-
1Academic Journal
المؤلفون: Laura Cucinotta, Deborah Mannino, Alessia Filippone, Adele Romano, Emanuela Esposito, Irene Paterniti
المصدر: Frontiers in Pharmacology, Vol 15 (2024)
مصطلحات موضوعية: Parkinson’s disease, gender differences, autophagy, ATG (autophagy-related) proteins, leucin rich repeat kinase 2 (LRRK2), Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
-
2Academic Journal
المؤلفون: Claudio Daniel Gonzalez, Roxana Resnik, Maria Ines Vaccaro
المصدر: Frontiers in Endocrinology, Vol 11 (2020)
مصطلحات موضوعية: unconventional protein secretion, IL-1β, aggregate-prone proteins, macroautophagy, ATG (autophagy-related) proteins, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
وصف الملف: electronic resource
-
3
المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins
-
4
المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
-
5
المؤلفون: Yang An, Jin Zhang, Xiaoxi Zeng, Yuqian Zhao, Shouyue Zhang, Ziyi Qin, Heng Xu, Bo Liu
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1227-1245 (2021)مصطلحات موضوعية: Druggable target, Programmed cell death, Candidate gene, CNA, copy number alteration, Regulator, Druggability, RM1-950, Biology, Autophagic regulator, TNBC, triple-negative breast cancer, SIRT3, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, BRCA, invasive breast carcinoma, ATG, autophagy-related gene, GO, Gene Ontology, Gene expression, medicine, General Pharmacology, Toxicology and Pharmaceutics, Migration, SNF, similarity network fusion, 030304 developmental biology, 0303 health sciences, LASSO, least absolute shrinkage and selection operator, Autophagy, SF3B3, medicine.disease, Multi-omics approach, PFS, progression-free survival, Invasive breast carcinoma, MET, DNA methylation, Anti-proliferation, EXP, gene expression, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, TCGA, The Cancer Genome Atlas, Original Article, Therapeutics. Pharmacology
-
6
المؤلفون: Grace L. Guo, Xiaoyun Chen, Zheng Dong, Bilon Khambu, Xiao Ming Yin, Shengmin Yan
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 973-997 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Gut Dysbiosis, OST-β, organic solute transporter subunit-β, SQSTM1, sequestosome-1, FGF15, CK19, cytokeratin 19, Gut flora, FEX, fexaramine, SHP, small heterodimer partner, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, AST, aspartate transaminase, MCA, muricholic acid, CYP8B1, cytochrome p450 family 8b1, BLU, Blu-9931, TCDCA, taurochenodeoxycholic acid, Original Research, FGFR4, fibroblast growth factor receptor 4, TBA, total bile acid, Liver injury, CA, cholic acid, biology, Bile acid, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, Liver, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, NRF2, nuclear factor erythroid 2-related factor 2, BA, bile acid, 030211 gastroenterology & hepatology, TDCA, taurodeoxycholic acid, medicine.drug, medicine.medical_specialty, GM, gut microbiota, ALT, alanine transaminase, medicine.drug_class, TCA, taurocholic acid, PBS, phosphate-buffered saline, IBABP, ileal bile acid-binding protein, OST-α, organic solute transporter subunit-α, Liver Injury, ASBT (SLC10A2), apical sodium–bile acid transporter, CDCA, chenodeoxycholic acid, Bile Acids and Salts, CYP7A1, cytochrome p450 7a1, 03 medical and health sciences, FXR, farnesoid X receptor, ATG, autophagy-related gene, TUDCA, tauroursodeoxycholic acid, Internal medicine, medicine, Autophagy, BAS, bile acid sequestrants, lcsh:RC799-869, Cholestyramine, ALP, alkaline phosphatase, FGF15, fibroblast growth factor 15, SE, standard error, Hepatology, Fibroblast growth factor receptor 4, biology.organism_classification, medicine.disease, Gastrointestinal Microbiome, 030104 developmental biology, Endocrinology, DCA, deoxycholic acid, PCoA, principal coordinates analysis, BSH, bile salt hydrolase, ABX, antibiotics, TLCA, taurolithocholic acid, TMCA, tauromuricholic acid, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease
