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1Academic Journal
المؤلفون: Korwisi, B, Hay, G, Attal, N, Aziz, Q, Bennett, MI, Benoliel, R, Cohen, M, Evers, S, Giamberardino, MA, Kaasa, S, Kosek, E, Lavand'homme, P, Nicholas, M, Perrot, S, Schug, S, Smith, BH, Svensson, P, Vlaeyen, JWS, Wang, SJ, Treede, RD, Rief, W, Barke, A
المصدر: Pain. 162(7):2087-2096
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2Academic Journal
المؤلفون: Treede, RD, Rief, W, Barke, A, Aziz, Q, Bennett, MI, Benoliel, R, Cohen, M, Evers, S, Finnerup, NB, First, MB, Giamberardino, MA, Kaasa, S, Korwisi, B, Kosek, E, Lavand'homme, P, Nicholas, M, Perrot, S, Scholz, J, Schug, S, Smith, BH, Svensson, P, Vlaeyen, JWS, Wang, SJ
المصدر: Pain. 160(1):19-27
مصطلحات موضوعية: Medicin och hälsovetenskap
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3Academic Journal
المؤلفون: Nicholas, M, Vlaeyen, JWS, Rief, W, Barke, A, Aziz, Q, Benoliel, R, Cohen, M, Evers, S, Giamberardino, MA, Goebel, A, Korwisi, B, Perrot, S, Svensson, P, Wang, SJ, Treede, RD, Bennett, MI, Finnerup, NB, First, M, Kaasa, S, Kosek, E, Lavand'homme, P, Scholz, J, Schug, S, Smith, BH, Vlaeyen, J
المصدر: Pain. 160(1):28-37
مصطلحات موضوعية: Medicin och hälsovetenskap
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4Academic Journal
المؤلفون: Scholz, J, Finnerup, NB, Attal, N, Aziz, Q, Baron, R, Bennett, MI, Benoliel, R, Cohen, M, Cruccu, G, Davis, KD, Evers, S, First, M, Giamberardino, MA, Hansson, P, Kaasa, S, Korwisi, B, Kosek, E, Lavand'homme, P, Nicholas, M, Nurmikko, T, Perrot, S, Raja, SN, Rice, ASC, Rowbotham, MC, Schug, S, Simpson, DM, Smith, BH, Svensson, P, Vlaeyen, JWS, Wang, SJ, Barke, A, Rief, W, Treede, RD
المصدر: Pain. 160(1):53-59
مصطلحات موضوعية: Medicin och hälsovetenskap
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5Academic Journal
المؤلفون: Ajeng Khori Alfani, Diah Fatimatuzzahro, Irna Nissa Nur Aisyah, Ressa Amara, Moh Adzkiyaunuha, Ikhwan Aziz Q, Wiwied Pratiwi, Eka Prasetiawati, Miftahur Rohman, Lukman Habibbul Umam
المصدر: Jurnal Pengabdian Multidisiplin, Vol 4, Iss 2 (2024)
مصطلحات موضوعية: Social Sciences
وصف الملف: electronic resource
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6Academic Journal
المؤلفون: Thol'atul Luthfi Al-Amri, Ikhwan Aziz Q, M. Zainal Arifin
المصدر: Jurnal Keislaman, Vol 7, Iss 1 (2024)
مصطلحات موضوعية: Discipline, habituation, congregational prayer, Islam, BP1-253
وصف الملف: electronic resource
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7Academic Journal
المؤلفون: Khoir, Arifatul, Ikhwan Aziz Q, Rina Mida Hayati
المصدر: Bustanul Ulum Journal of Islamic Education; Vol. 1 No. 2 (2023): Bustanul Ulum Journal of Islamic Education; 131-147 ; 2988-1994 ; 2988-5779 ; 10.62448/bujie.v1i2
مصطلحات موضوعية: social media, tik tok, moral education, adolescences, Pendidikan Islam, Pendidikan Informal, Literai Digital
وصف الملف: application/pdf
Relation: https://journal.bustanululum.ac.id/index.php/bujie/article/view/17/17; https://journal.bustanululum.ac.id/index.php/bujie/article/view/17
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8Academic Journal
المؤلفون: Al-amri, Thol'atul Luthfi, Aziz Q, Ikhwan, Arifin, M. Zainal
المصدر: Jurnal Keislaman; Vol. 7 No. 1 (2024): Jurnal Keislaman; 109-125 ; 2722-7804 ; 2089-7413 ; 10.54298/jk.v7i1
مصطلحات موضوعية: Discipline, habituation, congregational prayer
وصف الملف: application/pdf
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9Academic Journal
المؤلفون: Choudhary, A., Fikree, A., Ruffle, J.K., Takahashi, K., Palsson, O.S., Aziz, I., Aziz, Q.
