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1
المؤلفون: Barry Koplowitz, Wei H. Yang, Robert Jordan, Keith Barnett, John Dodd, Luana Pesco Koplowitz, Marie Makhlina, Carl Spana
المصدر: Drugs in R&D
مصطلحات موضوعية: Pharmacology, Agonist, medicine.medical_specialty, medicine.drug_class, Chemistry, Cmax, Absorption (skin), Urine, Healthy Volunteers, Melanocortins, Rats, Mice, Endocrinology, Dogs, Pharmacokinetics, Internal medicine, Area Under Curve, medicine, Animals, Humans, Dosing, Original Research Article, Geometric mean, Receptor, Receptor, Melanocortin, Type 1
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2
المصدر: Fundamental & Clinical Pharmacology. 36:171-181
مصطلحات موضوعية: Pharmacology, FOOD EFFECT, Cross-Over Studies, Pyridines, business.industry, Cmax, Healthy subjects, Administration, Oral, Crossover study, Healthy Volunteers, Bioavailability, Eating, Food-Drug Interactions, Pharmacokinetics, Area Under Curve, Cohort, Humans, Medicine, Pharmacology (medical), Dosing, business
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3
المؤلفون: Sarina, Tanimoto, Michael, Kaliner, Richard F, Lockey, Motohiro, Ebisawa, Luana Pesco, Koplowitz, Barry, Koplowitz, Richard, Lowenthal
المصدر: Annals of allergy, asthmaimmunology : official publication of the American College of Allergy, Asthma,Immunology.
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4
المصدر: Fundamental & Clinical Pharmacology. 35:485-495
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pyridines, Cmax, Antineoplastic Agents, CYP2C19, 030226 pharmacology & pharmacy, White People, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Asian People, Pharmacokinetics, Internal medicine, Humans, Medicine, Pharmacology (medical), Apatinib, Pharmacology, Volume of distribution, CYP3A4, business.industry, Mesylate, Middle Aged, United States, Vascular endothelial growth factor, Endocrinology, chemistry, Area Under Curve, business, 030217 neurology & neurosurgery
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5
المؤلفون: Sarina Tanimoto, Michael Kaliner, Richard F. Lockey, Motohiro Ebisawa, Luana Pesco Koplowitz, Barry Koplowitz, Richard Lowenthal
المصدر: Annals of Allergy, Asthma & Immunology. 130:508-514.e1
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Immunology, Immunology and Allergy
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6
المؤلفون: Luana Pesco Koplowitz, Akira Shiramizu, Hiroaki Suzuki, Kip Vought, Emileigh Greuber, Barry Koplowitz, Howard I. Maibach, Kazuhiro Usuda, Dmitri Lissin, Kalpana Patel
المصدر: AAPS PharmSciTech, vol 22, iss 6
AAPS PharmSciTechمصطلحات موضوعية: Drug, Male, Lidocaine, media_common.quotation_subject, Skin Absorption, Pharmaceutical Science, Human skin, Aquatic Science, Pharmacology, Bioequivalence, medicine.disease_cause, Administration, Cutaneous, TS, Permeability, Mice, Pharmacokinetics, In vivo, Clinical Research, Drug Discovery, in vitro permeation test, medicine, TS (topical system), Animals, Pharmacology & Pharmacy, Ecology, Evolution, Behavior and Systematics, media_common, Skin, Ecology, Chemistry, General Medicine, Pharmacology and Pharmaceutical Sciences, Cutaneous, Pharmaceutical Preparations, Drug delivery, Administration, lidocaine, Female, Irritation, Agronomy and Crop Science, pharmacokinetics, in vitro permeation test (IVPT), medicine.drug, Research Article
وصف الملف: application/pdf
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7
المؤلفون: Richard Lockey, Michael Kaliner, Motohiro Ebisawa, Luana Pesco Koplowitz, Barry Koplowitz, Richard Lowenthal, Sarina Tanimoto
المصدر: Journal of Allergy and Clinical Immunology. 149:AB3
مصطلحات موضوعية: Immunology, Immunology and Allergy
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8
المؤلفون: Sarina Tanimoto, Michael Kaliner, Richard Lockey, Motohiro Ebisawa, Luana Pesco Koplowitz, Barry Koplowitz, Richard Lowenthal
المصدر: Journal of Allergy and Clinical Immunology. 149:AB3
مصطلحات موضوعية: Immunology, Immunology and Allergy
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9
المؤلفون: Luana Pesco Koplowitz, Richard E. Lowenthal, Barry E. Gidal, Enrique Carrazana, R. Edward Hogan, Barry Koplowitz
المصدر: Epilepsia
مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Sleepiness, Adolescent, medicine.medical_treatment, Administration, Oral, Biological Availability, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Pharmacokinetics, Administration, Rectal, medicine, Humans, Adverse effect, Administration, Intranasal, Diazepam, business.industry, Nasal Sprays, Middle Aged, Crossover study, Healthy Volunteers, Bioavailability, 030104 developmental biology, Neurology, Tolerability, Nasal spray, Anesthesia, Full‐length Original Research, Nasal administration, Female, Neurology (clinical), business, bioavailability, Gels, acute repetitive seizures, 030217 neurology & neurosurgery, medicine.drug