-
7
المؤلفون: Cristiano Rumio, Fabrizio Marcucci
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 234-245 (2021)مصطلحات موضوعية: 0301 basic medicine, PFKFB3, PFKFB isoform 3, Cancer Research, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, OXPHOS, oxidative phosphorylation, ATG, autophagy related, Apoptosis, Drug resistance, Review Article, TKI, tyrosine kinase inhibitor, Oxidative Phosphorylation, 0302 clinical medicine, Neoplasms, Glycolysis, NADPH, nicotinamide adenine dinucleotide phosphate reduced, media_common, LDH, lactate dehydrogenase, Chemistry, ABC, ATP-binding cassette, mTOR, mechanistic target of rapamycin, EMT, TME, tumor microenvironment, PFKFB, phosphofructo-2-kinase/fructose-2,6-biphosphatase, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell biology, GLUT, glucose transporter, Mitochondria, HIF, hypoxia-inducible factor, PGK1, PGK isoform 1, ENO, enolase, 030220 oncology & carcinogenesis, Efflux, EMT, epithelial-mesenchymal transition, PI3K, phosphoinositide 3-kinase, Drug, PDK1, PDK isoform 1, ATP, adenosine triphosphate, Epithelial-Mesenchymal Transition, media_common.quotation_subject, DDR, DNA damage repair, HK2, HK isoform 2, PPP, pentose phosphate pathway, Antineoplastic Agents, lcsh:RC254-282, 03 medical and health sciences, ROS, reactive oxygen species, Cell Line, Tumor, PGK, phosphoglycerate kinase, PFKP, PFK platelet type, Animals, Humans, LDHA, LDH isoform A, mAb, monoclonal antibody, Tumors, Tumor microenvironment, Innate immune system, Autophagy, Danger, HK, hexokinase, PDH, pyruvate dehydrogenase, EGFR, epidermal growth factor receptor, Metabolic pathway, 030104 developmental biology, Glucose, Drug Resistance, Neoplasm, PK, pyruvate kinase, PKM2, PK isoform M2, ALDO, fructose biphosphate aldolase, ENO1, ENO isoform 1, Energy Metabolism, PDK, pyruvate dehydrogenase kinase
-
8
المؤلفون: Junichi Sadoshima, Daniela Zablocki, Jihoon Nah
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Ischemia, 030204 cardiovascular system & hematology, autophagic flux, STATE-OF-THE-ART REVIEW, Na k adenosine triphosphatase, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, PI3K, phosphatidylinositol 3 kinase, Late phase, ATG, autophagy-related, medicine, rubicon, Na+,K+–adenosine triphosphatase, business.industry, Tat, transactivation of transcription, Autophagy, beclin 1, autosis, PNS, perinuclear space, medicine.disease, I/R, ischemia-reperfusion, HIV, human immunodeficiency virus, 030104 developmental biology, autophagic cell death, Perinuclear space, Cancer research, Molecular mechanism, ATPase, adenosine triphosphatase, Cardiology and Cardiovascular Medicine, business, LBR, lamin B receptor
-
9
المؤلفون: Jifa Zhang, Bo Liu, Liang Ouyang, Honggang Xiang, Congcong Lin, Lan Zhang
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PINK1, PTEN-induced putative kinase 1, Review, PROTAC, proteolysis targeting chimeras, PTMs, post-translational modifications, Protein aggregation, PKCα, protein kinase C alpha type, AKT1, AKT serine/threonine kinase 1, PD, Parkinson's disease, Autophagy-related kinase, DAPK, death associated protein kinase, PKD1, polycystin-1, GAP, GTPase-activating protein, PKACα, a protein kinase cAMP-activated catalytic subunit alpha, 0302 clinical medicine, Human disease, TNBC - Triple-negative breast cancer, Protein kinases, LC3, microtubule-associated protein 1 light chain 3, UVRAG, ultraviolet resistance-associated gene, TFEB, transcription factor EB, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Rheb, the RAS homolog enriched in brain, TAK1, transforming growth factor activated kinase-1, 0303 health sciences, Kinase, mTORC1, mammalian target of rapamycin complex 1, PI3 kinase, phosphoinositide 3-kinase, Cell biology, GSK3α, glycogen synthase kinase 3 alpha, HMGB1, high mobility group protein B1, AMBRA1, autophagy/beclin-1 