وصف الملف: text
Relation: https://eprints.whiterose.ac.uk/219780/1/Neurogastroenterology%20Motil%20-%202024%20-%20Choudhary%20-%20A%20machine%20learning%20approach%20to%20stratify%20patients%20with%20hypermobile.pdf; Choudhary, A. orcid.org/0000-0003-3694-9798 , Fikree, A., Ruffle, J.K. orcid.org/0000-0001-6248-7203 et al. (4 more authors) (2024) A machine learning approach to stratify patients with hypermobile Ehlers‐Danlos syndrome/hypermobility spectrum disorders according to disorders of gut brain interaction, comorbidities and quality of life. Neurogastroenterology & Motility. ISSN 1350-1925
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10Academic Journal
المؤلفون: Brennan, S, Chen, S, Makwana, S, Esposito, S, McGuinness, LR, Alnaimi, AIM, Sims, MW, Patel, M, Aziz, Q, Ojake, L, Roberts, JA, Sharma, P, Lodwick, D, Tinker, A, Barrett-Jolley, R, Dart, C, Rainbow, RD
مصطلحات موضوعية: ATP‐sensitive potassium channel, KATP channels, Kir6.1, cardiomyocytes
Relation: Br J Pharmacol; https://qmro.qmul.ac.uk/xmlui/handle/123456789/97008
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11Academic Journal
المؤلفون: Gunn, D, Topan, R, Fried, R, Holloway, I, Brindle, R, Hartley, S, Barnard, L, Corsetti, M, Scott, SM, Farmer, A, Akbar, A, Eugenicos, M, Trudgill, N, Kapur, K, McLaughlin, J, Sanders, DS, Ramadas, A, Whorwell, P, Houghton, L, Dinning, PG, Aziz, Q, Ford, AC, Farrin, A, Spiller, R
مصطلحات موضوعية: Digestive Diseases, Clinical Research, Clinical Trials and Supportive Activities, Chronic Pain, Pain Research, 6 Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Oral and gastrointestinal
وصف الملف: 1 - 121
Relation: Efficacy and Mechanism Evaluation; https://qmro.qmul.ac.uk/xmlui/handle/123456789/93679
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12Academic Journal
المؤلفون: Kellett, DO, Aziz, Q, Humphries, JD, Korsak, A, Braga, A, Del Arroyo, AG, Crescente, M, Tinker, A, Ackland, GL, Gourine, AV
مصطلحات موضوعية: RNA sequencing, autonomic nervous system, heart, transcriptome, vagus nerve, Animals, Vagus Nerve Stimulation, Rats, Male, Myocardium, Sprague-Dawley, Optogenetics, Gene Expression Regulation, Transcription, Genetic, Gene Expression Profiling
وصف الملف: 167 - 178
Relation: Physiol Genomics; TY - JOUR T1 - Transcriptional response of the heart to vagus nerve stimulation AU - Kellett, Daniel O. AU - Aziz, Qadeer AU - Humphries, Jonathan D. AU - Korsak, Alla AU - Braga, Alice AU - Gutierrez Del Arroyo, Ana AU - Crescente, Marilena AU - Tinker, Andrew AU - Ackland, Gareth L. AU - Gourine, Alexander V. Y1 - 2023/12/04 PY - 2023 DA - 2024/02/01 N1 - doi:10.1152/physiolgenomics.00095.2023 DO - 10.1152/physiolgenomics.00095.2023 T2 - Physiological Genomics JF - Physiological Genomics SP - 167 EP - 178 VL - 56 IS - 2 PB - American Physiological Society N2 - Heart failure is a major clinical problem, with treatments involving medication, devices, and emerging neuromodulation therapies such as vagus nerve stimulation (VNS). Considering the ongoing interest in using VNS to treat cardiovascular disease, it is important to understand the genetic and molecular changes developing in the heart in response to this form of autonomic neuromodulation. This experimental animal (rat) study investigated the immediate transcriptional response of the ventricular myocardium to selective stimulation of vagal efferent activity using an optogenetic approach. Vagal preganglionic neurons in the dorsal motor nucleus of the vagus nerve were genetically targeted to express light-sensitive chimeric channelrhodopsin variant ChIEF and stimulated using light. RNA sequencing of the left ventricular myocardium identified 294 differentially expressed genes (false discovery rate < 0.05). Qiagen Ingenuity Pathway Analysis (IPA) highlighted 118 canonical pathways that were significantly modulated by vagal activity, of which 14 had a z score of ≥2/≤?2, including EIF-2, IL-2, integrin, and NFAT-regulated cardiac hypertrophy. IPA revealed the effect of efferent vagus stimulation on protein synthesis, autophagy, fibrosis, autonomic signaling, inflammation, and hypertrophy. IPA further predicted that the identified differentially expressed genes were the targets of 50 upstream regulators, including transcription factors (e.g., MYC and NRF1) and microRNAs (e.g., miR-335-3p and miR-338-3p). These data demonstrate that the vagus nerve has a major impact on the myocardial expression of genes involved in the regulation of key biological