المؤلفون: Naeem Asad, Michael Lyons, Shirley Muniz Machado Rodrigues, Justina M. Burns, Thomas D. Roper, G. Michael Laidlaw, Saeed Ahmad, B. Frank Gupton, Douglas Klumpp, Limei Jin

المصدر: Molecules, Vol 29, Iss 12, p 2705 (2024)

مصطلحات موضوعية: Lenacapavir, indazol-3-amine, hydrazine, regioselective cyclization, process development, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/12/2705; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/58370c2cdc4b470395e7f1bfe475e816

المؤلفون: Vijayagopal Gopalsamuthiram, Dang Binh Ho, Cheryl L. Peck, Vasudevan Natarajan, Toolika Agrawal, Justina M. Burns, John Bachert, Daniel W. Cook, Rodger W. Stringham, Ryan Nelson, Saeed Ahmad, B. Frank Gupton, David R. Snead, D. Tyler McQuade, Rajappa Vaidyanathan, Kai Donsbach, Joshua D. Sieber

المصدر: ACS Omega, Vol 7, Iss 8, Pp 7223-7228 (2022)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/5891606ae57846d2920a0e4a94cd083d

المؤلفون: Pankaj V. Khairnar, Sarah L. Aleshire, Ravi Kumar Ongolu, Limei Jin, Michael G. Laidlaw, Kai O. Donsbach, B. Frank Gupton, Ryan C. Nelson, Charles S. Shanahan

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, uncomplicated malaria treatment, two amino groups, starting material (<, providing effective access, organic salt formation, highly regioselective protecting, step protocol operates, highly regioselective synthesis, >-(+)- tartaric acid, step route, free synthesis, counter acid, success lies, subtle difference, resistance management, overall yield, mild conditions, high chemo, desired regioisomer, >)- propane

Relation: https://figshare.com/articles/journal_contribution/Highly_Regioselective_Protecting-Group-Free_Synthesis_of_the_Antimalarial_Drug_MMV693183/24781991

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00353.s001
https://figshare.com/articles/journal_contribution/Highly_Regioselective_Protecting-Group-Free_Synthesis_of_the_Antimalarial_Drug_MMV693183/24781991

المؤلفون: Supreeth Prasad, Dylan D. Rodene, Michael B. Burkholder, Kelling J. Donald, B. Frank Gupton

المصدر: ACS Omega, Vol 6, Iss 41, Pp 27216-27224 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/76b1b6d69d98447186e3e711a2418eb7

المؤلفون: Hany A. Elazab, Ali R. Siamaki, B. Frank Gupton, M. Samy El-Shall

المصدر: Bulletin of Chemical Reaction Engineering & Catalysis, Vol 14, Iss 3, Pp 478-489 (2019)

مصطلحات موضوعية: suzuki cross-coupling, 4-bromobenzaldehyde, pd- fe3o4/rgo, flow reactor, Chemical engineering, TP155-156

وصف الملف: electronic resource

Relation: https://journal.bcrec.id/index.php/bcrec/article/view/3518; https://doaj.org/toc/1978-2993

URL الوصول: https://doaj.org/article/740522f5f82e49349ef6e1c69ebdd56e

المؤلفون: Supreeth Prasad (4583203), Dylan D. Rodene (9256539), Michael B. Burkholder (5466299), Kelling J. Donald (1613794), B. Frank Gupton (1627126)

مصطلحات موضوعية: Biophysics, Biochemistry, Physiology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, useful predictive tools, transition state structure, suggest new avenues, halogen atoms ), 6 kj mol, 54 cases studied, internal reaction coordinate, pr amination reaction, reaction barriers, wide range, theoretical investigation, substituent types, substituent effects, solvent polarity, significant correlation, results indicate, progress toward, physical conditions, oxygen site, ortho <, noncatalyzed amination, momentary formation, lower barriers, lone pair, key insights

Relation: https://figshare.com/articles/journal_contribution/Substituent_Effects_and_the_Energetics_of_Noncatalyzed_Aryl_Halide_Aminations_A_Theoretical_Investigation/16764591

الاتاحة: https://doi.org/10.1021/acsomega.1c03934.s001

المؤلفون: Vijayagopal Gopalsamuthiram (8698608), Appasaheb L. Kadam (5931209), Jeffrey K. Noble (11819461), David R. Snead (2147977), Corshai Williams (11819464), Timothy F. Jamison (1316955), Chris Senanayake (1981135), Ajay K. Yadaw (11819467), Sarabindu Roy (2218909), Gopal Sirasani (1348278), B. Frank Gupton (1627126), Justina Burns (11819470), Daniel W. Cook (2796130), Rodger W. Stringham (2265970), Saeed Ahmad (704441), Rudy Krack (8698605)