regulator 1, ULK complex, ULK1–mATG13–FIP200–ATG101 complex, ARF, auxin response factor gene, 030220 oncology & carcinogenesis, TSC1/2, tuberous sclerosis complex proteins 1/2, PIM2, proviral insertion in murine lymphomas 2, LPS, lipopolysaccharide, PI3P, phosphatidylinositol triphosphate, Small-molecule kinase inhibitors/activators, JNK1, C-Jun N-terminal kinase, mTOR, mammalian target of rapamycin, ULK1, unc-51-like kinase 1, Biology, PPIs, protein–protein interactions, PI, phosphatidylinositol, TNBC, triple-negative breast cancer, FIP200, FAK family kinase-interacting protein of 200 kDa, 03 medical and health sciences, 4E-BP1, eukaryotic translation initiation factor 4E-binding protein, Organelle, Autophagy, LRRK2, leucine rich repeat kinase 2, ATG, autophagy-related protein, GO, gene ontology, 030304 developmental biology, PD - Parkinson's disease, lcsh:RM1-950, CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2, Human disease therapy, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, PIP2, phosphatidylinositol-4,5-bisphosphate, LKB1, serine/threonine-protein kinase stk11
-
10
المؤلفون: David Hood, Jonathan Memme, Ashley Oliveira
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: p53, muscle atrophy, mitochondrial biogenesis, ATF4, activating transcription factor 4, log2FC, log2 fold change, Biochemistry, mKO, muscle-specific KO, Mice, transcriptomics, 0302 clinical medicine, GSEA, gene set enrichment analysis, PINK1, phosphatase and tensin homolog–induced kinase 1, ClpP, caseinolytic mitochondrial matrix peptidase proteolytic subunit, SirT3, sirtuin 3, TFEB, transcription factor EB, UPRmt, mitochondrial unfolded protein response, PGC-1α, peroxisome proliferator–activated receptor gamma coactivator 1 alpha, 0303 health sciences, mitochondrial quality control, EDL, extensor digitorum longus, Mitophagy, unfolded protein response, LC3, microtubule-associated proteins 1a/1b light chain 3, CtsD, cathepsin D, Denervation, MQC, mitochondrial quality control, mitochondria, Muscular Atrophy, LonP, lon protease homolog, mitochondrial, CON, control, COX, cytochrome c oxidase, SDH, succinate dehydrogenase, lysosome, HSP, heat shock protein, Research Article, DEN, denervated, REVIGO, reduce and visualize Gene Ontology, CHOP, C/EBP homologous protein, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, GO, Gene Ontology, Animals, skeletal muscle, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Atg, autophagy-related protein, TA, tibialis anterior, ATF5, activating transcription factor 5, Prkn, Parkin, TFE3, transcription factor E3, Cell Biology, p62, sequestosome-1, Mitochondria, Muscle, mtDNA, mitochondrial DNA, Tumor Suppressor Protein p53, qPCR, quantitative PCR, 030217 neurology & neurosurgery
-
11
المؤلفون: Milana Fraiberg, Boris Macek, Zvulun Elazar, Philipp J. Kahle, Anna Lechado Terradas, Katharina Zittlau
المصدر: The Journal of Biological Chemistry
The journal of biological chemistry 297(5), 101339 (2021). doi:10.1016/j.jbc.2021.101339مصطلحات موضوعية: Mitochondrial fission factor, PTM, post-translational modification, Mitochondrial Turnover, MIM, mitochondrial inner membrane, NGLY1, N-glycanase 1, LIR, LC3-interacting region, BNIP, Bcl-2 19 kDa protein-interacting protein, Biochemistry, PD, Parkinson's disease, Mitochondrial Dynamics, DNM1L, FUNDC1, FUN14 domain-containing protein 1, USP, ubiquitin-specific protease, VPS, vacuolar sorting protein, Mitophagy, MFF, mitochondrial fission factor, TFEB, transcription factor EB, MFN, mitofusin, PARL, presenilin-associated rhomboid-like protease, HK2, hexokinase 2, OMA1, overlapping with the mitochondrial matrix ATPase associated with diverse cellular activities (m-AAA) protease 1, Chemistry, phosphorylation, SUMO, small ubiquitin-related modifier, DFCP1, double FYVE domain-containing protein 1, NBR1, next to breast cancer type 1 susceptibility gene 1 