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1
المؤلفون: Alejandro Chavez, Marcelle Tuttle, Brian M. Turczyk, George M. Church, Benjamin W. Pruitt, Michael Tung, Rebecca S. Shapiro, Jordan Winston, Ryan J Cecchi, James J. Collins
المصدر: Proceedings of the National Academy of Sciences. 115:3669-3673
مصطلحات موضوعية: 0301 basic medicine, Population, Computational biology, Biology, Mice, 03 medical and health sciences, Synthetic biology, Genomic mutation, Polymorphism (computer science), Drug Resistance, Bacterial, Escherichia coli, Animals, Guide RNA, education, Antibiotics, Antitubercular, education.field_of_study, Multidisciplinary, Cas9, Genomics, Biological Sciences, 3. Good health, 030104 developmental biology, Mutation, Mutation (genetic algorithm), Mouse Gastrointestinal Tract, CRISPR-Cas Systems, Rifampin, Genome, Bacterial, RNA, Guide, Kinetoplastida
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2
المؤلفون: Nili Ostrov, Julie E. Norville, Marc J. Lajoie, Natalie Cervantes, Marc Güell, Daniel B. Goodman, Michael G. Napolitano, Barry L. Wanner, Nicholas Conway, Minerva Zhou, Kerry Singh, Matthieu Landon, Gleb Kuznetsov, Ellen Shrock, Mark Moosburner, George M. Church, Benjamin W. Pruitt, Cameron L. Gardner, Alexandra Gonzales, Jun Teramoto, Gary Tyree
المصدر: Science. 353:819-822
مصطلحات موضوعية: 0301 basic medicine, Biology, 010402 general chemistry, medicine.disease_cause, 01 natural sciences, Genome, 03 medical and health sciences, Escherichia coli, Genes, Synthetic, medicine, Gene, Repurposing, Genetics, Genes, Essential, Multidisciplinary, Escherichia coli Proteins, Genetic code, Phenotype, 0104 chemical sciences, Synthetic genomics, 030104 developmental biology, Genetic Code, Protein Biosynthesis, Genes, Lethal, Identification (biology), Genetic Engineering, Genome, Bacterial
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3
المؤلفون: Benjamin E. Housden, Alejandro Chavez, Ben Ewen-Campen, Emma J. K. Kowal, Dmitry Ter-Ovanesyan, Norbert Perrimon, George M. Church, James J. Collins, Ryan J Cecchi, Benjamin W. Pruitt, Sabina J Haque, Joanna Buchthal, Raj Chari, Marcelle Tuttle
المصدر: Nature Methods. 13:563-567
مصطلحات موضوعية: 0301 basic medicine, biology, Activator (genetics), Cooperativity, Cell Biology, Computational biology, biology.organism_classification, Biochemistry, Molecular biology, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Transcription (biology), Gene expression, Drosophila melanogaster, Molecular Biology, Trans-Activators, Transcription factor, Gene, 030217 neurology & neurosurgery, Biotechnology
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4
المؤلفون: Samuel A. Inverso, George M. Church, Xiaoming Chen, Ingo Hütter, Meinolf Blawat, Brian M. Turczyk, Benjamin W. Pruitt, Klaus Gaedke
المصدر: ICCS
مصطلحات موضوعية: 0301 basic medicine, Computer science, DNA digital data storage, Bio-technology, 02 engineering and technology, Residual, computer.software_genre, digital data storage, 03 medical and health sciences, chemistry.chemical_compound, 0202 electrical engineering, electronic engineering, information engineering, A-DNA, Forward error correction, data preservation, General Environmental Science, DNA synthesis, business.industry, 020206 networking & telecommunications, DNA synthesis and sequencing, DNA, Dna storage, Digital Data Storage, archiving, 030104 developmental biology, chemistry, Computer data storage, General Earth and Planetary Sciences, Data mining, business, computer, Computer hardware
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5
المؤلفون: George M. Church, Richard N. Hall, Benjamin W. Pruitt, Suhani Vora, Mohammad R. Ebrahimkhani, Dmitry Ter-Ovanesyan, Jacob Beal, Alejandro Chavez, Samira Kiani, Ron Weiss, Emma J. K. Kowal, James J. Collins, Marcelle Tuttle, Joanna Buchthal, Jason Qian, Raj Chari
المساهمون: MIT Synthetic Biology Center, Massachusetts Institute of Technology. Department of Biological Engineering, Kiani, Samira, Hall, Richard N., Beal, Jacob S, Vora, Suhani Deepak, Kowal, Emma J., Ebrahimkhani, Mohammad Reza, Collins, James J., Weiss, Ron
المصدر: PMC
مصطلحات موضوعية: Transcription, Genetic, CRISPR-Associated Proteins, Genetic Vectors, Computational biology, Biology, Biochemistry, Genome, Article, Genome editing, Genes, Reporter, Transcriptional regulation, Humans, Guide RNA, Molecular Biology, Gene, Fluorescent Dyes, Genetics, Regulation of gene expression, Binding Sites, Cas9, Cell Biology, Flow Cytometry, HEK293 Cells, Microscopy, Fluorescence, Mutagenesis, RNA editing, Mutation, RNA Editing, CRISPR-Cas Systems, Genetic Engineering, Gene Deletion, RNA, Guide, Kinetoplastida, Biotechnology
