نتائج البحث - "Beebe, Jean S."

1

Academic Journal

Efficacy and Safety of the TYK2/ JAK1 Inhibitor Brepocitinib for Active Psoriatic Arthritis: A Phase IIb Randomized Controlled Trial

المؤلفون: Mease, Philip, Helliwell, Philip, Silwinska‐Stanczyk, Paula, Miakisz, Malgorzata, Ostor, Andrew, Peeva, Elena, Vincent, Michael S., Sun, Qiankun, Sikirica, Vanja, Winnette, Randall, Qiu, Ruolun, Li, Gang, Feng, Gang, Beebe, Jean S., Martin, David A.

المصدر: Arthritis & Rheumatology ; volume 75, issue 8, page 1370-1380 ; ISSN 2326-5191 2326-5205

الاتاحة: http://dx.doi.org/10.1002/art.42519
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.42519

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2

Academic Journal

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study

المؤلفون: Danto, Spencer I., Tsamandouras, Nikolaos, Reddy, Padmalatha, Gilbert, Steven, Mancuso, Jessica, Page, Karen, Peeva, Elena, Vincent, Michael S., Beebe, Jean S.

المصدر: The Journal of Clinical Pharmacology ; volume 64, issue 5, page 529-543 ; ISSN 0091-2700 1552-4604

الاتاحة: http://dx.doi.org/10.1002/jcph.2360
https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.2360

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3

Academic Journal

Efficacy and safety of topical brepocitinib cream for mild-to-moderate chronic plaque psoriasis: a phase IIb randomized double-blind vehicle-controlled parallel-group study

المؤلفون: Landis, Megan N, Smith, Stacy R, Berstein, Gabriel, Fetterly, Gerald, Ghosh, Pranab, Feng, Gang, Pradhan, Vivek, Aggarwal, Sudeepta, Banfield, Christopher, Peeva, Elena, Vincent, Michael S, Beebe, Jean S, Tarabar, Sanela

المساهمون: Pfizer Inc

المصدر: British Journal of Dermatology ; volume 189, issue 1, page 33-41 ; ISSN 0007-0963 1365-2133

الاتاحة: https://doi.org/10.1093/bjd/ljad098
https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljad098/50332584/ljad098.pdf
https://academic.oup.com/bjd/article-pdf/189/1/33/51959203/ljad098.pdf

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4

Periodical

Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

المصدر: The Lancet; January 2025, Vol. 405 Issue: 10473 p137-146, 10p

5

Academic Journal

A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14 C‐Microtracer Approach

المؤلفون: Singh, Ravi Shankar P., Dowty, Martin E., Salganik, Mikhail, Brodfuehrer, Joanne I., Walker, Gregory S., Sharma, Raman, Beebe, Jean S., Danto, Spencer I.

المصدر: Clinical Pharmacology in Drug Development ; volume 11, issue 7, page 815-825 ; ISSN 2160-763X 2160-7648

الاتاحة: https://doi.org/10.1002/cpdd.1109
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.1109
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cpdd.1109
https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.1109

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6

Academic Journal

Efficacy and safety of topical brepocitinib for the treatment of mild-to-moderate atopic dermatitis: a phase IIb, randomized, double-blind, vehicle-controlled, dose-ranging and parallel-group study

المؤلفون: Landis, Megan N., Arya, Mark, Smith, Stacy, Draelos, Zoe, Usdan, Lisa, Tarabar, Sanela, Pradhan, Vivek, Aggarwal, Sudeepta, Banfield, Christopher, Peeva, Elena, Vincent, Michael S., Sikirica, Vanja, Xenakis, Jason, Beebe, Jean S.

المساهمون: Pfizer Inc, Pfizer

المصدر: British Journal of Dermatology ; volume 187, issue 6, page 878-887 ; ISSN 1365-2133 0007-0963

الاتاحة: http://dx.doi.org/10.1111/bjd.21826
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjd.21826
https://onlinelibrary.wiley.com/doi/full-xml/10.1111/bjd.21826
https://academic.oup.com/bjd/article-pdf/187/6/878/51109327/bjd0878.pdf

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7

Academic Journal

Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis.

المؤلفون: Danto, Spencer I., Tsamandouras, Nikolaos, Reddy, Padma, Gilbert, Steven A., Mancuso, Jessica Y., Page, Karen, Beebe, Jean S., Peeva, Elena, Vincent, Michael S.

