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1Academic Journal
المؤلفون: Darren Le Grand (10864828), Martin Gosling (571081), Urs Baettig (1663810), Parmjit Bahra (10864831), Kamlesh Bala (10864834), Cara Brocklehurst (10864837), Emma Budd (10864840), Rebecca Butler (7411379), Atwood K. Cheung (1920859), Hedaythul Choudhury (10864843), Stephen P. Collingwood (10864846), Brian Cox (2163064), Henry Danahay (599989), Lee Edwards (2653597), Brian Everatt (10864849), Ulrike Glaenzel (10864852), Anne-Lise Glotin (10864855), Paul Groot-Kormelink (10864858), Edward Hall (2640643), Julia Hatto (1663819), Catherine Howsham (2426614), Glyn Hughes (10864861), Anna King (5147822), Julia Koehler (10864864), Swarupa Kulkarni (10864867), Megan Lightfoot (10864870), Ian Nicholls (10864873), Christopher Page (3819763), Giles Pergl-Wilson (7583486), Mariana Oana Popa (10864876), Richard Robinson (3807), David Rowlands (362028), Tom Sharp (10864879), Matthew Spendiff (10864882), Emily Stanley (10864885), Oliver Steward (1663813), Roger J. Taylor (2044099), Pamela Tranter (758896), Trixie Wagner (1639117), Hazel Watson (7126544), Gareth Williams (5148), Penny Wright (5750657), Alice Young (10864888), David A. Sandham (2820148)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Genetics, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, fibrosis transmembrane conductance ., Chronic Obstructive Pulmonary Disea., cigarette smoke exposure, COPD patients, Cystic Fibrosis, identification, ion channel, F 508del, Clinical Efficacy, QBW, development compound icenticaftor, dysfunctional airway epithelial ion., lung disease, throughput screening, wild-type CFTR channels, Cystic Fibrosis Transmembrane Condu.
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2Academic Journal
المؤلفون: Jake Axford (6081920), Moo Je Sung (2085337), John Manchester (2303572), Donovan Chin (1612576), Monish Jain (1948042), Youngah Shin (6059), Ina Dix (1639147), Lawrence G. Hamann (1436563), Atwood K. Cheung (1920859), Rajeev Sivasankaran (264843), Karin Briner (2725954), Natalie A. Dales (2990565), Brian Hurley (6081917)
مصطلحات موضوعية: Biochemistry, Genetics, Neuroscience, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, 2- fluorophenyl thiadiazole motif, exon -7 inclusion, survival motor neuron protein, gene SMN 2, SMA, 2- hydroxyphenyl pyridazine core, SMN protein, intramolecular hydrogen bond, survival motor neuron 1
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3
المؤلفون: Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
المصدر: Journal of Medicinal Chemistry. 64:7241-7260
مصطلحات موضوعية: Cystic Fibrosis, Drug Evaluation, Preclinical, Administration, Oral, Aminopyridines, Cystic Fibrosis Transmembrane Conductance Regulator, Pulmonary disease, 01 natural sciences, Cystic fibrosis, Rats, Sprague-Dawley, Pathogenesis, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, 03 medical and health sciences, Therapeutic approach, Drug Discovery, medicine, Animals, Humans, Clinical efficacy, 030304 developmental biology, 0303 health sciences, COPD, biology, Chemistry, Potentiator, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Rats, respiratory tract diseases, 0104 chemical sciences, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Solubility, Immunology, biology.protein, Molecular Medicine, Gene Deletion, Half-Life, Protein Binding
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4
المؤلفون: Youngah Shin, Moo Je Sung, Monish Jain, Jake Axford, Natalie Dales, Ina Dix, Brian Hurley, Lawrence G. Hamann, Karin Briner, Atwood K. Cheung, John I. Manchester, Donovan N. Chin, Rajeev Sivasankaran
المصدر: Journal of Medicinal Chemistry. 64:4744-4761
مصطلحات موضوعية: chemistry.chemical_classification, 0303 health sciences, Hydrogen bond, Stereochemistry, Aryl, SMN1, 01 natural sciences, nervous system diseases, 0104 chemical sciences, Pyridazine, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Intramolecular force, Drug Discovery, RNA splicing, Molecular Medicine, Non-covalent interactions, Amine gas treating, 030304 developmental biology
