المؤلفون: Jennifer Brown, Karen E. Parrish, Andrew J. Tebben, Jonathan Lippy, Kamalavenkatesh Palanisamy, Todd Kinsella, Chetan Padmakar Darne, Vinay K. Holenarsipur, Anwar Murtaza, Muthalagu Vetrichelvan, Chunhong Yan, Karen Augustine-Rauch, Max Ruzanov, Mark Fereshteh, Upender Velaparthi, Gopal Dhar, Gregory D. Vite, Peiying Liu, Steven Sheriff, Jayakumar Sankara Warrier, Aravind Anandam, Marina Gelman, Arvind Mathur, Barri Wautlet, Robert M. Borzilleri, Hasibur Rahaman, Zheng Yang, Anuradha Gupta, Arun Kumar Gupta, Rajinder Singh, Joseph Fargnoli, Jesse Swanson

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: biology, 010405 organic chemistry, business.industry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Regimen, Pharmacokinetics, In vivo, Drug Discovery, biology.protein, Medicine, Potency, Kinome, Dosing, Antibody, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c0a6b7db9a564a606d22c0c365bdb7
https://doi.org/10.1021/acsmedchemlett.9b00552

المؤلفون: Barri Wautlet, Lalgudi S. Harikrishnan, Jonathan Lippy, Andrew J. Tebben, Amol G. Dikundwar, P.N. Arunachalam, Raju Mannoori, Max Ruzanov, Yi Fan, Gopikishan Tonukunuru, Vishweshwaraiah Baligar, Mark Fereshteh, Balaji Seshadri, Jayakumar Warrier, Sudhakara R. Madduri, Joseph Fargnoli, Robert M. Borzilleri, Ching-Ping Ho, Brian E. Fink, Steven Sheriff, Hasibur Rahaman

المصدر: Bioorganic & Medicinal Chemistry. 26:1026-1034

مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, T-Lymphocytes, Clinical Biochemistry, Receptor, Transforming Growth Factor-beta Type I, Thiazines, Pharmaceutical Science, Smad Proteins, SMAD, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Bridged Bicyclo Compounds, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, In vivo, Drug Discovery, TGF beta signaling pathway, Humans, Pyrroles, Epithelial–mesenchymal transition, Phosphorylation, Molecular Biology, Cells, Cultured, Binding Sites, Chemistry, Organic Chemistry, In vitro, Protein Structure, Tertiary, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Signal transduction, Receptors, Transforming Growth Factor beta, Protein Binding, Transforming growth factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a455e12641eb310526027a244db0ac
https://doi.org/10.1016/j.bmc.2018.01.014

المؤلفون: Yufen Zhao, Barri Wautlet, Jonathan Lippy, Anne Rose, Andrew J. Tebben, Gregory D. Vite, Max Ruzanov, Joseph Fargnoli, Liping Zhang, Yong Zhang, Zheng Yang, Karen E. Parrish, Robert M. Borzilleri, Yi Fan, Jesse Swanson, Ching-Ping Ho, Karen Augustine-Rauch, Andrew F. Donnell, Brian E. Fink, Steven Sheriff, Mark Fereshteh

مصطلحات موضوعية: 0301 basic medicine, Antitumor immunity, biology, business.industry, Kinase, medicine.medical_treatment, Organic Chemistry, Biochemistry, Blockade, 03 medical and health sciences, 030104 developmental biology, Cytokine, Immune system, Murine tumor, Drug Discovery, Cancer research, biology.protein, Medicine, Antibody, business, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca61cd13f527f4d17df3df6c932c4f3
https://europepmc.org/articles/PMC6231184/

المؤلفون: David K. Williams, Kristen A. Kellar, Louis J. Lombardo, Veeraswamy Manne, Joseph Fargnoli, John S. Tokarski, Xiao-Tao Chen, Robert Jeyaseelan, Yongmi An, Barri Wautlet, Robert M. Borzilleri, George L. Trainor, Robert F. Kaltenbach, Benjamin J. Henley, Christine M. Tarby, John S. Sack, Zhen-Wei Cai, Johnni Gullo-Brown