مصطلحات موضوعية: Biophysics, Biochemistry, Ecology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, isolated via recrystallization, environmentally friendly solvents, 36 – 41, 19 antiviral molnupiravir, scalable four, purification procedures, nonenzymatic process, multigram scale, key steps, investigational covid, ester formation, earlier study, described herein, average purity, afford molnupiravir, 99 area, 98 wt

Relation: https://figshare.com/articles/journal_contribution/Toward_a_Practical_Nonenzymatic_Process_for_Investigational_COVID-19_Antiviral_Molnupiravir_from_Cytidine_Supply-Centered_Synthesis/17153239

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00219.s001

المؤلفون: Caroline Grundke (11112824), Caleb Kong (11112827), Christopher J. Kampf (1531933), B. Frank Gupton (1627126), D. Tyler McQuade (1554988), Till Opatz (1395832)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Pharmacology, Science Policy, Chemical Sciences not elsewhere classified, thiocyanate-mediated synthesis, acetone cyanohydrin, HCN tetramer DAMN, HCN Oligomers, hydrogen cyanide, mechanism, Programmed Formation, organosulfur catalysis, prebiotic chemistry, electrospray ionization mass spectr., ESI-MS

Relation: https://figshare.com/articles/journal_contribution/Programmed_Formation_of_HCN_Oligomers_through_Organosulfur_Catalysis/14959340

الاتاحة: https://doi.org/10.1021/acs.joc.1c01023.s001

المؤلفون: Jule-Philipp Dietz (10130402), Tobias Lucas (11113117), Jonathan Groß (6294548), Sebastian Seitel (11113120), Jan Brauer (11113123), Dorota Ferenc (2701327), B. Frank Gupton (1627126), Till Opatz (1395832)

مصطلحات موضوعية: Biochemistry, Medicine, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Developmental Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, carboxylic acid, ethoxymethylidene, diethyl, Amide formation, OEt, Six-Step Gram-Scale Synthesis, BC ring system, aminolysi, 1-butanol, Human Immunodeficiency Virus Integr., Final salt formation, ingredient dolutegravir sodium, synthesis, difluorobenzylamine, one-pot, convergent strategy, regioselective cyclization, dolutegravir sodium, ethyl ester, MgBr

Relation: https://figshare.com/articles/journal_contribution/Six-Step_Gram-Scale_Synthesis_of_the_Human_Immunodeficiency_Virus_Integrase_Inhibitor_Dolutegravir_Sodium/14959636

الاتاحة: https://doi.org/10.1021/acs.oprd.1c00139.s001

المؤلفون: Jule-Philipp Dietz (10130402), Dorota Ferenc (2701327), Timothy F. Jamison (1316955), B. Frank Gupton (1627126), Till Opatz (1395832)

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Physiology, Pharmacology, Biotechnology, Ecology, Developmental Biology, Mental Health, Plant Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Antiviral Drug Tenofovir Di, 5 g scale, butyl oxymethyl phosphonates, butyl Phosphonate Route, PMPA, phosphonomethylation reagent, tert, ingredient tenofovir

Relation: https://figshare.com/articles/journal_contribution/Di-_i_tert_i_-butyl_Phosphonate_Route_to_the_Antiviral_Drug_Tenofovir/13910912

الاتاحة: https://doi.org/10.1021/acs.oprd.0c00473.s001

المؤلفون: Eric Yu, Hari P. R. Mangunuru, Nakul S. Telang, Caleb J. Kong, Jenson Verghese, Stanley E. Gilliland III, Saeed Ahmad, Raymond N. Dominey, B. Frank Gupton

المصدر: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 583-592 (2018)

مصطلحات موضوعية: antimalarial, API manufacturing, flow chemistry, hydrogenation, hydroiodic acid, hydroxychloroquine, Science, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1860-5397

URL الوصول: https://doaj.org/article/edaae01b8fa240dc90d1188373e91ee9

المؤلفون: Vijayagopal Gopalsamuthiram (9354786), Appasaheb L. Kadam (9964407), Jeffrey Noble (9354791), David Snead (8649621), Corshai Williams (9354789), Timothy F. Jamison (5815215), Chris Senanayake (9524539), Ajay Yadaw (10119394), Sarabindu Roy (10119397), Gopal Sirasani (10190203), B. Frank Gupton (8492460), Justina Burns (8649631), Daniel W. Cook (9196434), Rodger W. Stringham (8492457), Saeed Ahmad (9964404), Rudy Krack (10927662)

مصطلحات موضوعية: Process Chemistry, Molnupiravir, MK-4482, EIDD-2801, COVID_19, Antivirals

Relation: https://figshare.com/articles/preprint/Towards_a_Practical_Non-enzymatic_Process_for_Molnupiravir_from_Cytidine/14738109

