نتائج البحث - "Bernhardt, Rita"

المصدر: Jóźwik , I K , Bombino , E , Abdulmughni , A , Hartz , P , Rozeboom , H J , Wijma , H J , Kappl , R , Janssen , D B , Bernhardt , R & Thunnissen , A-M W H 2023 , ' Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling ' , The FEBS Journal , vol. 290 , no. 20 , pp. 5016-5035 . https://doi.org/10.1111/febs.16906

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/6b6534ee-d6fc-4624-8036-c03526ab5ee1
https://research.rug.nl/en/publications/6b6534ee-d6fc-4624-8036-c03526ab5ee1
https://doi.org/10.1111/febs.16906
https://pure.rug.nl/ws/files/826152948/The_FEBS_Journal_-_2023_-_J_wik_-_Regio_and_stereoselective_steroid_hydroxylation_by_CYP109A2_from_Bacillus_megaterium_1_.pdf

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4

Academic Journal

SNPs in cytochrome P450 genes decide on the fate of individuals with genetic predisposition to Parkinson’s disease

المؤلفون: Petkova-Kirova, Polina, Baas, Stephan, Wagenpfeil, Gudrun, Hartz, Philip, Unger, Marcus Michael, Bernhardt, Rita

مصطلحات موضوعية: ddc:500, ddc:610, Parkinson’s disease, cytochromes P450, POR, Adx, eicosanoids, cholesterol, vitamin D, retinoic acid

Relation: hdl:20.500.11880/36206

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-402981
https://doi.org/10.22028/D291-40298
https://doi.org/10.3389/fphar.2023.1244516

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5

Academic Journal

A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease

المؤلفون: Hartz, Philip, Fehlmann, Tobias, Wagenpfeil, Gudrun, Unger, Marcus Michael, Bernhardt, Rita

المساهمون: Dr. Rolf M. Schwiete Stiftung

المصدر: Frontiers in Pharmacology ; volume 13 ; ISSN 1663-9812

الاتاحة: http://dx.doi.org/10.3389/fphar.2022.1094265
https://www.frontiersin.org/articles/10.3389/fphar.2022.1094265/full

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6

Academic Journal

A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson's disease

المؤلفون: Hartz, Philip, Fehlmann, Tobias, Wagenpfeil, Gudrun, Unger, Marcus Michael, Bernhardt, Rita

مصطلحات موضوعية: ddc:610, cytochrome P450, Parkinson’s disease, CYP46A1, POR, Adx, xenobiotica, cholesterol, PPMI

Relation: hdl:20.500.11880/35671

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-395777
https://doi.org/10.22028/D291-39577
https://doi.org/10.3389/fphar.2022.1094265

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7

Academic Journal

Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion

المؤلفون: Carius, Yvonne, Hutter, Michael, Kiss, Flora, Bernhardt, Rita, Lancaster, C. Roy D.

مصطلحات موضوعية: ddc:500, ddc:610, crystal structure, Cytochrome P450, docking, oxidoreductase, steroid conversion

Relation: https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1873-3468.14502&file=feb214502-sup-0001-FigureS1.tif; https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2F1873-3468.14502&file=feb214502-sup-0002-FigureS2.tif; hdl:20.500.11880/35201

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-390293
https://doi.org/10.22028/D291-39029
https://doi.org/10.1002/1873-3468.14502

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8

Academic Journal

Resurrection and characterization of ancestral CYP11A1 enzymes

المؤلفون: Hartz, Philip, Strohmaier, Silja J., El-Gayar, Basma M., Abdulmughni, Ammar, Hutter, Michael C., Hannemann, Frank, Gillam, Elizabeth M. J., Bernhardt, Rita

مصطلحات موضوعية: ddc:570, ancestral sequence reconstruction, cholesterol, cytochromes P450, pregnenolone formation

Relation: https://febs.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1111%2Ffebs.16054&file=febs16054-sup-0001-Supinfo.pdf; hdl:20.500.11880/36096

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-400931
https://doi.org/10.22028/D291-40093
https://doi.org/10.1111/febs.16054

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9

Book

Contributors

المؤلفون: Bennardo, Francesco, Chow, Ming Fai, Engels, Jan Frederick, Goodsell, David S., Halpern, Georges M., Kayser, Oliver, Ullrich, Oliver, Bernhardt, Rita, Bornscheuer, Uwe, Cautherley, George, Chakrabarty, Ananda, Charpentier, Emmanuelle, Chow, King, Clark, David P., Demain, Arnold L., Dingermann, Theodor, Dübel, Stefan, Friedrich, Roland, Fromherz, Peter, Fuchs, Dietmar, Fukui, Saburo, Gänßler, Karla, Ghisalba, Oreste, Grunz, Horst, Halpern, Georges, Hempel, Albrecht, Hew, Choy-L., Hillenkamp, Franz, Hock, Bertold, Holtzhauer, Martin, Huntoon, Jon, Kempken, Frank, Kiderlen, Albrecht F., Klenz, Uwe, Law, Louiza, Lewen-Dörr, Inca, Lim, Hwa A., Ludwig-Müller, Jutta, Martin, Stephan, Matter, Alex, Meyer, Wolfgang, van Montagu, Marc, Müller-Esterl, Werner, Niessner, Reinhard, Pauly, Susanne, Polle, Jürgen, Rapoport, Tom A., Reuss, Matthias, Reski, Ralf, Sahm, Hermann