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2998-3002

مصطلحات موضوعية: Clinical Biochemistry, Aminopyridines, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Humans, Transferase, Potency, Amines, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, Chemistry, Kinase, Organic Chemistry, Proto-Oncogene Proteins c-met, Xenograft Model Antitumor Assays, Human tumor, Design synthesis, Protein kinase domain, Cell culture, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce111ff8f72247a524ba96836e34c3c8
https://doi.org/10.1016/j.bmcl.2010.01.042

المؤلفون: Rajeev S. Bhide, Daniel W. Kukral, Harold Malone, Barri Wautlet, John T. Hunt, Anne Lewin, Joel C. Barrish, Bala Krishnan, Steven Mortillo, Joseph Fargnoli, Zhen-Wei Cai, Louis J. Lombardo, Benjamin J. Henley, Susan Galbraith, Robert Jeyaseelan

المصدر: Molecular Cancer Therapeutics. 9:369-378

مصطلحات موضوعية: Cancer Research, Time Factors, Angiogenesis, Antigens, CD34, Pharmacology, Fibroblast growth factor, Receptor tyrosine kinase, Mice, chemistry.chemical_compound, Cell Line, Tumor, Animals, Humans, Pyrroles, Receptor, Fibroblast Growth Factor, Type 1, Mice, Inbred BALB C, Alanine, Dose-Response Relationship, Drug, biology, Triazines, Fibroblast growth factor receptor 1, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Endothelial stem cell, Vascular endothelial growth factor, Drug Combinations, Brivanib alaninate, Oncology, chemistry, biology.protein, Female, Proteoglycans, Collagen, Laminin, Neoplasm Transplantation, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf992d6364e7e3d36187cb824da482c
https://doi.org/10.1158/1535-7163.mct-09-0472

المؤلفون: Robert J. Schmidt, Benjamin J. Henley, Celia D’Arienzo, Jonathan Lippy, John S. Sack, Yueping Zhang, Yongmi An, John T. Hunt, Amrita Kamath, John S. Tokarski, Barri Wautlet, Veeraswamy Manne, Dianlin Xie, Punit Marathe, Donna D. Wei, Louis J. Lombardo, Kyoung S. Kim, Robert Jeyaseelan, David K. Williams, Joseph Fargnoli, Liping Zhang, Yaquan Zhang, Johnni Gullo-Brown, Zhen-Wei Cai, George L. Trainor, Robert M. Borzilleri

المصدر: Journal of Medicinal Chemistry. 51:5330-5341

مصطلحات موضوعية: Male, Pyridones, medicine.drug_class, Stereochemistry, Antineoplastic Agents, Carboxamide, Crystallography, X-Ray, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, medicine, Animals, Humans, Transferase, Structure–activity relationship, Receptors, Growth Factor, Binding site, Protein Kinase Inhibitors, Cell Proliferation, chemistry.chemical_classification, Mice, Inbred BALB C, Kinase, Phosphotransferases, Proto-Oncogene Proteins c-met, Vascular Endothelial Growth Factor Receptor-2, Enzyme, fms-Like Tyrosine Kinase 3, Biochemistry, chemistry, Microsomes, Liver, Molecular Medicine, Signal transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a9baa70cfbe1d4ab37df5d6a6a243
https://doi.org/10.1021/jm800476q

المؤلفون: Ligang Qian, Carl Thibeault, Amrita Kamath, Barri Wautlet, Alain Martel, George L. Trainor, Punit Marathe, Celia D’Arienzo, Benjamin J. Henley, Steven Mortillo, Donna D. Wei, Robert Jeyaseelan, Ravindra W. Tejwani, John T. Hunt, Louis J. Lombardo, Rejean Ruel, Yueping Zhang, Zhen-Wei Cai, Joseph Fargnoli, Arvind Mathur, Alexandre L'Heureux, Joel C. Barrish, Rajeev S. Bhide, George M. Derbin

المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2985-2989

مصطلحات موضوعية: ERG1 Potassium Channel, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Angiogenesis Inhibitors, Biochemistry, Chemical synthesis, Cell Line, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Growth factor receptor, In vivo, Drug Discovery, Animals, Humans, Pyrroles, Molecular Biology, Mice, Inbred BALB C, Bicyclic molecule, biology, Triazines, Chemistry, Organic Chemistry, Protein-Tyrosine Kinases, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Ether-A-Go-Go Potassium Channels, In vitro, Enzyme inhibitor, Drug Design, biology.protein, Cytochrome P-450 CYP3A Inhibitors, Molecular Medicine, Tyrosine kinase, Isopropyl

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cfa6c308d852434ef38b9bf1d1ba3c
https://doi.org/10.1016/j.bmcl.2008.03.057

المؤلفون: Celia D’Arienzo, Daniel W. Kukral, Stephanie Barbosa, Steve Mortillo, John T. Hunt, Lawrence Wu, Punit Marathe, George M. Derbin, Joseph Fargnoli, Yong-Zheng Zhang, Robert M. Borzilleri, Joel C. Barrish, Zhongping Shi, Jeffrey A. Robl, Robert Jeyaseelan, Rajeev S. Bhide, Ligang Qian, Donna D. Wei, Junying Fan, Amrita Kamath, Xiaoping Zheng, Zhen-Wei Cai, Louis J. Lombardo, Barri Wautlet

المصدر: Journal of Medicinal Chemistry. 51:1976-1980

مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Fibroblast growth factor receptor 1, Kinase insert domain receptor, Prodrug, Chemical synthesis, stomatognathic diseases, chemistry.chemical_compound, Brivanib alaninate, Growth factor receptor, In vivo, Enzyme inhibitor, Drug Discovery, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3d4516933a25721ed5927f672b479f07
https://doi.org/10.1021/jm7013309

المؤلفون: Joseph Fargnoli, Daniel W. Kukral, Steve Mortillo, Viral Vyas, John S. Tokarski, John T. Hunt, Robert M. Borzilleri, Rajeev S. Bhide, Robert Jeyaseelan, Louis J. Lombardo, Amrita Kamath, Xiaoping Zheng, Ligang Qian, Barri Wautlet, Zhen-Wei Cai, Joel C. Barrish, Aberra Fura, Christopher D. Ellis

المصدر: Journal of Medicinal Chemistry. 48:3991-4008

مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, In Vitro Techniques, Hydroxamic Acids, Fibroblast growth factor, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Growth factor receptor, Drug Discovery, Animals, Humans, Pyrroles, Receptor, Fibroblast Growth Factor, Type 1, Cell Proliferation, Mice, Inbred BALB C, Oxadiazoles, Hydroxamic acid, Triazines, Fibroblast growth factor receptor 1, Receptor Protein-Tyrosine Kinases, Kinase insert domain receptor, Blood Proteins, Receptors, Fibroblast Growth Factor, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, chemistry, Drug Design, Microsomes, Liver, Molecular Medicine, Human umbilical vein endothelial cell, Endothelium, Vascular, Tyrosine kinase, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5efa6b92d3ff02bfeb512d007a2c1a
https://doi.org/10.1021/jm0501275

المؤلفون: Raj N. Misra, William G. Humphreys, K R Webster, John S. Sack, Y. F. Kelly, Janet G. Mulheron, Kimball Sd, Ligang Qian, Sam T. Chao, Kyoung S. Kim, Leslie Leith, John T. Hunt, Barri Wautlet, John S. Tokarski

