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1Academic Journal
المؤلفون: Yanwu Yang, Michael D. Glidden, Balamurugan Dhayalan, Alexander N. Zaykov, Yen-Shan Chen, Nalinda P. Wickramasinghe, Richard D. DiMarchi, Michael A. Weiss
المصدر: Frontiers in Endocrinology, Vol 13 (2022)
مصطلحات موضوعية: monogenic diabetes, peptide chemistry, protein folding, folding nucleus, oxidative folding intermediate, NMR spectroscopy, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
المصدر: Frontiers in Endocrinology, Vol 13 (2022)
مصطلحات موضوعية: monogenic diabetes, endoplasmic reticular stress, peptide chemistry, protein folding, oxidative folding intermediate, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
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3Academic Journal
المؤلفون: Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A. Weiss
المصدر: Molecular Metabolism, Vol 52, Iss , Pp 101325- (2021)
مصطلحات موضوعية: Protein engineering, Pharmacodynamics, Insulin action, Insulin signaling, Molecular pharmacology, Internal medicine, RC31-1245
وصف الملف: electronic resource
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4Academic Journal
المصدر: Frontiers in Endocrinology, Vol 12 (2021)
مصطلحات موضوعية: protein folding, protein structure, folding efficiency, hormone, metabolism, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
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5Academic Journal
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Biotechnology, Developmental Biology, Inorganic Chemistry, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, linked polypeptide chain, concomitant peptide splicing, backbone peptide bond, mediated protein splicing, like peptide, protein molecule, specific cleavage, side reaction, resolution step, nature ’, model compounds, chemical mechanism, chemical counterpart, branched ester, ant insulin
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6
المؤلفون: Anoop Arunagiri, Peter Arvan, Billy Tsai, Michael A. Weiss, Anis Hassan, Leena Haataja, Ming Liu, Balamurugan Dhayalan, Kaitlin Regan
المصدر: Cellular and Molecular Life Sciences
مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Adolescent, Stereochemistry, Mutant, Protein trafficking, Mutation, Missense, 030209 endocrinology & metabolism, Endoplasmic Reticulum, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Insulin-Secreting Cells, Missense mutation, Insulin, Humans, Cysteine, Disulfides, Disulfide bonds, Beta (finance), Molecular Biology, Cells, Cultured, Proinsulin, Pharmacology, chemistry.chemical_classification, Endoplasmic reticulum, Diabetes, ER retention, Cell Biology, Folding (chemistry), 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, Thiol, Molecular Medicine, Original Article
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7
المؤلفون: Deepak Chatterjee, Mark A. Jarosinski, Balamurugan Dhayalan, Michael A. Weiss, Nischay K. Rege
المصدر: Diabetologia
مصطلحات موضوعية: Blood Glucose, Pancreas, Artificial, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Pharmacology, Glucose responsive, Artificial pancreas, Article, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Therapeutic index, Inventions, Diabetes mellitus, Internal Medicine, medicine, Humans, Insulin, biology, business.industry, Blood Glucose Self-Monitoring, Type 2 Diabetes Mellitus, medicine.disease, Insulin receptor, Diabetes Mellitus, Type 1, Glucose, 030104 developmental biology, Diabetes Mellitus, Type 2, biology.protein, business, Hormone
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8
المؤلفون: Krystel El Hage, Nelson B. Phillips, Yen-Shan Chen, Balamurugan Dhayalan, Jonathan Whittaker, Kelley Carr, Linda Whittaker, Manijeh H. Phillips, Faramarz Ismail-Beigi, Markus Meuwly, Michael A. Weiss
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9
المؤلفون: Pamela Itkin-Ansari, Peter Arvan, Nalinda P. Wickramasinghe, Saiful A. Mir, Arfah Anjum, Michael A. Weiss, Xin Li, Leena Haataja, Yi Xiong, Nischay Rege, Li Lv, Wei Chen, David A. Ostrov, Randal J. Kaufman, Balamurugan Dhayalan, Rachel Madley, Dennis Larkin, Ming Liu, Jinhong Sun
المصدر: Diabetes. 69:954-964
مصطلحات موضوعية: 0301 basic medicine, Mutation, Chemistry, Endocrinology, Diabetes and Metabolism, Endoplasmic reticulum, Insulin, medicine.medical_treatment, Mutant, 030209 endocrinology & metabolism, medicine.disease_cause, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Protein structure, Cell culture, Internal Medicine, medicine, Unfolded protein response, Proinsulin
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10
المؤلفون: Balamurugan Dhayalan, Weiss Michael
المصدر: Current diabetes reportsPapers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance. 22(2)
مصطلحات موضوعية: Mammals, Protein Folding, Adolescent, Diabetes Mellitus, Type 2, Endocrinology, Diabetes and Metabolism, Insulin-Secreting Cells, Mutation, Internal Medicine, Diabetes Mellitus, Animals, Humans, Insulin, Proinsulin
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11
المؤلفون: Yanwu Yang, Michael D. Glidden, Balamurugan Dhayalan, Alexander N. Zaykov, Yen-Shan Chen, Nalinda P. Wickramasinghe, Richard D. DiMarchi, Michael A. Weiss
مصطلحات موضوعية: Endocrinology, Reproduction, Cell Metabolism, monogenic diabetes, peptide chemistry, protein folding, folding nucleus, oxidative folding intermediate, NMR spectroscopy
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12
المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
