المؤلفون: Barrio-Alonso, Estibaliz, Lituma, Pablo J., Notaras, Michael J., Albero, Robert, Bouchekioua, Youcef, Wayland, Natalie, Stankovic, Isidora N., Jain, Tanya, Gao, Sijia, Calderon, Diany Paola, Castillo, Pablo E., Colak, Dilek

المساهمون: National Institutes of Health

المصدر: Cell Reports ; volume 42, issue 4, page 112375 ; ISSN 2211-1247

الاتاحة: http://dx.doi.org/10.1016/j.celrep.2023.112375
https://api.elsevier.com/content/article/PII:S2211124723003868?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S2211124723003868?httpAccept=text/plain

المؤلفون: Allen, Megan, Huang, Ben S., Notaras, Michael J., Lodhi, Aiman, Barrio-Alonso, Estibaliz, Lituma, Pablo J., Wolujewicz, Paul, Witztum, Jonathan, Longo, Francesco, Chen, Maoshan, Greening, David W., Klann, Eric, Ross, M. Elizabeth, Liston, Conor, Colak, Dilek

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Mental Health

المصدر: Molecular Psychiatry ; volume 27, issue 5, page 2470-2484 ; ISSN 1359-4184 1476-5578

الاتاحة: http://dx.doi.org/10.1038/s41380-022-01486-x
https://www.nature.com/articles/s41380-022-01486-x.pdf
https://www.nature.com/articles/s41380-022-01486-x

المؤلفون: Notaras, Michael, Lodhi, Aiman, Barrio-Alonso, Estibaliz, Foord, Careen, Rodrick, Tori, Jones, Drew, Fang, Haoyun, Greening, David, Colak, Dilek

المصدر: Molecular Psychiatry ; volume 26, issue 12, page 7760-7783 ; ISSN 1359-4184 1476-5578

الاتاحة: http://dx.doi.org/10.1038/s41380-021-01189-9
https://www.nature.com/articles/s41380-021-01189-9.pdf
https://www.nature.com/articles/s41380-021-01189-9

المؤلفون: Barrio-Alonso, Estíbaliz, Fontana, Bérénice, Valero, Manuel, Frade López, José María

المساهمون: Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI), Frade López, José María

مصطلحات موضوعية: Neuronal cell cycle reentry, SV40 large T antigen, Neuron hypertrophy, Neurite retraction, Synaptic dysfunction, Neural network modeling, Synaptic firing rate, Oscillatory patterns

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68488-R; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095030- B-I00; RTI2018-095030- B-I00/AEI/10.13039/501100011033; Publisher's version; Barrio-Alonso, Estíbaliz; Fontana, Bérénice; Valero, Manuel; Frade, José María; 2020; “Neural network simulation with hyperploid neurons [Dataset]”; DIGITAL.CSIC; http://dx.doi.org/10.20350/digitalCSIC/10541. http://hdl.handle.net/10261/199386; https://doi.org/10.3389/fgene.2020.00287; Sí; Frontiers in Genetics 11: 287 (2020); http://hdl.handle.net/10261/205699; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100011033

الاتاحة: http://hdl.handle.net/10261/205699
https://doi.org/10.3389/fgene.2020.00287
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/501100011033

المؤلفون: Walton, Chaska C., Zhang, Wei, Patiño-Parrado, Iris, Barrio-Alonso, Estíbaliz, Garrido Jurado, Juan José, Frade López, José María

المساهمون: Ministerio de Economía y Competitividad (España), Ministerio de Educación, Cultura y Deporte (España)

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68488-R; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-65315-R; Publisher's version; https://doi.org/10.1038/s41598-019-40462-4; Sí; Scientific Reports 9: 4594 (2019); http://hdl.handle.net/10261/191179; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100003176

الاتاحة: http://hdl.handle.net/10261/191179
https://doi.org/10.1038/s41598-019-40462-4
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/501100003176

المؤلفون: Barrio-Alonso, Estíbaliz, Hernández-Vivanco, A., Walton, Chaska C., Perea, Gertrudis, Frade López, José María

المساهمون: Ministerio de Economía y Competitividad (España), Consejo Superior de Investigaciones Científicas (España)

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68488-R; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-47265-R; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75107-P; Publisher's version; https://doi.org/10.1038/s41598-018-32708-4; Sí; Scientific Reports 8: 14316 (2018); http://hdl.handle.net/10261/191116; http://dx.doi.org/10.13039/501100003329; http://dx.doi.org/10.13039/501100003339