المصدر: Journal of Medicinal Chemistry. 43:4126-4134

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Thio, Antineoplastic Agents, Cyclin B, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Structure-Activity Relationship, Piperidines, Cyclin-dependent kinase, Proto-Oncogene Proteins, CDC2 Protein Kinase, Cyclin E, Drug Discovery, CDC2-CDC28 Kinases, Tumor Cells, Cultured, Humans, Structure–activity relationship, Cyclin D1, Cyclin B1, Enzyme Inhibitors, Tumor Stem Cell Assay, Flavonoids, Cyclin-dependent kinase 1, Binding Sites, biology, Kinase, Chemistry, Cyclin-dependent kinase 4, Cyclin-Dependent Kinase 2, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Stereoisomerism, Biological activity, Cyclin-Dependent Kinases, Chromones, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5568dac892e0963a35d38f5129fb6811
https://doi.org/10.1021/jm000231g

المؤلفون: John S. Tokarski, Barri Wautlet, Amrita Kamath, Xiao-Tao Chen, Robert Jeyaseelan, Yingru Zhang, Joseph Fargnoli, Guoxiang Shen, Kyoung S. Kim, David K. Williams, Yongmi An, John T. Hunt, Jun Dai, Kevin Stefanski, Veeraswamy Manne, Simone Oppenheimer, Ashok Kumar Gupta, Louis J. Lombardo, Gretchen M. Schroeder, George L. Trainor, Robert M. Borzilleri, Robert J. Schmidt, Benjamin J. Henley, Jonathan Lippy, Johnni Gullo-Brown, Zhen-Wei Cai, Yueping Zhang, Donna D. Wei, Cornelius Lyndon A M, Cheryl M. Clark, John S. Sack

المصدر: Journal of medicinal chemistry. 52(5)

مصطلحات موضوعية: Models, Molecular, Dihydropyridines, medicine.drug_class, Stereochemistry, Pyridones, Administration, Oral, Aminopyridines, Mice, Nude, Carboxamide, Antineoplastic Agents, Crystallography, X-Ray, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Oral administration, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Potency, Animals, Humans, biology, Kinase, Dihydropyridine, Proto-Oncogene Proteins c-met, Xenograft Model Antitumor Assays, Rats, chemistry, Solubility, Enzyme inhibitor, Lactam, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4411d046c3b4238b43b53e12be5f7d4
https://pubmed.ncbi.nlm.nih.gov/19260711

المؤلفون: Donna D. Wei, Joseph Fargnoli, Zhong Chen, Yongmi An, David K. Williams, John T. Hunt, Louis J. Lombardo, Robert M. Borzilleri, Zhen-Wei Cai, Veeraswamy Manne, Michael A. Poss, David S. Nirschl, Gretchen M. Schroeder, Kristen A. Kellar, Barri Wautlet, Tai W. Wong, John S. Tokarski, Xiao-Tao Chen, Wayne Vaccaro, Johnni Gullo-Brown, John S. Sack, Tram N. Huynh

المصدر: Bioorganicmedicinal chemistry letters. 18(6)

مصطلحات موضوعية: Stereochemistry, Protein Conformation, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Stomach Neoplasms, Amide, Proto-Oncogene Proteins, Drug Discovery, Moiety, Transferase, Animals, Humans, Pyrroles, Receptors, Growth Factor, Kinase activity, Enzyme Inhibitors, Molecular Biology, Cells, Cultured, Triazine, Cell Proliferation, Glutathione Transferase, Molecular Structure, Chemistry, Kinase, Triazines, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-met, Ether-A-Go-Go Potassium Channels, Protein kinase domain, Hepatocytes, Microsomes, Liver, Molecular Medicine, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67232fdb495e6485b4bb94d3f20ac692
https://pubmed.ncbi.nlm.nih.gov/18289854

المؤلفون: Joseph Fargnoli, Amrita Kamath, Louis J. Lombardo, Robert M. Borzilleri, Zhen-Wei Cai, John T. Hunt, Robert Jeyaseelan, John S. Tokarski, Barri Wautlet, Benjamin J. Henley, Steven Mortillo, Donna D. Wei, Rajeev S. Bhide, Ligang Qian