protein, DRP1, dynamin-related protein 1, Far, factor arrest, RAB, Ras-associated binding protein, MIRO, mitochondrial Rho GTPase, GCN5L1, general control of amino acid synthesis protein 5-like 1, Cell biology, BAK, Bcl-2 homologous antagonist/killer, Mitochondria, mitochondria, OPA1, optic atrophy protein 1, ddc:540, ARIH1, ariadne-1 homolog in humans, SIRT, sirtuin, Mitochondrial fission, genetics [Mitochondrial Proteins], Signal Transduction, FIS1, autophagy, WIPI, WD40 repeat protein interacting with phosphoinositides, Bcl, B cell lymphoma, TBK1, tumor necrosis factor receptor-associated factor family member associated NF-κB activator-binding kinase 1, NF-κB, nuclear factor-κB, PINK1, PINK1, phosphatase and tensin homolog (PTEN)-induced kinase 1, mTOR, mammalian target of rapamycin, metabolism [Mitochondrial Proteins], CCCP, carbonyl cyanide m-chlorophenyl hydrazone, RING, really interesting new gene, Mitochondrial Proteins, SNARE, soluble N-ethylmaleimide-sensitive factor-attachment protein receptor, ΔΨm, mitochondrial membrane potential, LC3, microtubule-associated protein light chain 3, FKBP8, FK506-binding protein 8, GABARAP, γ-amino-butyric acid receptor-associated protein, MOM, mitochondrial outer membrane, Animals, HOPS, homotypic fusion and protein sorting, ubiquitylation, ATG, autophagy-related protein, FIS1, mitochondrial fission 1 protein, Molecular Biology, gp78, glycoprotein 78, CLEAR, coordinated lysosomal expression and regulation, MGRN1, mahogunin RING finger protein 1, ULK1, uncoordinated protein 51-like kinase 1, protein kinase PINK1, JBC Reviews, BH3, Bcl-2 homology 3 domain, Ubiquitination, AMBRA1, activating molecule in beclin-1 regulated autophagy protein 1, VDAC, voltage-dependent anion selective channel, Cell Biology, metabolism [Mitochondria], HUWE1, homologous to the E6-AP carboxyl terminus (HECT), ubiquitin-associated and WWE domain-containing protein 1, FIP200, focal adhesion kinase-interacting protein of 200 kDa, BAD, Bcl-2 associated agonist of cell death, DUB, deubiquitylating enzyme, Mcl-1, induced myeloid leukemia cell differentiation protein, AMPK, AMP-activated protein kinase, PI3P, phosphatidylinositol 3-phosphate, MUL1, genetics [Mitochondria], TOM, translocase of the outer membrane, mTORC1, mTOR complex 1, Ubl, ubiquitin-like domain, MTS, mitochondrial targeting sequence, MITOL, mitochondrial ubiquitin ligase, ubiquitin ligase parkin, MUL1, mitochondrial ubiquitin ligase 1, NDP52, nuclear dot protein of 52 kDa
-
12
المؤلفون: Qipeng Xie, Zhongxian Tian, Jingjing Wang, Ning Zhang, Jingxia Li, Haishan Huang, Junlan Zhu, Xiaohui Hua, Chao Huang, Chuanshu Huang, Minggang Peng
المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 9, Pp 908-920 (2019)مصطلحات موضوعية: 0301 basic medicine, Original article, Cancer Research, RNA Stability, ATG, Autophagy-related, lcsh:RC254-282, PI3K, Phosphatidylinositol 3-kinase, Autophagy-Related Protein 7, EGF, Epidermal growth factor receptor, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Epidermal growth factor, Cell Line, Tumor, EGFR, Epidermal growth factor receptor, Autophagy, Matrix Metalloproteinase 14, Humans, Receptor, PI3K/AKT/mTOR pathway, Cell Proliferation, Tissue Inhibitor of Metalloproteinase-2, Gene knockdown, MEFs, Mouse embryonic fibroblasts, Chemistry, BC, Bladder cancer, Cell migration, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, MMPs, Matrix metalloproteinases, Class Ia Phosphatidylinositol 3-Kinase, Enzyme Activation, Gene Expression Regulation, Neoplastic, TIMP-2, Tissue inhibitor of metalloproteinase-2, 030104 developmental biology, Urinary Bladder Neoplasms, Cell culture, 030220 oncology & carcinogenesis, Proteolysis, Cancer cell, Cancer research, Matrix Metalloproteinase 2, Ectopic expression
-
13