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10
المؤلفون: Luana Pesco Koplowitz, Enrique Carrazana, Barry Koplowitz, Richard E. Lowenthal, Adrian L. Rabinowicz, Sarina Tanimoto
المصدر: Clinical Pharmacology in Drug Development
مصطلحات موضوعية: Adult, Male, Coefficient of variation, Cmax, Pharmaceutical Science, Original Manuscript, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Tandem Mass Spectrometry, Medicine, Humans, Pharmacology (medical), Dosing, dose proportionality, Adverse effect, Administration, Intranasal, Cross-Over Studies, Diazepam, NRL‐1, Dose-Response Relationship, Drug, business.industry, Articles, Middle Aged, Crossover study, seizure cluster, 030220 oncology & carcinogenesis, Anesthesia, Area Under Curve, Nasal administration, Anticonvulsants, Female, business, intranasal diazepam, pharmacokinetics, acute repetitive seizures, medicine.drug, Chromatography, Liquid
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11
المؤلفون: Marie Makhlina, John Dodd, Luana Pesco Koplowitz, Barry Koplowitz, Wei H. Yang
المصدر: Gastroenterology. 160:S-327
مصطلحات موضوعية: Agonist, Hepatology, medicine.drug_class, business.industry, Gastroenterology, medicine, Dosing, Pharmacology, business, Pharmacokinetic analysis, Melanocortin 1 receptor
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12
المؤلفون: Claudio Mapelli, Ramakrishna Seethala, Songping Han, Ellen Sieber-McMaster, William R. Ewing, Ashish Khanna, Keith L. Constantine, Douglas James Riexinger, Daniel Longhi, John Krupinski, Zhengping Ma, Constance Smith-Monroy, Bastos Margarita M, Dan Shi, Michael S. Bernatowicz, Joseph R. Taylor, Christine Huang, Rajasree Golla, Gordon William Robinson, Jelka Pluscec, Jean M. Whaley, Sesha Natarajan, Jean-Philippe Meyer, Robert H. Stoffel, Li Xin, Ving G. Lee, Barry Koplowitz, Cecilia L Chi, Ildiko Antal-Zimanyi
المصدر: Journal of Medicinal Chemistry. 52:7788-7799
مصطلحات موضوعية: Male, Models, Molecular, endocrine system, Protein Conformation, Molecular Sequence Data, Peptide, CHO Cells, Glucagon-Like Peptide-1 Receptor, Mice, chemistry.chemical_compound, Cricetulus, Dogs, Cricetinae, Drug Discovery, Receptors, Glucagon, Peptide synthesis, Animals, Humans, Hypoglycemic Agents, Glucose homeostasis, Amino Acid Sequence, Receptor, Peptide sequence, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, Dipeptide, Dose-Response Relationship, Drug, digestive, oral, and skin physiology, Amino acid, chemistry, Biochemistry, Molecular Medicine, Oligopeptides
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13
المؤلفون: Kenneth E. Carlson, Stephen G. Walker, Barry Koplowitz, Kathleen M. Gillooly, John W. Haycock, Kim W. McIntyre, Ximao Wu, Stephen Roberts, Guixue Yu, John E. Macor, George C. Morton, Huji Tuerdi, Yifan Yang, Timothy F. Herpin, R. Michael Lawrence, Liya Kang, Judy Wardwell-Swanson, Ashish Khanna
المصدر: Journal of Leukocyte Biology. 80:897-904
مصطلحات موضوعية: Lipopolysaccharides, Male, Agonist, Time Factors, medicine.drug_class, medicine.medical_treatment, Immunology, Biology, Pharmacology, Cell Line, Mice, Structure-Activity Relationship, Cell Movement, In vivo, Leukocytes, medicine, Animals, Humans, Immunology and Allergy, Receptor, Lung, G protein-coupled receptor, Inflammation, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Imidazoles, Cell Biology, Mice, Inbred C57BL, Molecular Weight, Cytokine, Cytokines, Female, Tumor necrosis factor alpha, Melanocortin, Receptor, Melanocortin, Type 1, Melanocortin 1 receptor
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14
المؤلفون: Luana Pesco Koplowitz, Arlo N. McGinn, Barry Koplowitz, Cheol Hee Park
المصدر: Journal of Clinical Oncology. 35:e14049-e14049
مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Mesylate, business.industry, Healthy subjects, Advanced gastric cancer, Multiple dosing, 030226 pharmacology & pharmacy, Phase i study, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Pharmacokinetics, Internal medicine, medicine, Apatinib, business
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15
المؤلفون: Ving G. Lee, Tasir Shamsul Haque, Ming Feng, Douglas G. Riexinger, Rogelio L. Martinez, Claudio Mapelli, William R. Ewing, Cooper Christopher B, Ming Lei, Ge Zhang, Barry Koplowitz, John Krupinski, Christine Huang
المصدر: Peptides. 31(7)