المصدر: Bioorganicmedicinal chemistry letters. 18(4)

مصطلحات موضوعية: Cyclopropanes, Lung Neoplasms, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Mice, Nude, Carboxamide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Pyrroles, Kinase activity, Molecular Biology, Protein Kinase Inhibitors, Triazine, chemistry.chemical_classification, Oxadiazoles, biology, Kinase, Triazines, Organic Chemistry, Aromatic amine, Endothelial Cells, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c84f33295712d1e78d7a13e27d73e3f
https://pubmed.ncbi.nlm.nih.gov/18221875

المؤلفون: Robert Jeyaseelan, Steve Mortillo, Joseph Fargnoli, Rajeev S. Bhide, Ligang Qian, George M. Derbin, John T. Hunt, Punit Marathe, Louis J. Lombardo, Amrita Kamath, Xiaoping Zheng, John S. Tokarski, Daniel W. Kukral, Robert M. Borzilleri, Barri Wautlet, Joel C. Barrish, Celia D’Arienzo

المصدر: Journal of medicinal chemistry. 49(13)

مصطلحات موضوعية: Models, Molecular, Umbilical Veins, Stereochemistry, Administration, Oral, Aminopyridines, Mice, Nude, Angiogenesis Inhibitors, In Vitro Techniques, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Non-competitive inhibition, Growth factor receptor, Aminothiazole, Drug Discovery, Animals, Humans, Kinase activity, Benzamide, Cell Proliferation, Binding Sites, biology, Chemistry, Endothelial Cells, Kinase insert domain receptor, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Rats, Vascular endothelial growth factor, Macaca fascicularis, Thiazoles, Enzyme inhibitor, biology.protein, Molecular Medicine, Endothelium, Vascular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27832b94e54cf3ed19ac77606320613e
https://pubmed.ncbi.nlm.nih.gov/16789733

المؤلفون: Steven Mortillo, Donna D. Wei, Daniel W. Kukral, Viral Vyas, Arvind Mathur, Stephanie Barbosa, Laurence I. Wu, John T. Hunt, Zhen-Wei Cai, Soong-Hoon Kim, Robert Jeyaseelan, Kenneth J. Leavitt, Sam T. Chao, Joseph Fargnoli, Joel C. Barrish, Ligang Qian, Amrita Kamath, Punit Marathe, Xiaoping Zheng, Barri Wautlet, Yong-Zheng Zhang, Leslie Leith, Louis J. Lombardo, Celia D’Arienzo, George M. Derbin, Rajeev S. Bhide, Robert M. Borzilleri, Aberra Fura

المصدر: Journal of medicinal chemistry. 49(7)

مصطلحات موضوعية: Stereochemistry, Transplantation, Heterologous, Mice, Nude, Angiogenesis Inhibitors, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, Prodrugs, Pyrroles, Triazine, Mice, Inbred BALB C, Alanine, Triazines, Stereoisomerism, Prodrug, Vascular Endothelial Growth Factor Receptor-2, In vitro, Brivanib alaninate, chemistry, Alkoxy group, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439b47c951b45c2e8b163b987da049cc
https://pubmed.ncbi.nlm.nih.gov/16570908

المؤلفون: Xioping Zheng, Christopher D. Ellis, Robert M. Borzilleri, Bindu Goyal, Tracy Gerhardt, Rajeev S. Bhide, Aberra Fura, Steven Mortillo, Joseph Fargnoli, Viral Vyas, John T. Hunt, John S. Tokarski, Ligang Qian, Zhen-Wei Cai, Barri Wautlet

المصدر: Bioorganicmedicinal chemistry letters. 15(5)

مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Cell Survival, Clinical Biochemistry, Glucuronidation, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Side chain, Animals, Humans, Phenols, Enzyme Inhibitors, Molecular Biology, Triazine, Bicyclic molecule, biology, Molecular Structure, Triazines, Organic Chemistry, Vascular Endothelial Growth Factor Receptor-2, chemistry, Enzyme inhibitor, biology.protein, Microsomes, Liver, Molecular Medicine, Endothelium, Vascular, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5213e2870a952df3089316f5e7b1258
https://pubmed.ncbi.nlm.nih.gov/15713401