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5
المؤلفون: Jake, Axford, Moo Je, Sung, John, Manchester, Donovan, Chin, Monish, Jain, Youngah, Shin, Ina, Dix, Lawrence G, Hamann, Atwood K, Cheung, Rajeev, Sivasankaran, Karin, Briner, Natalie A, Dales, Brian, Hurley
المصدر: Journal of medicinal chemistry. 64(8)
مصطلحات موضوعية: Male, Motor Neurons, RNA Splicing, Molecular Conformation, Survival of Motor Neuron 1 Protein, Rats, Muscular Atrophy, Spinal, Oxygen, Pyridazines, Rats, Sprague-Dawley, Survival of Motor Neuron 2 Protein, Mice, Structure-Activity Relationship, Halogens, Drug Design, Thiadiazoles, Animals, Humans, Sulfur, Half-Life
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6
المؤلفون: Atwood K. Cheung, Susanne E. Swalley
المصدر: Phenotypic Drug Discovery ISBN: 9781788018760
مصطلحات موضوعية: Silent mutation, Mutation, Neuromuscular disease, Phenotypic screening, Survival of motor neuron, SMN1, Spinal muscular atrophy, Biology, medicine.disease, Bioinformatics, medicine.disease_cause, nervous system diseases, Exon, medicine
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7
المؤلفون: Natalie Dales, Monish Jain, Sanchez Carina Cristina, Ryan Kerrigan, Atwood K. Cheung, Cary Fridrich, Donovan N. Chin, Brian Hurley, Keith Hoffmaster, Lin Deng, Ronald Tomlinson, Marc Hild, Rajeev Sivasankaran, Jake Axford, Aleem Fazal, Gary O’Brien, Christopher Towler, Mailin Van Hoosear, Youngah Shin, Dione Kobayashi, Shen Yiping, Lei Shu, William F. Dietrich, Karen S. Chen, Lawrence G. Hamann, Karin Briner, Rebecca Servais, Cheng Song, Emma Cody, Robert Sun, Daniel Curtis, Moo Je Sung, Ying Hou
المصدر: Journal of Medicinal Chemistry. 61:11021-11036
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Spliceosome, RNA Splicing, Phenotypic screening, Drug Evaluation, Preclinical, Administration, Oral, Quantitative Structure-Activity Relationship, SMN1, Crystallography, X-Ray, Cell Line, Muscular Atrophy, Spinal, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, medicine, Animals, Humans, Gene, Motor Neurons, Dose-Response Relationship, Drug, Chemistry, Brain, Spinal muscular atrophy, Motor neuron, medicine.disease, SMA, Survival of Motor Neuron 1 Protein, nervous system diseases, Mice, Inbred C57BL, Pyridazines, Survival of Motor Neuron 2 Protein, 030104 developmental biology, medicine.anatomical_structure, RNA splicing, Molecular Medicine, Neuroscience, 030217 neurology & neurosurgery
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8
المؤلفون: Xiaolu Zhang, Jeffery A. Porter, Atwood K. Cheung, Vic E. Myer, Mark C. Fishman, Caroline Gubser Keller, Rajeev Sivasankaran, John A. Tallarico, Marc Hild, Sven Schuierer, Michael McLellan, Frada Berenshteyn, William F. Dietrich, Cecile Blaustein, Youngah Shin, Lei Shu, Michael Salcius, Monish Jain, Mailin Van Hoosear, Donovan N. Chin, Arnaud Lacoste, Martin Beibel, James Palacino, Nicole A. Renaud, Leo Murphy, Marcel J. J. Blommers, Lawrence G. Hamann, Caroline Bullock, Xiaoying Shi, Lin Deng, Jason R. Thomas, Daniel Curtis, Thomas M. Smith, Susanne E. Swalley, Gregory A. Michaud, Cheng Song, Brian Tseng, Guglielmo Roma, Natalie Dales, Rebecca Servais
المصدر: Nature Chemical Biology. 11:511-517
مصطلحات موضوعية: Models, Molecular, Gene Expression, Mice, Transgenic, SMN1, Biology, Ribonucleoprotein, U1 Small Nuclear, Muscular Atrophy, Spinal, Small Molecule Libraries, Mice, RNA Precursors, Animals, Humans, splice, snRNP, Enhancer, Molecular Biology, Gene, RNA, Double-Stranded, Binding Sites, Protein Stability, Cell Biology, SMA, Survival Analysis, Molecular biology, nervous system diseases, Survival of Motor Neuron 2 Protein, Alternative Splicing, Disease Models, Animal, Proteolysis, RNA splicing, Female, Precursor mRNA, Protein Binding
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9
المؤلفون: Atwood K. Cheung, Feng Cong, Shih-Min A. Huang
المصدر: Annual Review of Pharmacology and Toxicology. 52:57-78