المصدر: Biotechnology for Beginners ; page xiii-xiv ; ISBN 9780323855693

الاتاحة: http://dx.doi.org/10.1016/b978-0-323-85569-3.09981-5
https://api.elsevier.com/content/article/PII:B9780323855693099815?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:B9780323855693099815?httpAccept=text/plain

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10

Academic Journal

A Novel Thermostable Cytochrome P450 from Sequence-Based Metagenomics of Binh Chau Hot Spring as a Promising Catalyst for Testosterone Conversion

المؤلفون: Nguyen, Kim-Thoa, Nguyen, Ngọc-Lan, Tung, Nguyen Van, Nguyen, Huy Hoang, Milhim, Mohammed, Le, Thi-Thanh-Xuan, Lai, Thi-Hong-Nhung, Phan, Thi-Tuyet-Minh, Bernhardt, Rita

مصطلحات موضوعية: ddc:500, ddc:570, ddc:600, thermostable P450, CYP109C, metagenomic, P450-T3, fatty acids, testosterone, biocatalyst, redox partner, expression, half-life, melting temperature, Binh Chau hot spring

Relation: http://www.mdpi.com/2073-4344/10/9/1083/s1; Catalysts 10 (9): 1083 (2020); hdl:20.500.11880/30425

الاتاحة: http://nbn-resolving.org/urn:nbn:de:bsz:291--ds-323740
https://doi.org/10.22028/D291-32374
https://doi.org/10.3390/catal10091083

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11

Academic Journal

Characterization of the Stereoselective P450 Enzyme BotCYP Enables the Biosynthesis of the Bottromycin Core Scaffold.

المؤلفون: Adam, Sebastian, Franz, Laura, Milhim, Mohammed, Bernhardt, Rita, Kalinina, Olga V, Koehnke, Jesko

المساهمون: HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.

المصدر: 142 ; 49 ; 20560 ; 20565 ; Journal of the American Chemical Society ; United States

Relation: J Am Chem Soc. 2020 Dec 9;142(49):20560-20565. doi:10.1021/jacs.0c10361. Epub 2020 Nov 28.; http://hdl.handle.net/10033/622954; Journal of the American Chemical Society

الاتاحة: http://hdl.handle.net/10033/622954
https://doi.org/10.1021/jacs.0c10361

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12

Academic Journal

Six Uridine-Diphosphate Glycosyltransferases Catalyze the Glycosylation of Bioactive C 13 -Apocarotenols

المؤلفون: Sun, Guangxin, Putkaradze, Natalia, Bohnacker, Sina, Jonczyk, Rafal, Fida, Tarik, Hoffmann, Thomas, Bernhardt, Rita, Härtl, Katja, Schwab, Wilfried

المساهمون: China Scholarship Council, International Graduate School of Science and Engineering, Deutsche Forschungsgemeinschaft

المصدر: Plant Physiology ; volume 184, issue 4, page 1744-1761 ; ISSN 0032-0889 1532-2548

الاتاحة: http://dx.doi.org/10.1104/pp.20.00953
https://syndication.highwire.org/content/doi/10.1104/pp.20.00953

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13

Academic Journal

HIV Drug Efavirenz Inhibits CYP21A2 Activity with Possible Clinical Implications

المؤلفون: Malikova, Jana, Zingg, Tanja, Fingerhut, Ralph, Sluka, Susanna, Grössl, Michael, Brixius-Anderko, Simone, Bernhardt, Rita, McDougall, Jane, Pandey, Amit V, Flück, Christa E

المصدر: Malikova, Jana; Zingg, Tanja; Fingerhut, Ralph; Sluka, Susanna; Grössl, Michael; Brixius-Anderko, Simone; Bernhardt, Rita; McDougall, Jane; Pandey, Amit V; Flück, Christa E (2019). HIV Drug Efavirenz Inhibits CYP21A2 Activity with Possible Clinical Implications. Hormone Research in Paediatrics, 91(4):262-270.

