biol, 2012, 19 (1), pp.131-9. ⟨10.1016/j.chembiol.2011.12.009⟩

مصطلحات موضوعية: HIV, HIV entry inhibition, CCR5, CXCR4, GPCR, CD4, CD4 mimetic peptides, Heparan sulfate, Heparan sulfate mimetic peptides, Sulfotyrosine containing peptide, Peptide synthesis, Peptide conjugation, Surface Plasmon Resonance binding assay, Antiviral assay, Primary viral strains, Bifunctional inhibitor, Membrane protein, Biosensor, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

Relation: info:eu-repo/semantics/altIdentifier/pmid/22284360; hal-00664771; https://hal.science/hal-00664771; PUBMED: 22284360

الاتاحة: https://hal.science/hal-00664771
https://doi.org/10.1016/j.chembiol.2011.12.009

المؤلفون: Martina Huber-Wunderlich, Rudi Glockshuber, K. Maskos

المصدر: FEBS Letters. 397:11-16

مصطلحات موضوعية: Stereochemistry, Trypsin inhibitor, Biophysics, Disaccharide, Oligosaccharides, Serine proteinases, Biochemistry, Serine, chemistry.chemical_compound, Structural Biology, Genetics, medicine, α-Amylase, Trypsin, Amylase, Enzyme Inhibitors, Bovine serum albumin, Binding site, Molecular Biology, Ragi bifunctional inhibitor, Plant Proteins, chemistry.chemical_classification, Binding Sites, biology, Cell Biology, Hydrogen-Ion Concentration, Recombinant Proteins, Enzyme, chemistry, Eleusine coracana Gaertneri, Trypsin Inhibitor, Kazal Pancreatic, Amylases, biology.protein, alpha-Amylases, Trypsin Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe6017c270d758c6bfac1895ddf7044
https://doi.org/10.1016/s0014-5793(96)01131-3

المؤلفون: Bridgette Janine Connell, Pascal Clayette, Hugues Lortat-Jacob, David Bonnaffé, Yves-Marie Coïc, Françoise Baleux

المساهمون: Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Chimie des biomolécules, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Chimie Organique, Pharmacologie des rétrovirus, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANRS, Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Chem Biol
Chem Biol, 2012, 19 (1), pp.131-9. ⟨10.1016/j.chembiol.2011.12.009⟩

مصطلحات موضوعية: viruses, Clinical Biochemistry, Heparan sulfate, Plasma protein binding, HIV Envelope Protein gp120, Virus Replication, 01 natural sciences, Biochemistry, chemistry.chemical_compound, GPCR, Heparan sulfate mimetic peptides, Drug Discovery, Peptide sequence, 0303 health sciences, Virus receptor, virus diseases, General Medicine, Surface Plasmon Resonance binding assay, 3. Good health, Cell biology, Peptide synthesis, Antiviral assay, CD4 Antigens, Peptide conjugation, Molecular Medicine, Binding domain, Protein Binding, Receptors, CXCR4, Receptors, CCR5, CD4 mimetic peptides, Anti-HIV Agents, Biology, 010402 general chemistry, 03 medical and health sciences, HIV entry inhibition, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amino Acid Sequence, Sulfotyrosine containing peptide, Binding site, Molecular Biology, 030304 developmental biology, G protein-coupled receptor, Pharmacology, CXCR4, Binding Sites, Cell Membrane, HIV, Primary viral strains, CD4, 0104 chemical sciences, Bifunctional inhibitor, chemistry, Viral replication, Membrane protein, HIV-1, Heparitin Sulfate, Peptides, CCR5, Biosensor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2482ce40eb031513101435eeb8fdfe02
https://hal.archives-ouvertes.fr/hal-00664771

المؤلفون: Migliolo, Ludovico

المساهمون: Sales, Maurício Pereira de, http://lattes.cnpq.br/0805599101682606, http://lattes.cnpq.br/7890362793618911, Lima, João Paulo Matos Santos, http://lattes.cnpq.br/3289758851760692, Franco, Octávio Luiz, http://lattes.cnpq.br/8598274096498065

مصطلحات موضوعية: Adenanthera pavonina, Inibidor bifuncional, Modelagem comparativa, Estudos de interação, Bifunctional inhibitor, Homology modeling, Docking study, CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA

وصف الملف: application/pdf

Relation: MIGLIOLO, Ludovico. Construção de modelos de interação in silico e in vitro do inibidor do tipo Kunitz de Adenanthera pavonina L. para as enzimas cisteínicas e serínicas. 2008. 96 f. Dissertação (Mestrado em Bioquímica; Biologia Molecular) - Universidade Federal do Rio Grande do Norte, Natal, 2008.; https://repositorio.ufrn.br/jspui/handle/123456789/12533

الاتاحة: https://repositorio.ufrn.br/jspui/handle/123456789/12533

المؤلفون: Migliolo, Ludovico

Thesis Advisors: CPF:29706106391, Lima, Jo?o Paulo Matos Santos, CPF:79332021368, Franco, Oct?vio Luiz, CPF:75523400378, Sales, Maur?cio Pereira de

المصدر: Repositório Institucional da UFRNUniversidade Federal do Rio Grande do NorteUFRN.

مصطلحات موضوعية: Adenanthera pavonina, Inibidor bifuncional, Modelagem comparativa, Estudos de intera??o, Bifunctional inhibitor, Homology modeling, Docking study, CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA

وصف الملف: application/pdf

الاتاحة: http://repositorio.ufrn.br:8080/jspui/handle/123456789/12533

المؤلفون: Gour P. Pal, Christian Betzel, Klaus-Dieter Jany, Wolfram Saenger

المصدر: FEBS Letters. 197:111-114

مصطلحات موضوعية: Chemical Phenomena, Biophysics, Biochemistry, chemistry.chemical_compound, X-Ray Diffraction, Structural Biology, Endopeptidases, Genetics, medicine, Protease Inhibitors, Bifunctional, Molecular Biology, Plant Proteins, chemistry.chemical_classification, Gel electrophoresis, Molecular mass, biology, Chemistry, Physical, Chemistry, Subtilisin, Cell Biology, Trypsin, Proteinase K, Binding constant, Crystallography, Enzyme, Bifunctional inhibitor Amylase Enzyme inhibitor Proteinase K X-ray diffraction Crystallization, biology.protein, Electrophoresis, Polyacrylamide Gel, Endopeptidase K, alpha-Amylases, Crystallization, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9603394b240a58630575e6aef3f2888d
https://doi.org/10.1016/0014-5793(86)80308-8