المؤلفون: Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha

المصدر: Frontiers in Catalysis, Vol 4 (2024)

مصطلحات موضوعية: CoA ligase, enzyme structure, protein engineering, lactams, chemoenzymatic synthesis, biocatalysis, Chemistry, QD1-999

Relation: https://www.frontiersin.org/articles/10.3389/fctls.2024.1360129/full; https://doaj.org/toc/2673-7841; https://doaj.org/article/e79be1107d974a38a3146cf5d3218eee

الاتاحة: https://doi.org/10.3389/fctls.2024.1360129
https://doaj.org/article/e79be1107d974a38a3146cf5d3218eee

المؤلفون: Axel B. Janssen, Vincent de Bakker, Rieza Aprianto, Vincent Trebosc, Christian Kemmer, Michel Pieren, Jan-Willem Veening

المصدر: Microbiology Spectrum, Vol 12, Iss 1 (2024)

مصطلحات موضوعية: Klebsiella pneumoniae, OmpR, host-pathogen interaction, epithelial cells, infection, dual RNA-seq, Microbiology, QR1-502

Relation: https://doaj.org/toc/2165-0497; https://doaj.org/article/d2e736e5d5a64d4f9481108b5ba0e830

الاتاحة: https://doi.org/10.1128/spectrum.03966-23
https://doaj.org/article/d2e736e5d5a64d4f9481108b5ba0e830

المؤلفون: Walid Moudrous, Leo H. Visser, Tansel Yilmaz, Marjan H. Wieringa, Tim Alleman, Jörgen Rovers, Mark P.W.A. Houben, Paula M. Janssen, Johan J. B. Janssen, Pieter L. Rensma, Geert J. F. Brekelmans

المصدر: Annals of Medicine, Vol 54, Iss 1, Pp 2770-2776 (2022)

مصطلحات موضوعية: Headache, ultrasound, temporal artery, vasculitis, visual loss, biopsy, Medicine

وصف الملف: electronic resource

Relation: https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060

URL الوصول: https://doaj.org/article/c605b213549f41ef9eebd9a7aefc7153

المؤلفون: Maarten F. J. Seesing, Henricus J. B. Janssen, Tessa C. M. Geraedts, Teus J. Weijs, Ingrid van Ark, Thea Leusink-Muis, Gert Folkerts, Johan Garssen, Jelle P. Ruurda, Grard A. P. Nieuwenhuijzen, Richard van Hillegersberg, Misha D. P. Luyer

المصدر: Nutrients; Volume 15; Issue 10; Pages: 2327

مصطلحات موضوعية: vagus nerve, nerve stimulation, acetylcholine, cholecystokinin, agonist, high-fat, vagotomy, inflammation, rats

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Lipids; https://dx.doi.org/10.3390/nu15102327

الاتاحة: https://doi.org/10.3390/nu15102327

المؤلفون: Juana Claus, Thijs ten Doesschate, Cheyenne Gumbs, Cornelis H. van Werkhoven, Thomas W. van der Vaart, Axel B. Janssen, Gaby Smits, Rob van Binnendijk, Fiona van der Klis, Debbie van Baarle, Fernanda L. Paganelli, Helen Leavis, Lilly M. Verhagen, Simone A. Joosten, Marc J. M. Bonten, Mihai G. Netea, Janneke H. H. M. van de Wijgert

المصدر: mBio, Vol 14, Iss 2 (2023)

مصطلحات موضوعية: SARS-CoV-2, COVID-19, Bacillus Calmette-Guerin vaccine, randomized placebo-controlled clinical trial, health care workers, Microbiology, QR1-502

Relation: https://doaj.org/toc/2150-7511; https://doaj.org/article/de03d3eff55846609b67298b78f00f02

الاتاحة: https://doi.org/10.1128/mbio.00356-23
https://doaj.org/article/de03d3eff55846609b67298b78f00f02

المؤلفون: Sjors P. A. van der Lans, Manon Janet-Maitre, Frerich M. Masson, Kimberly A. Walker, Dennis J. Doorduijn, Axel B. Janssen, Willem van Schaik, Ina Attrée, Suzan H. M. Rooijakkers, Bart W. Bardoel

المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

مصطلحات موضوعية: Medicine, Science

Relation: https://doi.org/10.1038/s41598-023-39613-5; https://doaj.org/toc/2045-2322; https://doaj.org/article/4bc1a41af8354a7b8bc4d6d07f58d7bd

الاتاحة: https://doi.org/10.1038/s41598-023-39613-5
https://doaj.org/article/4bc1a41af8354a7b8bc4d6d07f58d7bd

المؤلفون: Qinglong Meng, Carlos Ramírez-Palacios, Hein J. Wijma, Dick B. Janssen

المصدر: Frontiers in Catalysis, Vol 2 (2022)

مصطلحات موضوعية: aminotransferase, enantiopure amine, protein design, thermostability, substrate specificity, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fctls.2022.1049179/full; https://doaj.org/toc/2673-7841

URL الوصول: https://doaj.org/article/39999081950b43df80b7f653713a0e58

المؤلفون: Ana Toplak, Eduardo F. Teixeira de Oliveira, Marcel Schmidt, Henriëtte J. Rozeboom, Hein J. Wijma, Linda K.M. Meekels, Rowin de Visser, Dick B. Janssen, Timo Nuijens

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1277-1287 (2021)

مصطلحات موضوعية: Enzyme catalysis, Chemo-Enzymatic Peptide Synthesis (CEPS), Peptiligases, Omniligase-1, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037021000532; https://doaj.org/toc/2001-0370

URL الوصول: https://doaj.org/article/6a85ba9608194f52a918b9a4228a5b84

المؤلفون: Karel C. Smit, Jeroen W. G. Derksen, Geerard L. O. Beets, Eric J. Th. Belt, Maaike Berbée, Peter Paul L. O. Coene, Hester van Cruijsen, Marjan A. Davidis, Jan Willem T. Dekker, Joyce M. van Dodewaard-de Jong, Annebeth W. Haringhuizen, Helgi H. Helgason, Mathijs P. Hendriks, Ronald Hoekstra, Ignace H. J. T. de Hingh, Jan N. M. IJzermans, Johan J. B. Janssen, Joop L. M. Konsten, Maartje Los, Leonie J. M. Mekenkamp, Peter Nieboer, Koen C. M. J. Peeters, Natascha A. J. B. Peters, Hans J. F. M. Pruijt, Patricia Quarles van Ufford-Mannesse, Ron C. Rietbroek, Anandi H. W. Schiphorst, Arjan Schouten van der Velden, Ruud W. M. Schrauwen, Mark P. S. Sie, Dirkje W. Sommeijer, Dirk J. A. Sonneveld, Hein B. A. C. Stockmann, Marleen Tent, Frederiek Terheggen, Manuel L. R. Tjin-A-Ton, Liselot Valkenburg-van Iersel, Ankie M. T. van der Velden, Wouter J. Vles, Theo van Voorthuizen, Johannes A. Wegdam, Johannes H. W. de Wilt, Miriam Koopman, Anne M. May, on behalf of the PLCRC Study Group on behalf of the PLCRC Study Group

المصدر: Cancers; Volume 14; Issue 4; Pages: 1001

مصطلحات موضوعية: metastatic colorectal cancer, physical activity, all-cause mortality, survival

وصف الملف: application/pdf

Relation: Cancer Nursing and Care; https://dx.doi.org/10.3390/cancers14041001

الاتاحة: https://doi.org/10.3390/cancers14041001

المؤلفون: Misun Lee, Henriëtte J. Rozeboom, Eline Keuning, Paul de Waal, Dick B. Janssen

المصدر: Biotechnology for Biofuels, Vol 13, Iss 1, Pp 1-18 (2020)

مصطلحات موضوعية: Xylose isomerase, Metalloenzyme, Directed evolution, Bioethanol, Protein engineering, Fuel, TP315-360, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1754-6834

