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1Academic Journal
المؤلفون: Frieder Bauss, Martin Lechmann, Ben-Fillippo Krippendorff, Roland Staack, Frank Herting, Matthias Festag, Sabine Imhof-Jung, Friederike Hesse, Marc Pompiati, Gwendlyn Kollmorgen, Rita da Silva Mateus Seidl, Birgit Bossenmaier, Wilma Lau, Christian Schantz, Jan O. Stracke, Ulrich Brinkmann, Masanori Onda, Ira Pastan, Klaus Bosslet, Gerhard Niederfellner
المصدر: Molecular Oncology, Vol 10, Iss 8, Pp 1317-1329 (2016)
مصطلحات موضوعية: Immunotoxin, De-immunization, Pharmacokinetics, Lung cancer, Patient-derived xenografts, Targeted therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
المصدر: PLoS ONE, Vol 8, Iss 6, p e67330 (2013)
وصف الملف: electronic resource
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3Academic Journal
المؤلفون: Tatjana Sela, Mads Mansø, Michel Siegel, Céline Marban-Doran, Axel Ducret, Jens Niewöhner, Jacob Ravn, Rainer E. Martin, Annika Sommer, Sabine Lohmann, Ben-Fillippo Krippendorff, Mette Ladefoged, Annette Indlekofer, Tom Quaiser, Florian Bueddefeld, Erich Koller, Mohamed Y. Mohamed, Tobias Oelschlaegel, Kurt V. Gothelf, Kerstin Hofer, Felix F. Schumacher
مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, currently established route, central nervous system, associated protein tau, 0 ] nonyne, diligent conjugate design, broader clinical application, peripherally delivered aso, aso payload could, peptide tags yryrq, create optimized molecules, overall conjugation performance, based conjugation technology, suited conjugation site, promising drug modality, conjugation performance, conjugation site, peripheral application, innovative site, aso conjugates, linker design, vivo <
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4
المؤلفون: Henry Lik-Yuen Chan, Ben Fillippo Krippendorff, Wendy Cheng, Cynthia Wat, Hyung Joon Kim, Vedran Pavlovic, Young-Suk Lim, Rémi Kazma, Annabelle Lemenuel-Diot, Tien Huey Lim, Miriam Triyatni, Tawesak Tanwandee, Sudip Das, Joseph F. Grippo, Man-Fung Yuen, Won Kim, Tsung Hui Hu, Apinya Leerapun, Dong Joon Kim, Henrik Mueller, Bernadette Surujbally, Edward Gane, Simon Buatois, Yuchen Zhang
المصدر: Hepatology. 74:1795-1808
مصطلحات موضوعية: Adult, Male, Hepatitis B virus, medicine.medical_specialty, HBsAg, Acetylgalactosamine, Sustained Virologic Response, Oligonucleotides, Asialoglycoprotein Receptor, Placebo, Gastroenterology, Hepatitis B, Chronic, Pharmacokinetics, Internal medicine, Healthy volunteers, medicine, Humans, Adverse effect, Hepatitis B Surface Antigens, Hepatology, business.industry, Middle Aged, Oligonucleotides, Antisense, Healthy Volunteers, Regimen, HBeAg, Pharmacodynamics, RNA, Viral, Female, business
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5
المؤلفون: Sherri Dudal, Caterina Bissantz, Antonello Caruso, Pascale David-Pierson, Wouter Driessen, Erich Koller, Ben-Fillippo Krippendorff, Martin Lechmann, Andrés Olivares-Morales, Axel Paehler, Caroline Rynn, Dietrich Türck, Arthur Van De Vyver, Ken Wang, Lotte Winther
المصدر: Drug discovery today. 27(6)
مصطلحات موضوعية: Pharmacology, Drug Discovery, Animals, Drugs, Investigational, Medical Oncology, Models, Biological
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6
المؤلفون: Vedran Pavlovic, Edward Gane, Ben Fillippo Krippendorff, Joseph F. Grippo, S Ottosen, Cynthia Wat, Man-Fung Yuen, Henrik Mueller
المصدر: Hepatology. 75:1050-1051
مصطلحات موضوعية: carbohydrates (lipids), HBsAg, Messenger RNA, Hepatitis B, Chronic, Hepatology, business.industry, Oligonucleotides, Humans, Potency, Medicine, Pharmacology, business, Healthy Volunteers