المصدر: Allergy, Asthma & Clinical Immunology; 8/30/2024, Vol. 20 Issue 1, p1-8, 8p

مصطلحات موضوعية: ATOPIC dermatitis, THERAPEUTICS, ALLERGIES, INTERLEUKIN-33, SINUSITIS

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8

Academic Journal

A Phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis

المؤلفون: Cohen, Stanley, Beebe, Jean S., Chindalore, Vishala, Guan, Shunjie, Hassan-Zahraee, Mina, Saxena, Madhurima, Xi, Li, Hyde, Craig, Koride, Sarita, Levin, Robert, Lubaczewski, Shannon, Salganik, Mikhail, Sloan, Abigail, Stevens, Erin, Peeva, Elena, Vincent, Michael S., Martin, David A., Chu, Myron

المصدر: Arthritis Research & Therapy; 6/6/2024, Vol. 26 Issue 1, p1-18, 18p

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9

Academic Journal

Patient-Reported Symptoms and Disease Impacts in Adults With Moderate-to-Severe Atopic Dermatitis: Results From a Phase 2b Study With Abrocitinib

المؤلفون: Simpson, Eric L., Wollenberg, Andreas, Bissonnette, Robert, Silverberg, Jonathan I., Papacharalambous, Jocelyne, Zhu, Linda, Zhang, Weidong, Beebe, Jean S., Vincent, Michael, Peeva, Elena, Bushmakin, Andrew G., Cappelleri, Joseph C., Chen, Linda, Sikirica, Vanja, Xenakis, Jason

المصدر: Dermatitis ; volume 32, issue 1S, page S53-S61 ; ISSN 2162-5220 1710-3568

الاتاحة: http://dx.doi.org/10.1097/der.0000000000000725
https://journals.lww.com/10.1097/DER.0000000000000725

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10

Academic Journal

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF‐06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study

المؤلفون: Danto, Spencer I., Tsamandouras, Nikolaos, Reddy, Padmalatha, Gilbert, Steven, Mancuso, Jessica, Page, Karen, Peeva, Elena, Vincent, Michael S., Beebe, Jean S.

المصدر: Journal of Clinical Pharmacology; May2024, Vol. 64 Issue 5, p529-543, 15p

11

Academic Journal

Efficacy and Safety of PF‐06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate‐to‐Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate

المؤلفون: Robinson, Michael F., Damjanov, Nemanja, Stamenkovic, Bojana, Radunovic, Goran, Kivitz, Alan, Cox, Lori, Manukyan, Zorayr, Banfield, Christopher, Saunders, Michael, Chandra, Deepa, Vincent, Michael S., Mancuso, Jessica, Peeva, Elena, Beebe, Jean S.

المصدر: Arthritis & Rheumatology ; volume 72, issue 10, page 1621-1631 ; ISSN 2326-5191 2326-5205

الاتاحة: http://dx.doi.org/10.1002/art.41316
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fart.41316
https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.41316
https://onlinelibrary.wiley.com/doi/full-xml/10.1002/art.41316

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12

Academic Journal

Efficacy and Safety of Oral Janus Kinase 1 Inhibitor Abrocitinib for Patients With Atopic Dermatitis ; A Phase 2 Randomized Clinical Trial

المؤلفون: Gooderham, Melinda J., Forman, Seth B., Bissonnette, Robert, Beebe, Jean S., Zhang, Weidong, Banfield, Chris, Zhu, Linda, Papacharalambous, Jocelyne, Vincent, Michael S., Peeva, Elena

المصدر: JAMA Dermatology ; volume 155, issue 12, page 1371 ; ISSN 2168-6068

الاتاحة: http://dx.doi.org/10.1001/jamadermatol.2019.2855
https://jamanetwork.com/journals/jamadermatology/articlepdf/2751870/jamadermatology_gooderham_2019_oi_190050.pdf

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13

Academic Journal

Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial

المؤلفون: Davenport, Emma E., Amariuta, Tiffany, Gutierrez-Arcelus, Maria, Slowikowski, Kamil, Westra, Harm Jan, Luo, Yang, Shen, Ciyue, Rao, Deepak A., Zhang, Ying, Pearson, Stephen, Von Schack, David, Beebe, Jean S., Bing, Nan, John, Sally, Vincent, Michael S., Zhang, Baohong, Raychaudhuri, Soumya

المصدر: Cell and Molecular Biology Faculty Publications

مصطلحات موضوعية: Clinical trials, Cytokines, eQTL, Interactions

وصف الملف: application/pdf

Relation: https://digitalcommons.uri.edu/cmb_facpubs/165; https://digitalcommons.uri.edu/context/cmb_facpubs/article/1168/viewcontent/Zhang_LupusTrial_2018.pdf

الاتاحة: https://digitalcommons.uri.edu/cmb_facpubs/165
https://doi.org/10.1186/s13059-018-1560-8
https://digitalcommons.uri.edu/context/cmb_facpubs/article/1168/viewcontent/Zhang_LupusTrial_2018.pdf

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14

Academic Journal

Efficacy and Safety of the TYK2/JAK1 Inhibitor Brepocitinib for Active Psoriatic Arthritis: A Phase IIb Randomized Controlled Trial.

