المؤلفون: Paul Y. Kim, Calvin H. Yeh, Brian J. Dale, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jack Hirsh, Jeffrey I. Weitz

المصدر: TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)

مصطلحات موضوعية: doac, inhibition kinetics, coagulation assays, coagulation inhibitors, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2512-9465

URL الوصول: https://doaj.org/article/4f047f8b39114affb255507bb976a3e4

المؤلفون: Calvin H Yeh, Alan R Stafford, Beverly A Leslie, James C Fredenburgh, Jeffrey I Weitz

المصدر: PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC4909201?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/81f882027936471b84dcf2a1f03f2040

المؤلفون: Trang T. Vu, Nima Vaezzadeh, James C. Fredenburgh, Ran Ni, Brett P. Monia, Jeffrey I. Weitz, Ji Zhou, Alan R. Stafford, Peter L. Gross, Willi Jahnen-Dechent, Beverly A. Leslie, Shengjun Qiao

المصدر: Blood. 125:2712-2719

مصطلحات موضوعية: Histidine-rich glycoprotein, RNase P, Immunology, Biology, Ferric Compounds, Biochemistry, Thrombosis and Hemostasis, Mice, Thrombin, Chlorides, medicine, Gene Knockdown Techniques, Animals, Blood Coagulation, Hemostasis, Factor XII, Gene knockdown, Proteins, RNA, Thrombosis, Cell Biology, Hematology, Molecular biology, Mice, Inbred C57BL, Coagulation, Female, Gene Deletion, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de28e0e698a18c4fa1d6a5bb1abb75
https://doi.org/10.1182/blood-2014-11-611319

المؤلفون: Alan R. Stafford, Jeffrey I. Weitz, Paul Y. Kim, Calvin H. Yeh, James C. Fredenburgh, Brian Dale, Jack Hirsh, Beverly A. Leslie

المصدر: TH Open: Companion Journal to Thrombosis and Haemostasis
TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)

مصطلحات موضوعية: Prothrombin time, lcsh:Diseases of the circulatory (Cardiovascular) system, 0303 health sciences, Rivaroxaban, medicine.diagnostic_test, Chemistry, DOAC, coagulation assays, coagulation inhibitors, Inhibition kinetics, 030204 cardiovascular system & hematology, Pharmacology, Differential effects, 03 medical and health sciences, 0302 clinical medicine, Coagulation, lcsh:RC666-701, inhibition kinetics, medicine, Apixaban, Original Article, 030304 developmental biology, medicine.drug, Partial thromboplastin time

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a294114d0be7a41c33c32c43be27ee8
https://pubmed.ncbi.nlm.nih.gov/31249942

المؤلفون: Paul Y. Kim, Jeffrey I. Weitz, Trang T. Vu, Alan R. Stafford, Beverly A. Leslie, James C. Fredenburgh

المصدر: Journal of Biological Chemistry. 289:27494-27503

مصطلحات موضوعية: Lysis, Plasmin, medicine.medical_treatment, Biochemistry, Tissue plasminogen activator, Fibrin, Thrombin, Fibrinolysis, medicine, Humans, Fibrinopeptide, Fibrinolysin, Blood Coagulation, Molecular Biology, Fibrinopeptide B, biology, Chemistry, Fibrinogen, Plasminogen, Cell Biology, Molecular biology, Kinetics, Enzymology, biology.protein, Factor XIIIa, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065fc35901e8624a474636ae1c13ebec
https://doi.org/10.1074/jbc.m114.588640

المؤلفون: Beverly A. Leslie, Teresa Lim, Howard H.W. Chan, James C. Fredenburgh, Alan R. Stafford, Jeffrey I. Weitz

المصدر: Journal of Biological Chemistry. 288:29394-29402

مصطلحات موضوعية: Plasmin, Molecular Sequence Data, Fibrinogen, Binding, Competitive, Biochemistry, Antithrombins, Fibrin, Thrombin, medicine, Humans, Platelet, Amino Acid Sequence, Molecular Biology, Binding Sites, Peptide analog, biology, Heparin, Chemistry, Antithrombin, Cell Biology, Surface Plasmon Resonance, Kinetics, Zinc, Spectrometry, Fluorescence, Protein Structure and Folding, Factor Xa, biology.protein, Peptides, Protein Binding, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e5a29aca2073da1364ba5e6e160e2
https://doi.org/10.1074/jbc.m113.469916

