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1Academic Journal
المؤلفون: Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors HW Scheres
المصدر: eLife, Vol 8 (2019)
مصطلحات موضوعية: E.coli over-expression, micro-tubule associated protein tau, cryo-EM, helical reconstruction, RELION, Medicine, Science, Biology (General), QH301-705.5
وصف الملف: electronic resource
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2
المؤلفون: Fuyuki Kametani, Ruben Vidal, Mike van Beers, Abhay Kotecha, H. Tanaka, Airi Tarutani, Tammaryn Lashley, Wenjuan Zhang, Yang Yang, Yang Shi, Benjamin Falcon, Takeshi Ikeuchi, Michel Goedert, Sjors H.W. Scheres, Holly J. Garringer, Bernardino Ghetti, Gabor G. Kovacs, Mari Yoshida, Masato Hasegawa, Akiyoshi Kakita, Alexey G. Murzin, Andrew C Robinson, David M. A. Mann, Tamas Revesz, Yuko Saito, G.I. Hallinan, Shigeo Murayama
المصدر: Nature
Shi, Y, Zhang, W, Yang, Y, Murzin, A G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H J, Vidal, R, Hallinan, G I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A C, Mann, D M A, Kovacs, G G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M & Scheres, S H W 2021, ' Structure-based classification of tauopathies ', Nature, vol. 598, no. 7880, pp. 359-363 . https://doi.org/10.1038/s41586-021-03911-7مصطلحات موضوعية: Male, Models, Molecular, Protein Folding, Pathology, medicine.medical_specialty, Denmark, Tau protein, tau Proteins, macromolecular substances, Neuropathology, Article, Progressive supranuclear palsy, Protein filament, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Humans, Protein Isoforms, Dementia, Corticobasal degeneration, Amino Acid Sequence, Aged, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, Multidisciplinary, biology, Cryoelectron Microscopy, Neurodegeneration, Intron, Middle Aged, medicine.disease, Introns, United Kingdom, Chronic traumatic encephalopathy, Tauopathies, Mutation, biology.protein, Female, Supranuclear Palsy, Progressive, Tauopathy, Neuroscience, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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3
المؤلفون: Wenjuan Zhang, Benjamin Falcon, Michel Goedert, Sjors H.W. Scheres
المصدر: Current Opinion in Structural Biology. 64:17-25
مصطلحات موضوعية: Gene isoform, 0303 health sciences, biology, Cryo-electron microscopy, Chemistry, Cryoelectron Microscopy, Tau protein, Brain, tau Proteins, macromolecular substances, Cofactor, In vitro, Protein filament, 03 medical and health sciences, 0302 clinical medicine, Tauopathies, Alzheimer Disease, Structural Biology, biology.protein, Biophysics, Humans, Protein Isoforms, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology
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4
المؤلفون: Kazuko Hasegawa, Ruben Vidal, Abhay Kotecha, Kathy L. Newell, Masato Hasegawa, Yuko Saito, Melissa Huang, Bernardino Ghetti, Tammaryn Lashley, G.I. Hallinan, Airi Tarutani, Tamas Revesz, Shigeo Murayama, Michel Goedert, Sofia Lövestam, Holly J. Garringer, John C. van Swieten, Yang Yang, Manuel Schweighauser, Diana Arseni, Masayuki Miyazaki, Masaki Takao, Benjamin Falcon, Mari Yoshida, Gabor G. Kovacs, Sjors H.W. Scheres, Yang Shi, Alexey G. Murzin, Wenjuan Zhang
مصطلحات موضوعية: Blot, Synucleinopathies, medicine.anatomical_structure, Amyloid, Chemistry, medicine, Age dependent, macromolecular substances, Human brain, Transmembrane protein, Cell biology
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5
المؤلفون: Alexey G. Murzin, Wenjuan Zhang, Melissa Huang, Kathy L. Newell, Isabelle Lavenir, Ellen Gelpi, Bernardino Ghetti, Sofia Lövestam, Michel Goedert, Holly J. Garringer, Sew Y. Peak-Chew, Abhay Kotecha, Benjamin Falcon, Yang Yang, Jennifer A. Macdonald, Gabor G. Kovacs, Sjors H.W. Scheres, Manuel Schweighauser, Diana Arseni, Ruben Vidal
المصدر: Science