pathways. The transcriptional response of the ventricular myocardium induced by stimulation of vagal efferents is consistent with the beneficial effect of maintained/increased vagal activity on the heart.NEW & NOTEWORTHY This experimental animal study investigated the immediate transcriptional response of the ventricular myocardium to selective stimulation of vagal efferent activity. Vagal stimulation induced significant transcriptional changes in the heart involving the pathways controlling autonomic signaling, inflammation, fibrosis, and hypertrophy. This study provides the first direct evidence that myocardial gene expression is modulated by the activity of the autonomic nervous system. AB - Heart failure is a major clinical problem, with treatments involving medication, devices, and emerging neuromodulation therapies such as vagus nerve stimulation (VNS). Considering the ongoing interest in using VNS to treat cardiovascular disease, it is important to understand the genetic and molecular changes developing in the heart in response to this form of autonomic neuromodulation. This experimental animal (rat) study investigated the immediate transcriptional response of the ventricular myocardium to selective stimulation of vagal efferent activity using an optogenetic approach. Vagal preganglionic neurons in the dorsal motor nucleus of the vagus nerve were genetically targeted to express light-sensitive chimeric channelrhodopsin variant ChIEF and stimulated using light. RNA sequencing of the left ventricular myocardium identified 294 differentially expressed genes (false discovery rate < 0.05). Qiagen Ingenuity Pathway Analysis (IPA) highlighted 118 canonical pathways that were significantly modulated by vagal activity, of which 14 had a z score of ≥2/≤?2, including EIF-2, IL-2, integrin, and NFAT-regulated cardiac hypertrophy. IPA revealed the effect of efferent vagus stimulation on protein synthesis, autophagy, fibrosis, autonomic signaling, inflammation, and hypertrophy. IPA further predicted that the identified differentially expressed genes were the targets of 50 upstream regulators, including transcription factors (e.g., MYC and NRF1) and microRNAs (e.g., miR-335-3p and miR-338-3p). These data demonstrate that the vagus nerve has a major impact on the myocardial expression of genes involved in the regulation of key biological pathways. The transcriptional response of the ventricular myocardium induced by stimulation of vagal efferents is consistent with the beneficial effect of maintained/increased vagal activity on the heart.NEW & NOTEWORTHY This experimental animal study investigated the immediate transcriptional response of the ventricular myocardium to selective stimulation of vagal efferent activity. Vagal stimulation induced significant transcriptional changes in the heart involving the pathways controlling autonomic signaling, inflammation, fibrosis, and hypertrophy. This study provides the first direct evidence that myocardial gene expression is modulated by the activity of the autonomic nervous system. SN - 1094-8341 M3 - doi:10.1152/physiolgenomics.00095.2023 UR - https://doi.org/10.1152/physiolgenomics.00095.2023 Y2 - 2024/08/01 ER -; https://qmro.qmul.ac.uk/xmlui/handle/123456789/98548
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13Academic Journal
المؤلفون: Elisa, Reni, Aziz Q, Ikhwan, Hayati, Rina Mida
المصدر: Indonesian Journal of Educational Management and Leadership; Vol. 2 No. 1 (2024): Indonesian Journal of Educational Management and Leadership; 1-12 ; 2985-7945
مصطلحات موضوعية: asmaul husna recitation, habituation, religious character
وصف الملف: application/pdf
Relation: https://journal.kurasinstitute.com/index.php/jemal/article/view/844/589; https://journal.kurasinstitute.com/index.php/jemal/article/view/844
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14Academic Journal
المصدر: Assyfa Journal of Multidisciplinary Education; Vol. 1 No. 1 (2024): Assyfa Journal of Multidisciplinary Education; 05-09 ; 3047-3942
مصطلحات موضوعية: Education, Implementation, Islamic Religious, Student Morals
وصف الملف: application/pdf; application/epub+zip
Relation: https://www.journal.assyfa.com/index.php/ajme/article/view/513/170; https://www.journal.assyfa.com/index.php/ajme/article/view/513/171; https://www.journal.assyfa.com/index.php/ajme/article/view/513
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15Academic Journal
المؤلفون: Listiyanti, Galuh, Aziz Q, Ihwan, Hasyim, Umar Alfaruq A.
