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1Academic Journal
المصدر: مجلة كلية الطب, Vol 64, Iss 1 (2022)
مصطلحات موضوعية: CRC : colorectal cancer BRAF : v-raf murine sarcoma viral oncogene homolog B1, Medicine, Medicine (General), R5-920
وصف الملف: electronic resource
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المؤلفون: Koki Otsuka, Ryo Sugimoto, Keisuke Koeda, Toshimoto Kimura, Masazumi Onishi, Takeshi Takahara, Hiroyuki Nitta, Shigeaki Baba, Yuji Akiyama, Akira Sasaki, Ryosuke Fujisawa, Takeshi Iwaya, Noriyuki Sasaki, Fumitaka Endo, Tamotsu Sugai, Haruka Nikai
المصدر: International Journal of Surgery Case Reports
مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Case Report, Standardized uptake value, Gastroenterology, HMB45, human melanoma black 45, PET, positron emission tomography, 03 medical and health sciences, Esophagus, 0302 clinical medicine, Internal medicine, Biopsy, medicine, Ascending colon, Malignant melanoma, medicine.diagnostic_test, business.industry, Anti-PD-1 antibody, Melanoma, medicine.disease, Retroperitoneal recurrence, CT, computed tomography, DCF, triple chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, UICC, Union for International Cancer Control classification, HMB-45, PMME, primary malignant melanoma of esophagus, Nivolumab, medicine.anatomical_structure, Esophagectomy, 030220 oncology & carcinogenesis, BRAF, V-raf murine sarcoma viral oncogene homolog B1, 030211 gastroenterology & hepatology, Surgery, PD-1, programmed cell death 1, business
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المؤلفون: Jennifer Landsberg, Dennis Niebel, Emma Grace Bawden, Holger Fröhlich, Judith Sirokay, Glen Kristiansen, Friedrich Bootz, Anne Fröhlich, Sophia Loick, Gonzalo Saavedra, Simon Fietz, Romina Zarbl, Jörn Dietrich, Gerrit H. Gielen, Dimo Dietrich, Eric Diekmann
المساهمون: Publica
المصدر: EBioMedicine, Vol 52, Iss, Pp-(2020)
EBioMedicineمصطلحات موضوعية: 0301 basic medicine, Research paper, medicine.medical_treatment, MAPK, Mitogen-activated protein kinase, lcsh:Medicine, Epigenesis, Genetic, 4-1BB, 0302 clinical medicine, Gene expression, Leukocytes, Neoplasm Metastasis, Melanoma, FFPET, Formalin-fixed and paraffin-embedded tissue, lcsh:R5-920, DNA methylation, NAT, Normal adjacent tissue, MR, Mixed response, CD137, PBMCs, Peripheral blood mononucleated cells, PD-1, Programmed cell death 1, General Medicine, Methylation, Prognosis, TNFRSF9, CTLA4, Cytotoxic T-lymphocyte associated protein 4, NA, Not assessable, Gene Expression Regulation, Neoplastic, Predictive biomarker, CpG site, Immune cell infiltration, NF-kB, Nuclear factor 'kappa-light-chain-enhancer' of activated B-cells, 030220 oncology & carcinogenesis, Cytokines, IDH1, Isocitrate dehydrogenase 1, 95% CI, 95% confidence interval, Immune checkpoint, Immunotherapy, LAG3, lymphocyte activating 3, lcsh:Medicine (General), PD, Progressive disease, IRB, Institutional Review Board, MYC, MYC proto-oncogene, Prognostic biomarker, n.c., Normalized counts, Tregs, Regulatory T cells, General Biochemistry, Genetics and Molecular Biology, TILs, Tumor infiltrating lymphocytes, TPM, Transcripts per million, Interferon-gamma, Tumor Necrosis Factor Receptor Superfamily, Member 9, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, CR, Complete response, PFS, Progression-free survival, Response prediction, Biomarkers, Tumor, medicine, Humans, RNA, Messenger, PD-L1, Programmed cell death 1 ligand 1, Epigenetics, Neoplasm Staging, TNFRS9, Tumor necrosis factor receptor super family 9, business.industry, qMSP, quantitative methylation-specific PCR, lcsh:R, NK cells, Natural killer cells, PR, Partial response, HIF1-α, Hypoxia-inducible factor 1-alpha, 030104 developmental biology, Case-Control Studies, OS, Overall survival, BRAF, V-raf murine sarcoma viral oncogene homolog B1, Cancer research, TCGA, The Cancer Genome Atlas, IL-2, Interleukin 2, LHR, Likelihood Ratio, Neoplasm Grading, SKCM, Skin cutaneous melanoma, business, ARID2, AT-rich interactive domain-containing protein 2, IFN-γ, Interferon gamma, TALs, Tumor-associated lymphocytes
وصف الملف: application/pdf