مصطلحات موضوعية: Male, Models, Molecular, Protein Folding, Amyloid β, Protein Conformation, Cryo-electron microscopy, macromolecular substances, Type (model theory), Article, Protein filament, Mice, Protein Domains, Alzheimer Disease, medicine, Animals, Humans, Amino Acid Sequence, Gene Knock-In Techniques, Beta (finance), Aged, Aged, 80 and over, Brain Chemistry, Multidisciplinary, Amyloid beta-Peptides, Chemistry, Cryoelectron Microscopy, Human brain, Middle Aged, Peptide Fragments, medicine.anatomical_structure, Models, Animal, Biophysics, Female, Protein Conformation, beta-Strand
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6
المؤلفون: Michel, Goedert, Maria Grazia, Spillantini, Benjamin, Falcon, Wenjuan, Zhang, Kathy L, Newell, Masato, Hasegawa, Sjors H W, Scheres, Bernardino, Ghetti
المصدر: Advances in experimental medicine and biology. 1281
مصطلحات موضوعية: Pick Disease of the Brain, Tauopathies, Alzheimer Disease, Frontotemporal Dementia, Humans, tau Proteins
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7
المؤلفون: Maria Grazia Spillantini, Benjamin Falcon, Wenjuan Zhang, Masato Hasegawa, Sjors H.W. Scheres, Michel Goedert, Bernardino Ghetti, Kathy L. Newell
المصدر: Advances in Experimental Medicine and Biology ISBN: 9783030511395
مصطلحات موضوعية: Pathology, medicine.medical_specialty, biology, business.industry, Neurodegeneration, Tau protein, medicine.disease, Progressive supranuclear palsy, 03 medical and health sciences, Chronic traumatic encephalopathy, 0302 clinical medicine, mental disorders, medicine, biology.protein, Corticobasal degeneration, Dementia, Pick's disease, 030212 general & internal medicine, Tauopathy, business
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8
المؤلفون: Alexey G. Murzin, Kathy L. Newell, Ruben Vidal, Ming-Kuei Jang, Michel Goedert, Benjamin Falcon, Yang Shi, Alexander Epstein, Makoto Higuchi, Paul Tempest, Jonathan Machin, Bernardino Ghetti, Sjors H.W. Scheres, Holly J. Garringer, Naruhiko Sahara
المساهمون: Apollo - University of Cambridge Repository
المصدر: Acta Neuropathologica
مصطلحات موضوعية: Original Paper, Positron emission tomography, Amyloid, Chemistry, Cryo-electron microscopy, Primary age-related tauopathy, Posterior cortical atrophy, Immunopurification, medicine.disease, Small molecule, Electron cryo-microscopy, Pathology and Forensic Medicine, Intraneuronal inclusions, Cellular and Molecular Neuroscience, Pet ligand, Biophysics, medicine, Neurology (clinical), Tauopathy, Binding site, Alzheimer’s disease
وصف الملف: text/xml; application/pdf
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9
المؤلفون: Manuel Schweighauser, Wenjuan Zhang, Michel Goedert, Alexey G. Murzin, Sjors H.W. Scheres, Benjamin Falcon, Holly J. Garringer, Ruben Vidal, Bernardino Ghetti
المصدر: Acta Neuropathologica
مصطلحات موضوعية: Immuno-gold negative-stain electron microscopy, Male, Models, Anatomic, 0301 basic medicine, Frontal cortex, Tau protein, tau Proteins, Paired helical filaments, macromolecular substances, Disease, Electron cryo-microscopy, Pathology and Forensic Medicine, Protein filament, Amyloid beta-Protein Precursor, 03 medical and health sciences, Cellular and Molecular Neuroscience, Apolipoproteins E, 0302 clinical medicine, Alzheimer Disease, Exome Sequencing, Straight filaments, Humans, Microscopy, Immunoelectron, 030304 developmental biology, Aged, Aged, 80 and over, 0303 health sciences, Original Paper, biology, Neurodegenerative diseases, Cryoelectron Microscopy, Brain, Posterior cortical atrophy, Neurofibrillary Tangles, Middle Aged, 030104 developmental biology, Mutation, biology.protein, Female, Neurology (clinical), Alzheimer’s disease, Neuroscience, 030217 neurology & neurosurgery
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10
المؤلفون: Garib N. Murshudov, Michel Goedert, Alexey G. Murzin, Sjors H.W. Scheres, R.A. Crowther, Ruben Vidal, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, H.J. Garringer
المصدر: Nature
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Tau protein, macromolecular substances, Article, 03 medical and health sciences, 0302 clinical medicine, mental disorders, medicine, Peptide sequence, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Chemistry, Human brain, medicine.disease, Phenotype, Tau isoforms, 030104 developmental biology, medicine.anatomical_structure, Biophysics, biology.protein, Phosphorylation, Protein folding, Pick's disease, Alzheimer's disease, 030217 neurology & neurosurgery, Frontotemporal dementia