مصطلحات موضوعية: Proteomics, Pharmacology, Molecular signaling, Proteomics methods, Transcription, Genetic, Drug discovery, Gene Expression Profiling, Phenotypic screening, Computational Biology, Computational biology, Biology, Toxicology, Bioinformatics, Drug Delivery Systems, Phenotype, Pharmacogenetics, Drug Design, Drug Discovery, Animals, Humans, Chemical genetics, Signal Transduction
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10
المؤلفون: Hong Cheng, Pascal D. Fortin, Feng Cong, Donovan N. Chin, Jutta Blank, Michael Shultz, Viraj Tyagi, Yun Feng, Christina A. Kirby, Ming Xu, Bailin Zhang, Atwood K. Cheung, Travis Stams, Wenlin Shao, Tami Hood, Olga Charlat
المصدر: Journal of Medicinal Chemistry. 55:1127-1136
مصطلحات موضوعية: Models, Molecular, Adenosine, Protein Conformation, Druggability, Sulfides, Crystallography, X-Ray, Structure-Activity Relationship, Tankyrases, Drug Discovery, medicine, Humans, Structure–activity relationship, Binding site, Wnt Signaling Pathway, Oxadiazoles, Binding Sites, Chemistry, HEK 293 cells, Wnt signaling pathway, Triazoles, Small molecule, Cell biology, HEK293 Cells, Molecular Medicine, medicine.drug
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11
المؤلفون: Aleem Fazal, Marc Hild, Christine D. Wilson, Shih Min A Huang, Stephen Fawell, Feng Cong, John A. Tallarico, Michael Shultz, Hong Cheng, Andreas Bauer, Christoph Lengauer, Chris Lu, Christina Rau, Judith Schlegl, Jeffery A. Porter, Daniel Curtis, Fabrizio C. Serluca, Stephanie Wiessner, Ronald Tomlinson, Sonja Ghidelli, Marc W. Kirschner, Xiaoying Shi, Elizabeth Wiellette, Vic E. Myer, Markus Schirle, Frank Stegmeier, Yue Zhang, Craig Mickanin, Atwood K. Cheung, Yuji Mishina, Wenlin Shao, Olga Charlat, Gregory A. Michaud, Shanming Liu, Peter Finan, Tewis Bouwmeester
المصدر: Nature. 461:614-620
مصطلحات موضوعية: Proteomics, Proteasome Endopeptidase Complex, Beta-catenin, Transcription, Genetic, Biology, Cell Line, Axin Protein, Cell Line, Tumor, AXIN1, Humans, Transcription factor, beta Catenin, Tankyrases, Multidisciplinary, Ubiquitin, Ubiquitination, Wnt signaling pathway, LRP6, LRP5, Cell biology, Repressor Proteins, Wnt Proteins, Catenin, biology.protein, Colorectal Neoplasms, Heterocyclic Compounds, 3-Ring, Cell Division, Protein Binding, Signal Transduction
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12
المؤلفون: Atwood K. Cheung, Feng Cong
المصدر: Concepts and Case Studies in Chemical Biology
مصطلحات موضوعية: Genetics, Chemistry, Wnt signaling pathway, Identification (biology), Haystack, Chemical genetics
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13
المؤلفون: Yongyao Xu, John A. Tallarico, Bailin Zhang, Atwood K. Cheung, Jean-Michel Rondeau, Peter Finan, Martin Klumpp, Pietro De Camilli, Tewis Bouwmeester, Jeffrey A. Porter, Andreas Billich, Yan Feng, Ronald Tomlinson, Vic E. Myer, Qian Huang, Gerard Joberty, Xinming Cai, Aleem Fazal, Leon Murphy, Christine D. Wilson, Daniel Baird, Abel R. Alcázar-Román, Mark Labow, Hidde L. Ploegh
مصطلحات موضوعية: medicine.medical_treatment, Morpholines, Clinical Biochemistry, Biology, Biochemistry, Interleukin-23, Article, Cell Line, Substrate Specificity, PIKFYVE, Mice, Phosphatidylinositol 3-Kinases, Immune system, Drug Discovery, Interleukin 23, medicine, Animals, Humans, Enzyme Inhibitors, Receptor, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Pharmacology, Toll-like receptor, Innate immune system, Kinase, Triazines, Toll-Like Receptors, Hydrazones, General Medicine, Interleukin-12, Cell biology, Cytokine, Pyrimidines, Gene Expression Regulation, Molecular Medicine, Cytokines, Protein Binding, Signal Transduction
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14
المؤلفون: Atwood K. Cheung, Minying Pu, Travis Stams, Donovan N. Chin, Dyuti Majumdar, Pascal D. Fortin, Francois Lenoir, Lei Huangshu, Pham Ly Luu, Run Ming Wang, Christina A. Kirby, Etienne Ochala, Aleem Fazal, Dipietro Lucian, Bharat Lagu, Chen Christine Hiu-Tung, Yun Feng, Palermo Mark G, Wenlin Shao, Ronald Tomlinson, Nigel J. Waters, Michael Shultz, Brant Firestone, Zhouliang Chen, Jianmei Fan, Ty Gould, Michael Scott Visser, B. Barry Touré, Troy Smith