المؤلفون: Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)مصطلحات موضوعية: GSSG, glutathione disulfide, LOOH, lipid hydroperoxides, NQO1, NAD(P)H:quinone oxidoreductase 1, TLR, toll like receptor, HNE, 4-hydroxynonenal, NAC, N-acetylcysteine, Apoptosis, Review, Bioinformatics, SMAC/DIABLO, second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI, GSH, glutathione, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, Innate immunity, BSO, buthionine sulfoximine, mTORC1, mammalian target of rapamycin complex 1, MCP-1, monocyte chemoattractant protein-1, Mitochondria, CYP, cytochrome P450 enzymes, GPX4, glutathione peroxidase 4, NRF2, nuclear factor erythroid 2-related factor 2, KEAP1, Kelch-like ECH-associated protein 1, LPO, lipid peroxidation, NF-κB, nuclear factor κB, medicine.drug, DMSO, dimethylsulfoxide, Inflammatory response, Gclm, glutamate–cysteine ligase modifier subunit, HMGB1, high mobility group box protein 1, APAP, acetaminophen, ARE, antioxidant response element, RM1-950, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, UGT, UDP-glucuronosyltransferases, Necrotic cell, MPT, mitochondrial permeability transition, Acetaminophen hepatotoxicity, NRF2, ROS, reactive oxygen species, EndoG, endonuclease G, medicine, Autophagy, Injury mechanisms, Ferroptosis, MnSOD, manganese superoxide dismutase, Antipyretic drugs, MDA, malondialdehyde, Drug metabolism, business.industry, ATG, autophagy-related genes, PUFAs, polyunsaturated fatty acids, Liver failure, medicine.disease, CAD, caspase-activated DNase, Gclc, glutamate–cysteine ligase catalytic subunit, Acetaminophen, LC3, light chain 3, AIF, apoptosis-inducing factor, AMPK, AMP-activated protein kinase, DAMPs, damage-associated molecular patterns, JNK, c-jun N-terminal kinase, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, NAPQI, N-acetyl-p-benzoquinone imine, FSP1, ferroptosis suppressing protein 1, MAP kinase, mitogen activated protein kinase
-
14
المؤلفون: Na Zhang, Tao Zhong, Li-Qiang Wang, Xiao-Ling Liu, Bin Dai, Yi Liang, Zhi-Xian Chen, Wang Chen, Jie Chen
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Tau toxicity, ATG5, Tau protein, tau Proteins, Protein aggregation, Biochemistry, protein liquid–liquid phase separation, Autophagy-Related Protein 5, protein aggregation, PI, propidium iodide, chemistry.chemical_compound, Protein Aggregates, myricetin, Alzheimer Disease, ATG, autophagy-related, Cell Line, Tumor, LC3, microtubule-associated protein 1 light chain 3, mental disorders, Autophagy, Humans, Propidium iodide, TEM, transmission electron microscopy, Molecular Biology, PI3K/AKT/mTOR pathway, TAMRA, 5(6)-carboxy-tetramethylrhodamine N-succinimidyl ester, Flavonoids, biology, Fluorescence recovery after photobleaching, FRAP, fluorescence recovery after photobleaching, IP, immunoprecipitation, Cell Biology, Alzheimer's disease, Cell biology, LLPS, liquid–liquid phase separation, ATG5, autophagy-related protein 5, chemistry, biology.protein, Myricetin, Signal Transduction, Research Article
-
15
المؤلفون: Jae Youl Cho, Wooram Choi, Haeyeop Kim, Chang-Kyun Han, Kon Kuk Shin, Jin Kyeong Kim, Sun Hee Hyun, Yo Han Hong, Yi-Seong Kwak
المصدر: Journal of Ginseng Research
Journal of Ginseng Research, Vol 45, Iss 6, Pp 717-725 (2021)مصطلحات موضوعية: 0301 basic medicine, autophagy, Inflammation, Pharmacology, Biochemistry, Genetics and Molecular Biology (miscellaneous), TNF-α, tumor necrosis factor-α, 03 medical and health sciences, Ginseng, 0302 clinical medicine, Korean Red Ginseng (KRG), RT-PCR, reverse transcription polymerase chain reaction, ATG, autophagy-related gene, medicine, NF-κB, nuclear factor-kappa B, Kidney, business.industry, Monocyte, Autophagy, aging, Botany, Interleukin, MCP-1, monocyte chemoattractant protein-1, IL, interleukin, Reverse transcription polymerase chain reaction, 030104 developmental biology, medicine.anatomical_structure, Complementary and alternative medicine, anti-inflammatory effect, QK1-989, 030220 oncology & carcinogenesis, Tumor necrosis factor alpha, medicine.symptom, business, AP-1, activator protein-1, Biotechnology, Research Article, KRG, Korean Red Ginseng