URL الوصول: https://doaj.org/article/c8ba0ea90cda4e39940ae571e707fd0b

المؤلفون: Axel B Janssen, Willem van Schaik

المصدر: PLoS Genetics, Vol 17, Iss 1, p e1009262 (2021)

مصطلحات موضوعية: Genetics, QH426-470

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

URL الوصول: https://doaj.org/article/97047bfdc68e487891bfb56f830598d3

المؤلفون: Qinglong Meng (3567785), Carlos Ramírez-Palacios (9944570), Nikolas Capra (8448186), Mattijs E. Hooghwinkel (11271953), Sebastian Thallmair (1339593), Henriëtte J. Rozeboom (2885936), Andy-Mark W. H. Thunnissen (8448201), Hein J. Wijma (1773142), Siewert J. Marrink (135518), Dick B. Janssen (1566727)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Pharmacology, Biotechnology, Biological Sciences not elsewhere classified, Information Systems not elsewhere classified, substrate scope, Pj TA mutants, 86L, Transaminase, ω- TAs, 58G, 58M, amine, 417L, synthesis, amines, ketone, Pj TA-R 6, protein engineering strategy, variant, Pj TA-R 6 redesign, Pseudomonas jessenii

Relation: https://figshare.com/articles/journal_contribution/Computational_Redesign_of_an_Transaminase_from_Pseudomonas_jessenii_for_Asymmetric_Synthesis_of_Enantiopure_Bulky_Amines/15163742

الاتاحة: https://doi.org/10.1021/acscatal.1c02053.s001

المؤلفون: Carlos Ramírez-Palacios (9944570), Hein J. Wijma (1773142), Sebastian Thallmair (1339593), Siewert J. Marrink (135518), Dick B. Janssen (1566727)

مصطلحات موضوعية: Biophysics, Biochemistry, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, relevant conformational space, generated complexes containing, external aldimine intermediate, 62 compounds gathered, attack conformations observed, presented framework makes, limited substrate range, starting conformations, range predictions, vibrio fluvialis, transamination reaction, screen thousands, quantitatively predicted, natural substrates, industrial production, experimentally determined, enzyme variants, enzyme design, ee <, different substrates, computational protocol, computational prediction, chiral amines, catalytic selectivity

Relation: https://figshare.com/articles/journal_contribution/Computational_Prediction_of_Transaminase_Specificity_by_a_Combination_of_Docking_and_Molecular_Dynamics_Simulations/16821262

الاتاحة: https://doi.org/10.1021/acs.jcim.1c00617.s001

المؤلفون: Megan V. Doble (5897411), Lorenz Obrecht (10269982), Henk-Jan Joosten (4033187), Misun Lee (3076299), Henriette J. Rozeboom (1658674), Emma Branigan (1989781), James. H. Naismith (10269985), Dick B. Janssen (1566727), Amanda G. Jarvis (1604599), Paul C. J. Kamer (8728521)

مصطلحات موضوعية: Biophysics, Biochemistry, Biotechnology, Evolutionary Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Catalytic Activity Protein engineering, Thermostable variants, metalloenzyme, thermostability, 1- octene, protein scaffold, reaction temperatures, metal catalyst, 3 DM database, protein engineering, carrier protein 2 L, engineering Thermostability, Artificial Metalloenzymes, turnover number

Relation: https://figshare.com/articles/journal_contribution/Engineering_Thermostability_in_Artificial_Metalloenzymes_to_Increase_Catalytic_Activity/14179099

الاتاحة: https://doi.org/10.1021/acscatal.0c05413.s001

المؤلفون: Henricus J. B. Janssen, Amaia Gantxegi, Laura F. C. Fransen, Grard A. P. Nieuwenhuijzen, Misha D. P. Luyer

المصدر: Nutrients; Volume 13; Issue 10; Pages: 3616

مصطلحات موضوعية: minimally invasive esophagectomy, esophageal cancer, nutrition, enhanced recovery after surgery, jejunostomy

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Clinical Nutrition; https://dx.doi.org/10.3390/nu13103616

