المؤلفون: Esther C. Y. Lee (10586857), Andrew J. McRiner (2512648), Katy E. Georgiadis (10756246), Julie Liu (6557627), Zooey Wang (10756249), Andrew D. Ferguson (1427719), Benjamin Levin (10185539), Moritz von Rechenberg (10586875), Christopher D. Hupp (2377594), Michael I. Monteiro (10586860), Anthony D. Keefe (3622769), Allison Olszewski (2671783), Charles J. Eyermann (1667878), Paolo Centrella (10756252), Yanbin Liu (231378), Shilpi Arora (130546), John W. Cuozzo (1665235), Ying Zhang (40767), Matthew A. Clark (1370337), Christelle Huguet (8932838), Anna Kohlmann (1417150)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, DNA-Encoded Chemical Library Screen., SAR, carboxylic acid-containing compounds, hydroxy acid oxidase 1, DNA-Encoded Chemical Library, PK, PH, novel chemical series, non-acid-containing HAO 1 inhibitors, HAO 1 inhibitors, Compound 5, potency, AGXT, exploration, DECL, ADME, Structure-based drug design

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Novel_Potent_Inhibitors_of_Hydroxy_Acid_Oxidase_1_HAO1_Using_DNA-Encoded_Chemical_Library_Screening/14547310

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02271.s001

المؤلفون: Jeremy S. Disch (1960423), Jennifer M. Duffy (10586854), Esther C. Y. Lee (10586857), Diana Gikunju (8932826), Betty Chan (1342416), Benjamin Levin (10185539), Michael I. Monteiro (10586860), Sarah A. Talcott (10586863), Anthony C. Lau (10586866), Fei Zhou (86034), Anton Kozhushnyan (10586869), Neil E. Westlund (10586872), Patrick B. Mullins (1601887), Yan Yu (56143), Moritz von Rechenberg (10586875), Junyi Zhang (290426), Yelena A. Arnautova (2710522), Yanbin Liu (231378), Ying Zhang (40767), Andrew J. McRiner (2512648), Anthony D. Keefe (3622769), Anna Kohlmann (1417150), Matthew A. Clark (1370337), John W. Cuozzo (1665235), Christelle Huguet (8932838), Shilpi Arora (130546)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Plant Biology, Chemical Sciences not elsewhere classified, Click chemistry synthesis, Bispecific Estrogen Receptor α Degr., novel PROTAC binding features, screening, ER α, breast cancer, ER α WT, novel bispecific degrader, bispecific nanomolar degraders, nanomolar ER α binding, alkyne E 3 ligase engagers panel, MCF 7 tumor growth, DNA-encoded chemical library, molecule exemplar 7, DECL, DNA-Encoded Chemical Library Screen., mouse xenograft model, GOF

Relation: https://figshare.com/articles/journal_contribution/Bispecific_Estrogen_Receptor_Degraders_Incorporating_Novel_Binders_Identified_Using_DNA-Encoded_Chemical_Library_Screening/14403457

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00127.s001

المؤلفون: Esther C. Y. Lee (10586857), Andrew J. McRiner (2512648), Katy E. Georgiadis (10756246), Julie Liu (6557627), Zooey Wang (10756249), Andrew D. Ferguson (1427719), Benjamin Levin (10185539), Moritz von Rechenberg (10586875), Christopher D. Hupp (2377594), Michael I. Monteiro (10586860), Anthony D. Keefe (3622769), Allison Olszewski (2671783), Charles J. Eyermann (1667878), Paolo Centrella (10756252), Yanbin Liu (231378), Shilpi Arora (130546), John W. Cuozzo (1665235), Ying Zhang (40767), Matthew A. Clark (1370337), Christelle Huguet (8932838), Anna Kohlmann (1417150)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, DNA-Encoded Chemical Library Screen., SAR, carboxylic acid-containing compounds, hydroxy acid oxidase 1, DNA-Encoded Chemical Library, PK, PH, novel chemical series, non-acid-containing HAO 1 inhibitors, HAO 1 inhibitors, Compound 5, potency, AGXT, exploration, DECL, ADME, Structure-based drug design

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_Potent_Inhibitors_of_Hydroxy_Acid_Oxidase_1_HAO1_Using_DNA-Encoded_Chemical_Library_Screening/14547316

