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1
المؤلفون: Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
مصطلحات موضوعية: Dihydropyridines, Phosphodiesterase Inhibitors, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Osteoarthritis, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, medicine, Animals, Structure–activity relationship, Binding site, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Azirines, Chemistry, fungi, Organic Chemistry, Active site, medicine.disease, Cyclic Nucleotide Phosphodiesterases, Type 2, Cyclic Nucleotide Phosphodiesterases, Type 4, Disease Models, Animal, Transformation (genetics), Enzyme, biology.protein, Molecular Medicine, Phosphodiesterase 2, Phosphodiesterase 4 Inhibitors, Protein Binding
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2
المؤلفون: Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
مصطلحات موضوعية: Dihydropyridines, Phosphodiesterase Inhibitors, Clinical Biochemistry, Analgesic, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, law.invention, Structure-Activity Relationship, Pharmacokinetics, law, In vivo, Catalytic Domain, Osteoarthritis, Drug Discovery, Animals, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Analgesics, Binding Sites, Azirines, fungi, Organic Chemistry, Azepines, Cyclic Nucleotide Phosphodiesterases, Type 2, Rats, Bioavailability, Disease Models, Animal, Enzyme, chemistry, Recombinant DNA, Pyrazoles, Molecular Medicine, Phosphodiesterase 2, Phosphodiesterase 4 Inhibitors, Half-Life, Protein Binding
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3
المؤلفون: Daniel F. Ortwine, Nadia Esmaeil, Haile Tecle, John Quin, Joseph S. Warmus, Michael Kaufman, William A. Denny, Jeffrey F. Ohren, and Alexander G. Pavlovsky, Ronald L. Merriman, Jared B. J. Milbank, Aurash B. Shahripour, Shannon Leigh Black, Judith Sebolt-Leopold, Christopher Whitehead, Julie Ann Spicer, Cathlin Marie Flamme, Heidi S. Camp, Kelley Moore, Richard Gowan, Charles Omer, Mark Stephen Plummer, Sally Pryzbranowski, Gordon W. Rewcastle, Stephen Douglas Barrett
المصدر: Journal of Medicinal Chemistry. 50:5090-5102
مصطلحات موضوعية: Male, Models, Molecular, Pyridones, medicine.drug_class, Stereochemistry, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Antineoplastic Agents, Carboxamide, Mitogen-activated protein kinase kinase, Chemical synthesis, Mice, Structure-Activity Relationship, Non-competitive inhibition, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Transferase, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, chemistry.chemical_classification, Aniline Compounds, Amides, In vitro, Rats, Enzyme, chemistry, Biochemistry, Benzamides, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation
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4
المؤلفون: John R. Rubin, Nigel Walker, Kenneth Dale Brady, Winnie W. Wong, Mark S. Plummer, Christine Humblet, Charles J. Stankovic, Aurash B Shahripour, Connolly Michael Kevin, Robert V. Talanian, Elizabeth A. Lunney, Hamish Allen, Tomi K. Sawyer
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:2779-2782
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Crystal structure, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, biology, Caspase 1, Organic Chemistry, Diphenyl ether, Active site, Caspase Inhibitors, Combinatorial chemistry, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Ethers
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5
المؤلفون: Aurash B. Shahripour, et al. et al.
المصدر: ChemInform. 33
مصطلحات موضوعية: Biochemistry, Chemistry, Caspase 1, Structure based, Interleukin 1β converting enzyme, General Medicine
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6
المؤلفون: Elizabeth A. Lunney, Catherine R. Kostlan, Kenneth Dale Brady, Sheryl Jeanne Hays, Christine Humblet, Aurash B Shahripour, Winnie W. Wong, Tomi K. Sawyer, Hamish Allen, Mark S. Plummer, Hans Albrecht, Robert V. Talanian, Nigel Walker
المصدر: Bioorganicmedicinal chemistry. 10(1)
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Drug Discovery, Moiety, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Active site, Substrate (chemistry), Small molecule, Caspase Inhibitors, Amino acid, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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7Academic Journal
المؤلفون: Julie A. Spicer, Gordon W. Rewcastle, Michael D. Kaufman, Shannon L. Black, Mark S. Plummer, William A. Denny, John Quin, III, Aurash B. Shahripour, Stephen D. Barrett, Christopher E. Whitehead, Jared B. J. Milbank, Jeffrey F. Ohren, Richard C. Gowan, Charles Omer, Heidi S. Camp, Nadia Esmaeil, Kelley Moore, Judith S. Sebolt-Leopold, Sally Pryzbranowski
المصدر: Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 21, p5090-5102, 13p