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7
المؤلفون: Annette Seidl, Fabian Birzele, Natascha Rieder, Martin Kaufmann, Stefan Scheiblich, Klaus Hirzel, Sabine Wilson, Gwendlyn Kollmorgen, Ben-Fillippo Krippendorff, Edgar Voss, Klara Palme, Christian Clemens, Frank Herting, Gerhard Niederfellner
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Immunoconjugates, endocrine system diseases, lcsh:Medicine, Antineoplastic Agents, Apoptosis, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immunotoxin, Cell Line, Tumor, medicine, Humans, Cytotoxic T cell, Pseudomonas exotoxin, Mesothelin, lcsh:Science, Cell Proliferation, Ovarian Neoplasms, Cisplatin, Multidisciplinary, biology, business.industry, Immunotoxins, Immunogenicity, lcsh:R, medicine.disease, 030104 developmental biology, Paclitaxel, chemistry, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Female, lcsh:Q, Ovarian cancer, business, medicine.drug
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8
المؤلفون: Michael B. Otteneder, Ludivine Fronton, Hans Peter Grimm, Ben-Fillippo Krippendorff, Miro J. Eigenmann
المصدر: mAbs. 9:1007-1015
مصطلحات موضوعية: 0301 basic medicine, Physiologically based pharmacokinetic modelling, Kidney, Biodistribution, biology, Chemistry, medicine.drug_class, Immunology, Spleen, Pharmacology, Monoclonal antibody, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Pharmacokinetics, Report, medicine, biology.protein, Immunology and Allergy, Antibody, Total Tissue
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9
المؤلفون: Thierry Lavé, Ben-Fillippo Krippendorff, Zhe Li, Antje Walz, Sharad Sharma, Dhaval K. Shah
المصدر: mAbs. 8:113-119
مصطلحات موضوعية: 0301 basic medicine, Biodistribution, Chemistry, medicine.drug_class, Immunology, Monoclonal antibody, Models, Biological, Molecular biology, Antibody fragments, Molecular Weight, 03 medical and health sciences, 030104 developmental biology, Biochemistry, Molecular size, Pharmacokinetics, Report, Immunoglobulin Fragments, medicine, Animals, Humans, Immunology and Allergy, Tissue Distribution, Tissue distribution, Protein size
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10
المؤلفون: Alain Bousquet-Mélou, Hofer Thomas U, Ben-Fillippo Krippendorff, Charlotte Bon, Mark R. Davies
المساهمون: Hoffmann-La Roche, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, QT-Informatics Limited, Partenaires INRAE
المصدر: mAbs
mAbs, Taylor & Francis, 2017, 9 (8), pp.1360-1369. ⟨10.1080/19420862.2017.1373924⟩مصطلحات موضوعية: 0301 basic medicine, Biodistribution, liver-targeted delivery, media_common.quotation_subject, [SDV]Life Sciences [q-bio], Immunology, ASGPR, Asialoglycoprotein Receptor, Pharmacology, Biology, Endocytosis, 03 medical and health sciences, Mice, Drug Delivery Systems, modeling and simulation, In vivo, Report, medicine, Immunology and Allergy, Animals, Humans, Tissue Distribution, Molecular Targeted Therapy, Internalization, Receptor, media_common, mAb, Antibodies, Monoclonal, drug targeting, 3. Good health, Kinetics, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, Targeted drug delivery, Liver, Pharmaceutical Preparations, Hepatocyte, Hepatocytes, Asialoglycoprotein receptor, TMDD, pharmacokinetics
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11
المؤلفون: Dhaval K. Shah, Zhe Li, Ben-Fillippo Krippendorff