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02271.s003

المؤلفون: Esther C. Y. Lee (10586857), Andrew J. McRiner (2512648), Katy E. Georgiadis (10756246), Julie Liu (6557627), Zooey Wang (10756249), Andrew D. Ferguson (1427719), Benjamin Levin (10185539), Moritz von Rechenberg (10586875), Christopher D. Hupp (2377594), Michael I. Monteiro (10586860), Anthony D. Keefe (3622769), Allison Olszewski (2671783), Charles J. Eyermann (1667878), Paolo Centrella (10756252), Yanbin Liu (231378), Shilpi Arora (130546), John W. Cuozzo (1665235), Ying Zhang (40767), Matthew A. Clark (1370337), Christelle Huguet (8932838), Anna Kohlmann (1417150)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Ecology, Inorganic Chemistry, Hematology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, DNA-Encoded Chemical Library Screen., SAR, carboxylic acid-containing compounds, hydroxy acid oxidase 1, DNA-Encoded Chemical Library, PK, PH, novel chemical series, non-acid-containing HAO 1 inhibitors, HAO 1 inhibitors, Compound 5, potency, AGXT, exploration, DECL, ADME, Structure-based drug design

Relation: https://figshare.com/articles/dataset/Discovery_of_Novel_Potent_Inhibitors_of_Hydroxy_Acid_Oxidase_1_HAO1_Using_DNA-Encoded_Chemical_Library_Screening/14547313

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02271.s002

المؤلفون: Jeremy S. Disch (1960423), Jennifer M. Duffy (10586854), Esther C. Y. Lee (10586857), Diana Gikunju (8932826), Betty Chan (1342416), Benjamin Levin (10185539), Michael I. Monteiro (10586860), Sarah A. Talcott (10586863), Anthony C. Lau (10586866), Fei Zhou (86034), Anton Kozhushnyan (10586869), Neil E. Westlund (10586872), Patrick B. Mullins (1601887), Yan Yu (56143), Moritz von Rechenberg (10586875), Junyi Zhang (290426), Yelena A. Arnautova (2710522), Yanbin Liu (231378), Ying Zhang (40767), Andrew J. McRiner (2512648), Anthony D. Keefe (3622769), Anna Kohlmann (1417150), Matthew A. Clark (1370337), John W. Cuozzo (1665235), Christelle Huguet (8932838), Shilpi Arora (130546)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Cancer, Plant Biology, Chemical Sciences not elsewhere classified, Click chemistry synthesis, Bispecific Estrogen Receptor α Degr., novel PROTAC binding features, screening, ER α, breast cancer, ER α WT, novel bispecific degrader, bispecific nanomolar degraders, nanomolar ER α binding, alkyne E 3 ligase engagers panel, MCF 7 tumor growth, DNA-encoded chemical library, molecule exemplar 7, DECL, DNA-Encoded Chemical Library Screen., mouse xenograft model, GOF

Relation: https://figshare.com/articles/dataset/Bispecific_Estrogen_Receptor_Degraders_Incorporating_Novel_Binders_Identified_Using_DNA-Encoded_Chemical_Library_Screening/14403460

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00127.s002

المؤلفون: Christen Vagts (10185530), Christian Ascoli (4526632), Dustin R. Fraidenburg (10185533), Robert P. Baughman (7923512), Yue Huang (285485), Russell Edafetanure-Ibeh (10185536), Samreen Ahmed (6018968), Benjamin Levin (10185539), Yang Lu (59885), David L. Perkins (3183234), Patricia W. Finn (3183231), Nadera J. Sweiss (7923464)

مصطلحات موضوعية: Dermatology, Emergency Medicine, Gastroenterology and Hepatology, Geriatrics and Gerontology, Intensive Care, Medical Genetics (excl. Cancer Genetics), Nephrology and Urology, Nuclear Medicine, Orthopaedics, Otorhinolaryngology, Pathology (excl. Oral Pathology), Radiology and Organ Imaging, Foetal Development and Medicine, Obstetrics and Gynaecology, Family Care, Primary Health Care, Medical and Health Sciences not elsewhere classified, sarcoidosis, lymphopenia, 18FDG-PET/CT, immunopathogenesis, cluster analysis, phenotype

Relation: https://figshare.com/articles/dataset/Data_Sheet_1_Unsupervised_Clustering_Reveals_Sarcoidosis_Phenotypes_Marked_by_a_Reduction_in_Lymphocytes_Relate_to_Increased_Inflammatory_Activity_on_18FDG-PET_CT_CSV/14099753

الاتاحة: https://doi.org/10.3389/fmed.2021.595077.s001