مصطلحات موضوعية: Endocrinology, Reproduction, Cell Metabolism, monogenic diabetes, endoplasmic reticular stress, peptide chemistry, protein folding, oxidative folding intermediate
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13
المؤلفون: Deepak Chatterjee, Yen-Shan Chen, Balamurugan Dhayalan, Michael A. Weiss, Mark A. Jarosinski, Nicolás Varas
المصدر: J Clin Endocrinol Metab
مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, New horizons, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Insulins, Hypoglycemia, Bioinformatics, Biochemistry, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Animals, Humans, Hypoglycemic Agents, Insulin, Glycemic, business.industry, Biochemistry (medical), Molecular Pharmacology, Mini-Review, medicine.disease, Basal (medicine), Diabetes Mellitus, Type 2, Pharmacodynamics, business, Goals
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14
المؤلفون: Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
المصدر: Frontiers in endocrinology. 13
مصطلحات موضوعية: Protein Folding, Adolescent, Endocrinology, Diabetes and Metabolism, Diabetes Mellitus, Humans, Insulin, Disulfides, Peptides, Proinsulin
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15
المؤلفون: Peter Arvan, Faramarz Ismail-Beigi, Yanwu Yang, Mark A. Jarosinski, Balamurugan Dhayalan, Nelson B. Phillips, Rachel Grabowski, Shayan Poordian, Michael A. Weiss, Deepak Chatterjee, Yen-Shan Chen
مصطلحات موضوعية: Chemistry, Endoplasmic reticulum, Mole, Mutant, Protein folding, Gene, Molecular biology, In vitro, Molten globule, Proinsulin
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16
المصدر: Frontiers in Endocrinology, Vol 12 (2021)
Frontiers in Endocrinologyمصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Mutant, hormone, Review, Biology, Diseases of the endocrine glands. Clinical endocrinology, Evolution, Molecular, folding efficiency, Endocrinology, Protein structure, protein folding, Diabetes Mellitus, Humans, Insulin, protein structure, Gene, Proinsulin, Genetics, RC648-665, Proteotoxicity, Mutation, Unfolded protein response, Protein folding, Trans-acting, metabolism
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17
المؤلفون: Nicolás Varas, Deepak Chatterjee, Yen-Shan Chen, Mark A. Jarosinski, Michael A. Weiss, Balamurugan Dhayalan
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)مصطلحات موضوعية: Blood Glucose, IGF, insulin-like growth factor, Computer science, medicine.medical_treatment, Chemistry, Pharmaceutical, Insulins, Review, Chemistry Techniques, Synthetic, Protein Engineering, Protein structure, time in range. Amino acids are designated by standard three-letter code, residue numbers in insulin are shown by chain in superscript. Names of insulin analogs are italicized in lower case whereas tradenames of products are capitalized without italics, NPH, neutral protamine Hagedorn, Internal medicine, PEG, polyethylene-glycol, biology, GLP-1RA, glucagon-like peptide 1 receptor agonist, FRI, fructose responsive insulin, T1D, type 1 diabetes mellitus, Molecular Pharmacology, Insulin signaling, FDA, United States Food & Drug Administration, Insulin analog, Computational biology, GLUT1, glucose transporter 1, CGM, continuous glucose monitor, PK, pharmacokinetic, History, 21st Century, IR, insulin receptor (isoforms IR-A or IR-B), medicine, Diabetes Mellitus, Animals, Humans, GLP-1, glucagon-like peptide 1, GRI, glucose-responsive insulin, Molecular Biology, cryo-EM, cryogenic electron microscopy, Insulin action, HbA1c, hemoglobin A1c, Insulin, SQ, subcutaneous, Cell Biology, Protein engineering, SCI, single-chain insulin, History, 20th Century, RC31-1245, T2D type 2 diabetes mellitus, TiR, Insulin receptor, Disease Models, Animal, GPCR, G-protein coupled receptor, Structural biology, Basal (medicine), Pharmacodynamics, FRC, fixed-ratio combination, Drug Design, biology.protein, Molecular pharmacology
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18
المؤلفون: Nalinda P. Wickramasinghe, Nischay K. Rege, Faramarz Ismail-Beigi, Yen-Shan Chen, Ming Liu, Leili Rahimi, Peter Arvan, Yanwu Yang, Huan Guo, Nelson B. Phillips, Balamurugan Dhayalan, Michael A. Weiss, Leena Haataja, Jinhong Sun
المصدر: Proc Natl Acad Sci U S A
مصطلحات موضوعية: Protein Folding, medicine.medical_treatment, Cell Line, Structure-Activity Relationship, Protein structure, Cell Line, Tumor, Insulin-Secreting Cells, Native state, medicine, Diabetes Mellitus, Animals, Humans, Insulin, Gene Regulatory Networks, Disulfides, Proinsulin, Multidisciplinary, biology, Chemistry, Endoplasmic reticulum, Biological Sciences, Receptor, Insulin, Cell biology, Rats, Insulin receptor, HEK293 Cells, Amino Acid Substitution, Unfolded protein response, biology.protein, MCF-7 Cells, Protein folding, Protein Binding
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19
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20
المؤلفون: Balamurugan Dhayalan, Mamuni Swain, Norman Metanis, Michael A. Weiss, Faramarz Ismail-Beigi, Mark A. Jarosinski, Ali Mirsalehi, Nischay K. Rege, Yen-Shan Chen, Nelson B. Phillips
المصدر: Chemistry
مصطلحات موضوعية: Proteolysis, medicine.medical_treatment, Pharmacology, 010402 general chemistry, 01 natural sciences, Catalysis, Article, Diselenide, chemistry.chemical_compound, medicine, Insulin lispro, chemistry.chemical_classification, Serine protease, medicine.diagnostic_test, Selenocysteine, biology, 010405 organic chemistry, Insulin, Organic Chemistry, Wild type, General Chemistry, 0104 chemical sciences, chemistry, biology.protein, Selenoprotein, medicine.drug
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