مصطلحات موضوعية: Tissue concentrations, Pharmacology toxicology, Pharmaceutical Science, 030226 pharmacology & pharmacy, Models, Biological, Antibody fragments, Article, Small Molecule Libraries, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, Molecular size, Animals, Humans, Pharmacology (medical), Immunoglobulin Fragments, Protein size, Pharmacology, Protein therapeutics, Molecular Structure, Chemistry, Organic Chemistry, Antibodies, Monoclonal, Haplorhini, Rats, Molecular Weight, Kinetics, Plasma exposure, 030220 oncology & carcinogenesis, Immunology, Biophysics, Molecular Medicine, Allometry, Rabbits, Biotechnology
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12
المؤلفون: Fernando López-Caamal, Duncan I. Jodrell, Frances M. Richards, Ben-Fillippo Krippendorff, Diego A. Oyarzún, Jo L. Bramhall
المصدر: Integr. Biol.. 6:736-742
مصطلحات موضوعية: Time Factors, MAP Kinase Signaling System, medicine.medical_treatment, Active Transport, Cell Nucleus, Biophysics, Endosomes, MAPK cascade, Ligands, Models, Biological, Biochemistry, Epidermal growth factor, medicine, Extracellular, Humans, Epidermal growth factor receptor, Phosphorylation, Receptor, Cell Nucleus, biology, Growth factor, Cell Membrane, Cell biology, ErbB Receptors, Signalling, biology.protein, Signal transduction, HeLa Cells
وصف الملف: text
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13
المؤلفون: Ben-Fillippo Krippendorff, Carlos Caldas, Christopher J. Lowe, Keith I.E. McLuckie, Marco Di Antonio, David Tannahill, Shankar Balasubramanian, Jian Xian, Heather Zecchini
المصدر: Journal of the American Chemical Society
مصطلحات موضوعية: DNA repair, Cell Survival, Morpholines, Antineoplastic Agents, Synthetic lethality, medicine.disease_cause, Biochemistry, Catalysis, chemistry.chemical_compound, Structure-Activity Relationship, Colloid and Surface Chemistry, Cell Line, Tumor, Neoplasms, medicine, Humans, Picolinic Acids, Cell Proliferation, BRCA2 Protein, Mutation, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Communication, DNA Breaks, General Chemistry, DNA, Neoplasm, DNA repair protein XRCC4, Molecular biology, Cell biology, Non-homologous end joining, G-Quadruplexes, Chromones, Cancer cell, Aminoquinolines, Drug Screening Assays, Antitumor, DNA
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14
المصدر: Journal of Pharmacokinetics and Pharmacodynamics
مصطلحات موضوعية: Pharmacology, Original Paper, Cell-level kinetics, medicine.drug_class, Systems biology, In silico, Therapeutic proteins, EGFR, Institut für Mathematik, Biology, Monoclonal antibody, In vitro, Drug development, Pharmacokinetics, In vivo, ddc:540, medicine, Biophysics, biology.protein, Epidermal growth factor receptor, Mathematisch-Naturwissenschaftliche Fakultät, Pharmacokinetic models
وصف الملف: application/pdf
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15
المؤلفون: Wilhelm Huisinga, Roland Neuhaus, Andreas Reichel, Philip Lienau, Ben-Fillippo Krippendorff
المصدر: SLAS Discovery. 14:913-923
مصطلحات موضوعية: Time Factors, Cytochrome P-450 CYP1A2 Inhibitors, Stereochemistry, Mechanism based, Binding, Competitive, Biochemistry, Analytical Chemistry, Inhibitory Concentration 50, Interaction potential, Cytochrome P-450 CYP1A2, Ic50 values, Cytochrome P-450 CYP3A, Humans, Enzyme Inhibitors, Mode of action, Biology, Drug Antagonism, Inhibition constant, Inhibitory potential, Chemistry, Models, Theoretical, Combinatorial chemistry, Enzyme Activation, Enzyme inhibition, Models, Chemical, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Hamilton Institute, Biotechnology
وصف الملف: application/pdf
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16