المؤلفون: Beverly A. Leslie, Louise Jawerth, David A. Weitz, Ben Fabry, Jeffrey I. Weitz, Stefan Münster

المصدر: Proceedings of the National Academy of Sciences. 110:12197-12202

مصطلحات موضوعية: Fight-or-flight response, Nonlinear system, Multidisciplinary, Materials science, Buckling, Rheology, biology, biology.protein, Slip (materials science), Composite material, Elasticity (physics), Plasticity, Fibrin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5497726b795d9117bb801b36a87f254c
https://doi.org/10.1073/pnas.1222787110

المؤلفون: Alan R. Stafford, Jeffrey I. Weitz, Beverly A. Leslie, James C. Fredenburgh, Calvin H. Yeh

المصدر: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)

مصطلحات موضوعية: 0301 basic medicine, Glycobiology, lcsh:Medicine, Amperometry, Plasma protein binding, Biochemistry, Argatroban, Substrate Specificity, Binding Analysis, Mathematical and Statistical Techniques, Catalytic Domain, lcsh:Science, Enzyme Chemistry, Antithrombins, Sulfonamides, Multidisciplinary, biology, Chemistry, Organic Compounds, Thrombin, Dabigatran, Bioassays and Physiological Analysis, Pipecolic Acids, Physical Sciences, Regression Analysis, Statistics (Mathematics), medicine.drug, circulatory and respiratory physiology, Research Article, Biotechnology, Protein Binding, Allosteric regulation, Research and Analysis Methods, Arginine, Fibrin, Enzyme Regulation, 03 medical and health sciences, Allosteric Regulation, medicine, Humans, Binding site, Statistical Methods, Blood Coagulation, Bioelectrochemical Analysis, Chemical Characterization, Glycoproteins, Binding Sites, 030102 biochemistry & molecular biology, lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Fibrinogen, Surface Plasmon Resonance, 030104 developmental biology, Small Molecules, biology.protein, Biophysics, Enzymology, Biocatalysis, lcsh:Q, Biochemical Analysis, Mathematics, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9340109ea5a33d902111691d52088eb
http://europepmc.org/articles/PMC4909201

المؤلفون: Robin S. Roberts, Howard H.W. Chan, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jeffrey I. Weitz, Nadine N Al-Aswad

المصدر: Biochemistry. 51:7964-7973

مصطلحات موضوعية: Models, Molecular, Time Factors, Protein Conformation, Plasma protein binding, Biochemistry, Antithrombins, Fibrin, Plasma, Thrombin, Protein structure, medicine, Humans, Thrombus, Blood Coagulation, biology, Heparin, Protein Stability, Chemistry, Antithrombin, medicine.disease, Zinc, biology.protein, Biophysics, Ternary operation, Protein Binding, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5819677aec4caa02ebedfb90ace1180f
https://doi.org/10.1021/bi301046b

المؤلفون: Huayin Wu, Jeffrey I. Weitz, Sara J. Henderson, Beverly A. Leslie, David A. Weitz, Jing Xia, James C. Fredenburgh, Alan R. Stafford

المصدر: Thrombosis and haemostasis. 115(3)

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Polymers, medicine.medical_treatment, chemistry.chemical_element, Zinc, 030204 cardiovascular system & hematology, Fibrinogen, Fibrin, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Protein Domains, Fibrinolysis, medicine, Humans, Platelet activation, Blood Coagulation, Binding Sites, biology, Dose-Response Relationship, Drug, Factor XIII, Chemistry, Coagulants, Batroxobin, Hematology, Fibrin Monomer, 030104 developmental biology, Biochemistry, biology.protein, Biophysics, Microscopy, Electron, Scanning, Rheology, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c72e5e5ee6afa5a11863ce38e675f5e
https://pubmed.ncbi.nlm.nih.gov/26489782

المؤلفون: Alan R. Stafford, Jeffrey I. Weitz, Ji Zhou, James C. Fredenburgh, Trang T. Vu, Beverly A. Leslie

المصدر: Thrombosis and haemostasis. 115(1)