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11
المؤلفون: Benjamin Falcon, Felix Randow, Jessica Noad, Michel Goedert, Harvey T. McMahon
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, autophagy, Galectins, tau Proteins, Protein aggregation, Endocytosis, Biochemistry, seeded aggregation, protein aggregation, Cell Line, 03 medical and health sciences, Protein Aggregates, 0302 clinical medicine, Cytosol, Neurobiology, galectin-8, mental disorders, medicine, NDP52, Humans, Endomembrane system, Nuclear protein, Molecular Biology, prion-like, galectin, p62 (sequestosome 1 (SQSTM1)), Chemistry, Neurodegeneration, Autophagy, tauopathy, neurodegeneration, food and beverages, Brain, Nuclear Proteins, Neurodegenerative Diseases, Cell Biology, medicine.disease, Cell biology, Galectin-8, 030104 developmental biology, Tauopathy, Tau protein (Tau), 030217 neurology & neurosurgery
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12
المؤلفون: Airi Tarutani, Benjamin Falcon, Bernardino Ghetti, Sjors H.W. Scheres, Takeshi Ikeuchi, Ruben Vidal, Kathy L. Newell, Masato Hasegawa, Tomoyasu Matsubara, Michel Goedert, Shigeo Murayama, Holly J. Garringer, Yang Shi, Alexey G. Murzin, Wenjuan Zhang
المصدر: Nature
مصطلحات موضوعية: Gene isoform, chemistry.chemical_classification, 0303 health sciences, Haplotype, Biology, medicine.disease, Molecular biology, 3. Good health, Progressive supranuclear palsy, Amino acid, Protein filament, 03 medical and health sciences, Chronic traumatic encephalopathy, 0302 clinical medicine, chemistry, medicine, Corticobasal degeneration, Tauopathy, 030217 neurology & neurosurgery, 030304 developmental biology
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13
المصدر: Cold Spring Harbor symposia on quantitative biology. 83
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, chemistry.chemical_classification, Chemistry, macromolecular substances, Biochemistry, Amino acid, Protein filament, 03 medical and health sciences, 030104 developmental biology, Genetics, Biophysics, Molecular Biology, Conformational isomerism
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14Correction to: Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607
المؤلفون: Benjamin Falcon, Kathy L. Newell, Jonathan Machin, Bernardino Ghetti, Holly J. Garringer, Naruhiko Sahara, Makoto Higuchi, Paul Tempest, Yang Shi, Ming-Kuei Jang, Alexey G. Murzin, Ruben Vidal, Alexander Epstein, Sjors H.W. Scheres, Michel Goedert
المصدر: Acta Neuropathologica
مصطلحات موضوعية: Aged, 80 and over, Male, Fluorine Radioisotopes, Binding Sites, Cryo-electron microscopy, Chemistry, Cryoelectron Microscopy, Correction, tau Proteins, Computational biology, Middle Aged, Ligands, Pathology and Forensic Medicine, Cellular and Molecular Neuroscience, Alzheimer Disease, Positron-Emission Tomography, Pet ligand, Humans, Female, Benzothiazoles, Neurology (clinical), Radiopharmaceuticals, Aged
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15
المؤلفون: Marina Vaysburd, Adrian L. Oblak, Leo C. James, Benjamin Falcon, Bernardino Ghetti, Dean Clift, Michel Goedert, William A. McEwan
المصدر: Proceedings of the National Academy of Sciences. 114:574-579
مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Tau protein, Fc receptor, tau Proteins, Receptors, Fc, In Vitro Techniques, Protein Aggregation, Pathological, Mice, Protein Aggregates, 03 medical and health sciences, Cytosol, medicine, Animals, Humans, Proteostasis Deficiencies, Receptor, Cells, Cultured, Mice, Knockout, Neurons, Multidisciplinary, biology, Neurodegeneration, food and beverages, medicine.disease, Antibodies, Neutralizing, AAA proteins, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Ribonucleoproteins, Proteasome, Nerve Degeneration, Immunology, biology.protein, Antibody, Intracellular
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16
المؤلفون: Benjamin Falcon, Masami Masuda-Suzukake, Michel Goedert
المصدر: Brain. 140:266-278
مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, tau Proteins, Protein aggregation, Protein Aggregation, Pathological, Prion Proteins, Prodromal phase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Humans, Synucleinopathies, Alpha-synuclein, Chemistry, Intracellular protein, Neurodegeneration, Neurodegenerative Diseases, medicine.disease, 030104 developmental biology, alpha-Synuclein, α synuclein, Neurology (clinical), Neuroscience, 030217 neurology & neurosurgery
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17
المؤلفون: Alexey G. Murzin, Wenjuan Zhang, R. Anthony Crowther, Michel Goedert, Benjamin Falcon, Sjors H.W. Scheres, Juan Fan
مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Chemistry, Internal medicine, medicine, Heparin, medicine.drug
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18
المؤلفون: Michel Goedert, Benjamin Falcon, Alexey G. Murzin, Kathy L. Newell, Wenjuan Zhang, R. Anthony Crowther, Ruben Vidal, Jasenko Zivanov, Sjors H.W. Scheres, Bernardino Ghetti, Holly J. Garringer
المصدر: Nature
مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, Protein Folding, Tau protein, tau Proteins, Molecular neuroscience, Article, Chronic Traumatic Encephalopathy, Protein filament, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, medicine, Humans, Aged, Multidisciplinary, biology, Chemistry, Dementia pugilistica, Neurodegeneration, Cryoelectron Microscopy, Brain, medicine.disease, 3. Good health, Frontal Lobe, Chronic traumatic encephalopathy, 030104 developmental biology, biology.protein, Biophysics, Protein folding, Tauopathy, Hydrophobic and Hydrophilic Interactions, 030217 neurology & neurosurgery
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19
المؤلفون: Alexey G. Murzin, Sjors H.W. Scheres, Juan Fan, Michel Goedert, R.A. Crowther, Wenjuan Zhang, Benjamin Falcon
المصدر: eLife
Elife
bioRxiv
eLife, Vol 8 (2019)مصطلحات موضوعية: 0301 basic medicine, Cryo-electron microscopy, Protein Conformation, Structural Biology and Molecular Biophysics, law.invention, 0302 clinical medicine, law, Biology (General), Microscopy, Immunoelectron, 0303 health sciences, biology, Chemistry, General Neuroscience, General Medicine, Heparin, E.coli over-expression, RELION, 3. Good health, Homogeneous, Recombinant DNA, Medicine, medicine.drug, Research Article, helical reconstruction, Human, Amyloid, QH301-705.5, Science, Tau protein, tau Proteins, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, micro-tubule associated protein tau, 03 medical and health sciences, Pick Disease of the Brain, Alzheimer Disease, mental disorders, medicine, Humans, 030304 developmental biology, General Immunology and Microbiology, Cryoelectron Microscopy, medicine.disease, 030104 developmental biology, Structural biology, Multiprotein Complexes, biology.protein, Biophysics, cryo-EM, Pick's disease, Protein Multimerization, 030217 neurology & neurosurgery
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20
المؤلفون: Tuomas P. J. Knowles, David Klenerman, Andrey Y. Abramov, Thomas C. T. Michaels, William A. McEwan, Liu Hong, Noemí Esteras, Michel Goedert, Franziska Kundel, Georg Meisl, Benjamin Falcon
المساهمون: Kundel, Franziska [0000-0001-5013-0004], Meisl, Georg [0000-0002-6562-7715], Knowles, Tuomas JP [0000-0002-7879-0140], Apollo - University of Cambridge Repository, Apollo-University Of Cambridge Repository
المصدر: ACS Chemical Neuroscience (2018)
ACS Chemical Neuroscienceمصطلحات موضوعية: 0301 basic medicine, Amyloid, Physiology, Prions, Cognitive Neuroscience, Replication Process, tau Proteins, Prion propagation, Biochemistry, Article, Amyloidogenic Proteins, Protein filament, 03 medical and health sciences, Time frame, Alzheimer Disease, biophysics, medicine, single-molecule microscopy, Humans, tau, Fragmentation (cell biology), Prion protein, Cytoskeleton, Chemistry, Brain, Neurofibrillary Tangles, Cell Biology, General Medicine, Human brain, kinetic modeling, 030104 developmental biology, medicine.anatomical_structure, Tauopathies, Protein folding, Neuroscience, Alzheimer’s disease
وصف الملف: application/pdf
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