المؤلفون: Wen-Ching Han, Tai Wong, John T. Hunt, Gregory D. Vite, Robert M. Borzilleri, Toomas Mitt, Barri Wautlet, Xiaoping Zheng, Chiang Yu, Steven Mortillo, Rajeev S. Bhide, Johnni Gullo-Brown, Brian E. Fink, Joseph Fargnoli

المصدر: Journal of medicinal chemistry. 47(16)

مصطلحات موضوعية: Umbilical Veins, Stereochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Growth factor receptor, Drug Discovery, Quinazoline, Structure–activity relationship, Humans, Pyrroles, Cells, Cultured, chemistry.chemical_classification, biology, Kinase, Triazines, Molecular Mimicry, Biological activity, Vascular Endothelial Growth Factor Receptor-2, ErbB Receptors, Enzyme, Biochemistry, chemistry, Enzyme inhibitor, biology.protein, Quinazolines, Molecular Medicine, Endothelium, Vascular, Tyrosine kinase, Cell Division

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6504ffc16a7aa1cb1f1a73969874deb
https://pubmed.ncbi.nlm.nih.gov/15267243

المؤلفون: Kevin R. Webster, Kevin G. Coleman, Janet G. Mulheron, Sylvia A. Sedman, David Morrissey, Barri Wautlet, Pamela M. Brinkley, Sandy Price

المصدر: The Journal of biological chemistry. 272(30)

مصطلحات موضوعية: endocrine system diseases, Cyclin D, Molecular Sequence Data, Biochemistry, Cyclin D1, Cyclin-dependent kinase, Cyclins, Proto-Oncogene Proteins, Escherichia coli, Humans, Amino Acid Sequence, Binding site, Enzyme Inhibitors, neoplasms, Molecular Biology, Protein Kinase Inhibitors, Cyclin-Dependent Kinase Inhibitor p16, Cyclin, Oncogene Proteins, Cyclin-dependent kinase 1, Cyclin binding, integumentary system, biology, Cyclin-Dependent Kinase 4, Cell Biology, Molecular biology, Cyclin-Dependent Kinases, Enzyme Activation, biology.protein, Cyclin-dependent kinase complex, Mutagenesis, Site-Directed, biological phenomena, cell phenomena, and immunity, Carrier Proteins, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988f97431efe9a7aaf34a52bf6266cc
https://pubmed.ncbi.nlm.nih.gov/9228064

المؤلفون: Barri Wautlet, Benjamin Henley, John T. Hunt, Joseph Fargnoli, Robert Jeyaseelan, Anne Lewin

المصدر: Molecular Cancer Therapeutics. 8:B12-B12

مصطلحات موضوعية: Cancer Research, biology, Angiogenesis, medicine.medical_treatment, Pharmacology, Fibroblast growth factor, Receptor tyrosine kinase, Vascular endothelial growth factor, chemistry.chemical_compound, Cytokine, Brivanib alaninate, Oncology, chemistry, In vivo, Fibroblast growth factor receptor, medicine, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f56331a6414829de3d2da2c49f6b8875
https://doi.org/10.1158/1535-7163.targ-09-b12

المؤلفون: Kyoung Soon Kim, Liping Zhang, Robert Schmidt, Zhen-Wei Cai, Donna Wei, David K. Williams, Louis J. Lombardo, George L. Trainor, Dianlin Xie, Yaquan Zhang, Yongmi An, John S. Sack, John S. Tokarski, Celia Darienzo, Amrita Kamath, Punit Marathe, Yueping Zhang, Jonathan Lippy, Robert Jeyaseelan Sr., Barri Wautlet

المصدر: Journal of Medicinal Chemistry; Jul2008, Vol. 51 Issue 17, p5330-5341, 12p