مصطلحات موضوعية: Medical Clinic, 610 Medicine & health, Pediatrics, Perinatology, and Child Health, Endocrinology, Diabetes and Metabolism

وصف الملف: application/pdf

Relation: https://www.zora.uzh.ch/id/eprint/177701/1/500522.pdf; info:pmid/31256164; urn:issn:1663-2818

الاتاحة: https://www.zora.uzh.ch/id/eprint/177701/
https://www.zora.uzh.ch/id/eprint/177701/1/500522.pdf
https://doi.org/10.1159/000500522

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14

Academic Journal

Identification and circumvention of bottlenecks in CYP21A2‐mediated premedrol production using recombinant Escherichia coli

المؤلفون: König, Lisa, Brixius‐Anderko, Simone, Milhim, Mohammed, Tavouli‐Abbas, Daniela, Hutter, Michael C., Hannemann, Frank, Bernhardt, Rita

المصدر: Biotechnology and Bioengineering ; volume 117, issue 4, page 901-911 ; ISSN 0006-3592 1097-0290

الاتاحة: http://dx.doi.org/10.1002/bit.27246
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbit.27246
https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27246
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/bit.27246

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15

Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion

المؤلفون: Carius, Yvonne, Hutter, Michael, Kiss, Flora, Bernhardt, Rita, Lancaster, C. Roy D.

مصطلحات موضوعية: crystal structure, docking, Cytochrome P450, steroid conversion, oxidoreductase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dfd101717c81130c59eac1870fc82e51

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16

Academic Journal

New Arabidopsis thaliana cytochrome c partners: A look into the elusive role of cytochrome c in programmed cell death in plants

المؤلفون: Martínez Fábregas, Jonathan, Díaz Moreno, Irene, González Arzola, Katiuska, Janocha, Simon, Navarro Carruesco, José Antonio, Hervás Morón, Manuel, Bernhardt, Rita, Díaz Quintana, Antonio Jesús, Rosa Acosta, Miguel Ángel de la

المساهمون: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular, Ministerio de Ciencia e Innovación (MICIN). España, Junta de Andalucía

Relation: Molecular and Cellular Proteomics, 12 (12), 3666-3676.; BFU2009-07190; BIO198; http://dx.doi.org/10.1074/mcp.M113.030692; https://idus.us.es/handle//11441/70250

الاتاحة: https://idus.us.es/handle//11441/70250

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17

Academic Journal

Structural insights into oxidation of medium-chain fatty acids and flavanone by myxobacterial cytochrome P450 CYP267B1

المؤلفون: Jóźwik, Ilona K, Litzenburger, Martin, Khatri, Yogan, Schifrin, Alexander, Girhard, Marco, Urlacher, Vlada, Thunnissen, Andy-Mark W H, Bernhardt, Rita

المصدر: Jóźwik , I K , Litzenburger , M , Khatri , Y , Schifrin , A , Girhard , M , Urlacher , V , Thunnissen , A-M W H & Bernhardt , R 2018 , ' Structural insights into oxidation of medium-chain fatty acids and flavanone by myxobacterial cytochrome P450 CYP267B1 ' , Biochemical Journal , vol. 475 , no. 17 , pp. 2801-2817 . https://doi.org/10.1042/BCJ20180402

مصطلحات موضوعية: SORANGIUM-CELLULOSUM, STREPTOMYCES-AVERMITILIS, ESCHERICHIA-COLI, P450, HYDROXYLATION, SUBSTRATE, CE56, METABOLISM, TOOL, CRYSTALLOGRAPHY

وصف الملف: application/pdf

الاتاحة: https://hdl.handle.net/11370/610942f1-999a-4fbd-8e9a-3821b177000a
https://research.rug.nl/en/publications/610942f1-999a-4fbd-8e9a-3821b177000a
https://doi.org/10.1042/BCJ20180402
https://pure.rug.nl/ws/files/65257922/2801.full.pdf

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18

Academic Journal

Structure-based engineering of steroidogenic CYP260A1 for stereo- and regioselective hydroxylation of progesterone

المؤلفون: Khatri, Yogan, Jóźwik, Ilona K, Ringle, Michael, Ionescu, Irina Alexandra, Litzenburger, Martin, Hutter, Michael Christopher, Thunnissen, Andy-Mark W H, Bernhardt, Rita

المصدر: Khatri , Y , Jóźwik , I K , Ringle , M , Ionescu , I A , Litzenburger , M , Hutter , M C , Thunnissen , A-M W H & Bernhardt , R 2018 , ' Structure-based engineering of steroidogenic CYP260A1 for stereo- and regioselective hydroxylation of progesterone ' , ACS chemical biology , vol. 13 , no. 4 , pp. 1021-1028 . https://doi.org/10.1021/acschembio.8b00026

مصطلحات موضوعية: SITE-DIRECTED MUTAGENESIS, CYTOCHROME-P450 MONOOXYGENASES, SORANGIUM-CELLULOSUM, HETEROLOGOUS EXPRESSION, ESCHERICHIA-COLI, P450, IDENTIFICATION, DELIVERY, REVEALS, UPDATE