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1
المؤلفون: Apurva A. Govande, Sichen Shao, Rotem Sorek, Alexander F.A. Keszei, Gal Ofir, Adi Millman, B.R. Morehouse, Philip J. Kranzusch, B. Lowey
المصدر: Nature
مصطلحات موضوعية: Models, Molecular, Cell signaling, Crystallography, X-Ray, Second Messenger Systems, Article, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, Transcription (biology), Animals, Bacteriophages, Cyclic GMP, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Innate immune system, Bacteria, Effector, Chemistry, Membrane Proteins, NAD, Nucleotidyltransferases, eye diseases, Cell biology, Sting, Stimulator of interferon genes, Second messenger system, NAD+ kinase, 030217 neurology & neurosurgery
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2
المؤلفون: Jean-Luc Imler, Martin König, Ziming Wei, Adelyn E. Ragucci, Roland Seifert, Heike Bähre, Amy S. Lee, Philip J. Kranzusch, Xianlong Ai, Yuqiang Chen, Hua Cai, Wen Zhou, Lihua Li, B.R. Morehouse, Kailey Slavik
المساهمون: Harvard Medical School [Boston] (HMS), Dana-Farber Cancer Institute [Boston], Guangdong University of Science and Technology (GUST), Southern Medical University [Guangzhou], Hannover Medical School [Hannover] (MHH), Modèles Insectes de l'Immunité Innée (M3I), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte
المصدر: Nature
Nature, Nature Publishing Group, 2021, 597 (7874), pp.109-113. ⟨10.1038/s41586-021-03743-5⟩
Nature, 2021, 597 (7874), pp.109-113. ⟨10.1038/s41586-021-03743-5⟩مصطلحات موضوعية: Innate immunity, 0303 health sciences, Multidisciplinary, Innate immune system, biology, [SDV.IMM] Life Sciences [q-bio]/Immunology, Pattern recognition receptor, RNA, biology.organism_classification, Article, 3. Good health, Cell biology, 03 medical and health sciences, 0302 clinical medicine, Stimulator of interferon genes, Second messenger system, Sense (molecular biology), [SDV.IMM]Life Sciences [q-bio]/Immunology, Drosophila melanogaster, Receptor, Structural biology, 030217 neurology & neurosurgery, 030304 developmental biology
وصف الملف: application/pdf
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3
المؤلفون: Aaron T. Whiteley, E.A. Nieminen, James B. Eaglesham, B. Lowey, John J. Mekalanos, Olga Danilchanka, Philip J. Kranzusch, B.R. Morehouse, David S. King, C.C. de Oliveira Mann, Amy S. Lee
المصدر: Nature
مصطلحات موضوعية: Purine, Cell signaling, Purine nucleoside phosphorylase, Biology, Crystallography, X-Ray, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, Bacterial Proteins, Operon, Transferase, Animals, Humans, Nucleotide, Symbiosis, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, Innate immune system, 030306 microbiology, Nucleotides, HEK 293 cells, Nucleotidyltransferases, 3. Good health, HEK293 Cells, chemistry, Biochemistry, Second messenger system, Dinucleoside Phosphates
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4
المؤلفون: Alexander F.A. Keszei, Carmel Avraham, Tevie Mehlman, B.R. Morehouse, Avigail Stokar-Avihail, Sichen Shao, Taya Fedorenko, Erez Yirmiya, Adi Millman, Rotem Sorek, Yaara Oppenheimer-Shaanan, Philip J. Kranzusch, Gil Amitai, Nitzan Tal, Alexander Brandis, Ehud Herbst
المصدر: Cell
مصطلحات موضوعية: Cytidine monophosphate, Models, Molecular, CCMP, Burkholderia, viruses, Defence system, Biology, Cyclase, Microbiology, General Biochemistry, Genetics and Molecular Biology, Article, chemistry.chemical_compound, Guanosine monophosphate, Uridine monophosphate, Escherichia coli, Nucleotide, Cyclic adenosine monophosphate, Cyclic CMP, Bacteriophages, Amino Acid Sequence, reproductive and urinary physiology, chemistry.chemical_classification, Bacteria, General Immunology and Microbiology, Pyrimidines, Infectious Diseases, chemistry, Biochemistry, Cyclization, Second messenger system, Mutation, embryonic structures, Nucleotides, Cyclic, Phosphorus-Oxygen Lyases, CRISPR-Cas Systems, Uridine Monophosphate
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5
المؤلفون: Hongkun Lin, Karan Malik, Ramasamy P. Kumar, B.R. Morehouse, Isaac J. Krauss, Jason O. Matos, Daniel D. Oprian
المصدر: Biochemistry. 56:1716-1725
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Allylic rearrangement, Stereochemistry, Recombinant Fusion Proteins, Gene Expression, Stereoisomerism, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Biochemistry, Article, Protein Structure, Secondary, 03 medical and health sciences, Polyisoprenyl Phosphates, Protein Domains, Catalytic Domain, Cyclohexenes, Escherichia coli, Enzyme kinetics, Cloning, Molecular, Enzyme Inhibitors, Intramolecular Lyases, Enzyme Assays, Plant Proteins, chemistry.chemical_classification, ATP synthase, biology, Terpenes, Ligand, Substrate (chemistry), Lyase, Organophosphates, 0104 chemical sciences, Kinetics, 030104 developmental biology, Enzyme, chemistry, biology.protein, Diterpenes, Apoproteins, Limonene, Citrus sinensis
