المؤلفون: G. Leslie Burnett (1530964), Yu C. Yang (14271182), James B. Aggen (1748029), Jennifer Pitzen (1332948), Micah K. Gliedt (14271185), Chris M. Semko (2126905), Abby Marquez (14271188), James W. Evans (1360215), Gang Wang (36685), Walter S. Won (14271191), Aidan C. A. Tomlinson (14271194), Gert Kiss (1345821), Christos Tzitzilonis (275867), Arun P. Thottumkara (2677906), James Cregg (7306595), Kevin T. Mellem (1892248), Jong S. Choi (14271197), Julie C. Lee (2983218), Yongyuan Zhao (14271200), Bianca J. Lee (11216484), Justin G. Meyerowitz (14271203), John E. Knox (2523913), Jingjing Jiang (128923), Zhican Wang (2275534), David Wildes (9434006), Zhengping Wang (1434643), Mallika Singh (202117), Jacqueline A. M. Smith (14271206), Adrian L. Gill (2396434)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, multiple allosteric inhibitors, also preserving selectivity, also present evidence, allosteric binding sites, steric inhibitors ”, mutant cancer drivers, activated tumors hyperactivation, >< sup ><, orthosteric dual inhibitors, development candidate rmc, g12c , g12c <, steric inhibitor, mutant nsclc, many tumors, >, “ bi, selective bi, preclinical profile, preclinical model

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_RMC-5552_a_Selective_Bi-Steric_Inhibitor_of_mTORC1_for_the_Treatment_of_mTORC1-Activated_Tumors/21741425

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01658.s001

المؤلفون: G. Leslie Burnett (1530964), Yu C. Yang (14271182), James B. Aggen (1748029), Jennifer Pitzen (1332948), Micah K. Gliedt (14271185), Chris M. Semko (2126905), Abby Marquez (14271188), James W. Evans (1360215), Gang Wang (36685), Walter S. Won (14271191), Aidan C. A. Tomlinson (14271194), Gert Kiss (1345821), Christos Tzitzilonis (275867), Arun P. Thottumkara (2677906), James Cregg (7306595), Kevin T. Mellem (1892248), Jong S. Choi (14271197), Julie C. Lee (2983218), Yongyuan Zhao (14271200), Bianca J. Lee (11216484), Justin G. Meyerowitz (14271203), John E. Knox (2523913), Jingjing Jiang (128923), Zhican Wang (2275534), David Wildes (9434006), Zhengping Wang (1434643), Mallika Singh (202117), Jacqueline A. M. Smith (14271206), Adrian L. Gill (2396434)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, multiple allosteric inhibitors, also preserving selectivity, also present evidence, allosteric binding sites, steric inhibitors ”, mutant cancer drivers, activated tumors hyperactivation, >< sup ><, orthosteric dual inhibitors, development candidate rmc, g12c , g12c <, steric inhibitor, mutant nsclc, many tumors, >, “ bi, selective bi, preclinical profile, preclinical model

Relation: https://figshare.com/articles/dataset/Discovery_of_RMC-5552_a_Selective_Bi-Steric_Inhibitor_of_mTORC1_for_the_Treatment_of_mTORC1-Activated_Tumors/21741428

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01658.s002

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_2_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089637

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s003

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/dataset/DataSheet_1_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_docx/15089631

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s001

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_1_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089634

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s002

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_5_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089646

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s006

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_3_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089640

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s004

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_4_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089643

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s005

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/dataset/Table_2_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_pdf/15089655

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s009

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/dataset/Table_1_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_pdf/15089652

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s008

المؤلفون: Bianca J. Lee (11216484), Sharmila Mallya (525784), Nuntana Dinglasan (5574860), Amos Fung (11216487), Tram Nguyen (3917399), Lee-or Herzog (11216490), Joshua Thao (11216493), Edward G. Lorenzana (8081669), David Wildes (9434006), Mallika Singh (202117), Jacqueline A. M. Smith (9434030), David A. Fruman (11141171)

مصطلحات موضوعية: Cancer, Cancer Cell Biology, Cancer Diagnosis, Cancer Genetics, Cancer Therapy (excl. Chemotherapy and Radiation Therapy), Chemotherapy, Haematological Tumours, Molecular Targets, Radiation Therapy, Solid Tumours, Oncology and Carcinogenesis not elsewhere classified, mTORC1, targeted (selective) treatment, 4EBP1, combination therapy, Ph+ B-ALL

Relation: https://figshare.com/articles/figure/Image_6_Efficacy_of_a_Novel_Bi-Steric_mTORC1_Inhibitor_in_Models_of_B-Cell_Acute_Lymphoblastic_Leukemia_tiff/15089649

الاتاحة: https://doi.org/10.3389/fonc.2021.673213.s007