الاتاحة: https://doi.org/10.3390/nu13103616

المؤلفون: Axel B. Janssen, Toby L. Bartholomew, Natalia P. Marciszewska, Marc J. M. Bonten, Rob J. L. Willems, Jose A. Bengoechea, Willem van Schaik

المصدر: mSphere, Vol 5, Iss 2 (2020)

مصطلحات موضوعية: Escherichia coli, antibiotic resistance, colistin, two-component regulatory systems, whole-genome sequencing, Microbiology, QR1-502

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2379-5042

URL الوصول: https://doaj.org/article/f3252623321a4b8a8b5cbada519deefc

المؤلفون: Nikolas Capra, Chloé Lelièvre, Océane Touré, Aurélie Fossey-Jouenne, Carine Vergne-Vaxelaire, Dick B. Janssen, Andy-Mark W. H. Thunnissen, Anne Zaparucha

مصطلحات موضوعية: Catalytic Process Engineering, Organic Chemical Synthesis, Catalysis and Mechanisms of Reactions, Electrochemistry, Biocatalysis and Enzyme Technology, CoA ligase, enzyme structure, protein engineering, lactams, chemoenzymatic synthesis, biocatalysis

Relation: https://figshare.com/articles/dataset/DataSheet1_Adapting_an_acyl_CoA_ligase_from_Metallosphaera_sedula_for_lactam_formation_by_structure-guided_protein_engineering_pdf/25332940

الاتاحة: https://doi.org/10.3389/fctls.2024.1360129.s001
https://figshare.com/articles/dataset/DataSheet1_Adapting_an_acyl_CoA_ligase_from_Metallosphaera_sedula_for_lactam_formation_by_structure-guided_protein_engineering_pdf/25332940

المؤلفون: Anna B. Janssen, Katrina A. Savory, Samantha M. Garay, Lorna Sumption, William Watkins, Isabel Garcia-Martin, Nicola A. Savory, Anouk Ridgway, Anthony R. Isles, Richard Penketh, Ian R. Jones, Rosalind M. John

المصدر: BJPsych Open, Vol 4, Pp 354-360 (2018)

مصطلحات موضوعية: Perinatal psychiatry, anxiety disorders, elective caesarean, Psychiatry, RC435-571

وصف الملف: electronic resource

Relation: https://www.cambridge.org/core/product/identifier/S2056472418000480/type/journal_article; https://doaj.org/toc/2056-4724

URL الوصول: https://doaj.org/article/afe36821dfa243f4bb6f2e32d09eab1c

المؤلفون: Mark A. Ashworth, Elvira Bombino, René M. de Jong, Hein J. Wijma, Dick B. Janssen, Kirsty J. McLean, Andrew W. Munro

المساهمون: Biotechnology

المصدر: ACS Catalysis, 12(24), 15028-15044. AMER CHEMICAL SOC

مصطلحات موضوعية: enzyme engineering, biocatalysis, asymmetric synthesis, chiral precursor, computational design, in silico screening, General Chemistry, stereoselectivity, Catalysis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271774f14d5e45b6c65127419547b8d
https://doi.org/10.1021/acscatal.2c03974

المؤلفون: Thijs ten Doesschate, Simone J. C. F. M. Moorlag, Thomas W. van der Vaart, Esther Taks, Priya Debisarun, Jaap ten Oever, Chantal P. Bleeker-Rovers, Patricia Bruijning Verhagen, Arief Lalmohamed, Rob ter Heine, Reinout van Crevel, Janneke van de Wijgert, Axel B. Janssen, Marc J. Bonten, Cornelis H. van Werkhoven, Mihai G. Netea, on behalf of the BCG-CORONA study team#

المصدر: Trials, Vol 21, Iss 1, Pp 1-2 (2020)

مصطلحات موضوعية: COVID-19, Randomised controlled trial, protocol, BCG-vaccine, Health-Care Workers, Elderly, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13063-020-04389-w; https://doaj.org/toc/1745-6215

URL الوصول: https://doaj.org/article/cdc83b13bfe146958bfc1645d0fbaaef