المؤلفون: Mease, Philip, Helliwell, Philip, Silwinska‐Stanczyk, Paula, Miakisz, Malgorzata, Ostor, Andrew, Peeva, Elena, Vincent, Michael S., Sun, Qiankun, Sikirica, Vanja, Winnette, Randall, Qiu, Ruolun, Li, Gang, Feng, Gang, Beebe, Jean S., Martin, David A.

المصدر: Arthritis & Rheumatology; Aug2023, Vol. 75 Issue 8, p1370-1380, 11p

مصطلحات موضوعية: PSORIATIC arthritis, DRUG efficacy, ORAL drug administration, JANUS kinases, PROTEIN-tyrosine kinase inhibitors, SEVERITY of illness index, RANDOMIZED controlled trials, PLACEBOS, INFECTION, TRANSFERASES, BLIND experiment, DOSE-effect relationship in pharmacology, DESCRIPTIVE statistics, STATISTICAL sampling, PATIENT safety, LONGITUDINAL method, EVALUATION

مصطلحات جغرافية: EUROPE

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15

Academic Journal

Increased Serum Enzyme Levels Associated with Kupffer Cell Reduction with No Signs of Hepatic or Skeletal Muscle Injury

المؤلفون: Radi, Zaher A., Koza-Taylor, Petra H., Bell, Rosonald R., Obert, Leslie A., Runnels, Herbert A., Beebe, Jean S., Lawton, Michael P., Sadis, Seth

المصدر: The American Journal of Pathology ; volume 179, issue 1, page 240-247 ; ISSN 0002-9440

الاتاحة: http://dx.doi.org/10.1016/j.ajpath.2011.03.029
https://api.elsevier.com/content/article/PII:S0002944011003531?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0002944011003531?httpAccept=text/plain

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16

Academic Journal

A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a ¹⁴C‐Microtracer Approach.

المؤلفون: Singh, Ravi Shankar P., Dowty, Martin E., Salganik, Mikhail, Brodfuehrer, Joanne I., Walker, Gregory S., Sharma, Raman, Beebe, Jean S., Danto, Spencer I.

المصدر: Clinical Pharmacology in Drug Development; Jul2022, Vol. 11 Issue 7, p815-825, 11p

مصطلحات موضوعية: BIOAVAILABILITY, ACCELERATOR mass spectrometry, ORAL drug administration, EXCRETION, RADIOACTIVITY

17

Patent

Combination therapy for hyperproliferative disease

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18

Academic Journal

Microarray analysis uncovers retinoid targets in human bronchial epithelial cells

المؤلفون: Ma, Yan, Koza-Taylor, Petra H, DiMattia, Debra A, Hames, Lynn, Fu, Haoning, Dragnev, Konstantin H, Turi, Tom, Beebe, Jean S, Freemantle, Sarah J, Dmitrovsky, Ethan

المصدر: Oncogene ; volume 22, issue 31, page 4924-4932 ; ISSN 0950-9232 1476-5594

الاتاحة: http://dx.doi.org/10.1038/sj.onc.1206728
https://www.nature.com/articles/1206728.pdf
https://www.nature.com/articles/1206728

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19

Periodical

A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach

المؤلفون: Singh, Ravi Shankar P., Dowty, Martin E., Salganik, Mikhail, Brodfuehrer, Joanne I., Walker, Gregory S., Sharma, Raman, Beebe, Jean S., Danto, Spencer I.

المصدر: Clinical Pharmacology in Drug Development; July 2022, Vol. 11 Issue: 7 p815-825, 11p

20

Academic Journal

Anti‐IL21 receptor monoclonal antibody (ATR‐107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: A phase I, first‐in‐human study

المؤلفون: Hua, Fei, Comer, Gail M., Stockert, Lori, Jin, Bo, Nowak, John, Pleasic‐Williams, Susan, Wunderlich, David, Cheng, John, Beebe, Jean S.

المصدر: The Journal of Clinical Pharmacology ; volume 54, issue 1, page 14-22 ; ISSN 0091-2700 1552-4604

الاتاحة: http://dx.doi.org/10.1002/jcph.158
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjcph.158
https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.158

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