الاتاحة: https://doi.org/10.26434/chemrxiv.14738109.v1

المؤلفون: Sarabindu Roy (10119397), Ajay Yadaw (10119394), Subho Roy (10190200), Gopal Sirasani (10190203), Joseph D. Armstrong (10124750), B. Frank Gupton (8492460), Chris Senanayake (9524539), David Snead (8649621)

مصطلحات موضوعية: Process Chemistry, Antiviral, COVID_19, remdesivir

Relation: https://figshare.com/articles/preprint/Facile_and_Scalable_Methodology_for_the_Pyrrolo_2_1-f_1_2_4_triazine_of_Remdesivir/14109650

الاتاحة: https://doi.org/10.26434/chemrxiv.14109650.v1

المؤلفون: Robert E. McMillin, Brian Clark, Kaitlin Kay, B. Frank Gupton, James K. Ferri

المصدر: International Journal of Chemical Reactor Engineering. 21:313-327

مصطلحات موضوعية: General Chemical Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::55998b572e62b0bb816022270e9399a4
https://doi.org/10.1515/ijcre-2022-0117

المؤلفون: Michael Burkholder, Stanley E. Gilliland, Adam Luxon, Christina Tang, B. Frank Gupton

المصدر: Catalysts; Volume 9; Issue 1; Pages: 95

مصطلحات موضوعية: flow chemistry, continuous reactor, tube-in-tube, multiphase catalysis, oxidation, aerobic

وصف الملف: application/pdf

Relation: Environmental Catalysis; https://dx.doi.org/10.3390/catal9010095

الاتاحة: https://doi.org/10.3390/catal9010095

المؤلفون: Sarabindu Roy, Ajay Yadaw, Subho Roy, Gopal Sirasani, Aravind Gangu, Jack D. Brown, Joseph D. Armstrong, Rodger W. Stringham, B. Frank Gupton, Chris H. Senanayake, David R. Snead

المصدر: Organic Process Research & Development

مصطلحات موضوعية: supply centered synthesis, API, Organic Chemistry, antiviral agents, remdesivir, triazine, Physical and Theoretical Chemistry, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983e136e84bfddd6c883973d853a5823
http://europepmc.org/articles/PMC8787819

المؤلفون: Vijayagopal Gopalsamuthiram, Appasaheb L. Kadam, Jeffrey K. Noble, David R. Snead, Corshai Williams, Timothy F. Jamison, Chris Senanayake, Ajay K. Yadaw, Sarabindu Roy, Gopal Sirasani, B. Frank Gupton, Justina Burns, Daniel W. Cook, Rodger W. Stringham, Saeed Ahmad, Rudy Krack

المصدر: Organic Process Research & Development

مصطلحات موضوعية: antivirals, Organic Chemistry, COVID-19, molnupiravir, EIDD-2801, Physical and Theoretical Chemistry, Article, MK-4482

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326c06bc704cbcf2b7623e2bd23ed12c
http://europepmc.org/articles/PMC8689649

المؤلفون: Dylan D. Rodene, Kelling J. Donald, B. Frank Gupton, Michael Burkholder, Supreeth Prasad

المصدر: ACS Omega
ACS Omega, Vol 6, Iss 41, Pp 27216-27224 (2021)

مصطلحات موضوعية: chemistry.chemical_classification, Steric effects, General Chemical Engineering, Aryl halide, Aryl, Substituent, General Chemistry, Article, Reaction coordinate, chemistry.chemical_compound, Chemistry, Organic reaction, chemistry, Computational chemistry, Lone pair, QD1-999, Amination

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744366eb05683b7bd530f9fe76952b6a
http://europepmc.org/articles/PMC8529657

المؤلفون: Caroline Grundke, Till Opatz, D. Tyler McQuade, Christopher J. Kampf, Caleb J. Kong, B. Frank Gupton

المصدر: The Journal of Organic Chemistry. 86:10320-10329

مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Chemistry, Pharmaceutical, Electrospray ionization, Organic Chemistry, Cationic polymerization, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, chemistry, Tetramer, Diaminomaleonitrile, Molecule, Disulfides, Organosulfur compounds, Acetone cyanohydrin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9a1bea313cfa45842aba76f0dfe402
https://doi.org/10.1021/acs.joc.1c01023

المؤلفون: B. Frank Gupton, Jule-Philipp Dietz, Dorota Ferenc, Till Opatz, Tobias Lucas, Jonathan Groß, Jan Brauer, Sebastian Seitel

المصدر: Organic Process Research & Development. 25:1898-1910

مصطلحات موضوعية: Scale (ratio), Chemistry, Organic Chemistry, Human immunodeficiency virus (HIV), medicine, Integrase inhibitor, Dolutegravir sodium, Physical and Theoretical Chemistry, medicine.disease_cause, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Virology, Gram

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f618e39ec1302d3e48041db5da55ed28
https://doi.org/10.1021/acs.oprd.1c00139