مصطلحات موضوعية: 0301 basic medicine, Kininogen, High-Molecular-Weight, Whole Blood Coagulation Time, Histidine-rich glycoprotein, High-molecular-weight kininogen, 030204 cardiovascular system & hematology, Biology, Factor XIIa, Binding, Competitive, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Thrombin, medicine, Humans, Blood Coagulation, Prekallikrein, RNA, Proteins, Hematology, DNA, Surface Plasmon Resonance, Enzyme Activation, 030104 developmental biology, Coagulation, chemistry, Biochemistry, Nucleic acid, circulatory and respiratory physiology, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010c377e379738a6e28237ffd62ff3fb
https://pubmed.ncbi.nlm.nih.gov/26354857

المؤلفون: Paul Y. Kim, Nima Vaezzadeh, Jeffrey I. Weitz, Alan R. Stafford, Ran Ni, James C. Fredenburgh, Sara J. Henderson, Beverly A. Leslie

المصدر: Thrombosis and haemostasis. 113(6)

مصطلحات موضوعية: 0301 basic medicine, Blood Platelets, Plasmin, medicine.medical_treatment, chemistry.chemical_element, Zinc, 030204 cardiovascular system & hematology, Fibrinogen, Fibrin, Catalysis, 03 medical and health sciences, 0302 clinical medicine, Fibrinolysis, medicine, Humans, Platelet, Trypsin, Platelet activation, Fibrinolysin, biology, Chemistry, Plasminogen, Hematology, Surface Plasmon Resonance, Platelet Activation, Enzyme Activation, Kinetics, 030104 developmental biology, Spectrometry, Fluorescence, Biochemistry, Tissue Plasminogen Activator, Proteolysis, biology.protein, Biophysics, Plasminogen activator, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23386716722d5ddcef771fa4a585fb0
https://pubmed.ncbi.nlm.nih.gov/25789495

المؤلفون: Jeffrey I. Weitz, Monika Hudoba, Beverly A. Leslie

المصدر: Circulation. 97:544-552

مصطلحات موضوعية: Antithrombin III, In Vitro Techniques, Thrombomodulin, Tissue plasminogen activator, Fibrin, Fibrin Fibrinogen Degradation Products, Thrombin, Physiology (medical), medicine, Humans, Thrombolytic Therapy, Fibrinopeptide, Fibrinopeptide A, Analysis of Variance, biology, Heparin, business.industry, T-plasminogen activator, Antithrombin, Enzyme Activation, Biochemistry, Tissue Plasminogen Activator, biology.protein, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49ec9f077c8cc934c29de5b0c332a3f
https://doi.org/10.1161/01.cir.97.6.544

المؤلفون: Trang T. Vu, James C. Fredenburgh, Alan R. Stafford, Paul Y. Kim, Jeffrey I. Weitz, Beverly A. Leslie

المصدر: The Journal of biological chemistry. 286(35)

مصطلحات موضوعية: Histidine-rich glycoprotein, Plasma protein binding, Fibrinogen, Ligands, Biochemistry, Fibrin, Thrombin, medicine, Humans, Binding site, Molecular Biology, chemistry.chemical_classification, Immunoassay, Binding Sites, biology, Dose-Response Relationship, Drug, Chemistry, Fibrinogens, Abnormal, Proteins, Cell Biology, Surface Plasmon Resonance, Molecular biology, Kinetics, Zinc, Coagulation, Immunoglobulin G, Protein Structure and Folding, biology.protein, Glycoprotein, Peptides, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f89e94c402e721cda27306e40075381
https://pubmed.ncbi.nlm.nih.gov/21757718

المؤلفون: Beverly A. Leslie, Jacob Kuint, Jeffrey I. Weitz, Jack Hirsh

المصدر: Thrombosis and Haemostasis. 65:541-544

مصطلحات موضوعية: biology, Chemistry, medicine.drug_class, medicine.medical_treatment, Low molecular weight heparin, Hematology, Heparin, Thrombolysis, Pharmacology, medicine.disease, Tissue plasminogen activator, Fibrin, Fibrinogenolysis, Fibrinolysis, Immunology, medicine, biology.protein, Plasminogen activator, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5a3cc408881fbe32b787f83058597dc2
https://doi.org/10.1055/s-0038-1648186

المؤلفون: Beverly A. Leslie, James C. Fredenburgh, Jeffrey I. Weitz, Alan R. Stafford