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المؤلفون: Liwu Fu, Lihua Huang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 390-401 (2015)مصطلحات موضوعية: MAPK/ERK pathway, IGF, insulin growth factor, BCL2L11/BIM, BCL2-like 11, STAT, signal transducers and activators of transcription, Resistance, PDGFs, platelet-derived growth factors, Review, GAS6, growth-arrest-specific protein 6, PI3K, phosphatidylinositol-3-kinase, ABCC1, ATP binding cassette, sub-family C, member 1, T790M, PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha, FGFs, fibroblast growth factors, Mechanisms, Medicine, BCL-2, B-cell CLL/lymphoma-2, CML, chronic myelogenous leukemia, Epidermal growth factor receptor, ABC, ATP binding cassette, General Pharmacology, Toxicology and Pharmaceutics, RAF, rapidly accelerated fibrosarcoma, BH3, BCL2-homology domain 3, ABCB1, ATP binding cassette, sub-family B, member 1, biology, ABCG2, ATP binding cassette, sub-family G, member 2, IGF-1R, IGF-1 receptor, TKIs, tyrosine kinase inhibitors, VEGF, vascular endothelial growth factor, VEGFR, vascular endothelial growth factor receptor, HER, human epidermal receptor, FGFRs, fibroblast growth factor receptors, IL-6R, IL-6 receptor, medicine.drug, EGFR-TKIs, epidermal growth factor receptor tyrosine kinase inhibitors, RTK, tyrosine kinase receptor, ERK1/2, extracellular signal-regulated kinases, ABCC10, ATP binding cassette, sub-family C, member 10, EGFR, BRAF, v-RAF murine sarcoma viral oncogene homolog B1, PDGFRs, platelet-derived growth factor receptors, EMT, epithelial mesenchymal transition, JAK, janus kinase, AKT, protein kinase B, Gefitinib, CRKL, Crk-like protein, NSCLC, non-small cell lung cancer, PTEN, RAS, rat sarcoma, Protein kinase B, EML4, echinoderm microtubule-associated protein-like 4, SOCS3, suppressor of cytokine signaling 3, PI3K/AKT/mTOR pathway, SF, scatter factor, business.industry, GAS6, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, TKs, tyrosine kinases, PTEN, phosphatase and tensin homolog, respiratory tract diseases, EGFR, epidermal growth factor receptor, IL, interleukin, lcsh:Therapeutics. Pharmacology, TKIs, IGFBPs, IGF-binding proteins, EGFRvIII, EGFR variant III, Cancer research, biology.protein, HGF, hepatocyte growth factor, AXL, Anexelekto, business, MAPK, mitogen-activated protein kinase, MEK, mitogen-activated protein kinase
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المؤلفون: Caroline J. Springer, Ruth Kirk, Richard Marais, David Matthew Wilson, Bart M. J. M. Suijkerbuijk, Frank Friedlos, Alfonso Zambon, Delphine Menard, Coulter Thomas, Andrew K. Takle, Jean-François Pons, Arnaud Nourry, Neus Cantarino, Dan Niculescu-Duvaz, Douglas Hedley, Ion Niculescu-Duvaz, Lesley Ogilvie, Lawrence Davies, Helen A. Manne, Steven R. Whittaker
المصدر: Bioorganic & Medicinal Chemistry
مصطلحات موضوعية: Triarylimidazole, Clinical Biochemistry, Mutant, Pharmaceutical Science, Boc, tert-butoxycarbonyl, Pyrazole, 01 natural sciences, Biochemistry, Proto-Oncogene Proteins B-raf, Mice, chemistry.chemical_compound, Drug Discovery, Melanoma, Medicine(all), 0303 health sciences, biology, Chemistry, Kinase, Imidazoles, DCM, dichloromethane, 3. Good health, BRAF, V-RAF murine sarcoma viral oncogene homolog B1, Anticancer, MOM, methoxymethyl, Enzyme inhibitor, RAF, rapidly growing fibrosarcoma, Molecular Medicine, Female, DMF, dimethylformamide, THF, tetrahydrofuran, Article, BRAF, TFA, trifluoroacetic acid, Structure-Activity Relationship, 03 medical and health sciences, SAR, structure–activity relationship, medicine, Animals, Humans, Computer Simulation, Furans, Dihydroindenopyrazole, Kinase inhibitors, Binding Sites, Mutation, Protein Kinase Inhibitors, Protein Structure, Tertiary, Pyrazoles, Molecular Biology, 3003, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Protein kinase A, neoplasms, ERK, extracellular regulated kinase, 030304 developmental biology, 010405 organic chemistry, medicine.disease, digestive system diseases, 0104 chemical sciences, MEK, MAPK/ERK kinase, Cutaneous melanoma, Cancer research, biology.protein, PK, pharmacokinetics, MAPK, mitogen-activated protein kinase
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المؤلفون: Haraldsdottir, Sigurdis, Shah, Manisha H.
المصدر: Oncology in Clinical Practice; Vol 10, No 2 (2014); 121-130
مصطلحات موضوعية: multikinase inhibitor, rearranged during transfection (RET), targeted therapy, thyroid cancer, v-raf murine, sarcoma viral oncogene homolog B1 (BRAF), inhibitor wielokinazowy, RET (rearranged during transfection), leczenie ukierunkowane molekularnie, rak tarczycy, protoonkogenna kinaza serynowo-treoninowa BRAF(v-raf murine sarcoma viral oncogene homolog B1)
وصف الملف: application/pdf