المصدر: Assyfa Journal of Islamic Studies; Vol. 2 No. 1 (2024): Assyfa Journal of Islamic Studies; 11-18 ; 2988-7399
وصف الملف: application/pdf
Relation: https://www.journal.assyfa.com/index.php/ajis/article/view/512/129; https://www.journal.assyfa.com/index.php/ajis/article/view/512
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16Academic Journal
المؤلفون: Wahid, Abdullah Khairul, Aziz Q, Ikhwan, Arifin, M. Zainal
المصدر: Assyfa Journal of Islamic Studies; Vol. 2 No. 1 (2024): Assyfa Journal of Islamic Studies; 19-25 ; 2988-7399
مصطلحات موضوعية: Islamic Religious Education Teacher Strategy, Overcoming, Juvenile Delinquency
وصف الملف: application/pdf
Relation: https://www.journal.assyfa.com/index.php/ajis/article/view/514/130; https://www.journal.assyfa.com/index.php/ajis/article/view/514
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17Academic Journal
المؤلفون: Lal, S., Paine, P., Tack, J., Aziz, Q., Barazzoni, R., Cuerda, C., Jeppesen, P., Joly, F., Lamprecht, G., Mundi, M., Schneider, S., Szczepanek, K., Van Gossum, A., Wanten, G., Vanuytsel, T., Pironi, L.
المصدر: Neurogastroenterology & Motility ; ISSN 1350-1925 1365-2982
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18Academic Journal
المؤلفون: Treede, RD, Rief, W, Barke, A, Aziz, Q, Bennett, MI, Benoliel, R, Cohen, M, Evers, S, Finnerup, NB, First, MB, Giamberardino, MA, Kaasa, S, Kosek, E, Lavand'homme, P, Nicholas, M, Perrot, S, Scholz, J, Schug, S, Smith, BH, Svensson, P, Vlaeyen, JWS, Wang, SJ
المصدر: Pain. 156(6):1003-1007
مصطلحات موضوعية: Medicin och hälsovetenskap
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19Academic Journal
المؤلفون: Tiara Ayu Astriana, Ikhwan Aziz Q, Rina Mida Hayati
المصدر: Bustanul Ulum Journal of Islamic Education; Vol. 1 No. 1 (2023): Bustanul Ulum Journal of Islamic Education; 1-15 ; 2988-1994 ; 2988-5779 ; 10.62448/bujie.v1i1
مصطلحات موضوعية: PAI teacher, habitutation, asmaul husna, Pendidikan Agama Islam
وصف الملف: application/pdf
Relation: https://journal.bustanululum.ac.id/index.php/bujie/article/view/3/3; https://journal.bustanululum.ac.id/index.php/bujie/article/view/3
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20Academic Journal
المؤلفون: Coxon, L, Vollert, J, Perro, D, Lunde, CE, Ferreira-Gomes, J, Charrua, A, Abreu-Mendes, P, Krassowski, M, Birch, J, Meijlink, J, Hummelshoj, L, Hoffman, A, Aziz, Q, Arendt-Nielsen, L, Pogatzki-Zahn, E, Evans, E, Demetriou, L, McMahon, SB, Missmer, SA, Becker, CM, Zondervan, KT, Horne, AW, Cruz, F, Sieberg, CB, Treede, R-D, Nagel, J, Vincent, K
Relation: https://ora.ox.ac.uk/objects/uuid:9fbb3edf-9683-43a4-bdf2-8608830944ef; https://doi.org/10.1097/j.pain.0000000000002955