الاتاحة: http://hdl.handle.net/10261/191116
https://doi.org/10.1038/s41598-018-32708-4
https://doi.org/10.13039/501100003329
https://doi.org/10.13039/501100003339

المؤلفون: Allen, Megan, Huang, Ben S., Notaras, Michael J., Lodhi, Aiman, Barrio-Alonso, Estibaliz, Lituma, Pablo J., Wolujewicz, Paul, Witztum, Jonathan, Longo, Francesco, Chen, Maoshan, Greening, David W., Klann, Eric, Ross, M. Elizabeth, Liston, Conor, Colak, Dilek

المصدر: Molecular Psychiatry ; volume 27, issue 5, page 2369-2369 ; ISSN 1359-4184 1476-5578

الاتاحة: http://dx.doi.org/10.1038/s41380-022-01606-7
https://www.nature.com/articles/s41380-022-01606-7.pdf
https://www.nature.com/articles/s41380-022-01606-7

المؤلفون: Barrio-Alonso, Estíbaliz, Valero, Manuel, Fontana, Bérénice, Frade López, José María

المساهمون: Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Barrio-Alonso, Estíbaliz, Valero, Manuel, Frade López, José María, Fontana, Bérénice

مصطلحات موضوعية: Neuronal cell cycle reentry, SV40 large T antigen, Neuron hypertrophy, Neurite retraction, Synaptic dysfunction, Neural network modelling, Synaptic firing rate, Oscillatory patterns

وصف الملف: All experiments folders contains: (i) a feat.cvs file with metadata of the experiment in a single column. See simulation code for more information about the metadata; (ii) log.cvs file with the percentages of hyperploid population and the target cell type (for instance, simulation with 20% of the hyperploid interneurons); (iii) mv.cvs, membrane potential for all neurons across simulations M x N, being M a given cell, and time points in N; (iV) spk.cvs, action potential for all neurons as 2xM, being the first column the cell ID, and the second column, the time of the spike; (v) tetData.mat contains feat.cvs and log.cvs data as MALTAB variables (vi) sumarized plots of the simulation as png files (raster plot and some membrane potential traces).; 107 Gb; cvs, .mat, .png

Relation: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-68488-R; RTI2018-095030-B-I00/AEI/10.13039/501100011033; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095030-B-I00; Barrio-Alonso, E., Hernández-Vivanco, A., Walton, C. C., Perea, G., and Frade, J. M. (2018). Cell cycle reentry triggers hyperploidization and synaptic dysfunction followed by delayed cell death in differentiated cortical neurons. Sci. Rep. 8, 14316. doi:10.1038/s41598-018-32708-4; Goodman, D., and Brette, R. (2008). Brian: a simulator for spiking neural networks in Python. Front. Neuroinform. 2, 5. doi:10.3389/neuro.11.005.2008; Knight, B. W. (1972). Dynamics of encoding in a population of neurons. J. Gen. Physiol. 59, 734-766. doi:10.1085/jgp.59.6.734; Stimberg, M., Goodman, D. F. M., Brette, R., and De Pittà, M. (2017). Modeling neuron-glia interactions with the Brian 2 simulator. bioRxiv 198366. doi:10.1101/198366; Barrio-Alonso, Estíbaliz; Fontana, Bérénice; Valero, Manuel; Frade López, José María (2020) Pathological Aspects of Neuronal Hyperploidization in Alzheimer’s Disease Evidenced by Computer Simulation. Front. Genet. 11: 287. https://doi.org/10.3389/fgene.2020.00287. http://hdl.handle.net/10261/205699; MATLAB or Octave Any text editor; Sí; Barrio-Alonso, Estíbaliz; Fontana, Bérénice; Valero, Manuel; Frade, José María; 2020; “Neural network simulation with hyperploid neurons [Dataset]”; DIGITAL.CSIC; http://dx.doi.org/10.20350/digitalCSIC/10541; http://hdl.handle.net/10261/199386; http://dx.doi.org/10.13039/501100011033; http://dx.doi.org/10.13039/501100003329

الاتاحة: http://hdl.handle.net/10261/199386
https://doi.org/10.20350/digitalCSIC/10541
https://doi.org/10.13039/501100011033
https://doi.org/10.13039/501100003329

المؤلفون: Barrio Alonso, Estíbaliz

المساهمون: Frade López, José María, UAM. Departamento de Bioquímica, CSIC. Instituto Cajal (IC)

مصطلحات موضوعية: Enfermedad de Alzheimer - Tesis doctorales, Sistema nervioso - Degeneración - Tesis doctorales, Biología y Biomedicina / Biología

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10486/687570

الاتاحة: http://hdl.handle.net/10486/687570