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6
المؤلفون: Sadie P. Antine, Amy S. Lee, Ian T. Mathews, B. Lowey, Mohit Jain, Victor J. Cabrera, John J. Mekalanos, Alexander F.A. Keszei, Frank Schwede, Aaron T. Whiteley, Sichen Shao, B.R. Morehouse, Percy Niemann, Dmitry Kashin, Philip J. Kranzusch
المصدر: Cell. 182(1)
مصطلحات موضوعية: Oligonucleotides, Biology, Ligands, Second Messenger Systems, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Bacterial Proteins, CRISPR, Deoxyribonuclease I, Nucleotide, Bacteriophages, Amino Acid Sequence, Receptor, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Bacteria, Oligonucleotide, Effector, Immunity, Nucleotidyltransferase, Nucleotidyltransferases, Cell biology, chemistry, Mutagenesis, Second messenger system, CRISPR-Cas Systems, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction
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7
المؤلفون: B.R. Morehouse, Q Yu, Ramasamy P. Kumar, A Bannister, J.S Temme, Daniel D. Oprian, K Malik, Isaac J. Krauss, Jason O. Matos
المصدر: ACS Chem Biol
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Direct evidence, Acyclic Monoterpenes, Substrate analog, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Article, Catalysis, Terpene, 03 medical and health sciences, chemistry.chemical_compound, Polyisoprenyl Phosphates, Catalytic Domain, Limonene synthase, Enzyme Inhibitors, Intramolecular Lyases, Enzyme Assays, chemistry.chemical_classification, Obligate, 010405 organic chemistry, General Medicine, Lyase, 0104 chemical sciences, body regions, Diphosphates, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine, Diterpenes, Citrus sinensis
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المؤلفون: Daniel H. Zhou, Molly O. Lorenz, Josiane Fofana, Daniel D. Oprian, B.R. Morehouse, Melissa M. Trieu, Ramasamy P. Kumar
مصطلحات موضوعية: 0301 basic medicine, Rhodopsin, Stereochemistry, Dimer, Substrate analog, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Cyclic nucleotide, Protein Domains, Blastocladiella, Catalytic Domain, Escherichia coli, Amino Acid Sequence, Molecular Biology, Cyclic GMP, 030102 biochemistry & molecular biology, biology, Escherichia coli Proteins, Cell Biology, Lyase, Optogenetics, 030104 developmental biology, Monomer, chemistry, Guanylate Cyclase, Protein Structure and Folding, biology.protein, Protein quaternary structure, Nucleotides, Cyclic, Cyclase activity, Signal Transduction
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المؤلفون: Sarah Naomi Olsen, Ramasamy P. Kumar, Sonya Entova, Jason O. Matos, B.R. Morehouse, Daniel D. Oprian
المصدر: Biochemistry. 56(12)
مصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Models, Molecular, Stereochemistry, Monoterpene, Recombinant Fusion Proteins, Gene Expression, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mentha spicata, Protein Structure, Secondary, Article, Terpene, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, Protein Domains, Catalytic Domain, Cyclohexenes, Escherichia coli, Cloning, Molecular, Intramolecular Lyases, Enzyme Assays, Plant Proteins, Limonene, ATP synthase, biology, Terpenes, Active site, Stereoisomerism, Lyase, Diphosphates, Kinetics, 030104 developmental biology, chemistry, Mutation, biology.protein, Mutagenesis, Site-Directed, Diterpenes, Apoproteins, Citrus × sinensis, 010606 plant biology & botany, Citrus sinensis
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المؤلفون: Carina C. de Oliveira Mann, Aaron T. Whiteley, Philip J. Kranzusch, Radosław P. Nowak, John J. Mekalanos, Eric S. Fischer, Nathanael S. Gray, Wen Zhou, B.R. Morehouse
المصدر: Cell. 174:300-311.e11
مصطلحات موضوعية: 0301 basic medicine, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, Enzyme activator, chemistry.chemical_compound, Immune system, Species Specificity, Catalytic Domain, Animals, Humans, Immunologic Surveillance, Vibrio cholerae, Benzofurans, chemistry.chemical_classification, Binding Sites, ATP synthase, biology, Chemotaxis, DNA, Nucleotidyltransferases, Immune surveillance, Recombinant Proteins, Protein Structure, Tertiary, Amino acid, Cell biology, Molecular Docking Simulation, Cytosol, 030104 developmental biology, chemistry, Mutagenesis, Site-Directed, biology.protein, Nucleotides, Cyclic, Protein Multimerization, Dna complex