مصطلحات موضوعية: Functional assay, Agonist, Models, Molecular, endocrine system, Physiology, medicine.drug_class, Stereochemistry, Molecular Sequence Data, Peptide, CHO Cells, Biochemistry, Glucagon-Like Peptide-1 Receptor, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Structure-Activity Relationship, Endocrinology, Cricetulus, Dogs, Biosynthesis, Peptide Library, Cricetinae, medicine, Receptors, Glucagon, Animals, Humans, Amino Acid Sequence, Receptor, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, In vitro, Amino acid, chemistry, Peptides
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16
المؤلفون: William N. Washburn, Jean M. Whaley, Bruce A. Ellsworth, Wenying Li, Sreeneeranj Kasichayanula, Ming Yao, Wei Meng, Ashish Khanna, Lorell Discenza, Bernard J. Komoroski, Mary T. Obermeier, Mingshe Zhu, William G. Humphreys, Barry Koplowitz
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 38(3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Metabolite, Glucuronidation, Drug Evaluation, Preclinical, Pharmaceutical Science, Biological Availability, Pharmacology, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Dogs, Pharmacokinetics, Cytochrome P-450 Enzyme System, Glucosides, Internal medicine, Membrane Transport Modulators, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Hypoglycemic Agents, ATP Binding Cassette Transporter, Subfamily B, Member 1, Dapagliflozin, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors, Biotransformation, Cells, Cultured, Mice, Inbred BALB C, biology, Cytochrome P450, Biological activity, In vitro, Rats, Isoenzymes, Kinetics, Macaca fascicularis, medicine.anatomical_structure, Endocrinology, chemistry, Hepatocyte, biology.protein, Hepatocytes, Microsomes, Liver, Caco-2 Cells, Half-Life
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17
المؤلفون: Mark S. Kirby, David W. Boulton, Shu-Ying Chang, W. Griffith Humphreys, Viral Vyas, Lisa J. Christopher, Barry Koplowitz, Ashish Khanna, Aberra Fura, Lawrence G. Hamann, Kristina D. Chadwick, Christian Caporuscio
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 37(6)
مصطلحات موضوعية: medicine.medical_specialty, Metabolic Clearance Rate, Metabolite, Drug Evaluation, Preclinical, Pharmaceutical Science, Biological Availability, Adamantane, Dipeptidyl peptidase-4 inhibitor, Biology, Saxagliptin, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Pharmacokinetics, Species Specificity, Internal medicine, medicine, Animals, Humans, Dipeptidyl peptidase-4, Pharmacology, Volume of distribution, Dipeptidyl-Peptidase IV Inhibitors, Dipeptides, Haplorhini, Bioavailability, Rats, Rats, Zucker, Endocrinology, chemistry, Pharmacodynamics, Microsomes, Liver, medicine.drug, Half-Life, Protein Binding
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18
المؤلفون: David K. Williams, Sarah C. Traeger, Johnni Gullo-Brown, Carolyn S. Ricca, Rajeev S. Bhide, Barry Koplowitz, Louis J. Lombardo, John S. Tokarski, Kelly McGlinchey, Yufen Zhao, Francis Y. Lee, John L. Clark, Ivan Inigo, David Kan, Amy Camuso, Krista Fager, Veeraswamy Manne, John T. Hunt, Ligang Qian, G. C. Rovnyak, Laurence I. Wu
المصدر: Bioorganicmedicinal chemistry letters. 15(7)
مصطلحات موضوعية: Farnesyltransferase, Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, Antineoplastic Agents, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, Nude mouse, Cell Line, Tumor, Drug Discovery, Potency, Animals, Farnesyltranstransferase, Enzyme Inhibitors, Molecular Biology, Farnesyl-diphosphate farnesyltransferase, Alkyl and Aryl Transferases, biology, Chemistry, Organic Chemistry, Farnesyltransferase inhibitor, biology.organism_classification, Small molecule, Enzyme inhibitor, biology.protein, Quinolines, Molecular Medicine, Drug Screening Assays, Antitumor
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19
المؤلفون: Rongan Zhang, Eddie C.-K. Liu, Mark A. Hermsmeier, Maria L. Webb, Ping Chen, Zhengxiang Gu, Richard A. Morrison, Natesan Murugesan, T.L. Waldron, Leslie Leith, Steven H. Spergel, Suzanne Moreland, Eileen Bird, Marian Young, Barry Koplowitz, Anthony M. Marino, Nick C. Trippodo, Saeho Chong, W. Griffith Humphreys, Arvind Mathur, Joel C. Barrish
المصدر: Journal of medicinal chemistry. 46(1)
مصطلحات موضوعية: Endothelin Receptor Antagonists, Male, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Blood Pressure, CHO Cells, In Vitro Techniques, Rats, Sprague-Dawley, Structure-Activity Relationship, Cricetinae, Drug Discovery, medicine, Potency, Structure–activity relationship, Animals, Humans, Receptor, Oxazoles, Sulfonyl, chemistry.chemical_classification, Sulfonamides, Antagonist, Isoxazoles, Receptor antagonist, Receptor, Endothelin A, Receptor, Endothelin B, Rats, Macaca fascicularis, Carotid Arteries, chemistry, Molecular Medicine, Rabbits, Caco-2 Cells, Endothelin receptor, Muscle Contraction