المصدر: The Journal of biological chemistry. 283(5)

مصطلحات موضوعية: Macromolecular Substances, In Vitro Techniques, Fibrinogen, Biochemistry, Fibrin, Dermatan sulfate, Antithrombins, chemistry.chemical_compound, Thrombin, medicine, Humans, Molecular Biology, Ternary complex, Blood Coagulation, Heparin cofactor II, Binding Sites, biology, Chemistry, Heparin, Antithrombin, Cell Biology, Surface Plasmon Resonance, Molecular biology, biology.protein, circulatory and respiratory physiology, medicine.drug, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab99364990248b0c9de3e850d2d24b4
https://pubmed.ncbi.nlm.nih.gov/18055456

المؤلفون: Alan R. Stafford, Amy V L Schaefer, Jeffrey I. Weitz, Janice Rischke, James C. Fredenburgh, Beverly A. Leslie

المصدر: Biochemistry. 45(13)

مصطلحات موضوعية: Lysis, Plasmin, medicine.medical_treatment, Fibrinogen, Biochemistry, Fibrin, Fibrin Fibrinogen Degradation Products, Fibrinolysis, medicine, Humans, Fibrinolysin, Blood Coagulation, biology, Chemistry, Plasminogen, Trypsin, Molecular biology, Carboxypeptidase B, Peptide Fragments, Enzyme Activation, Hemostasis, biology.protein, Plasminogen activator, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d55b6923f67345d77ab0eca6e4d9818
https://pubmed.ncbi.nlm.nih.gov/16566600

المؤلفون: Colin A. Kretz, Jeffrey I. Weitz, Nicolas S. Petrera, James C. Fredenburgh, Beverly A. Leslie, Alan R. Stafford

المصدر: Journal of Biological Chemistry. 290:4814

مصطلحات موضوعية: Aptamer, Allosteric regulation, Hirudin, Plasma protein binding, Fibrinogen, Biochemistry, Fibrin, Thrombin, Allosteric Regulation, medicine, Humans, Molecular Biology, Range (particle radiation), Dose-Response Relationship, Drug, biology, Chemistry, Heparin, Cell Biology, Surface Plasmon Resonance, Protein Structure, Tertiary, Protein Structure and Folding, biology.protein, Biophysics, Additions and Corrections, Peptides, Function (biology), Protein Binding, circulatory and respiratory physiology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1009ee4c904381220735df2aaaece1e6
https://doi.org/10.1074/jbc.a109.000042

المؤلفون: James C. Fredenburgh, Jeffrey I. Weitz, Bruce Keyt, Beverly A. Leslie, Janice Rischke, Ronald J. Stewart

المصدر: The Journal of biological chemistry. 275(14)

مصطلحات موضوعية: Models, Molecular, Glycosylation, medicine.medical_treatment, Fibrinogen, Biochemistry, Tissue plasminogen activator, Fibrin, Protein Structure, Secondary, Substrate Specificity, chemistry.chemical_compound, medicine, Humans, Molecular Biology, chemistry.chemical_classification, Protease, Alanine, biology, Genetic Variation, Cell Biology, Molecular biology, Recombinant Proteins, Amino acid, Kinetics, chemistry, Amino Acid Substitution, Plasminogen activator inhibitor-1, Tissue Plasminogen Activator, biology.protein, Plasminogen activator, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184f764c25e13cda85a50afcc7fc3fdd
https://pubmed.ncbi.nlm.nih.gov/10744692

المؤلفون: Jack Hirsh, Petr Klement, J. I. Weitz, Beverly A. Leslie

المصدر: The Journal of clinical investigation. 91(4)

مصطلحات موضوعية: medicine.medical_specialty, Plasmin, medicine.medical_treatment, Alpha (ethology), Hemorrhage, Tissue plasminogen activator, Fibrinogenolysis, Aprotinin, Alpha 2-antiplasmin, Internal medicine, Fibrinolysis, medicine, Animals, Humans, alpha-2-Antiplasmin, business.industry, Fibrinogen, Drug Synergism, General Medicine, Thrombolysis, medicine.disease, Endocrinology, Tissue Plasminogen Activator, Immunology, Rabbits, business, medicine.drug, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee21b9f30de39ca54982efe1fc3f394
https://pubmed.ncbi.nlm.nih.gov/7682569