-
16
المؤلفون: Keith Munson, Toshimasa Takahashi, Anna S. Gukovskaya, Iskandar Yakubov, Carli J. Wightman, Ilya Gukovsky, Olga A. Mareninova, Dustin L. Dillon, David W. Dawson, Herbert Y. Gaisano, Masaki Ohmuraya
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 599-622 (2022)
Cellular and molecular gastroenterology and hepatology, vol 13, iss 2مصطلحات موضوعية: Autophagosome, IB, immunoblot, RC799-869, Vacuole, Acinar Cells, Mitochondrion, RabGDI, Arg-AP, L-arginine–induced acute pancreatitis, Cat, cathepsin, Oral and gastrointestinal, Mice, GTPase, guanosine triphosphatase, LC3, microtubule-associated protein 1 light chain 3, 2.1 Biological and endogenous factors, Aetiology, ANOVA, analysis of variance, Original Research, Chemistry, Gastroenterology, Diseases of the digestive system. Gastroenterology, Cell biology, medicine.anatomical_structure, Pancreas, 1.1 Normal biological development and functioning, ATG8, ATG5, SEM, standard error of the mean, ER, endoplasmic reticulum, ATG, autophagy-related (proteins), Underpinning research, Alternative Autophagy, medicine, Autophagy, AP, acute pancreatitis, Animals, CER, cerulein (ortholog of CCK), IF, immunofluorescence, RabGDI, Rab guanosine dissociation inhibitor, Rab9TG, transgenic mice overexpressing Rab9, Hepatology, Autophagosomes, medicine.disease, WT, wild-type, CCK, cholecystokinin-8, Pancreatitis, rab GTP-Binding Proteins, Digestive Diseases, Rab GTPase
وصف الملف: application/pdf
-
17
المؤلفون: Rui Jia, Juan S. Bonifacino
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, NGS, Next-generation sequencing, Ubiquitin-Activating Enzymes, Biochemistry, Deubiquitinating enzyme, Inhibitor of Apoptosis Proteins, Ubiquitin, Sequestosome-1 Protein, LC3, Monoubiquitination, deubiquitination, Gene knockdown, biology, LC3B, microtubule-associated protein 1 light chain 3 beta or MAP1LC3B, Chemistry, Intracellular Signaling Peptides and Proteins, RRA, robust ranking aggregation, Ubiquitin ligase, Cell biology, DUB, deubiquitinating enzyme, CRISPR/cas, Microtubule-Associated Proteins, Ubiquitin Thiolesterase, Deubiquitination, Research Article, autophagy, Cell Line, protein aggregation, MAGeCK, model-based analysis of genome-wide CRISPR-Cas9 knockout, 03 medical and health sciences, CHX, cycloheximide, Cell Line, Tumor, ATG, autophagy-related gene, Endopeptidases, ubiquitin, Gene silencing, Humans, USP10, ubiquitin-specific peptidase 10, tfLC3B, tandem fluorescent-tagged LC3B, Molecular Biology, ALIS, aggresome-like induced structures, KD, knockdown, KO, knockout, 030102 biochemistry & molecular biology, Autophagy, Ubiquitination, Cell Biology, USP10, 030104 developmental biology, biology.protein, Protein Processing, Post-Translational
-
18
المؤلفون: Albin John, Willayat Yousuf Wani, Jayalakshmi Vallamkondu, Suguru Pathinti Ramadevi, Kishore Kumar Jella, Ramesh Kandimalla, P. Hemachandra Reddy
المصدر: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease
Biochimica et Biophysica Acta. Molecular Basis of Diseaseمصطلحات موضوعية: NSP, non-structural protein, 0301 basic medicine, viruses, Disease, Viral Nonstructural Proteins, medicine.disease_cause, Diabetes mellitus, 0302 clinical medicine, CNS, Center nervous System, IFN, Interferons, Viral Envelope Proteins, Central Nervous System Diseases, DM, diabetes mellitus, Pandemic, IL, Interleukin, 030212 general & internal medicine, HAPE, High altitude pulmonary edema, skin and connective tissue diseases, Lung, Coronavirus, AT2 Cells, alveolar epithelial type2 cells, Brain, MERS-CoV, Middle East respiratory syndrome coronavirus, Molecular Medicine, COVID-19, Coronavirus Disease discovered in 2019, Coronavirus Infections, DMV, double-membrane vesicles, medicine.medical_specialty, BBB, blood-brain barrier, Pneumonia, Viral, Therapeutics, Neutralizing