وصف الملف: application/pdf
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6
المؤلفون: Jonathan L. Braff, John Aach, Norbert Perrimon, Dmitry Ter-Ovanesyan, Benjamin E. Housden, Samira Kiani, Daniel J. Wiegand, Christopher D. Guzman, Shuailiang Lin, Jonathan Scheiman, James J. Collins, Eswar Prasad Ramachandran Iyer, Noah Davidsohn, Alejandro Chavez, Ron Weiss, George M. Church, Benjamin W. Pruitt, Suhani Vora, Marcelle Tuttle
المصدر: Nature methods
مصطلحات موضوعية: Transcriptional Activation, Staphylococcus aureus, Cellular differentiation, Induced Pluripotent Stem Cells, Biology, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, Transcriptional regulation, Humans, Induced pluripotent stem cell, Molecular Biology, Transcription factor, Gene, 030304 developmental biology, Regulation of gene expression, Genetics, Neurons, 0303 health sciences, Activator (genetics), Gene targeting, Cell Differentiation, Cell Biology, Endonucleases, Cell biology, HEK293 Cells, Genetic Techniques, 030217 neurology & neurosurgery, Biotechnology, RNA, Guide, Kinetoplastida
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7
المؤلفون: Ryan J Cecchi, Rebecca S. Shapiro, James J. Collins, Jordan Winston, Alejandro Chavez, Marcelle Tuttle, Michael Tung, George M. Church, Benjamin W. Pruitt, Brian M. Turczyk
مصطلحات موضوعية: Genetics, 0303 health sciences, education.field_of_study, Cas9, Population, Single-nucleotide polymorphism, Biology, 3. Good health, 03 medical and health sciences, Synthetic biology, 0302 clinical medicine, Genomic mutation, Mutation (genetic algorithm), Mouse Gastrointestinal Tract, Guide RNA, education, 030217 neurology & neurosurgery, 030304 developmental biology
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8
المؤلفون: John Aach, Marcelle Tuttle, Benjamin W. Pruitt, Christopher D. Guzman, Daniel J. Wiegand, James J. Collins, Jonathan L. Braff, Suhani Vora, Samira Kiani, George M. Church, Noah Davidsohn, Jonathan Scheiman, Eswar Prasad Ramachandran Iyer, Alejandro Chavez, Ron Weiss, Dmitry Ter-Ovanesyan
مصطلحات موضوعية: Regulation of gene expression, 0303 health sciences, Nuclease, biology, Activator (genetics), Rational design, Cell biology, 03 medical and health sciences, 0302 clinical medicine, biology.protein, Transcriptional regulation, Induced pluripotent stem cell, Gene, Transcription factor, 030217 neurology & neurosurgery, 030304 developmental biology
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9
المؤلفون: Oscar A. Negrete, Brooke Harmon, Anup K. Singh, Benjamin W. Pruitt, Vinay V. Abhyankar, Benjamin Schudel
المصدر: Lab on a chip. 13(5)
مصطلحات موضوعية: Microarray, Microfluidics, Caveolin 1, Green Fluorescent Proteins, Biomedical Engineering, Bioengineering, Computational biology, Endocytosis, Caveolae, Transfection, Biochemistry, Dynamin II, Phosphatidylinositol 3-Kinases, Viral entry, RNA interference, Humans, Dimethylpolysiloxanes, RNA, Small Interfering, Phosphoinositide-3 Kinase Inhibitors, biology, General Chemistry, Vesiculovirus, Microfluidic Analytical Techniques, Virus Internalization, biology.organism_classification, Rift Valley fever virus, Virology, p21-Activated Kinases, Vesicular stomatitis virus, Host-Pathogen Interactions, RNA Interference, DNA microarray, Functional genomics, HeLa Cells
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10
المؤلفون: Grace A. Spatafora, Evan G. Smith, Christopher L. Coe, Louis P. Cornacchione, Benjamin W. Pruitt, Jeffrey R. Haswell
مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Protein Conformation, Mutant, Molecular Sequence Data, Mutagenesis (molecular biology technique), Repressor, Electrophoretic Mobility Shift Assay, Biology, Real-Time Polymerase Chain Reaction, Microbiology, Streptococcus mutans, Structure-Activity Relationship, Bacterial Proteins, Electrophoretic mobility shift assay, Overlap extension polymerase chain reaction, Amino Acid Sequence, Molecular Biology, Gene, Derepression, Genetics, Reporter gene, Manganese, Virulence, Reverse Transcriptase Polymerase Chain Reaction, Circular Dichroism, Articles, Gene Expression Regulation, Bacterial, Molecular biology, Protein Structure, Tertiary, RNA, Bacterial, Mutation, Mutagenesis, Site-Directed, Protein Binding