المصدر: Journal of Pharmacokinetics and Pharmacodynamics
مصطلحات موضوعية: Drug, Receptor trafficking, Recepter mediated endocytosis, Therapeutic proteins, media_common.quotation_subject, Biology, Michaelis–Menten kinetics, Article, Antibodies, Biopharmaceuticals, Pharmacokinetics, Nonlinear pharmacokinetics, Distribution (pharmacology), Epidermal growth factor receptor, Internalization, Receptor, media_common, Pharmacology, Membrane Proteins, Receptor-mediated endocytosis, Michaelis–Menten, Endocytosis, ErbB Receptors, Protein Transport, Chemistry, Nonlinear Dynamics, Biochemistry, Biophysics, biology.protein, Nonlinear dispostition, Signal Transduction, Hamilton Institute
وصف الملف: application/pdf
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17
المصدر: Pharmaceutical Sciences Encyclopedia
مصطلحات موضوعية: Physiologically based pharmacokinetic modelling, Pharmacokinetics, Drug disposition, Chemistry, Computational biology, Pharmacology, Prior information
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18
المؤلفون: Ben-Fillippo Krippendorff, Tashinga E. Bapiro, Albrecht Neesse, Aurélie Courtin, David A. Tuveson, Jo L. Bramhall, Natalie Cook, Frances M. Richards, Duncan I. Jodrell
المساهمون: Richards, Fran [0000-0001-7947-7853], Jodrell, Duncan [0000-0001-9360-1670], Apollo - University of Cambridge Repository
المصدر: PLoS ONE, Vol 8, Iss 6, p e67330 (2013)
PLoS ONEمصطلحات موضوعية: endocrine system diseases, Cancer Treatment, lcsh:Medicine, Pharmacology, medicine.disease_cause, Deoxycytidine, chemistry.chemical_compound, Mice, Antineoplastic Combined Chemotherapy Protocols, Medicine, Prodrugs, Tissue Distribution, lcsh:Science, Multidisciplinary, Oncology, Fluorouracil, Adenocarcinoma, Oncology Agents, KRAS, medicine.drug, Research Article, Carcinoma, Pancreatic Ductal, Drugs and Devices, Clinical Research Design, Mice, Transgenic, Capecitabine, Pancreatic Cancer, Therapeutic index, Pancreatic cancer, Cell Line, Tumor, Cytidine Deaminase, Gastrointestinal Tumors, Animals, Pharmacokinetics, Animal Models of Disease, business.industry, lcsh:R, Cancers and Neoplasms, Chemotherapy and Drug Treatment, medicine.disease, Gemcitabine, Pancreatic Neoplasms, Disease Models, Animal, chemistry, Pharmacodynamics, Cancer research, lcsh:Q, Drug Screening Assays, Antitumor, business, Neoplasm Transplantation
وصف الملف: application/pdf
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19
مصطلحات موضوعية: Drug discovery, Drug-drug interaction, Computational biology, Biology, Bioinformatics, Biochemistry, Substrate Specificity, Analytical Chemistry, Isoenzymes, Inhibitory Concentration 50, Risk class, Ranking, Drug Design, Cytochrome P-450 Enzyme Inhibitors, Humans, Molecular Medicine, Drug Interactions, Enzyme Inhibitors, Risk classification, High potential, Biotechnology, Hamilton Institute
وصف الملف: application/pdf
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20
المؤلفون: Martin Lechmann, Frieder Bauss, Rita Mateus, Sven Kronenberg, Roland Staak, Ben Fillippo Krippendorff, Wolfgang F. Richter, Ira Pastan, Ulli Brinkmann, Friederike Hesse, Klaus Bosslet, Sabine Imhof-Jung, Masanori Onda, Gerhard Niederfellner, Gwendlyn Kollmorgen
المصدر: Cancer Research. 74:4510-4510
مصطلحات موضوعية: Cancer Research, Antibody-drug conjugate, biology, Chemistry, Fusion protein, Microtubule polymerization, Oncology, Immunotoxin, Cancer cell, biology.protein, Cancer research, Pseudomonas exotoxin, Mesothelin, Mesothelin Positive
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