المصدر: Journal of medicinal chemistry. 56(16)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Tankyrases, Dihydropyran, Druggability, Antagonist, Wnt signaling pathway, Administration, Oral, Biological Availability, Pyrimidinones, Tankyrase-1, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Enzyme, chemistry, Biochemistry, In vivo, Lipophilic efficiency, Area Under Curve, Drug Discovery, Acetamides, Molecular Medicine, Animals, Enzyme Inhibitors
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15
المؤلفون: Guglielmo Roma, Natalie Dales, Atwood K. Cheung, Thomas M. Smith, Susanne E. Swalley, Jason R. Thomas, Jeffery A. Porter, Rajeev Sivasankaran, Xiaolu Zhang, Monish Jain, Lei Shu, Leo Murphy, Gregory A. Michaud, Michael Salcius, Mailin Van Hoosear, Caroline Gubser Keller, Mark C. Fishman, Frada Berenshteyn, Cheng Song, William F. Dietrich, Youngah Shin, Caroline Bullock, Brian Tseng, John A. Tallarico, Nicole A. Renaud, Michael McLellan, Sven Schuierer, Vic E. Myer, Donovan N. Chin, Marcel J. J. Blommers, Marc Hild, James Palacino, Martin Beibel, Lin Deng, Arnaud Lacoste, Lawrence G. Hamann, Rebecca Servais, Cecile Blaustein, Daniel Curtis, Xiaoying Shi
المصدر: Nature Chemical Biology. 12:304-304
مصطلحات موضوعية: business.industry, Medicine, Physiology, splice, Cell Biology, Computational biology, business, SMA, Precursor mRNA, Molecular Biology
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16
المؤلفون: Atwood K. Cheung, Michael Shultz, Travis Stams, Christina A. Kirby, Aleem Fazal
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Biophysics, Crystal structure, Crystallography, X-Ray, Biochemistry, law.invention, Crystal, chemistry.chemical_compound, Structural Biology, law, Genetics, medicine, Molecule, Structural Communications, Humans, Protein Interaction Domains and Motifs, Crystallization, Enzyme Inhibitors, Tankyrases, Nicotinamide, Phenanthrenes, Condensed Matter Physics, Adenosine, Small molecule, Crystallography, chemistry, NAD+ kinase, Heterocyclic Compounds, 3-Ring, medicine.drug
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17
المؤلفون: Atwood K, Cheung, Rishi K, Jain
المصدر: IDrugs : the investigational drugs journal. 13(12)
مصطلحات موضوعية: Pharmacology, Proteomics, Structure-Activity Relationship, Drug Industry, Drug Discovery, Drug Evaluation, Preclinical, Animals, Humans, Molecular Targeted Therapy, Signal Transduction
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18
المؤلفون: Marc L. Snapper, Ryan P. Murelli, and Atwood K. Cheung
المصدر: The Journal of organic chemistry. 72(5)
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Molecular Conformation, Alkyne, Phospholipases A, chemistry.chemical_compound, Phospholipase A2, Decalin, 4-Butyrolactone, Side chain, Animals, Humans, Furaldehyde, Enzyme Inhibitors, Pyrans, chemistry.chemical_classification, Natural product, biology, Organic Chemistry, Nuclear magnetic resonance spectroscopy, Recombinant Proteins, Porifera, Bee Venoms, Phospholipases A2, Enzyme, chemistry, biology.protein, Indicators and Reagents, Aliphatic compound
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19
المؤلفون: Atwood K. Cheung, Marc L. Snapper, Ryan P. Murelli
المصدر: ChemInform. 35
مصطلحات موضوعية: chemistry.chemical_classification, Natural product, biology, Stereochemistry, Dihydropyran, General Medicine, Ring (chemistry), chemistry.chemical_compound, Cacospongionolide B, Phospholipase A2, Enzyme, chemistry, biology.protein, Side chain, Moiety
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المؤلفون: Atwood K. Cheung, Marc L. Snapper
المصدر: ChemInform. 34
مصطلحات موضوعية: chemistry.chemical_classification, Natural product, biology, Stereochemistry, Dihydropyran, Metabolite, Total synthesis, General Medicine, chemistry.chemical_compound, Enzyme, Phospholipase A2, chemistry, biology.protein, Side chain, Moiety