antibodies, Antiviral Agents, Article, MS, multiple sclerosis, Multiple sclerosis, NAb's, Neutralizing antibodies, Betacoronavirus, 03 medical and health sciences, ORF, open reading frame, ACE2, Angiotensin-converting enzyme 2, medicine, Animals, Humans, Dementia, SARS-CoV, Severe Acute Respiratory Syndrome Coronavirus, Intensive care medicine, MHV, mouse hepatitis virus, Pandemics, Molecular Biology, SARS-CoV-2, business.industry, ATG, autophagy-related genes, ULK, ubiquitin-like ligase, fungi, COVID-19, Outbreak, HCQ, hydroxychloroquine, ssRNA, single-strand RNA, medicine.disease, body regions, Pneumonia, 030104 developmental biology, COPD, chronic obstructive pulmonary disease, EM, electron microscope, TNF, Tumor Necrosis Factor, Middle East respiratory syndrome, MMPs, matrix metalloproteinases, business, Viral Fusion Proteins
-
19
المؤلفون: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)مصطلحات موضوعية: Review, Mitochondrion, PD, Parkinson's disease, 0302 clinical medicine, FOXO, forkhead box O, Mitophagy, HD, Huntington's disease, TFEB, transcription factor EB, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, TIGAR, TP53-induced glycolysis and apoptosis regulator, Stroke, 0303 health sciences, AMPK, 5′-adenosine monophosphate-activated protein kinase, mTOR, mechanistic target of rapamycin, eIF2a, eukaryotic translation-initiation factor 2, PI3K, phosphatidylinositol 3-kinase, OGD/R, oxygen and glucose deprivation-reperfusion, Cerebral ischemia, ALS, amyotrophic lateral sclerosis, PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase, Neuroprotection, Mitochondria, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, ULK, Unc-51- like kinase, AD, Alzheimer's disease, Intracellular, Programmed cell death, ATF6, activating transcription factor 6, IRE1, inositol-requiring enzyme 1, RM1-950, Natural compounds, IPC, ischemic preconditioning, ER, endoplasmic reticulum, 03 medical and health sciences, COPII, coat protein complex II, LKB1, liver kinase B1, ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential, medicine, Autophagy, Lysosomal activation, ATG, autophagy related genes, 030304 developmental biology, Uro-A, urolithin A, business.industry, FUNDC1, FUN14 domain containing 1, medicine.disease, LC3, light chain 3, GPCR, G-protein coupled receptor, BNIP3L, BCL2/adenovirus, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, Neuroscience, Homeostasis, Neurological disorders, BCL-2, B-cell lymphoma 2
-
20
المؤلفون: Chunzhao Yin, Hongzhi Liu, Ningning Wang, Xia Shen, Huiyong Yin, Min Li, Guijun Liu, Xuxiao He, Wenqiang Bai, Yongzhen Tao, Qiang Wang, Qiaochu Tu
المصدر: Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, Autophagy inhibition, MMP, mitochondrial membrane potential, Hepatocellular carcinoma, Clinical Biochemistry, CQ, chloroquine, Cathepsin D, ATG, autophagy related, Apoptosis, Biochemistry, Cathepsin B, WSG, water-soluble yeast β-D-glucan, Mice, RFP, red fluorescent protein, 0302 clinical medicine, β-D-glucan, Glucans, Lysosomal function, lcsh:QH301-705.5, GFP, green fluorescent protein, chemistry.chemical_classification, lcsh:R5-920, Liver Neoplasms, PCC, Pearson correlation coefficient, medicine.anatomical_structure, lcsh:Medicine (General), Research Paper, Carcinoma, Hepatocellular, Saccharomyces cerevisiae, Caspase 8, 03 medical and health sciences, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, Cell Line, Tumor, medicine, Autophagy, Animals, Baf A1, Bafilomycin A1, HBSS, Hank's Balanced Salt Solution, Antitumour, Cathepsin, Reactive oxygen species, MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3, tbid, truncated BID, Organic Chemistry, Cat D, cathepsin D, 030104 developmental biology, chemistry, lcsh:Biology (General), Cat B, cathepsin B, Cancer research, Lysosomes, Reactive Oxygen Species, HCC, hepatocellular carcinoma, 030217 neurology & neurosurgery
Full Text Finder